Reducing levels of a spliceosome-associated factor, SYF2, attenuates TDP-43 pathology in models of diverse forms of ALS. Therefore, these findings by Linares et al. indicate that SYF2 suppression may function as a broadly acting therapeutic strategy
The maturation of human induced pluripotent stem cell (hiPSC)-derived neurons in 2D is dependent upon cell attachment, spreading, and pathfinding across a biomaterial substrate. In this issue of Cell Stem Cell, Álvarez et al.1 demonstrate that high
The generation of donor-derived induced pluripotent stem cells (iPSCs) for allogeneic transplantation is a major challenge in regenerative medicine. Yoshida et al. now report on the establishment of an HLA-homozygous haplobank of iPSCs that covers a
A new antimicrobial suture material that glows in medical imaging could provide a promising alternative for mesh implants and internal stitches.
Rockville, Md.—The Association for Research in Vision and Ophthalmology (ARVO) congratulates Tasneem Khatib DM, FRCOphth—recipient of the 2022 Point of View Award. Established by the Point of View Foundation (Fundació Punt de Vista), the award provides a $20,000 cash prize in recognition of an outstanding scholarly article related to efforts to restore vision through regenerative ophthalmology, biotechnology, whole eye transplantation or other approaches.
A new biomaterial that can be injected intravenously, reduces inflammation in tissue and promotes cell and tissue repair. The biomaterial was tested and proven effective in treating tissue damage caused by heart attacks in both rodent and large animal models. Researchers also provided proof of concept in a rodent model that the biomaterial could be beneficial to patients with traumatic brain injury and pulmonary arterial hypertension.
Engineering professor Jamey Young at Vanderbilt University is developing new strategies for engineering the metabolism of cyanobacteria. He is working to create “green cell factories” for producing renewable fuel compounds.
As a component of moors, mosses are important for climate conservation. They are also gaining increasing significance in biotechnology and the manufacture of biopharmaceuticals.
A University of Queensland-led study has shown that expanding global seaweed farming could go a long way to addressing the planet’s food security, biodiversity loss and climate change challenges.
UC San Diego and its collaborating partners have been awarded $10 million from the Howard Hughes Medical Institute to leverage the biomedical promise of viruses known as bacteriophages as new therapeutic agents in the fight against the rising crisis of antibiotic-resistant bacterial infections.
BACKGROUNDThe therapeutic effects of various stem cells in acute liver failure (ALF) have been demonstrated in preclinical studies. However, the specific type of stem cells with the highest therapeutic potential has not been determined. AIMTo
The Chan Zuckerberg Initiative awarded a two-year grant for Advancing Imaging Through Collaborative Projects to Kirk Czymmek, PhD, director of the Donald Danforth Plant Science Center’s Advanced Bioimaging Laboratory, Michele Darrow of Rosalind Franklin Institute, and Paul Verkade of the University of Bristol, along with an international team of eight additional scientists.
In new research published by Biophysical Reports, researchers from Florida State University and Cleveland State University lay out a mathematical model that explains how bacteria communicate within a larger ecosystem. By understanding how this process works, researchers can predict what actions might elicit certain environmental responses from a bacterial community.
Investigators have developed an artificial skin that is even more sensitive than human skin in its ability to detect pressure applied by an object as well as its approach.
Today the U.S. Department of Energy (DOE) and the National Science Foundation (NSF) signed a Memorandum of Understanding (MOU) that will continue a longstanding collaboration on scientific and engineering research and enable increased partnership to address the most important challenges of the 21st century.
NIBIB has established the Center for Biomedical Engineering Technology Acceleration—BETA Center, a new intramural research program to solve a range of medicine’s most pressing problems. The BETA Center will serve the wider NIH intramural research program as a biotechnology resource and catalyst for NIH research discoveries.
Engineers and physicians have developed a wearable ultrasound device that can assess both the structure and function of the human heart. The portable device, which is roughly the size of a postage stamp, can be worn for up to 24 hours and works even during strenuous exercise.
In a new study using a rat model of Crohn’s disease, a biodegradable hydrogel composite loaded with stem cells, developed by Johns Hopkins Medicine researchers, in a collaborative effort with the Whiting School of Engineering, has shown significant success in treating perianal fistulas (PAF) — one of the many complications of Crohn’s disease.
Scientists have taken the first step at estimating the best large-scale uses for food processing waste, first analyzing its contents and, based on those findings, proposing production opportunities ranging from sustainable fuels, biogas and electricity to useful chemicals and organic fertilizer.
Adjuvants are added to vaccines to improve protection, extend the duration of protection and reduce the dose or number of boosters required.
The flexible copper sensor is made from ordinary materials: conductive copper adhesive tape, sheet of transparency film, paper label, nail varnish, circuit fabrication solution, and acetone.
Researchers and chefs at the University of Reading aim to encourage British consumers and food producers to switch to bread containing faba beans (commonly known as broad beans), making it healthier and less damaging to the environment.
Methanogens are microorganisms that produce methane when little or no oxygen is present in their surroundings.
Researchers have designed the first ‘living medicine’ to treat lung infections.
APRINOIA Therapeutics Inc. ("APRINOIA"), a clinical-stage biotechnology company focused on neurodegenerative diseases such as Alzheimer's Disease ("AD") and Progressive Supranuclear Palsy ("PSP"), and Ross Acquisition Corp II (NYSE: ROSS, ROSS.U, ROSS WS) ("ROSS"), a special purpose acquisition company founded by former Commerce Secretary Wilbur Ross, today announced that they have entered into a definitive agreement (the "Business Combination Agreement") for a business combination (the "Business Combination").
Research on fungi underway at the University of Kansas has helped transform tough-to-recycle plastic waste from the Pacific Ocean into key components for making pharmaceuticals.
To tackle the climate crisis, biodiversity loss, and pollution, humanity will need to move to a circular economy, where all resources are recycled.
Human cells are often a mixture of both abnormal and normal DNA – a mosaic, so to speak, and like the art form, this complex montage is difficult to understand. Neuroscience researchers are training computers to unveil new methods for DNA mosaic recognition.
A smart intraocular lens that can be inserted into the eye to diagnose Alzheimer's has been developed for the first time in Korea.
GenVault, one of the nation’s most secure, comprehensive commercial facilities for bioinventory storage and transport, recently received three significant certifications, augmenting its already robust list of certifications, registrations, and compliance.
Lignin, the complex polymer that gives plants their structural integrity, makes them difficult to break down and creates challenges for the creation of biochemicals and bioproducts. Building blocks that are present in small amounts in the lignin of the bioenergy crop poplar are valuable platform chemicals that are easy to “clip-off” during plant deconstruction. Scientists engineered a new type of poplar to have more of a specific building block in its lignin and less lignin overall. This results in wood that is easier to deconstruct and more valuable as a bioproduct raw material.
Arthrex, a global leader in minimally invasive surgical technology, announced today its ACL TightRope implant has received clearance from the U.S. Food and Drug Administration (FDA) for pediatric indications.
A durable copper-based coating developed by Dartmouth College researchers can be precisely integrated into fabric to create responsive and reusable materials such as protective equipment, environmental sensors, and smart filters, according to a recent study.
Despite some hesitation about gene-edited foods, taste trumps everything, according to a Washington State University-led survey of U.S. consumers.
Cheng et al. delineate a comprehensive m6A landscape during acute myeloid leukemia (AML) development and identify PRMT6, regulated by IGF2BP2, acting as a key for leukemia stem cell maintenance by restraining MFSD2A expression and docosahexaenoic ac
Chemical modifications of RNA are regulated by a series of readers, writers, and erasers that dictate gene expression. Two new studies in Cell Stem Cell1,2 identify roles for the N6-methyladenosine (m6A) methyltransferase METTL16 and the m6A reader I
By generating a multiomic cell atlas of embryonic human lungs and establishing a human tip progenitor cell organoid culture system, two recent studies demonstrated the exciting research advances in human lung development.
Serrano et al. used human iPSC-derived cardiomyocytes and deep learning data analysis to establish an in vitro safety margin that predicts clinical proarrhythmic effects of drugs. Their platform shows high accuracy in identifying risky drugs as wel
Organoids provide a platform for recapitulating and exploring development, and synthetic biology offers a toolbox to genetically manipulate cell communication, adhesion, and even cell fate. Using modular synthetic biology tools in organoids will impr
Editors’ note: The Ogawa-Yamanaka Stem Cell Prize recognizes groundbreaking work in translational regenerative medicine using reprogrammed cells. The prize is supported by Gladstone Institutes, in partnership with Cell Press. This article features
While many animals can completely repair injured tissues, the mammalian heart possesses limited regenerative capabilities. Yan and Cigliola et al. show that AAV-mediated, zebrafish-derived tissue regeneration enhancer elements (TREEs) can direct pro
(Cell Stem Cell 26, 657–674; May 7, 2020)
Deng and colleagues identify METTL16, an m6A writer, as a strong dependency in AML. METTL16 exerts its tumor-promoting role by altering the abundance of m6A-regulated proteins, BCAT1 and BCAT2, and rewiring BCAA metabolism in AML.
Building tissues and organs is one of the most complex and important tasks that cells must accomplish during embryogenesis.
Porpiglia and colleagues identify a dysfunctional CD47hi muscle stem cell (MuSC) subset in aged mice, which arises from increased U1 snRNA-driven CD47 alternative polyadenylation. CD47hi MuSCs trigger deleterious thrombospondin-1/CD47 signaling. A th
Sights, smells and sounds of everyday life can supply the triggers that take someone with PTSD right back to the scarring scene they’re trying to forget.
BACKGROUNDIschemic stroke is a condition in which an occluded blood vessel interrupts blood flow to the brain and causes irreversible neuronal cell death. Transplantation of regenerative stem cells has been proposed as a novel therapy to restor
BACKGROUNDSpermatogonial stem cells (SSCs) are the origin of male spermatogenesis, which can reconstruct germ cell lineage in mice. However, the application of SSCs for male fertility restoration is hindered due to the unclear mechanisms of pro
BACKGROUNDThere is still no consensus on which concentration of mesenchymal stem cells (MSCs) to use for promoting fracture healing in a rat model of long bone fracture. AIMTo assess the optimal concentration of MSCs for promoting fracture hea
Intervertebral disc degeneration is the main cause of low back pain. In the past 20 years, the injection of mesenchymal stromal cells (MSCs) into the nucleus pulposus of the degenerative disc has become the main approach for the treatment of lo
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