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Medicine

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Biologics, Personalized Medicine, polymyalgia rheumatica, Precision Medicine, Rheumatoid Arthritis, Sarcoidosis, Vasculitis

Mayo Clinic Research Sheds Light on Why Some Rheumatoid Arthritis Patients Respond Poorly to Biologics

A Mayo Clinic study is shedding light on why some rheumatoid arthritis patients respond poorly when treated with tumor necrosis factor inhibitors, part of a class of drugs called biologics.

Medicine

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CDC, Antibiotic, Antibiotic Resistant Infections, Resistant Bacteria, Drug Resistant Bacteria, Infection

Let’s “Get Smart About Antibiotics” Week

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The discovery of antibiotics remains one of the most important medical advances to date, but overuse and inappropriate use of antibiotics has led to many infections becoming resistant to treatment.

Medicine

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Celebrex, Celecoxib, Lexapro, Depression, inflammation and depression, Bipolar Disorder

Arthritis Drug Boosts Effectiveness of Antidepressant Medication

Giving severely depressed patients the arthritis drug celecoxib (Celebrex®) dramatically boosted the effectiveness of their antidepressant medication, a Loyola study has found.

Medicine

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genes, Genome, Health, Biochemistry, Personalized Medicine, DNA, Medicine

First Cellular Atlas of DNA-Binding Molecule Could Advance Precision Therapies

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Biochemists at the University of Wisconsin–Madison have created the first atlas that maps where molecular tools that can switch genes on and off will bind to the human genome. It is a development they say could enable these tools to be targeted to specific parts of an individual’s genome for use in precision medicine, developing therapies and treating disease.

Medicine

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interleukin 33, IL-33, Itch Gene, Antibodies, Poison Ivy Rash, Poison Ivy Treatment, Atopic Dermatitis, Psoriasis, Dermatologic Conditions, Duke Health, PNAS

Mouse Study Shows Antibody Can Soothe Raging, Nerve-Driven Poison Ivy Itch

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Scientists at Duke Health and Zhejiang Chinese Medical University have developed a strategy to stop the uncontrollable itch caused by urushiol, the oily sap common to poison ivy, poison sumac, poison oak and even mango trees. The team found that by blocking an immune system protein in the skin with an antibody, they could halt the processes that tell the brain the skin is itchy.

Medicine

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Sirna, Cancer, Ovarian Cancer, nanohydrogel, Targeted Drug Delivery, Cisplatin, Chemo Therapy, Kinase, EGF receptor, EGFR, EGFR inhibitor, Egfr Mutations, EGFR gene, Carcinoma, Tumor, epithelial cancer

Punching Cancer with RNA Knuckles

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Researchers achieved an unexpected eye-popping reduction of ovarian cancer during a successful test of targeted nanohydrogel delivery in vivo in mice. Adding cisplatin eliminated or starkly diminished tumors.

Medicine

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Ribosome, catalytic center, chloramphenicol, Linezolid

Two Antibiotics Fight Bacteria Differently Than Thought

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Two widely prescribed antibiotics — chloramphenicol and linezolid — may fight bacteria in a different way from what scientists and doctors thought for years, University of Illinois at Chicago researchers have found. Instead of indiscriminately stopping protein synthesis, the drugs put the brakes on the protein synthesis machinery only at specific locations in the gene.

Medicine

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HTA, voice of the patient, rare disease, Orphan Drugs

ISPOR 19th Annual European Congress Explores How HTA Bodies Can Consider the Voice of Patients with Rare Diseases

The International Society for Pharmacoeconomics and Outcomes Research (ISPOR) led a session this afternoon entitled, "From Testimonials to Qualitative Research Embedded in Clinical Trials: How Do Health Technology Assessment Bodies Consider the Voice of Rare Disease Patients When Granting Access to Orphan Drugs?" The discussion took place at the Society’s 19th Annual European Congress—in Vienna, Austria.

Medicine

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Rna Interference, Rnai, Drug Development, RNA, RXi Pharmaceuticals, Geert Cauwenbergh, sd-rxRNA, RXI-109, connective tissue growth factor, CTGF, Fibrosis, scar formation, retinal scarring, age-related macular degeneration, AMD, hypertrophic scar

Expert: How Can ‘RNA Interference’ Enhance Drug Development?

Medicine

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Cancer, Brain Cancer, Pediatric Cancer, MEK inhibitors

Promise of Better Targeted Treatments Now Possible in Children’s Brain Cancer

More than 4,000 children and teens are diagnosed with brain cancer each year and the disease kills more children than any other cancer. Writing this week in the journal Cell Reports, researchers at Huntsman Cancer Institute (HCI) at the University of Utah report they have identified an existing group of drugs that appear to reduce or eliminate a certain subgroup of childhood brain cancers while sparing normal brain tissue. The research was conducted using a new zebrafish animal model system developed by the researchers, which closely resembles an aggressive subtype of pediatric brain tumors.







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