Newswise — In order to validate our observation that Sorafenib was the cause of the gross changes seen in the ileostomy, full thickness biopsies of the ileostomy were taken shortly after Sorafenib was discontinued. There was ulceration of small bowel mucosa and a lack of the expected granulation tissue response as demonstrated by prominent stromal cells and paucity of capillary proliferation fig. 1A, B, C. This was confirmed by the vimentin staining highlighting the prominence of stromal cells fig. 1C. The paucity of endothelial proliferation was illustrated by the lack of CD34 positive cells fig. 1D. These findings are unlike the usual appearances of granulation tissue involved in ulcer related repair and were postulated to be related to the antiangiogenesis effect of Sorafenib.
Fig 1. Histology of stoma: (4 images with captions)
Written byFCS Eng, MD, AM Easson, MD, E Szentgyorgyi, MD, and JJ Knox, MD, as part of Beyond the Abstract on UroToday.com. This initiative offers a method of publishing for the professional urology community. Authors are given an opportunity to expand on the circumstances, limitations etc... of their research by referencing the published abstract.
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European Journal of Surgical Oncology
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