Newswise — ENDO 07 Embargo Policy In general, all abstracts are embargoed until the date and time of their presentation. For Press Briefings the embargo lifts at the date and time of the briefing.

WHAT: Press events scheduled for Monday, June 4, 2007, at ENDO 07, The Endocrine Society's 89th annual meeting at the Metro Toronto Convention Centre. Following brief presentations by participating investigators, questions will be fielded from members of the press. All events will be webcast: http://www.webcastcanada.ca/endo. WHEN: Monday, June 4, 2007 Breaking Research: Bone Health and Vitamin D, 9:30 " 10:30 a.m. EDT"¢ Vitamin D may protect against age-related DNA shortening in women, a known risk factor for heart attacks. Researchers hypothesized that sufficient vitamin D levels may alter aging of chromosomes, which could affect age-related diseases. Unfortunately, vitamin D deficiency is prevalent, especially in elderly persons. Serum Vitamin D Levels and Leukocyte Telomere Length in Women presented by Dr. J. Brent Richards, Centre for Twin Research & Genetic Epidemiology, King's College, London"¢ The effects of Vitamin D insufficiency are well studied in women but not in African American males. This study suggests that in African American men, vitamin D insufficiency may contribute to lower hip bone mineral density. Vitamin D Insufficiency Is Associated with Lower Hip Bone Density in African American Men presented by Dr. Elena Barengolts, Henry Ford Hospital, Detroit."¢ Menstrual disorders, low bone density and fractures are common in young women who exercise regularly or restrict their diets, resulting in low energy availability. Reproductive function in adolescents is dependent on energy availability. Although this need is greatly reduced in adults, low energy availability continues to impair bone formation in adults as it does in adolescents. Low Energy Availability Impairs Bone Formation Similarly in Older Adolescent and Young Adult Women presented by Dr. Anne Loucks, Ohio University, Athens, OH.

Weight Loss Maintenance: Preventing Weight Gain, 11:30 " 12:30 p.m. EDT"¢ Three key researchers in the field of weight loss and treatment will discuss current topics and new research."¢ Although lifestyle and drug interventions for obesity can induce weight loss, their ability to promote weight maintenance is questionable. Data suggest this may be due to leptin resistance, which persists even with drug therapy. Leptin resistance causes reduced energy expenditure and increased appetite, insulin secretion, and energy storage; all of which interfere with further weight loss. Future treatments may include a combination of leptin and insulin therapies. Pharmacotherapy to Avoid Weight Regain presented by Dr. Robert Lustig, University of California-San Francisco. "¢ Behavioral changes play a key role in long-term successful weight control, including diet and activity but also techniques such as "weighing in," avoiding television and learning to love eating breakfast. Key learnings from the STOP REGAIN program and the National Weight Control Registry will be presented. Behavioral Aspects of Long-Term Successful Weight Control presented by Dr. Suzanne Phelan, Brown University Medical School and The Miriam Hospital."¢ Understanding how energy metabolism is altered in obese individuals and in individuals who lose weight is helping determine how to successfully maintain the weight loss. . Physiology of the Reduced Obese State presented by Dr. Holly Wyatt, University of Colorado Health Science Center, Denver.

WHERE: Metro Toronto Convention Centre255 Front Street WestToronto, Ontario News Room: 206E (North): Phone (416) 585-3624; Fax: (416) 585-3629

Founded in 1916, The Endocrine Society is the world's oldest, largest, and most active organization devoted to research on hormones and the clinical practice of endocrinology. Today, The Endocrine Society's membership consists of over 14,000 scientists, physicians, educators, nurses and students in more than 80 countries. Together, these members represent all basic, applied, and clinical interests in endocrinology. The Endocrine Society is based in Chevy Chase, Md. To learn more about the Society, and the field of endocrinology, visit our web site at http://www.endo-society.org.

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ENDO 07