Scientists from UC San Francisco describe capturing and studying individual metastatic cells from human breast cancer tumors implanted into mice as the cells escaped into the blood stream and began to form tumors elsewhere in the body.
A team of scientists at the Children’s Research Institute at UT Southwestern (CRI) has become the first to use a tissue-clearing technique to localize a rare stem cell population, in the process cracking open a black box containing detailed information about where blood-forming stem cells are located and how they are maintained.
Deploying a set of tools called “exometabolomics,” a Berkeley Lab team harnessed the analytical capabilities of mass spectrometry techniques to quantitatively measure how individual microbes and the biocrust community transform complex mixtures of metabolites from soil. The study published September 22, 2015 in Nature Communications.
Invention of the first integrated circularly polarized light detector on a silicon chip opens the door for development of small, portable sensors could expand the use of polarized light for drug screening, surveillance, etc.
Working with tissue, blood and DNA from six people with precancerous and cancerous lung lesions, a team of Johns Hopkins scientists has identified what it believes are among the very earliest “premalignant” genetic changes that mark the potential onset of the most common and deadliest form of disease.
University at Buffalo researchers and their colleagues at other institutions are publishing a paper online in Nature Communications on Sept. 18 about a new method they developed to more precisely capture how brain cells interact.
According to a study published1 on 14 September in Nature Climate Change, snowpack in the Sierra Nevada Mountains is its lowest level in 500 years. Snowpack is crucial for the water supply of California.
A pair of supermassive black holes appeared to be spiraling together toward a cataclysmic collision that could have big repercussions.
Scientists have identified the precise nerve cells that allow the brain to make a split-second change of course, like jamming on the brakes.
New research on sickle cell disease (SCD) has found that using antibiotics to deplete the body’s microbiome may prevent acute sickle cell crisis and could offer the first effective strategy for warding off the disease’s long-term complications, such as organ failure. The study, conducted by scientists at Albert Einstein College of Medicine and Montefiore Health System, could also lead to better treatment for other inflammatory blood-vessel disorders including septic shock. The findings were published online today in Nature.
BRD4 inhibitors are among the most promising new agents in cancer therapy that are currently evaluated in clinical trials. In a study published in NATURE, a team of researchers at the Research Institute of Molecular Pathology (IMP) and Boehringer Ingelheim in Vienna reveals how leukemia cells can evade the deadly effects of BRD4 inhibition. Understanding this adaptation process could aid the development of sequential therapies to outsmart
University of Vermont scientists have invented a new way to create what they are calling “an electron superhighway” in an organic semiconductor that promises to allow electrons to flow faster and farther--aiding the hunt for flexible electronics, organic solar cells, and other low-cost alternatives to silicon.
Scientists used high-power laser beams at the Department of Energy’s SLAC National Accelerator Laboratory to simulate the shock effects of a meteorite impact in silica, one of the most abundant materials in the Earth’s crust. They observed, for the first time, its shockingly fast transformation into the mineral stishovite – a rare, extremely hard and dense form of silica.
Bacteria aren’t the only nonhuman invaders to colonize the gut shortly after a baby’s birth. Viruses also set up house there, according to new research at Washington University School of Medicine in St. Louis. The study is one of the first surveys of viruses that reside in the intestine, providing a first look at a healthy gut virome.
Three antibiotics that, individually, are not effective against a drug-resistant staph infection can kill the deadly pathogen when combined as a trio, according to researchers at Washington University School of Medicine in St. Louis. They have killed the bug — methicillin-resistant Staphylococcus aureus (MRSA) — in test tubes and laboratory mice, and believe the same strategy may work in people.
"In the hydrogen evolution reaction, the whole game is coming up with inexpensive alternatives to platinum and the other noble metals," says Song Jin, a professor of chemistry at the University of Wisconsin-Madison. In the online edition of Nature Materials that appears today, Jin's research team reports a hydrogen-making catalyst containing phosphorus and sulfur — both common elements — and cobalt, a metal that is 1,000 times cheaper than platinum.
Researchers at Cardiff University have devised a way of increasing the yield of biodiesel by using the waste left over from its production process.
Researchers at Missouri University of Science and Technology have developed a relatively inexpensive and simple way to split water into hydrogen and oxygen through a new electrodeposition method.
Using metallic osmium (Os) in experimentation, an international group of researchers have demonstrated that ultra-high pressures cause core electrons to interplay, which results in experimentally observed anomalies in the compression behavior of the material.
A team of Stony Brook University and international researchers have found that biogenic materials in sea spray may affect ice cloud formation and thus climate on a global scale.
Astronomers using ALMA have discovered an unexpected population of compact interstellar clouds hidden within the nearby dwarf irregular galaxy WLM.
New research led by NYU Langone Medical Center has uncovered why a particular strain of Staphylococcus aureus -- known as HA-MRSA -- becomes more deadly than other variations. These new findings open up possible new pathways to vaccine development against this bacterium, which the Centers for Disease Control and Preventions says accounts for over 10,000 deaths annually, mostly among hospital patients.
Astronomers from the University of California, Irvine and Baltimore’s Space Telescope Science Institute have generated the most accurate statistical description yet of faint, early galaxies as they existed in the universe 500 million years after the Big Bang.
The study, published in Nature Genetics, paves the way for potential personalized medicine approaches for the deadly cancer type.
Multi-institutional, multidisciplinary study looks past antibiotics and sanitation to a third strategy to control infectious disease: Adjusting the landscape of the human body to remove the mechanism that allows pathogens to cause disease.
Through the use of custom-engineered synthetic proteins known as monobodies, scientists have now resolved the atomic structure of the fluoride ion. The study sheds light on the evolution of these channels and enables new approaches to modify their function, with potential applications such as the development of novel antibiotics.
In the breast, cancer stem cells and normal stem cells can arise from different cell types and tap into distinct yet related stem cell programs, according to Whitehead Institute researchers. The differences between these stem cell programs may be significant enough to be exploited by future therapeutics.
In some patients, aggressive cancers can become resistant to chemotherapy and radiation treatments. In a paper published in the journal Nature Communications, University of California, San Diego School of Medicine researchers identified a pathway that causes the resistance and a new therapeutic drug that targets this pathway.
Aggressive cancer growth and alterations in gene activity without changes in DNA sequence (epigenetics) are associated with mutant p53 proteins, which has implications for such difficult-to-treat cancers as those in the pancreas and breast.
A team led by NYIT Assistant Professor Gaberiel Bever has determined that Eunotosaurus africanus is the earliest known branch of the turtle tree of life
A new study by Florida State University is showing that rapid evolution can occur in response to environmental changes.
Scientists discovered a material that exhibits an unprecedented mechanism for carbon dioxide capture-and-release with only small shifts in temperature. The material’s structure closely resembles an enzyme found in plants that captures carbon dioxide for conversion into nutrients.
Scientists can now get a high-resolution view of a sample or the details of the first steps in ultra-fast processes, thanks to researchers at SLAC National Accelerator Laboratory’s Linac Coherent Light Source.
Vaccines to protect against an avian influenza pandemic as well as seasonal flu may be mass produced more quickly and efficiently using technology described today (Sept. 2) by researchers at the University of Wisconsin-Madison in the journal Nature Communications.
Unlike current methods that coat nanoparticles with light-sensitive molecules, a new technique from the Weizmann Institute instead suspends the particles in a light-sensitive medium, then self-assemble. Possible applications include rewritable paper, water decontamination, and a way to precisely deliver medicines.
Scientists correlated atomic-scale defects in graphene with a “bucket brigade” style mechanism that lets protons travel through the graphene. Demonstrating such a mechanism and the prospect for gating it could enable directing proton pathways for improved fuel cells and other uses.
Researchers at the University of Warwick’s School of Engineering are using imaging technologies, that are normally applied to automotive engines and sprays, to image thousands of mosquitoes to help develop better netting and physical protection against the malaria spreading insect.
At extremely high intensities, X-rays stop behaving like the ones in your doctor’s office and begin interacting with matter in very different ways. This “nonlinear” X-ray behavior can only be seen at X-ray free-electron lasers. Recent experiments at the Department of Energy’s SLAC National Accelerator Laboratory have revealed a new, unexpected twist in that behavior that may be one for the textbooks and could change the way these powerful lasers probe matter.
When we move our head, the whole visual world moves across our eyes. Yet we can still make out a bee buzzing by or a hawk flying overhead, thanks to unique cells in the eye called object motion sensors. A new study on mice helps explain how these cells do their job, and may bring scientists closer to understanding how complex circuits are formed throughout the nervous system. The study was funded by the National Institutes of Health, and was published online in Nature.
Scientists have developed a novel approach to control the activity of enzymes through the use of synthetic, antibody-like proteins known as monobodies. The findings have widespread implications for a broad range of industrial, scientific and medical applications in which enzymes are used.
UCSF researchers have developed a technique to build tiny models of human tissues using a process that turns human cells into a biological equivalent of LEGO bricks. These mini-tissues in a dish can be used to study how particular structural features of tissue affect normal growth or go awry in cancer.
Large volcanic eruptions inject considerable amounts of sulphur in the stratosphere which, once converted into aerosols, block sun rays and tend to cool the surface of the Earth down for several years. An international team of researchers has just developed a method, published in Nature Geoscience, to accurately measure and simulate the induced drop in temperature.
Researchers developed a new, protein-based system that can mine certain types of uranium from sea water with exceedingly high affinity and selectivity.
Scientists have – for the first time – precisely tracked the surprisingly rapid process by which light rearranges the outermost electrons of a metal compound and turns it into a catalyst. These details could help scientists predict and control the quick, early steps in reactions vital to renewable fuels.
Johns Hopkins researchers say they have discovered some of the first steps in how a very common gene mutation causes the brain damage associated with both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
St. Jude Children’s Research Hospital and University of Massachusetts Medical School uncover the mechanism underlying the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia
Scientists from The Scripps Research Institute Florida campus have uncovered the structural details of how some proteins interact to turn two different signals into a single integrated output, findings that could aid future drug design.
New research by scientists from the University of Southampton has found that water molecules react differently to electric fields, which could provide a new way to study spin isomers at the single-molecule level.
Scientists who analyzed the genes involved in 10 autoimmune diseases that begin in childhood have found 22 genome-wide signals shared by two or more diseases. These shared gene sites may reveal potential targets for treatment with existing drugs.
JACKSONVILLE, Fla. — Cancer researchers dream of the day they can force tumor cells to morph back to the normal cells they once were. Now, researchers on Mayo Clinic’s Florida campus have discovered a way to potentially reprogram cancer cells back to normalcy.
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right