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Medicine

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Influenza, Viral, Immunology, BEZ235, St. Jude Children's Research Hospital, Influenza Virus

A New Strategy Reported to Combat Influenza and Speed Recovery

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St. Jude Children’s Research Hospital scientists have used a drug being developed to fight solid tumors to restore normal metabolism in flu-infected cells and reduce viral production without the threat of drug resistance

Medicine

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Acute Myeloid Leukemia, Cancer, Genetics, DNA

Study Leads to Breakthrough in Better Understanding Acute Myeloid Leukaemia

A study led by the University of Birmingham has made a breakthrough in the understanding of how different genetic mutations cause acute myeloid leukaemia.

Medicine

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Ebola, Viruses, Virus, Vaccines, Antibodies, Epidemic, Research, Global Health, Disease, Prevention, Infection, Infectious Diseases

Researchers Discover First Human Antibodies That Work Against All Ebolaviruses

After analyzing the blood of a survivor of the 2013-16 Ebola outbreak, a team of scientists from academia, industry and the government has discovered the first natural human antibodies that can neutralize and protect animals against all three major disease-causing ebolaviruses. The findings, published online today in the journal Cell, could lead to the first broadly effective ebolavirus therapies and vaccines.

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blood-brain barrier, Allan-Herndon-Dudley syndrome, Clive Svendsen

Scientists Show How Defects in Blood-Brain Barrier Could Cause Neurological Disorder

Scientists for the first time have assembled a "disease in a dish" model that pinpoints how a defect in the blood-brain barrier can produce an incurable psychomotor disorder, Allan-Herndon-Dudley syndrome. The findings point to a path for treating this syndrome and hold promise for analyzing other neurological diseases.

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Endothelial Cells, Huntington’s disease, Blood Vessels

Basis of ‘Leaky’ Brain Blood Vessels in Huntington’s Disease Identified

By using induced pluripotent stem cells to create endothelial cells that line blood vessels in the brain for the first time for a neurodegenerative disease, University of California, Irvine neurobiologists and colleagues have learned why Huntington’s disease patients have defects in the blood-brain barrier that contribute to the symptoms of this fatal disorder.

Medicine

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Stem Cells, Diseases, Pharmaceuticals, Brain, Neurological Deficits, Thyroid Hormone

Patient’s cells used to replicate dire developmental condition

A team of scientists from the University of Wisconsin-Madison and Cedars-Sinai in Los Angeles have used the cells of AHDS patients to recreate not only the disease, but a mimic of the patient’s blood-brain barrier in the laboratory dish using induced pluripotent stem cell technology.

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Science

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antibiotic resisistance, Antibiotic Resistant Bacteria, dinosaur extinction

Antibiotic-Resistant Microbes Date Back to 450 MYA, Well Before the Age of Dinosaurs

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Leading hospital “superbugs,” known as the enterococci, arose from an ancestor that dates back 450 million years — about the time when animals were first crawling onto land (and well before the age of dinosaurs), according to a new study.

Science

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Mutualism, Symbiosis, Symbiotic Bacteria, Weevil, Quorum Sensing, Sodalis

Controlling Bacteria’s Necessary Evil

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Until now, scientists have only had a murky understanding of how these relationships arise. Now Colin Dale and his colleagues at the University of Utah have an answer. It’s good news and bad news, germophobes: The bad news? Mutualistic bacteria start out by invading animal cells just like malevolent disease-causing bacteria do. The good news? Once they’re in, they calm down and play nice.

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Mount Sinai Health System, Lung Cancer, Immunotherapy, PD-1, PD-1 blockade, PD-L1 checkpoint inhibitors, Thoracic Surgery

Researchers Identify Immunotherapy Targets in Early-Stage Lung Cancer

Immunotherapy, which has achieved remarkable results in late-stage lung cancer patients, can also hold great hope for newly diagnosed patients, cutting the deadly disease off before it has the chance to take hold and offering a potential cure, according to a new Mount Sinai study published today in Cell.

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Diabetes, Endocrinology, Metabolic Diseases, Cell Biology, Beta Cells

Pathways Leading to Beta Cell Division Identified, May Aid Diabetes Treatment

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Pancreatic beta cells help maintain normal blood glucose levels by producing the hormone insulin — the master regulator of energy (glucose). Impairment and the loss of beta cells interrupts insulin production, leading to type 1 and 2 diabetes. Using single-cell RNA sequencing, researchers at University of California San Diego School of Medicine have, for the first time, mapped out pathways that regulate beta cell growth that could be exploited to trick them to regenerate.







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