The article "A Blueprint to Advance Colorectal Cancer Immunotherapies” was written by leaders in oncology and immunotherapy convened by Fight Colorectal Cancer and Cancer Research Institute with the intent of furthering and guiding colorectal cancer research.
Using data from blood and brain tissue, a team led by researchers at Johns Hopkins Bloomberg School of Public Health found that they could gain insights into mechanisms that might help explain autism by analyzing the interplay between genes and chemical tags that control whether genes are used to make a protein, called epigenetic marks.
Researchers may have found a way to treat insulin resistance, a precursor to type 2 diabetes, while avoiding side effects such as weight gain.
Research to Prevent Blindness-supported researchers in New York (at Columbia University and University of Rochester) made a critical discovery about the gene mutation that causes many retinal degenerative diseases, opening the door for a new line of research into potential treatments.
Sound waves could be the future of biomedical research, diagnosing and treatment, says Peng Li, a chemistry professor at West Virginia University. Li is a data analyst for an ongoing research study using an acoustic device to separate extracellular vesicles for a deeper look at their properties.
Rutgers University–New Brunswick and other institutions have discovered a “molecular pencil sharpener” that chews away its outer coating to release a powerful antibiotic. Their discovery opens the door to finding new antibacterial agents and drugs to fight toxins.
A team of researchers from the University of Wisconsin-Madison reports that in long-lived animals, renewed but thin myelin sheaths are enough to restore the impaired nervous system and can do so for years after the onset of disease.
New research from the University of Illinois at Chicago College of Medicine suggests that the lung microbiome plays a significant role in asthma severity and response to treatment.
Researchers at University of Utah Health have identified a protein (ARF6) that when inhibited reduces diabetic retinopathy, a condition that results when blood vessels at the back of the eye leak fluid into the eye, impairing vision.
An international team of scientists, led by structural biologists at Van Andel Research Institute, has shed new light on a critical step in DNA replication, offering fresh insights into a fundamental process of life and driver of many different diseases, including cancer.
The scientific leader of Chan Zuckerberg Initiative to kick off 2017 ASCB|EMBO Meeting in Philadelphia.
As cells with a propensity for cancer break down food for energy, they reach a fork in the road: They can either continue energy production as healthy cells, or shift to the energy production profile of cancer cells. In a new study, University of Wisconsin–Madison researchers map out the molecular events that direct cells’ energy metabolism down the cancerous path. Their findings could lead to ways to interrupt the process.
Researchers found that in B cell tumors, mutated overactive versions of the Notch protein directly drive the expression of the Myc gene and many other genes that participate in B cell signaling pathways. Myc is a critical gene in governing cell proliferation and survival.
When babies are born with atypical sex anatomy, how a hospital responds has a major impact on a family’s experience and decisions about sometimes irreversible procedures.
By combining engineered polymeric materials known as hydrogels with complex intestinal tissue known as organoids – made from human pluripotent stem cells – researchers have taken an important step toward creating a new technology for controlling the growth of these organoids and using them for treating wounds in the gut that can be caused by disorders such as inflammatory bowel disease (IBD).
Three faculty members from the Icahn School of Medicine at Mount Sinai have been elected to the National Academy of Medicine (NAM).
Scientists combine biology, nanotechnology into composites that light up upon chemical stimulation.
A new five-year study of nearly 1,600 patients finds that genetic testing can help determine the safest dose of the blood thinner warfarin, with fewer side effects, in patients undergoing joint replacement surgery.
A new study from UT Southwestern suggests that more people with Duchenne muscular dystrophy could live longer by identifying and more aggressively treating patients with certain risk factors.
Biologists have uncovered a mechanism linking a human gene’s function to chronic inflammation and cancer. They discovered that “mutant p53” taps the body’s immune response system to fuel pro-inflammatory responses that increase cancer growth.
Following a successful clinical trial involving Dana-Farber Cancer Institute and Brigham and Women’s Hospital, the first chimeric antigen receptor (CAR) T-cell therapy for adult cancers was approved by the Food and Drug Administration (FDA) today. Dana-Farber/Brigham and Women’s Cancer Center, the only facility in the northeast to be part of the clinical trial, is one of a few locations certified to offer this new therapy nationwide.
University of California San Diego researchers have developed the first 3D spatial visualization tool for mapping “’omics” data onto whole organs. The tool helps researchers and clinicians understand the effects of chemicals, such as microbial metabolites and medications, on a diseased organ in the context of microbes that also inhabit the region. The work could advance targeted drug delivery for cystic fibrosis and other conditions where medications are unable to penetrate.
A protein shaped like a "Y" makes scientists do a double-take and may change the way they think about a protein sometimes implicated in glaucoma. The Y is a centerpiece in myocilin, binding four other components nicknamed propellers together like balloons on strings.
In a study in today’s issue of Science, researchers at Albert Einstein College of Medicine, part of Montefiore Medicine, report that certain nerves sustain prostate cancer growth by triggering a switch that causes tumor vessels to proliferate. Their earlier research—which first implicated nerves in fueling prostate cancer—has prompted Montefiore-Einstein to conduct a pilot study testing whether beta blockers (commonly used for treating hypertension) can kill cancer cells in tumors of men diagnosed with prostate cancer.
A team of scientists has uncovered a surprising molecular link connecting how cells regulate growth with how they sense and make available nutrients. The findings also implicate a new protein as a potential drug target in pancreatic cancer.
A new study published online this week in the American Journal of Human Genetics from Penn researchers uncovers the mechanisms of the genetic mutations, or variants, associated with the TMEM106B gene.
University of Pittsburgh scientists are unlocking the complexities of a recently discovered cell death process that plays a key role in health and disease, and new findings link their discovery to asthma, kidney injury and brain trauma. The results, reported today in the journal Cell, are the early steps toward drug development that could transform emergency and critical care treatment.
Small RNA molecules originally developed as a tool to study gene function trigger a mechanism hidden in every cell that forces the cell to commit suicide, reports a new Northwestern Medicine study, the first to identify molecules to trigger a fail-safe mechanism that may protect us from cancer.
A new animal study shows how insulin controls the movement and storage of fat molecules in the liver and how a breakdown in this system could lead to non-alcoholic fatty liver disease and changes in circulating lipid levels associated with cardiovascular disease.
Breast cancer cells recycle ammonia, a waste byproduct of cell metabolism, and use it as a source of nitrogen to fuel tumor growth. The insights shed light on the biological role of ammonia in cancer and may inform the design of new therapeutic strategies to slow tumor growth.
Ben Garcia is working with Professor Marty Condon on a long-running research project that focuses on the evolutionary biology of some unique flies, the flowers they live on, and their predators, to better understand the diverse species from Central and South America.
Wearable sensors are revolutionizing the tech-world, capable of tracking processes in the body, such as heart rates. They’re even becoming fashionable, with many of them sporting sleek, stylish designs. But wearable sensors also can have applications in detecting threats that are external to the body. Researchers now report in ACS Sensors a first-of-its kind device that can do just that. And to stay fashionable, they’ve designed it as a ring.
Science has long inspired the arts, but examples of the reverse scenario are sparse. Now scientists who set out to produce a “Star Wars” parody have inadvertently created such an example. Incorporating animation techniques from the film industry, the researchers developed a robust new modeling tool that could help spur new molecular discoveries. Their project, reported in ACS Nano,resulted in a short film about fertilization called “The Beginning.”For a look behind-the-scenes, watch ACS' Headline Science video.
In a paper published in Nature Communications, Christoph Adami, Michigan State University professor of microbiology and molecular genetics, and graduate student Thomas LaBar have provided a look at how certain species survive by evolving a greater ability to weed out harmful mutations – a new concept called “drift robustness”.
A targeted therapy resurrected by the Moon Shots Program™ at The University of Texas MD Anderson Cancer Center has produced unprecedented response rates among patients with metastatic non-small cell lung cancer that carries a highly treatment-resistant mutation.
A Northwestern University research team has discovered how scalding heat and tissue injury activate an ancient “pain” receptor in simple animals. The findings could lead to new strategies for analgesic drug design for the treatment of humans.The simplest (and often first) component of our experience of pain is called “nociception."
Scientists have discovered for the first time how to accurately predict cellular radiation resistance without actually irradiating cells, instead measuring their internal ‘manganese-complexes’ responsible for resistance. This new broad measure of radiation resistance opens exciting scientific possibilities such as: allowing for more personalized cancer treatments, development of radioprotectors needed for astronauts to get to Mars and back, all while minimizing the need for animals in radiation studies, according to “Across the Tree of Life, Radiation Resistance is Governed by Antioxidant Mn2+, Gauged by Paramagnetic Resonance” published in the October 17 online issue of the Proceedings of the National Academy of Sciences USA.
Scientists have for the first time shown that a novel compound effectively suppresses production of the virus in chronically infected cells.
Prof. Uri Nir, of the Mina and Everard Goodman Faculty of Life Sciences at Bar-Ilan University, and his team have identified an enzyme that supports the survival and dissemination of metastatic cells, and developed a synthetic compound that targets the enzyme and kills the metastatic cells in mice with cancer.
A team of neuroscientists has uncovered a neural network that can restore diaphragm function after spinal cord injury. The network allows the diaphragm to contract without input from the brain, which could help paralyzed spinal cord injury patients breathe without a respirator.
A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) identifies potential new therapeutic avenues for patients with Alagille syndrome.
Scientists around Tetyana Milojevic from the Faculty of Chemistry at the University of Vienna are in search of unique biosignatures, which are left on synthetic extraterrestrial minerals by microbial activity. The biochemist and astrobiologist investigates these signatures at her own miniaturized "Mars farm" where she can observe interactions between the archaeon Metallosphaera sedula and Mars-like rocks. These microbes are capable of oxidizing and integrating metals into their metabolism. The original research was currently published in the journal "Frontiers in Microbiology".
Global Biological Standards Institute (GBSI) today brought top scientists and biomedical researchers together with science inventors and programmers to consider the laboratory of the future and explore how newly affordable and accessible digital tools, technologies and lab automation advances will increase reproducibility in preclinical research… and ultimately to accelerate the discovery of treatments and cures. GBSI’s 3rd BioPolicy Summit: “Improving Reproducibility of Research Through Digital Tools, Technologies and Laboratory Automation,” marked the first time the science tech community had brought their expertise to the reproducibility case.
SimPath has licensed a novel cloning system developed by the Department of Energy’s Oak Ridge National Laboratory that generates and assembles the biological building blocks necessary to synthetically bioengineer new medicines and fuels.
At first glance, the yeast Candida krusei seems as innocuous as microbes come: it’s used for fermenting cocoa beans and gives chocolate its pleasant aroma. But it’s increasingly being found as a pathogen in immunocompromised patients—and C. krusei infections aren’t always easy to cure.
In a potential major breakthrough in breast cancer research, scientists at the Center for Translational Cancer Research (CTCR) at the Helen F. Graham Cancer Center & Research Institute of Christiana Care Health System have developed a revolutionary new blood test to diagnose breast cancer.
The NIH has awarded $6.5 million to Berkeley Lab to integrate existing synchrotron structural biology resources to better serve researchers. The grant will establish a center based at the Lab’s Advanced Light Source (ALS) called ALS-ENABLE that will guide users through the most appropriate routes for answering their specific biological questions.
A prominent and inventive chemical biologist, Cravatt’s research focuses on the role proteins play in cellular processes.
This year’s Nobel Prize in Physiology or Medicine was awarded to Jeffrey C. Hall, Michael Rosbash, and Michael W. Young for their studies of the circadian clock in fruit flies. But their discoveries weren’t just insect idiosyncrasies—they held true across much of the living world, from animals to plants and even some bacteria. And, as many researchers building on their work have found, circadian rhythms have immense importance in human health.
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