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Newswise Special Wire
Tuesday, April 16, 2013

Public edition | newswise.com

Newswise + NCI Cancer Research Wire for 16-Apr-2013
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Cancer Research Wire

Brought to you by Newswise and the National Cancer Institute, working together to promote cancer research news to the public and news media. More stories can be found at the Newswise Cancer News Source.

Transcription Factors Regulating Blood Oxygen Linked to Melanoma Metastases

Researchers at the University of North Carolina have discovered that transcription factors regulating the levels of oxygen in the blood also play a role in the spread of the skin cancer melanoma.

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Journal of Clinical Investigation, April, 8

– University of North Carolina School of Medicine

Innovative Delaware Program Dramatically Reduces Colorectal Cancer Disparities, Mortality Rates Among African American Patients

A study analyzing the impact of the Delaware Cancer Consortium, the state's cancer control program, reports a 41 percent reduction in colorectal mortality rates for African Americans. The study, published April 15 in the Journal of Clinical Oncology, provides analysis on a novel design and approach used to eliminate colorectal cancer disparities for the first time by a state cancer control program.

Journal of Clinical Oncology

– American Society of Clinical Oncology (ASCO)

Scientists Identify New Subtypes of Kidney Cancer, Will Allow Individualized Treatment

Researchers with the Institute of Urologic Oncology and the Department of Urology at UCLA have classified kidney cancer into several unique subtypes, a finding that will help physicians tailor treatment to individual patients and that moves cancer care one step closer to personalized medicine.

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Cancer Discovery

– University of California, Los Angeles (UCLA), Health Sciences

Gene Sequencing Project Finds New Mutations to Blame for a Majority of Brain Tumor Subtype

The St. Jude Children’s Research Hospital – Washington University Pediatric Cancer Genome Project advances understanding of genetic defects underlying childhood low-grade gliomas and identifies promising new drug therapies.

(Embargo expired on 14-Apr-2013 at 13:00 ET)

Nature Genetics

– St. Jude Children's Research Hospital

Soy-Based Compound May Reduce Tumor Cell Proliferation In Colorectal Cancer

Mount Sinai Researchers Present Targets, Treatments for Prostate, Colon, and Ovarian Cancer at the American Association for Cancer Research Annual Meeting

American Association for Cancer Research 2013 Annual Meeting

– Mount Sinai Medical Center

The Cancer Institute of New Jersey Celebrates National Library Week: April 14 - 20

The Cancer Institute of New Jersey joins communities, schools and other institutions across the nation in recognizing National Library Week (April 14 - 20). The Cancer Institute of New Jersey houses its own library known as the Resource and Learning Center, which provides a source of comfort and information for many patients and family members unfamiliar with the many aspects of cancer.

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Expert(s) available

– Cancer Institute of New Jersey

Ludwig Presents Immunotherapy and Epigenetics at AACR

A dozen Ludwig scientists presented the latest advancements in basic and clinical cancer research at this week’s American Association for Cancer Research Annual Meeting. Progress in immunotherapy and epigenetics led the program with important treatment implications for emerging cancer therapy.

AACR Annual Meeting 2013

– Ludwig Institute for Cancer Research

Researchers Engineer 'Protein Switch' to Dissect Role of Cancer’s Key Players

Researchers at the University of North Carolina at Chapel Hill School of Medicine have “rationally rewired” some of the cell’s smallest components to create proteins that can be switched on or off by command. These “protein switches” can be used to interrogate the inner workings of each cell, helping scientists uncover the molecular mechanisms of human health and disease.

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PNAS

– University of North Carolina School of Medicine

Naturally-Occurring Substance Proves Effective Against Deadly Skin Cancer in Test Tube and Mice Studies

For the first time, scientists have demonstrated the mechanism of action of gossypin, a naturally-occurring substance found in fruits and vegetables, as a treatment for melanoma, which causes the majority of deaths from skin cancer.

;Molecular Cancer Therapeutics

– Texas Biomedical Research Institute

Testing for BRAF Genetic Mutation Beneficial Only in Aggressive Thyroid Cancers

Late stage thyroid cancer patients with aggressive disease may benefit from a genetic test, but experts caution that use of this test in early stage patients is inappropriate because it is unlikely to lead to better outcomes, according to an accompanying editorial in JAMA co-authored by two Perelman School of Medicine researchers at the University of Pennsylvania.

(Embargo expired on 09-Apr-2013 at 16:00 ET)

JAMA

– Perelman School of Medicine at the University of Pennsylvania

2-Drug Combo More Effective in Treating Sarcomas

Researchers at Moffitt Cancer Center and colleagues at the University of South Florida have found that when given together, a two-drug combination acts synergistically in test animals modeled with sarcoma tumors. They report that the drug combination of MK-1775 and gemcitabine resulted in a 70 percent decrease in the tumor volume when compared to receiving one drug or the other.

PLOS ONE, 03/08/2013

– Moffitt Cancer Center

Engineered Small Pox May Kill Liver Cancer

As part of a multicenter clinical trial, researchers at University of California, San Diego School of Medicine are evaluating Pexa-Vec (JX-594) to slow the progression of hepatocellular carcinoma or liver cancer. Pexa-Vec is a genetically engineered virus that is used in the smallpox vaccine.

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– University of California, San Diego Health Sciences

Announcements

T Cell Biology Pioneer Allison Wins First AACR Honor for Cancer Immunology

Discoverer of drug to treat T cells, not tumors, receives inaugural AACR-CRI Lloyd J. Old Award in Cancer Immunology

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– University of Texas M. D. Anderson Cancer Center

Gabriel Hortobagyi Honored for Mentoring Minority Researchers

AACR-Minorities in Cancer Research bestows Jane Cooke Wright Lectureship Award

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– University of Texas M. D. Anderson Cancer Center

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