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Medicine

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Head And Neck Cancer, TCGA

UNC Researcher Co-Leads Effort to Map Genomic Changes in Head and Neck Cancer

In an analysis of 279 head and neck cancer tumors, researchers with The Cancer Genome Atlas identified subtypes of head and neck cancer based on their genomic characteristics, changes in smoking-related tumors, as well as genomic differences in head and neck cancer tumors linked to HPV, the most common sexually transmitted disease in the United States.

Medicine

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Ut Southwestern Medical Center, Ut Southwestern, Breast Cancer, Beclin 1, Autophagy, Beth Levine, triple-negative breast cancer, Cancer, cancer genome project

Study Links Deficiency of Cellular Housekeeping Gene with Aggressive Forms of Breast Cancer

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UT Southwestern Medical Center scientists have identified a strong link between the most aggressive type of breast cancer and a gene that regulates the body’s natural cellular recycling process, called autophagy.

Medicine

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Nationwide Children's Hospital, Genome Biology, Human Genome Sequence, Churchill

New Software Analyzes Human Genomes Faster than Other Available Technologies, Empowering Population Scale Genomic Analysis

Investigators at Nationwide Children’s Hospital have developed an analysis “pipeline” that slashes the time it takes to search a person’s genome for disease-causing variations from weeks to hours. An article describing the ultra-fast, highly scalable software was published in the latest issue of Genome Biology.

Science

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Structure of World’s Largest Single Cell Is Reflected at the Molecular Level

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Daniel Chitwood, Ph.D., assistant member, used the world’s largest single-celled organism, an aquatic alga called Caulerpa taxifolia, to study the nature of structure and form in plants. It was recently reported the results of their work in the online journal, PLOS Genetics.

Medicine

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Cancer, Folate, Epidemiology, Breast Cancer, African-Americans, Genetics, Cancer Genetics, Tumor Markers, Diet And Cancer

Analysis of Key Breast Cancer Genes Reveals Distinct Profiles for African-American and European-American Women

In a large study using data from the Women's Circle of Health Study, epidemiologists have determined that gene variations associated with breast cancer risk diverged significantly between African-American and women of European descent.

Science

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XPC, , Dna Damage Repair, DNA recognition

Damaged DNA May Stall Patrolling Molecule to Initiate Repair

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Sites where DNA is damaged may cause a molecule that slides along the DNA strand to scan for damage to slow on its patrol, delaying it long enough to recognize and initiate repair. The finding suggests that the delay itself may be the key that allows the protein molecule to find its target, according to researchers at the University of Illinois at Chicago.

Science

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Evolution, Human Health, Psoriasis, Genetics, genes, genetic deletions, Neanderthals, denisovans

Did Genetic Links to Modern Maladies Provide Ancient Benefits?

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Researchers have discovered that genetic variations associated with some modern maladies are extremely old, predating the evolution of Neanderthals, Denisovans (another ancient hominin) and contemporary humans.

Science

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blind beetles, Evolution, Genetics, Aquifers, non adaptive evolution

Blind Beetles Show Extraordinary Signs of Sight

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University of Adelaide researchers have made a surprising discovery in the aquifers beneath the Western Australian desert, which challenges the traditional Darwinian view of evolution.

Medicine

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Klotho, Neuroscience, Aging, Memory, Dementia, Genetics, Longevity, Cognition

Brain Region Vulnerable to Aging is Larger in Those with Longevity Gene Variant

People who carry a variant of a gene that is associated with longevity also have larger volumes in a front part of the brain involved in planning and decision-making, according to researchers at UC San Francisco.

Medicine

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Ovarian Cancer, Genetics

Researchers Pinpoint Two Genes That Trigger Severest Form of Ovarian Cancer

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Researchers create first mouse model of ovarian clear cell carcinoma using data from human cancer genome atlas. They show how when the genes ARID1A and PIK2CA are mutated in specific ways, the result is ovarian cancer 100 percent of the time. They show that a known drug can suppress tumor growth.







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