For his work discovering the basis for hemoglobin gene switching and applying those insights to develop a therapy for sickle cell disease and other blood diseases, the Institute for Regenerative Medicine at the University of Pennsylvania awarded Stuart Orkin, MD the third Elaine Redding Brinster Prize in Science or Medicine.
Fernando Muñiz, a research academic from the University of Seville, participates in a discovery that represents a unique opportunity in the fight against climate change.
Bacteria are nearly ubiquitous and have tremendous impacts on human and ecological health. And yet, they remain largely mysterious to us. Princeton MOL faculty Zemer Gitai, Britt Adamson and Ned Wingreen launched a joint effort to develop new tools to help us better understand bacteria.
CAR T cell therapy pioneer Carl June, MD, the Richard W. Vague Professor in Immunotherapy in the Perelman School of Medicine at the University of Pennsylvania and director of the Center for Cellular Immunotherapies (CCI) at Penn Medicine’s Abramson Cancer Center, has been named a winner of the 2024 Breakthrough Prize in Life Sciences.
The Smidt Heart Institute at Cedars-Sinai has earned a prestigious designation for its excellence in adult and pediatric extracorporeal membrane oxygenation, or ECMO—an often lifesaving treatment where blood is pumped outside of a patient’s body to a portable heart-lung machine, giving the patient’s own organs a rest.
New UC Riverside research has revealed COVID’s Achilles heel — its dependence on key human proteins for its replication — which can be used to prevent the virus from making people sick.
Researchers at UT Southwestern Medical Center have discovered an intracellular mechanism that converts protective intestinal cells into disease-driving pathogenic cells, a finding that could lead to improved treatments for patients with inflammatory bowel disease (IBD).
Oak Ridge National Laboratory scientists studied hot springs on different continents and found similarities in how some microbes adapted despite their geographic diversity. The findings yield clues to the evolution of life and whether some of the hardiest microbes may be harnessed for biotechnology.
Researchers have shown that high concentrations of key proteins in human breast milk, especially osteopontin and κ-casein, are associated with a greater abundance of two species of bacteria in the gut of babies: Clostridium butyricum and Parabacteroides distasonis, known to be beneficial for human health and used as probiotics. These results suggest that proteins in breast milk influence the abundance of beneficial gut microbes in infants, playing an important role in early immune and metabolic development.
Ochsner MD Anderson Cancer Center at The Gayle and Tom Benson Cancer Center in New Orleans is proud to be the first institution in Louisiana to use CAR T cell therapy in adults, the revolutionary treatment for certain types of blood cancers.
Scientists at Johns Hopkins All Children’s Hospital are shedding new light on the causes of Type 2 diabetes and offering a potential strategy for developing new therapies, or perhaps, even prevent Type 2 diabetes from developing.
Over the years, dedicated sickle cell disease programs and research initiatives have greatly improved patient care and life expectancy. But, giving these patients the care they require still presents a number of challenges, including inadequate funding for sickle cell programs, lack of research, and limited access to healthcare.
Researchers at Karolinska Institute have developed a novel method using DNA Nanoballs to detect pathogens, aiming to simplify nucleic acid testing and revolutionize pathogen detection.
The study identified a molecule that reduced the spread of the herpes simplex virus in human cells.
FASEB’s Excellence in Science Awards highlight outstanding achievements by women in the biological and biomedical sciences. The awards are bestowed to female scientists demonstrating not only excellence and innovation in their research fields, but exemplary leadership and mentorship as well.
The blood-brain barrier (BBB) has been found to play a significant role in controlling behavior critical to how ant colonies function, according to new research from the Perelman School of Medicine at the University of Pennsylvania.
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The immunotherapy drug, durvalumab, has been the standard of care for patients with stage III non-small cell lung cancer(NSCLC) to improve survival, when prescribed after chemotherapy and radiation therapy.
Researchers at the Icahn School of Medicine at Mount Sinai have identified the structure of a special transporter found in red blood cells and how it interacts with drugs.
Scientists at St. Jude Children’s Research Hospital found that a subset of CD8+ T cells in the brain lessens the activation of microglia and limits disease pathology in a model of Alzheimer’s disease.
Human immune cells are capable of coordinating their own movement more independently than previously thought.
A research team, affiliated with UNIST has achieved a groundbreaking milestone in tissue regeneration by developing a technology that utilizes autologous blood to produce three-dimensional microvascular implants.
September is National Sickle Cell Awareness Month. Johns Hopkins Medicine experts who specialize in sickle cell disease are available to speak with reporters about health equity issues related to sickle cell disease.
Beckman researchers and collaborators received $30 million from the U.S. National Science Foundation to establish the NSF Science and Technology Center for Quantitative Cell Biology.
Russian neurobiologists have created computer software that can automatically analyze and classify the shape of dendritic spines. The program is based on machine learning techniques.
Van Andel Institute scientists and collaborators have identified a key part of a mechanism that annotates genetic information before it is passed from fathers to their offspring.
A newly discovered way of optimising plant enzymes through bioengineering has increased knowledge of how plant material can be converted into biofuels, biochemicals and other high-value products.
We have decided to tell about very interesting method of genetic coding of iron nanoparticles right in cells for MRT-tomography.
Researchers have determined how Leishmaniasis vaccine candidates, created using mutated disease-causing parasites, prompt molecular-level changes in host cells that have specific roles in helping generate the immune response.
A group of researchers has unearthed the secrets behind a tiny but crucial protein that shuttles zinc ions (Zn2+) within our bodies. The discovery offers a deeper understanding of how our cells maintain optimal health.
Our cells are powered by tiny “powerplants” called mitochondria, which transform nutrients into fuel that sustains life. But there’s more to the story of mitochondria, says Van Andel Institute Assistant Professor Sara Nowinski, Ph.D.
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back. Recent developments include a novel computational tool to detect single base pair DNA changes in single-cell sequencing data, a potential target to treat hypertension caused by drugs commonly used in organ transplants, further insights into the steps involved in genetic recombination, a novel treatment target for a subset of adenoid cystic carcinoma (ACC), a combination therapy that improves outcomes in certain patients with acute myeloid leukemia (AML), and a target for treating prolonged cytopenia in patients with relapsed/refractory large B cell lymphoma treated with chimeric antigen receptor (CAR) T cell therapy.
The EMSL User Meeting: Visualizing Chemical Processes Across the Environment is planned for Oct. 3-5 at Pacific Northwest National Laboratory.
Olgica Milenkovic’s group has been developing machine learning approaches that can tell revealing new stories about biological phenomena—but her work has very old roots.
In Journal of Applied Physics, Markus Buehler combines attention neural networks with graph neural networks to better understand and design proteins. The approach couples the strengths of geometric deep learning with those of language models to predict existing protein properties and envision new proteins that nature has not yet devised. Buehler’s model turns numbers, descriptions, tasks, and other elements into symbols for his neural networks to use.
Bacteria in the mouth mostly survived infection — and that’s a good thing, says a Rutgers researcher.
Dr. Yoon Ki Joung and Dr. Juro Lee of the Biomaterials Research Center at the Korea Institute of Science and Technology (KIST), together with Prof. Hun-Jun Park and Dr. Bong-Woo Park of the Catholic University of Korea College of Medicine, have developed a new treatment for myocardial infarction that uses nanovesicles derived from fibroblasts with induced apoptosis to modulate the immune response.
Short-lived proteins control gene expression in cells to carry out a number of vital tasks, from helping the brain form connections to helping the body mount an immune defense. These proteins are made in the nucleus and are quickly destroyed once they’ve done their job.
Researchers at The University of Texas MD Anderson Cancer Center have uncovered a functional role for KRAS mutations in pancreatic cancer and rapidly translated these findings into a novel therapeutic approach combining a KRAS G12D inhibitor with immune checkpoint inhibitors for early- and late-stage KRAS G12D-mutant pancreatic cancer.
The University of Michigan researchers found some bacteria ship cellular cargo by “surfing” along proteins called ParA/MinD ATPases
Now, scientists at The Wistar Institute have discovered a potential target for gastric cancers associated with Epstein-Barr Virus; study results were published in the journal mBio.
As a single organ, our skin is able to perform a broad repertoire of vital functions. Dermatology experts call for a reference guide to single-cell composition of normal human skin, which is still lacking.
The discovery that birds evolved from small carnivorous dinosaurs of the Late Jurassic was made possible by recently discovered fossils of theropods such as Tyrannosaurus rex and the smaller velociraptors. In a way, you could say that dinosaurs are still with us and seen tweeting from your own backyard! Below are the latest research headlines in the Birds channel on Newswise.
According to new research in the journal Immunity, T cells have a nuclear receptor doing something very odd—but very important—to help them fight pathogens and destroy cancer cells.
A new study highlights the potential of artificial DNA structures that, when fitted with antibodies, instruct the immune system to specifically target cancerous cells.
The August 2023 issue of SLAS Technology, the open access journal emphasizing scientific and technical advances across the life sciences, is now available.
Imagine a few roughly cut slices of bread on a plate. With just those slices, could you picture, in fine detail, the loaf they came from?
New animal research suggests that little-studied brain cells known as astrocytes are major players in controlling sleep need and may someday help humans go without sleep for longer without negative consequences such as mental fatigue and impaired physical health.
St. Jude Children’s Research Hospital scientists found that immune cells present in individuals long before influenza infection predict whether the illness is symptomatic.
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