Don't give up the fight. Read the latest news about drug and antibiotic resistance
NewswiseHere are some of the latest articles that have been added to the Drug Resistance channel on Newswise, a free source for journalists.
Here are some of the latest articles that have been added to the Drug Resistance channel on Newswise, a free source for journalists.
Physicians and researchers from UK HealthCare's Transplant Center and the University of Kentucky Markey Cancer Center conducted a study of patients over the age of 70 with a type of liver cancer called hepatocellular carcinoma (HCC) and how the outcomes of ablative treatments compare to liver transplants. The findings were published in the May 2022 issue of the Journal of the American College of Surgeons.
People with sedentary lifestyles and unhealthy sleep behaviors could develop fatty liver disease, according to new research published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
In mouse studies, UC San Diego researchers report that lactating mothers expose their feeding pups to triclosan, an antimicrobial commonly used in consumer products, resulting in early signs of liver damage.
Clinical advances include treating hematologic cancers with effective targeted therapies, circulating tumor DNA as a biomarker for recurrence with colorectal liver metastases, and using magnetic resonance imaging (MRI) to guide surgical decisions for patients with lateral pelvic lymph node metastases in rectal cancer. Laboratory findings offer new understanding of the pancreatic cancer immune microenvironment, melanoma cell states, TP53 mutation status in acute myeloid leukemia (AML), and potential targets for metastatic prostate cancer and GNAS-mutant colorectal cancer.
Pantothenate acid, also known as vitamin B5, stimulated the production of brown fat in both cell cultures and mice, a new study finds. “[B5] has therapeutic potential for treating obesity and type II diabetes,” researchers conclude. The study was chosen as an APSselect article for July.
Fuad Gandhi Torizal, Tia Utami, Lau Qiau You, Kousuke Inamura, Masaki Nishikawa, Yasuyuki Sakai
Treating liver cancer tumors to shrink them in order to allow the patient to qualify for a liver transplant leads to excellent 10-year post-transplant outcomes, according to new Mount Sinai research published in JAMA Surgery. The results validate current national policies around transplant eligibility.
Researchers have created a liquid biopsy test, which uses two circulating proteins, to test for major liver diseases.
People who have non-alcoholic fatty liver disease, a buildup of fat cells in the liver, may have a higher risk of dementia, according to a new study published in the July 13, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology. Researchers also found that people with this form of liver disease who also have heart disease or who have had a stroke may have an even higher risk of dementia.
p53 is one of the most important proteins in cancer biology. Often referred to as a “guardian of the genome,” p53 becomes activated in response to various cellular stressors like DNA damage.
A longitudinal cohort study of persons with a history of injection drug use has found that more people who inject drugs (PWID) are receiving Hepatitis C virus (HCV) treatment, which is associated with significant reductions in liver disease and mortality.
Researchers at Saint Louis University's School of Medicine, in collaboration with Arrowhead Pharmaceuticals and Takeda Pharmaceuticals, report the first effective drug to treat a rare, genetic liver disease that formerly could only be treated with a liver transplant.
The growing incidence of a potentially cancer-causing liver disease in children is associated with prenatal exposure to several endocrine-disrupting chemicals, Mount Sinai researchers report.
The July issue of The American Journal of Gastroenterology highlights new clinical science including using a smartphone app to assess stool form, rural-urban disparities in cirrhosis mortality, and lung infection risk in severe alcohol-related hepatitis. This issue also includes articles on pediatric IBD, therapy options for Crohn’s disease, a novel endoscopic suturing device, proton pump inhibitors, and more.
UNC School of Medicine scientists discovered that hepatitis A viral replication requires specific interactions between a human protein and a group of enzymes, and they used a molecule to stop replication at this key interactive step, making it impossible for the virus to infect liver cells.
New Mayo Clinic research finds that machine-learning algorithms can help health care staff distinguish the two conditions. In an article published in Mayo Clinic Proceedings, researchers show how algorithms may be effective predictive tools using a few simple variables and routinely available structured clinical information.
Carbon monoxide is best known as a potentially deadly gas. However, in small doses it also has beneficial qualities: It has been shown to reduce inflammation and can help stimulate tissue regeneration.
The human liver has amazing regeneration capabilities: Even if up to 70 percent of it is removed, the remaining tissue can regrow a full-sized liver within months.
In a pair of studies, UC San Diego School scientists have deepened investigations into the genetic origins of nonalcoholic fatty liver disease in children, describing multiple gene variants that contribute to disease risk.
For the first time, a team led by UAH, a part of the University of Alabama System, has characterized the metabolic function of a phosphatase enzyme called mitogen-activated protein kinase phosphatase-2 (MKP-2), as well as the enzyme’s pathophysiology in obesity, Type 2 diabetes and nonalcoholic fatty liver disease.
Afzal A. Siddiqui, Ph.D., director of the Center for Tropical Medicine and Infectious Disease and chair of the Department of Immunology and Molecular Microbiology at the Texas Tech University Health Sciences Center School of Medicine, began his quest to develop a schistosomiasis vaccine in 1991. With funding from the National Institutes of Allergies and Infectious Diseases (NIAID) at the National Institutes of Health (NIH) and the Thrasher Foundation, he began conducting bench studies and pre-clinical development of what was known as the Sm-p80/GLA-SE schistosomiasis vaccine, which would eventually be branded SchistoShield®.
Researchers conducted an original research study utilizing the U.S. Centers for Disease Control and Prevention’s Wide-ranging Online Data for Epidemiologic Research (WONDER) to compare trends in mortality from alcoholic cirrhosis in the U.S. in 1999 with those 20 years later in 2019.
Here are some of the latest articles that have been added to the Aging channel on Newswise, a free source for journalists.
A study of more than 90,000 postmenopausal women found that those who consumed at least one sugar-sweetened beverage daily faced a 78% higher risk of developing liver cancer compared with people who consumed less than three servings per month of such beverages.
Growth hormone improves liver health in patients with nonalcoholic fatty liver disease (NAFLD) by reducing liver fat and inflammation, according to a new study presented Tuesday, June 14 at ENDO 2022, the Endocrine Society’s annual meeting in Atlanta, Ga.
UC San Diego researchers describe connection between pediatric liver disease and increased risk of developing type 2 diabetes. Both rates are rising in children.
While many 21-year-olds celebrate their coming of age in bars and nightclubs, Andrew Solis is celebrating freedom by finally going home—equipped with a new heart and liver—after nearly eight months at Cedars-Sinai.
High fructose consumption should be avoided to prevent the development of non-alcoholic fatty liver disease (NAFLD), according to research being presented Sunday, June 12 at ENDO 2022, the Endocrine Society’s annual meeting in Atlanta, Ga.
Racial and ethnic minorities diagnosed with advanced liver cancer have a lower chance of receiving immunotherapy, the most effective treatment for patients with the disease, according to a new study led by Cedars-Sinai Cancer investigators.
According to ARRS’ American Journal of Roentgenology (AJR), ultrasound-derived fat fraction (UDFF) is strongly associated with MRI proton-density fat fraction (PDFF) and provides high sensitivity for detecting hepatic steatosis.
UC San Diego researchers report that the causes and death rates of liver cancer are changing around the world.
The Liver4Life research team owes its perfusion machine, which was developed in house, to the fact that it became possible to implant a human organ into a patient after a storage period of three days outside a body.
Cells produce proteins like little factories. But if they make too much at the wrong times it can lead to diseases like cancer, so they control production with a process called RNA interference (RNAi).
Scientists have identified a new disease in a ground-breaking discovery that could help patients with unexplained liver and kidney problems.
Nowadays doctors define and diagnose most diseases on the basis of symptoms.
An advanced radiotherapy technique called radiation segmentectomy may be effective against very early to early-stage hepatocellular carcinoma (HCC), a type of liver cancer that cannot be treated surgically or thermally.
A multicenter study performed by a large international consortium that includes UT Southwestern has outlined a set of risk factors and outcomes for patients with autoimmune hepatitis (AIH) that recurs after liver transplantation. The findings, published in the Journal of Hepatology, represent a first step toward better managing and potentially preventing this uncommon condition.
A national policy change to facilitate the broader sharing of donor livers through “acuity circles” has resulted in procurement delays, according to a researcher at the University of Miami Miller School of Medicine.
Scientists make inroads in understanding the relationship between certain enzymes that are normally produced in the body and their role in regulating obesity and controlling liver diseases.
The National Academy of Sciences (NAS) today elected UT Southwestern scientist Jonathan Cohen, Ph.D., into its membership, one of the highest honors for American scientists. Dr. Cohen, Professor of Internal Medicine in the Center for Human Nutrition and the Eugene McDermott Center for Human Growth and Development at UT Southwestern, was elected by his peers in recognition of distinguished and continuing achievements in original research. His research centers on identifying genes that play major roles in the metabolism of cholesterol and triglycerides and elucidating the biological roles of their protein products.
Exercise supports the treatment of non-alcoholic fatty liver disease by impacting on several metabolic pathways in the body, a new study from the University of Eastern Finland shows.
Nanotherapeutics have shed new light onto HCC treatment by enabling site-specific in vivo delivery of chemotherapeutics specifically to neoplastic hepatocytes without affecting normal hepatocytes.
A hormone that triggers puberty and controls fertility in humans might be developed as a treatment for non-alcoholic fatty liver disease, according to new Rutgers research.
Since the start of the COVID-19 pandemic, alcohol use has been on the rise ― and so is alcohol-associated liver disease. Two Penn State Health doctors discuss what alcohol does to the liver and when it’s time for a transplant in this week’s Medical Minute.
A vaccine for hepatitis C has eluded scientists for more than 30 years, for several reasons.
Throughout the month of April—Donate Life Month—experts from Cedars-Sinai Comprehensive Transplant Center and the Smidt Heart Institute are available for interviews on issues related to transplantation, immunology and organ donation.
Here are some of the latest articles that have been added to the Clinical Trials channel on Newswise.
Results from a new study suggest that two sugar substitutes disrupt the function of a protein that plays a vital role in liver detoxification and the metabolism of certain drugs. These sugar substitutes, also known as non-nutritive sweeteners, provide a sweet taste with few or no calories.
While 2021 proved to be a record-breaking year for organ donation in the U.S., many people are still hesitant to register to become a donor. Nationwide, only about 48% of people are registered to be organ donors, according to LifeSource. That's despite surveys showing that 95% of people in the U.S. support organ donation.