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Medicine

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HMS, Chris Harvey, Neuroscience, Navigation, Memory, Plasticity, Brain, Neurons, Learning, neuronal network, Cell journal, Neurobiology, Memory formation

Mind Flex

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New research from Harvard Medical School casts doubt on the prevailing model of memory formation, suggesting that the brain may be far more flexible and less rigid in the way it incorporates, stores and recalls information.

Science

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ants, Social Insects, Genetic Engineering, Danny reinberg, Smell, orco

Genetically Engineered Ants Showcase Smell’s Role in Social Behavior

After creating mutant Indian jumping ants with no sense of smell, HHMI Investigator Danny Reinberg and colleagues saw profound abnormalities in the ants’ behavior and brains. The results show that the sense of smell is fundamental to maintaining colony harmony.

Medicine

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Neuroscience, Neurological Disorders, Stem Cells, Auto Immune Disease, Genetics, Aicardi-Goutieres Syndrome

Novel Stem Cell-Derived Model Created of Inflammatory Neurological Disorder

An international team of scientists, led by University of California San Diego School of Medicine researchers, has created a human stem cell-based model of a rare, but devastating, inherited neurological autoimmune condition called Aicardi-Goutieres Syndrome (AGS). In doing so, the team was able to identify unusual and surprising underlying genetic mechanisms that drive AGS and test strategies to inhibit the condition using existing drugs.

Science

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CRISPR, Gene Editing, ALS, Huntington's Disease, Genetics, Cell Biology, Biotechnology, Molecular Biology, Neurology, Neurobiology

New Version of DNA Editing System Corrects Underlying Defects in RNA-based Diseases

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Until recently, CRISPR-Cas9 gene editing could only be used to manipulate DNA. In 2016, University of California San Diego School of Medicine researchers repurposed the technique to track RNA in live cells in a method called RNA-targeting Cas9. In a study published August 10 in Cell, the team took RCas9 a step further: they corrected molecular mistakes that lead to microsatellite repeat expansion diseases, which include a type of ALS and Huntington's disease.

Science

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Metabolism, Aging, Caloric Restriction, Circadian Rhythm

Link Between Biological Clock and Aging Revealed

UCI scientists studying how aging affects the biological clock’s control of metabolism have discovered that a low-calorie diet helps keep these energy-regulating processes humming and the body younger.

Medicine

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Gene Therapy, skin transplant, Obesity, Diabetes, CRISPR, glucagon-like peptide 1

Gene Therapy via Skin Could Treat Many Diseases, Even Obesity

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A research team has overcome challenges that have limited gene therapy. They demonstrate how their novel approach with skin transplantation could enable a wide range of gene-based therapies to treat human diseases. The researchers provide “proof-of-concept,” treating mice with two common related human ailments: type-2 diabetes and obesity.

Medicine

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Cancer, Colorectal Cancer, Chemoresistance, Immunotherapy

Cancer-Death Button Gets Jammed by Gut Bacterium

Researchers at Michigan Medicine and in China showed that a type of bacterium is associated with the recurrence of colorectal cancer and poor outcomes. They found that Fusobacterium nucleatum in the gut can stop chemotherapy from causing a type of cancer cell death called apoptosis.

Science

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Biological and Environmental Research, biological and environmental sciences, Basic Energy Research, Basic Energy Sciences, SSRL, Stanford Synchrotron Radiation Lightsource, Biology, Light Source, lightsource, Molecular Biology, Virus, zika virus, Zika Virus prevention, structural molecular biology, cell, Antibodies, Brazil, Structural Molecular Biology Pr

On Track Towards a Zika Virus Vaccine

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Antibody’s molecular structure reveals how it recognizes the Zika virus

Medicine

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Cancer, Metastasis, Metastasis research, LOX, cancer surgery, Israel

Discovery Could Lead to Ways for Decreasing Metastatic Disease

An international research team has discovered a central mechanism that accelerates the development of metastases after surgery for cancerous tumors in the abdominal area. This study provides a possible treatment modality for cancer patients that can decrease incidence of deadly metastatic disease.

Medicine

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Research, Calories, Circadian Rhythms, O’Donnell Brain Institute, Ut Southwestern

Study: Eating at ‘Wrong Time’ Affects Body Weight, Circadian Rhythms

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A new high-precision feeding system for lab mice reinforces the idea that the time of day food is eaten is more critical to weight loss than the amount of calories ingested.







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