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Alzheimer's and Dementia

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Medicine

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Alzheimer's Disease, Patent, Transgenic Mice, Lawsuit

Law and Disorder—APPswe Patent Suits Raise Ruckus Again

Is this the modus operandi for a self-described "leading not-for-profit research and development institution" that is suing 10 AD research entities, from pharma and biotech companies to not-for-profit institutions, over use of mice, cells, and other tools derived from the Swedish APP mutation? The discovery of this mutation 18 years ago helped open up the molecular biology of Alzheimer's research, but advances in this area have become ensnared in litigation again and again. Esther Landhuis and Gabrielle Strobel investigated: Buckle your seatbelt for a ride through the maze that is U.S. patent law, and sit in wonder at the multitude of obstacles that stand in the way of finding treatments for loved ones.

Medicine

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Alzheimer's Disease, Mild Cognitive Impairment, Learning, Visuomotor processing, Depression

Memory Problems Not the Only Predictor of Later Mild Cognitive Impairment

Researchers at Rush University Medical Center have found that lower, though not necessarily impaired, performance on tests measuring story learning or retention and processing speed in motor tasks dependent on visual control, as well as symptoms of depression, predicted subsequent cognitive decline in a normal population.

Medicine

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MRI, Alzheimer's Disease, imaging study, Early Detection, Myelin, Axon Degeneration

Alzheimer's Imaging Study Identifies Changes in Brain's White Matter

Study used MRI to detect deterioration of white matter bracts in the brains of healthy adults at high risk for Alzheimer's disease. Data suggest that changes in white matter connections may be among the earliest brain changes in Alzheimer's disease, which may prove important for early detection by non-invasive imaging.

Medicine

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Alzheimer's Disease, retinal imaging, noninvasive optical imaging, Amyloid Plaques

Hallmark Alzheimer’s Disease Changes Found in Retinas of Humans and Imaged in Live Animals

Scientists at Cedars-Sinai Medical Center have discovered characteristic amyloid plaques in retinas from Alzheimer’s disease patients and used a noninvasive optical imaging technique to detect retinal plaques in live laboratory mice, suggesting the possibility of early noninvasive diagnosis of Alzheimer’s disease.

Medicine

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Radioactive, Brain Scan, radiotracer, PIB, Pittsburgh compound, Alzheimer's Disease

Novel Radiotracer Shines New Light on the Brains of Alzheimer’s Disease Patients

A trial of a novel radioactive compound readily and safely distinguished the brains of Alzheimer’s disease patients from healthy volunteers on brain scans and opens the doors to making such imaging available beyond facilities that can manufacture their own radioactive compounds. The results, reported by a Johns Hopkins team in the June Journal of Nuclear Medicine, could lead to better ways to distinguish Alzheimer’s from other types of dementia, track disease progression and develop new therapeutics to fight the memory-ravaging disease.

Medicine

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Alzheimer's Disease, Hypertension, Neurology, Mount Sinai School Of Medicine

Antihypertensive Drugs May Protect against Alzheimer’s Disease Independent from Reduction of Blood Pressure Lowering Activities

Researchers at Mount Sinai School of Medicine have found that the drug carvedilol, currently prescribed for the treatment of hypertension, may lessen the degenerative impact of Alzheimer’s disease and promote healthy memory functions.

Medicine

Science

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Research, Rensselaer Polytechnic Institute, Resveratrol, Aggregation, Alzheimer's Disease

Compound Found in Red Wine Neutralizes Toxicity of Proteins Related to Alzheimer's

An organic compound found in red wine – resveratrol – has the ability to neutralize the toxic effects of proteins linked to Alzheimer’s disease, according to research led by Rensselaer Professor Peter M. Tessier.

Medicine

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Gamma-secretase, Amyloid Beta, Inhibitor, Alzheimer's Disease

Feared Side Effect of Alzheimer's Drugs Is Unlikely

The first trial of a new model for testing Alzheimer's treatments has reassured researchers that a promising class of drugs does not exacerbate the disease if treatment is interrupted.

Medicine

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Neurobiology, Neuroscience, Parkinson Disease, Neurodegeneration

Over-Abundant Protein Prompts Neurodegenerative Cascade

In diverse neurodegenerative diseases ranging from Parkinson’s to Alzheimer’s, researchers have long noted accumulations of a little-understood neuronal protein called α-synuclein. Pathological and genetic evidence strongly suggested that excessive α-synuclein played a role in the evolution of these diseases, but it was unclear how too much α-synuclein culminated in synaptic damage and neurodegeneration.

Medicine

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For Better Health – Please Don’t Stop the Music!

CIHR experts discuss the impact of music on people’s health.







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