UNC-Chapel Hill scientists and colleagues provide indirect evidence for the existence of a distinct latent reservoir of CD4+ T cells in the central nervous system, by analyzing rebound virus in the cerebral spinal fluid during the period when people had just stopped taking ART.
Having levels of potassium that are too high or too low can be fatal. A new mathematical model sheds light on the often mysterious ways the body regulates this important electrolyte.
A team of researchers from the Cancer Science Institute of Singapore at the National University of Singapore has breathed new life into an existing drug — combatting a type of blood cancer called T-cell acute lymphoblastic leukaemia, or T-ALL. The drug, called PIK-75, was initially discovered over a decade ago but was dismissed in favour of newer ones. Now, it has made a comeback that deems it unmissable — the researchers established that the drug could block not just one but two crucial cancer-causing pathways of T-ALL, enabling them to develop new treatments that could effectively stem the disease.
Patients with myelofibrosis had clinically significant improvement in disease-related symptoms, including anemia and spleen enlargement, when treated with the targeted therapy momelotinib, according to results from the international Phase III MOMENTUM trial led by researchers at The University of Texas MD Anderson Cancer Center.
People with an additional X or Y chromosome—a genetic condition known as supernumerary sex chromosome aneuploidy—have an increased risk of developing blood clots known as venous thromboembolism (VTE), a Geisinger study found.
Scientists at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have illuminated how treatments for multiple myeloma and other aggressive blood cancers can lead to future malignancies, called therapy-related myeloid neoplasms (tMNs).
University of Maryland School of Medicine’s researchers have discovered that a certain type of cell that sits on top of the brain’s smallest blood vessels senses when their brain region needs energy. When glucose levels are low, these cells signal blood vessels to dilate, increasing the blood flow regionally and allowing more energy to fuel that part of the brain.
Sepsis can cause dangerously low blood pressure, which is typically treated with intravenous (IV) fluids and/or a vasopressor, a drug that causes constriction of the blood vessels. Whether treatment of sepsis-induced low pressure should primarily be treated with IV fluids or vasopressors has been debated for decades with no clear answer.
Many cardiovascular diseases, such as atherosclerosis, or ‘hardening of the arteries,’ correlate to mitochondrial dysfunction and endothelial impairment in the tissues of the heart and blood vessels.
The next frontier of continuous health monitoring could be skin deep.
Nearly half a million people missed out on starting medication to lower their blood pressure during the Covid-19 pandemic, according to research supported by the British Heart Foundation (BHF) Data Science Centre at Health Data Research UK published today in Nature Medicine [1].
New UCLA-led research suggests that antiretroviral drugs called TAF and TDF directly reduce energy production by mitochondria, structures inside cells that generate the power that cells use to function. Both drugs led to reduced cellular oxygen consumption rates, a measure of the ability of the mitochondria to produce energy, compared with controls.
Patients hospitalized with fractures typically receive an injectable blood thinner, low-molecular-weight heparin, to prevent life-threatening blood clots.
Frequent visits to urban green spaces, such as parks and community gardens in Finland, rather than the amount, or views of them from home, may be linked to lower use of certain prescription meds, suggests research published online in Occupational & Environmental Medicine.
The researchers screened a library of drugs using a mouse endothelial cell line to identify pathways that are involved in the regulation of Robo4 and found that two competitive SMAD signaling pathways appear to regulate Robo4 expression. When the researchers treated LPS-injected mice with a drug that inhibits ALK1-SMAD signaling, they observed increased Robo4 expression, decreased vascular permeability, and reduced mortality.
Doctors at Queen Mary University of London and Barts Hospital, and Cambridge University Hospital, have led research using a new type of CT scan to light up tiny nodules in a hormone gland and cure high blood pressure by their removal. The nodules are discovered in one-in-twenty people with high blood pressure.
Promising results from an ongoing clinical trial a three-drug treatment may improve survival in patients with newly diagnosed multiple myeloma who have undergone preliminary treatment followed by a stem cell transplant.
CAR T cell therapy may enhance the effectiveness of surgery for solid tumors, according to a preclinical study from researchers in the Perelman School of Medicine at the University of Pennsylvania.
The University of Texas MD Anderson Cancer Center’s Research Highlights provides a glimpse into recent basic, translational and clinical cancer research from MD Anderson experts.
School garden-based interventions can improve metabolic parameters such as blood sugar and cholesterol in children, according to a new study from UTHealth Houston.
Doctors from RUDN, in collaboration with the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, evaluated a fresh approach to diagnose the preclinical predictors of arterial hypertension.
A newly published study from York University sheds light on the biological underpinnings in sex differences in obesity-related disease, with researchers observing “striking” differences in the cells that build blood vessels in the fatty tissue of male versus female mice.
Dr. Scott E. Smith, Section Chief of Hematology and Medical Director of the Bone Marrow Transplant Program at Loyola University Medical Center, is available today to discuss the non-Hodgkin's Lymphoma diagnosis of 33-year-old Chicago White Sox pitcher Liam Hendriks.
A group of international researchers is calling for revised guidelines to help improve access to hepatitis B treatment in Africa.
Scientists from St. Jude Children’s Research Hospital performed the largest study yet examining drug sensitivity in childhood acute lymphoblastic leukemia across genomic subtypes and its association with treatment response.
Still in the giving spirit as the new year begins? Consider giving blood.
Researchers at Washington University School of Medicine in St. Louis have identified an important transition point in the shift from chronic to aggressive leukemia.
A roundup of the latest medical discoveries and faculty news at Cedars-Sinai.
In cancer patients with neutropenic fever, delaying antibiotic treatment past 60 minutes from the time of fever detection does not reduce the short-term chance of survival, according to a study in the American Journal of Medical Quality. The journal is published in the Lippincott portfolio by Wolters Kluwer.
Clinical scientists with UC Davis and University of Cincinnati perform first-of-its-kind analysis showing a clear difference in cost-effectiveness of medication types for life-threatening condition
In a new study evaluating the Mediterranean diet and adverse pregnancy outcomes, investigators from the Smidt Heart Institute at Cedars-Sinai found that women who conceived while adhering to the anti-inflammatory diet had a significantly lower risk of developing preeclampsia during pregnancy.
Nerve cells need a lot of energy and oxygen. They receive both through the blood. This is why nerve tissue is usually crisscrossed by a large number of blood vessels.
In people with active secondary progressive multiple sclerosis (MS), hematopoietic stem cell transplants may delay disability longer than some other MS medications, according to a study published in the December 21, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study involved autologous hematopoietic stem cell transplants, which use healthy blood stem cells from a person’s own body to replace diseased cells.
New data show the University of Chicago Medicine's David and Etta Jonas Center for Cellular Therapy has the highest one-year survival rate in Illinois for adults undergoing blood and bone marrow stem cell transplants. UChicago Medicine had an 80% one-year survival rate among adult stem cell patients, according to the latest statistics released in mid-December by the Center for International Blood & Marrow Transplant Research (CIBMTR).
Less than three years after joining the Cedars-Sinai Cancer faculty, hematologist-oncologists Justin Darrah, MD, and Akil Merchant, MD, are pioneering new research and bringing a new, comprehensive set of treatment options to patients in the recently established Lymphoma Program.
As outlined in their recent publication in Biomaterials Science, researchers from the Terasaki Institute for Biomedical Innovation, (TIBI), have developed an injectable, temperature sensitive, shear-thinning hydrogel (T-STH) hemostat that works rapidly at body temperature to stop bleeding from a wound.
The claim that a blood transfusion could pass on the inoculation from a vaccine is entirely false.
Patients in the Emergency Room (ER) should be blood-tested for hazardous drinking rather than evaluated by questionnaires alone, according to a new study comparing alcohol use screening methods. A sizeable minority of patients attend the ER for alcohol-related reasons (12–15% in the UK). That proportion is growing, a US study has found. The ER offers valuable opportunities to identify hazardous drinking and intervene with treatments that can help patients reduce their alcohol use. This requires efficiently and reliably screening ER patients for risky consumption. Validated methods include the Alcohol Use Disorders Identification Test (AUDIT) — and its shorter version, AUDIT-C —which are among the most frequently used screening questionnaires. Another, the Timeline Followback Questionnaire (TLFB), is a retrospective self-administered survey estimating daily alcohol consumption over a specific prior period. In contrast, phosphatidylethanol (PEth), a metabolite of ethanol, is a direct and
Researchers have uncovered a protein produced by the immune system, suPAR, that causes atherosclerosis. Investigators say it's the first immune target to treat cardiovascular disease, which affects over 1 billion people worldwide. Researchers believe treatment could be developed within five years.
Cedars-Sinai aortic aneurysm expert Ali Azizzadeh, MD is available for interviews about the telltale signs, risk factors and available treatment options for aortic aneurysms, a rare but often fatal condition.
Researchers at The Tisch Cancer Institute at Mount Sinai have identified a treatment that is effective and safer than the standard of care for a serious, and sometimes fatal, side effect of bone marrow transplant in cancer patients. Results from a phase 2 clinical trial were presented at the annual meeting of the American Society of Hematology (ASH) in December.
Featured in the December issue of SLAS Technology, the article “Freestanding hydrogel lumens for modeling blood vessels and vasodilation” by Dostie, et al, outlines a new method capable of solving some of the issues existing methods face.
Researchers have found a method using molecular profiling and machine learning to develop blood-based dietary signatures that more accurately predict both diet and the risk of cardiovascular disease and type 2 diabetes. They say the metabolic snapshot could allow those studying food science to better understand the implications of diet and nutrition on health.
A new clinical tool developed by a team of researchers led by the Dana-Farber Cancer Institute pinpoints which clonal hematopoiesis patients are at highest risk for cancer progression.
UC San Diego Health has been awarded the prestigious 2022 California Association of Public Hospitals and Health Systems Quality Leaders Award in the category of health equity.
Researchers from The University of Texas MD Anderson Cancer Center are presenting compelling findings from three clinical trials at the 2022 American Society of Hematology (ASH) Annual Meeting. These oral presentations highlight encouraging results to advance the use of targeted therapies and novel combinations in multiple types of leukemia, including high-risk and newly diagnosed acute myeloid leukemia (AML) in older and younger patients and Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL).
Study uncovers the genomic features of Richter's and how it emerges from CLL Researchers identify molecular subtypes of Richter's and y show that, in some cases, Richter's can be detected in a blood test, rather than a biopsy, potentially leading to earlier treatment.
A new therapy that makes the immune system kill bone marrow cancer cells was successful in as many as 73 percent of patients in two clinical trials, according to researchers from The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai.
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