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Medicine

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Bacteriology, Microbiology, Cell Biology, Biotechnology, Pharmaceutical Science, Pulmonary and Respiratory Medicine, Cystic Fibrosis, Metabolomics, 3d modeling

The Microbial Anatomy of an Organ

University of California San Diego researchers have developed the first 3D spatial visualization tool for mapping “’omics” data onto whole organs. The tool helps researchers and clinicians understand the effects of chemicals, such as microbial metabolites and medications, on a diseased organ in the context of microbes that also inhabit the region. The work could advance targeted drug delivery for cystic fibrosis and other conditions where medications are unable to penetrate.

Science

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Whitehead Institute, David M. Sabatini, Mtor, Pancreatic Cancer, Nutrients, Cell Growth

Study Reveals Key Molecular Link in Major Cell Growth Pathway

A team of scientists has uncovered a surprising molecular link connecting how cells regulate growth with how they sense and make available nutrients. The findings also implicate a new protein as a potential drug target in pancreatic cancer.

Medicine

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Influenza, Viruses, Virology, H7N9, flu, Bird Flu

H7N9 Influenza Is Both Lethal and Transmissible in Animal Model for Flu

In 2013, an influenza virus began circulating among poultry in China. It caused several waves of human infection and as of late July 2017, nearly 1,600 people had tested positive for avian H7N9. Nearly 40 percent of those infected had died. In 2017, Yoshihiro Kawaoka of the University of Wisconsin-Madison received a sample of H7N9 virus isolated from a patient in China who had died of the flu. He and his research team subsequently began work to characterize and understand it.

Medicine

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ferroptosis, Hülya Bayɪr, Valerian Kagan, Sally Wenzel, Cell Death, PEBP1, Asthma, Kidney Injury, Brain Trauma, 15LO

Tracing Cell Death Pathway Points to Drug Targets for Brain Damage, Kidney Injury, Asthma

University of Pittsburgh scientists are unlocking the complexities of a recently discovered cell death process that plays a key role in health and disease, and new findings link their discovery to asthma, kidney injury and brain trauma. The results, reported today in the journal Cell, are the early steps toward drug development that could transform emergency and critical care treatment.

Medicine

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Cancer, Cornell, Center for Disease Control and Prevention, Center for Disease, cell

New Findings Explain How UV Rays Trigger Skin Cancer

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Melanoma, a cancer of skin pigment cells called melanocytes, will strike an estimated 87,110 people in the U.S. in 2017, according to the Centers for Disease Control and Prevention. A fraction of those melanomas come from pre-existing moles, but the majority of them come from sources unknown – until now.

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3-D Packaging of DNA Regulates Cell Identity

A new study suggests that the ability of a stem cell to differentiate into cardiac muscle (and by extension other cell types) depends on what portions of the genome are available for activation, which is controlled by the location of DNA in a cell’s nucleus.

Medicine

Science

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Autism, Autism Spectrum Disorder, whole genome sequencing, Genetic Test, Simons Simplex Collection, Evan

Whole Genome Sequencing Identifies New Genetic Signature for Autism

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An analysis of the complete genomes of 2,064 people reveals that multiple genetic variations could contribute to autism. The work suggests that scanning whole genomes may one day be useful for clinical diagnostics.

Medicine

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Mark Lemmon, PhD, Yale Cancer Center, EGFR, Epidermal Growth Factor Receptor, Cancer, Cancer Drugs, Cancer Treatment

Crystallizing Discovery on a Key Target for Cancer Drugs

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Yale Cancer Center scientists now have made a fundamental discovery about EGFR signaling, reported in the journal Cell, that may open the potential for new types of cancer drugs.

Medicine

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Johns Hopkins, Hypertrophic Cardiomyopathy, Enlarged Heart, Anthony Cammarato

Fruit Fly Muscles with a Hypertrophic Cardiomyopathy Mutation Don’t Relax Properly

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Using fruit flies, Johns Hopkins researchers have figured out why a particular inherited human heart condition that is almost always due to genetic mutations causes the heart to enlarge, thicken and fail. They found that one such mutation interferes with heart muscle’s ability to relax after contracting, and prevents the heart from fully filling with blood and pumping it out.

Medicine

Science

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SBP Medical Discovery Institute, Cancer, p62 protein, ATF4

New Insights on the Addictions of Tumors

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Stromal tissue may provide novel targets to disrupt tumor supply lines







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