Harvard Medical School scientists develop new CRISPR-based tool to study the immune function of genes.
New gene-editing approach could optimize how scientists study the immune system’s role in cancer and other immune-mediated diseases.
The work will help researchers tune surface properties of perovskites, a promising alternative and supplement to silicon, for more efficient photovoltaics.
The eyes have been called the window to the brain. It turns out they also serve as an immunological barrier that protects the organ from pathogens and even tumors, Yale researchers have found.
Researchers at Washington University School of Medicine in St. Louis have found that brain cell activity during sleep is responsible for propelling fluid into, through and out of the brain, cleaning it of debris.
Researchers at The University of Texas MD Anderson Cancer Center built a new atlas of lung cells, uncovering new cellular pathways and precursors in the development of lung adenocarcinoma, the most common type of lung cancer. These findings, published today in Nature, open the door for development of new strategies to detect or intercept the disease in its earliest stages.
L-Nutra Inc., a leading nutrition technology company developing evidence-based Nutrition for Longevity and Nutrition as Medicine programs, is excited to announce the release of a groundbreaking longevity and healthy aging study published in Nature Communications, a prestigious Nature portfolio journal.
Molecules that are induced by light to rotate bulky groups around central bonds could be developed into photo-activated bioactive systems, molecular switches, and more.
The colon is often thought of as one organ, but the right and left parts of the colon have different molecular features in cancers. New research in mice from investigators at the Johns Hopkins Kimmel Cancer Center demonstrates that these regions also have distinct transcriptional programs, or cellular processes, that regulate the development of normal and cancerous cells.
In a first-of-its-kind study, researchers at the Georgia Institute of Technology discovered that sea cucumbers — sediment-eating organisms that function like autonomous vacuum cleaners of the ocean floor — play an enormous role in protecting coral from disease. The problem is, they've been overharvested for more than 100 years, and they're now rare.
As Canada’s flu season collides with record strep A cases and ongoing COVID-19 concerns, a new study is shedding light on our understanding of respiratory immune responses
Cedars-Sinai investigators have detailed a new way that bacteria use iron to cooperate and resist antibiotic treatment. The study, led by the Cedars-Sinai departments of Biomedical Sciences and Pathology and Laboratory Medicine, is published in the peer-reviewed journal Nature Microbiology and is the first to show this type of antibiotic cross-protection.
With time scheduled to use a certain beamline at the National Synchrotron Light Source-II (NSLS-II), scientists from NSLS-II and their partner institutions faced a challenge. They planned on researching a special type of region in magnetic materials that could be useful for next-generation computers. Regions in magnetic materials - called magnetic domains - determine a material's magnetic properties. The scientists wanted to study how these magnetic domains changed over time under the influence of an outside magnetic field.
In a new paper published in the journal Nature, Michigan State University researchers Robert Quinn and Doug Guzior report the discovery of the enzyme responsible for producing microbially conjugated bile acids, some of the most abundant and crucial molecules in our gut.
About eight million people live with Type 1 diabetes (T1D) worldwide, a chronic autoimmune condition in which the body attacks and destroys its own insulin-producing β-cells (pronounced “beta”) in the pancreas, leading to a lack of insulin and inability to regulate blood sugar. It’s not known why the body suddenly perceives its own β-cells as the enemy; some lines of evidence suggest environmental factors such as viral infections may trigger the onset of T1D, others suggest genetics may also play some role.
Groundbreaking research by investigators at Joslin Diabetes Center sheds new light on the specific changes β-cells go through at the onset of T1D. Their findings—published in Nature Cell Biology—offer new avenues for targeted interventions for the chronic autoimmune condition.
The idea that people make decisions based on social context is not a new one in neural economic games. But now, for the first time, researchers publishing in Nature Human Behavior show the impact of the social context may spring from the dynamic interactions of dopamine and serotonin. Researchers built carbon-fiber electrodes that were implanted in patients receiving Deep Brain Stimulation surgery. The method allows researchers to measure more than one neurotransmitter at a time, revealing a dance that has never been seen before
From the invention of the wheel to the advent of the printing press to the splitting of the atom, history is replete with cautionary tales of new technologies emerging before humanity was ready to cope with them.
Undersea anchors of ice that help prevent Antarctica’s land ice from slipping into the ocean are shrinking at more than twice the rate compared with 50 years ago, research shows.
A new study led by the University of Oxford has found that a high proportion of SARS-CoV-2 infections in the general population lead to persistent infections lasting a month or more. The findings have been published today in the journal Nature.
Scientists report a major step toward a simple blood test for Alzheimer’s disease. Researchers at Washington University School of Medicine in St. Louis and Lund University in Sweden showed that a blood test is as good at identifying people in early stages of the disease as cerebrospinal fluid tests approved by the Food and Drug Administration (FDA) for Alzheimer’s diagnosis. The findings indicate that a blood test soon may replace more expensive and invasive brain scans and spinal taps for detecting signs of Alzheimer’s in the brain.
Systemic sclerosis causes the skin to tighten and harden resulting in a potentially fatal autoimmune condition that is associated with lung fibrosis and kidney disease. University of Michigan Health researchers have studied the pathology of systemic sclerosis to understand better the disease and identify key pathways in the disease process that can be targeted therapeutically.
Kun Luo is combining his experience in materials experimentation and theoretical simulations to explain the atomic mechanisms that create special properties in high-performance materials.
Weedy rice is an agricultural pest with a global economic impact. It is an aggressive weed that outcompetes cultivated rice and causes billions of dollars in yield losses worldwide. A study from Washington University in St. Louis offers new insights into genetic changes that give weedy rice its edge over cultivated rice in tropical regions of the world.
Membranes of vertically aligned carbon nanotubes (VaCNT) can be used to clean or desalinate water at high flow rate and low pressure. Recently, researchers of Karlsruhe Institute of Technology (KIT) and partners carried out steroid hormone adsorption experiments to study the interplay of forces in the small pores. They found that VaCNT of specific pore geometry and pore surface structure are suited for use as highly selective membranes. The researchers report in Nature Communications. (DOI: 10.1038/s41467-024-44883-2)
The recent approval of a CRISPR-Cas9 therapy for sickle cell disease demonstrates that gene editing tools can do a superb job knocking out genes to cure hereditary disease.
For the first time, researchers from The University of Queensland (UQ) have mapped out the proteins implicated in the early stages of motor neurone disease (MND).
Cycles of a diet that mimics fasting can reduce signs of immune system aging, as well as insulin resistance and liver fat in humans, resulting in a lower biological age, according to a new USC Leonard Davis School of Gerontology-led study.
Any drug that is taken orally must pass through the lining of the digestive tract. Transporter proteins found on cells that line the GI tract help with this process, but for many drugs, it’s unknown which of those transporters they use to exit the digestive tract.
Published today in Nature Climate Change, the study found that exported used vehicles generate at least 13-53% more emissions per mile than those that are scrapped or on the road in Great Britain.
Microalgae in water are responsible for roughly 50% of the photosynthesis that converts carbon dioxide from the atmosphere into organic carbon. Researchers have now quantified the activity in the microbiome associated with these microalgae to investigate how the microbiome’s members process and exchange carbon and nitrogen from algal cells. They used isotopes and high-resolution imaging mass spectrometry to quantify these exchanges at the single-cell level.
With GPS data from as little as 6% of vehicles on the road, University of Michigan researchers can recalibrate traffic signals to significantly reduce congestion and delays at intersections.
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A team led by scientists at the Case Western Reserve University School of Medicine has identified a new therapeutic approach for combating neurodegenerative diseases.
An ingredient in many toothpastes is sodium fluoride, a compound of fluorine. It is added to protect teeth against decay. But compounds containing fluorine have other practical uses that might surprise you. The U.S. Department of Energy’s Argonne National Laboratory scientists have discovered a fluoride electrolyte that could protect a next generation battery against performance decline.
The U.S. Department of Energy’s Argonne National Laboratory scientists have discovered a new pathway to enhance lithium-sulfur batteries, addressing their major drawback of short lifetimes. The discovery, published in Nature, reveals a previously unknown reaction mechanism that overcomes rapid performance decline in lithium-sulfur batteries.
Researchers at Umeå University in Sweden, led by Professor Felipe Cava, have identified a new family of enzymes that creates a unique type of cross-linking between the building blocks of bacterial cell walls. This discovery could help develop new antibiotics against infectious diseases.
As part of a nationwide collaboration, Broad Clinical Labs researchers have optimized 10 polygenic scores for use in clinical research as part of a study on how to implement genetic risk prediction for patients.
University of Pittsburgh School of Medicine researchers discovered a molecular mechanism by which excessive dietary protein could increase atherosclerosis risk.
An analysis of genomic data from nearly 250,000 participants in the National Institutes of Health’s Research Program has identified more than 275 million previously unreported genetic variations, nearly 4 million of which have potential health consequences. The data, reported Feb. 19 in the journal , constitutes a research resource that is unprecedented in its scale and diversity, as 77% of the participants historically have been underrepresented in biomedical research, and 46% are from underrepresented racial and ethnic minorities.
Cleveland Clinic researchers have identified a new pathway that contributes to cardiovascular disease associated with high levels of niacin, a common B vitamin previously recommended to lower cholesterol.
A revolutionary nanomaterial with huge potential to tackle multiple global challenges could be developed further without acute risk to human health, research suggests.
The qualities of flowing blood, or hemodynamics, hold important insights into vascular diseases, but technological limitations have largely kept measurements of these properties out of reach in the clinic. Now, there may be a potential solution on the horizon.
Scientists at the UCLA Health Jonsson Comprehensive Cancer Center have built and demonstrated the potential efficacy of a new chimeric antigen receptor (CAR) T-cell-based immunotherapy specifically designed to treat patients with cutaneous and rare subtypes of melanoma.