Immunotherapy — drug treatment that stimulates the immune system to attack tumors — works well against some types of cancer, but it has shown mixed success against lung cancer.
Around 12,000 years ago, the Neolithic revolution radically changed the economy, diet and structure of the first human societies in the Fertile Crescent of the Near East.
Inmazeb (REGN-EB3), developed by Regeneron, is a three-antibody cocktail designed to target the Ebola virus glycoprotein. The drug was first approved for clinical use in October 2020, but its exact mechanism of action has remained unclear.
The complexity of the human brain is unparalleled. Fortunately, thanks to constant progress in neuroscience over the past decades, we have started to make some sense of the human brain.
Vinegar flies use pheromones to ensure that they court and mate with members of the same species. As new fly species split off from a common ancestor, but continue to share the same environment, they need a way to rapidly diversify their pheromones to suppress inter-species mating. New research identifies a link between the genetic instructions for the production and perception of sex pheromones.
Researchers at the Francis Crick Institute and King’s College London have created a tool to predict the effects of different diets on both cancerous cells and healthy cells.
A new study that analyzed the tumor microenvironment of pancreatic cancer revealed the cause of tumor cell resistance to immunotherapy and resulted in new treatment strategies.
People with diabetes who experience periods of low blood sugar — a common occurrence in those new to blood sugar management — are more likely to have worsening diabetic eye disease. Now, researchers at Johns Hopkins Medicine say they have linked such low blood sugar levels with a molecular pathway that is turned on in oxygen-starved cells in the eye.
In new research published by Biophysical Reports, researchers from Florida State University and Cleveland State University lay out a mathematical model that explains how bacteria communicate within a larger ecosystem. By understanding how this process works, researchers can predict what actions might elicit certain environmental responses from a bacterial community.
University of Maryland School of Medicine’s researchers have discovered that a certain type of cell that sits on top of the brain’s smallest blood vessels senses when their brain region needs energy. When glucose levels are low, these cells signal blood vessels to dilate, increasing the blood flow regionally and allowing more energy to fuel that part of the brain.
A leading laboratory in photonics and renewable energy at the University of Ottawa has developed a new method for measuring the solar energy produced by bifacial solar panels, the double-sided solar technology which is expected to meet increased global energy demands moving forward.
This basic scientific research provides a comprehensive structural framework that should help drug developers rationally design safer drugs to relieve severe pain.
Researchers studied human colon cancer tissue samples and animal models and found that exposure to salmonella was linked with colon cancers that developed earlier and grew larger.
A new study led by scientists at La Jolla Institute for Immunology (LJI) shows how ideal antibodies against SARS-CoV-2 hit their marks. Now scientists are looking at how we might harness their power in new antibody therapeutics and even more effective COVID-19 vaccines.
A novel peptide designed by University of California, Irvine researchers has been found to suppress the damaging lung inflammation seen in acute respiratory distress syndrome, or ARDS. Their study, which appears in iScience, describes the first specific treatment designed to prevent the deadly disease, which can appear in patients with severe lung injury from infections with bacteria and viruses, like pneumonia, flu, respiratory syncytial virus (RSV) and COVID-19.
Scientists from the Institut Pasteur, Université Paris Cité, the CNRS and the Collège de France have used paleogenomics to trace 10,000 years of human immune system evolution.
Humans and chimpanzees differ in only one percent of their DNA. Human accelerated regions (HARs) are parts of the genome with an unexpected amount of these differences.
A new study led by Cedars-Sinai and the University of California, San Francisco (UCSF), has determined that altering a cellular process can lead stem cells—cells from which other cells in the body develop—to die or regenerate.
Researchers at Washington University School of Medicine in St. Louis have found that a defect in an enzyme called APT1 interferes with the ability to secrete insulin, contributing to the development of Type 2 diabetes in people who are overweight or obese.
The skin is presumably the largest and one of the most versatile body organs. By providing a physical barrier, it protects our body from environmental assaults.
A newly published study from York University sheds light on the biological underpinnings in sex differences in obesity-related disease, with researchers observing “striking” differences in the cells that build blood vessels in the fatty tissue of male versus female mice.
A Ludwig Cancer Research study has discovered that the immune system’s surveillance of cancer can itself induce metabolic adaptations in the cells of early-stage tumors that simultaneously promote their growth and equip them to suppress lethal immune responses.
UT Southwestern immunologists have uncovered a key pathogenic event prompted by obesity that can trigger severe forms of nonalcoholic fatty liver disease and potential liver failure.
High levels of ammonia in tumors leads to fewer T cells and immunotherapy resistance in mouse models of colorectal cancer, new findings from the University of Michigan Rogel Cancer Center revealed. Researchers found that ammonia inhibits the growth and function of T cells, which are vital for anti-tumor immunity. The findings appear in Cell Metabolism.
Nerve cells need a lot of energy and oxygen. They receive both through the blood. This is why nerve tissue is usually crisscrossed by a large number of blood vessels.
Investigators from the Smidt Heart Institute at Cedars-Sinai have identified how biological pacemaker cells—cells that control your heartbeat—can “fight back” against therapies to biologically correct abnormal heartbeat rates.
Neuroscience graduate students at Children’s Hospital Los Angeles have developed an automated method that could save time and work for laboratories around the country by streamlining the process of identifying and mapping brain cells. Scientists want to understand how brain cells develop over time because the way these cells, called neurons, develop, influences how they function, or how they malfunction in neurodevelopmental disorders.
Researchers from Boston Children’s Hospital and Harvard, using Argonne’s Advanced Photon Source, have characterized the structure of integrins, a type of cell surface receptor involved in the immune response.
Sometimes a name is just a name. Take bears, for example. In Yellowstone National Park, black bears outnumber their brownish-colored grizzly bear cousins, and in coastal areas of the Pacific Northwest, if someone says “brown bear,” they mean grizzly bear. But not all brown bears are grizzly bears.
Scientists at Johns Hopkins Medicine say they have developed a computer model — dubbed quantitative fate mapping — that looks back in the developmental timeline to trace the origin of cells in a fully grown organism.
The developing human lung has been mapped in unprecedented detail, identifying 144 cell states in the early stages of life, and uncovering new links between developmental cells and lung cancer.
A landmark study by researchers at the Department of Energy’s SLAC National Accelerator Laboratory and Stanford University reveals how a tiny cellular machine called TRiC directs the folding of tubulin, a human protein that is the building block of microtubules that serve as the cell’s scaffolding and transport system.
Investigators at Cedars-Sinai conduct more than 2,500 research projects annually, and many of these studies have resulted in new treatments or have opened the door to future innovations.