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Alzheimer's and Dementia

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Genetic Variations Associated With Alzheimer Disease, But Do Not Help Predict Risk

Although genome-wide analysis identified two genetic variations associated with Alzheimer disease (AD), these variations did not improve the ability to predict the risk of AD, according to a study in the May 12 issue of JAMA.

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University of Alabama at Birmingham, Memory Loss, Cognitive Decline, Alzheimer's Disease, Histone Deacetylase Inhibitors

Science Closing in on Mystery of Age-Related Memory Loss, Says UAB Neurobiologist

The world’s scientific community may be one step closer to understanding age-related memory loss, and to developing a drug that might help boost memory, says UAB neurobiologist David Sweatt in an editorial in Science.

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Cirrhosis, Liver Disease, hepatic encephalopathy, Ammonia, Digestive Disease Week, rbans

More than Half of Liver Patients Have Neurocognitive Impairments

Fifty-four percent of liver patients also display neurocognitive impairments such as short term memory loss, a study found. Average score of impaired patients was lower than that of patients with early-stage Alzheimer's disease.

Medicine

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Dementia, Psychiatry, Geriatrics, Caregiver, Alzheimer's Disease

Spouses Who Care for Partners with Dementia at Sixfold Higher Risk of Same Fate

Husbands or wives who care for spouses with dementia are six times more likely to develop the memory-impairing condition than those whose spouses don’t have it, according to results of a 12-year study led by Johns Hopkins, Utah State University, and Duke University. The increased risk that the researchers saw among caregivers was on par with the power of a gene variant known to increase susceptibility to Alzheimer’s disease, they report in the May Journal of the American Geriatrics Society.

Medicine

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Normal Pressure Hydrocephalus (NPH), Dementia, Beta-amyloid Plaque, Cerebrospinal Fluid (CSF), Shunts, T-tau, P-tau, Tau Tangles, Gait Disturbance, Alzheimer's Disease, Urinary Incontinence (UI)

Research Explores the Connection between Normal Pressure Hydrocephalus and Alzheimer’s Disease

Normal Pressure Hydrocephalus (NPH) is a neurological condition which typically affects adults ages 55 and older. An estimated 5.3 million Americans have Alzheimer’s disease (AD). Research analyzes the connection between NPH and AD, studying tau-protein abnormalities of the brain and the efficacy of shunt placement in these patients.

Medicine

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SLU, Saint Louis University, St. Louis University, Aging, Brain

Doctor Shares Keys to Healthy Brain Aging

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As researchers learn more about how we age, they’re finding that genetics are only half of the story when it comes to developing Alzheimer’s disease.

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Gandy, Plaque, Amyloid Beta, Oligomers, Alzheimer's Disease

Alzheimer’s Memory Problems Originate with Protein Clumps Floating in the Brain, Not Amyloid Plaques

Using a new mouse model of Alzheimer's disease, researchers at Mount Sinai School of Medicine have found that Alzheimer’s pathology originates in Amyloid-Beta (Abeta) oligomers in the brain, rather than the amyloid plaques previously thought by many researchers to cause the disease.

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Mild Cognitive Impairment, Alzheimer's Disease

Biomarkers Weigh In at Mild Cognitive Impairment Meeting

Forget sun, sand, and surf—it was biomarker pools and a sea change in neurocognitive testing that rejuvenated attendees at the 8th Annual Symposium on Early Alzheimer's, held 12-13 March 2010, in Miami Beach, Florida. Our intrepid reporter Pat McCaffrey brings you a full meeting summary, complete with a slide deck that covers the majority of presentations.

Medicine

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Aan Annual Meeting, AAN, American Academy Of Neurology, Genetics

New Gene Associated with Increased Risk of Alzheimer’s Disease

Researchers have identified a gene that appears to increase a person’s risk of developing late-onset Alzheimer’s disease, the most common type of Alzheimer’s disease. The research will be presented as part of the late-breaking science program at the American Academy of Neurology’s 62nd Annual Meeting in Toronto, April 10 – 17, 2010. The gene, abbreviated MTHFD1L, is located on chromosome six.







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