Feature Channels: Immunology

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Released: 2-Feb-2023 11:05 AM EST
Children’s Hospital Los Angeles Study of Childhood COVID-19 Immunity Could Safeguard Babies Too Young for COVID-19 Vaccination
Children's Hospital Los Angeles

Pia Pannaraj, MD, MPH, an infectious disease specialist at Children's Hospital Los Angeles, was awarded $4.2 million from the National Institutes of Health to study COVID-19 immunity in children.

Newswise: Boosting anti-cancer antibodies by reducing their grip
Released: 1-Feb-2023 5:35 PM EST
Boosting anti-cancer antibodies by reducing their grip
University of Southampton

New research from the Centre for Cancer Immunology at the University of Southampton, published ahead of World Cancer Day (4 February), has shown that changing how tightly an antibody binds to a target could improve treatments for cancer.

Released: 1-Feb-2023 5:25 PM EST
Immunocompromised patients remain at higher risk of COVID-19 death in hospital
University of Liverpool

People with weakened immune systems remain more likely to die if hospitalised with COVID-19 than patients with normal immune systems, a new UK study has confirmed.

Released: 1-Feb-2023 4:25 PM EST
Season two of Unraveled: A Dana-Farber podcast is now available
Dana-Farber Cancer Institute

The second season of Unraveled: A Dana-Farber Cancer Institute podcast is now available with six new episodes telling stories of the science and scientists behind some of the most important cancer discoveries, diving deep into the lab.

Newswise: Thirumala-Devi Kanneganti, Ph.D. named 2022 AAAS Fellow
Released: 31-Jan-2023 5:05 PM EST
Thirumala-Devi Kanneganti, Ph.D. named 2022 AAAS Fellow
St. Jude Children's Research Hospital

Immunologist recognized for her achievements in the field of innate immunity, developing new concepts in inflammasome biology and inflammatory cell death, PANoptosis.

Newswise: SLU Research Finds Cancer Immunotherapy Does Not Interfere With COVID-19 Immunity
Released: 31-Jan-2023 1:45 PM EST
SLU Research Finds Cancer Immunotherapy Does Not Interfere With COVID-19 Immunity
Saint Louis University

Research findings published in Frontiers in Immunology show that cancer immunotherapy does not interfere with COVID-19 immunity in previously vaccinated patients. These findings support recommending vaccination for patients with cancer, including those receiving systemic therapies, say Saint Louis University scientists.

Released: 31-Jan-2023 10:05 AM EST
Wistar Institute Announces New Cotswold Foundation Postdoctoral Fellowship and Selected Fellow
Wistar Institute

The Cotswold Foundation Postdoctoral Fellowship is a new fellowship totaling $500,000 over the course of five years to support a postdoctoral researcher studying immunology, cancer research, or vaccine biology at The Wistar Institute.

Newswise: Artificial Intelligence Aids Discovery of Super Tight-Binding Antibodies
Released: 30-Jan-2023 5:45 PM EST
Artificial Intelligence Aids Discovery of Super Tight-Binding Antibodies
University of California San Diego

UC San Diego scientists developed an artificial intelligence tool that could accelerate the development of new high affinity antibody drugs.

Newswise: Tumor microbiome linked to immunotherapy success in sarcoma patients
Released: 30-Jan-2023 4:55 PM EST
Tumor microbiome linked to immunotherapy success in sarcoma patients
UC Davis Health

A new UC Davis study reveals the interaction between tumor microbiome and the immune system may be the secret to improving outcomes for sarcoma patients.

Newswise: LJI scientists uncover the structure and function of Inmazeb, the first FDA-approved drug for Ebola virus infection
Released: 30-Jan-2023 4:30 PM EST
LJI scientists uncover the structure and function of Inmazeb, the first FDA-approved drug for Ebola virus infection
La Jolla Institute for Immunology

Inmazeb (REGN-EB3), developed by Regeneron, is a three-antibody cocktail designed to target the Ebola virus glycoprotein. The drug was first approved for clinical use in October 2020, but its exact mechanism of action has remained unclear.

   
Released: 30-Jan-2023 1:55 PM EST
Coffee with milk may have an anti-inflammatory effect
University of Copenhagen, Faculty of Science

Can something as simple as a cup of coffee with milk have an anti-inflammatory effect in humans? Apparently so, according to a new study from the University of Copenhagen.

Released: 30-Jan-2023 12:45 PM EST
Study finds how our brains turn into smarter disease fighters
University of California, Irvine

Irvine, Calif., Jan. 30, 2023 — Combating Alzheimer’s and other neurodegenerative diseases by inserting healthy new immune cells into the brain has taken a leap toward reality. Neuroscientists at the University of California, Irvine and the University of Pennsylvania have found a way to safely thwart the brain’s resistance to them, vaulting a key hurdle in the quest.

Newswise: ‘Hard to Lose’ Mutations in Tumors May Predict Response to Immunotherapy
25-Jan-2023 9:15 AM EST
‘Hard to Lose’ Mutations in Tumors May Predict Response to Immunotherapy
Johns Hopkins Medicine

Investigators at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy have found that a subset of mutations within the overall TMB, termed “persistent mutations,” are less likely to be edited out as cancer evolves, rendering tumors continuously visible to the immune system and predisposing them to respond to immunotherapy.

Newswise: Keys to Making Immunotherapy Work Against Pancreatic Cancer Found in Tumor Microenvironment
Released: 26-Jan-2023 10:00 AM EST
Keys to Making Immunotherapy Work Against Pancreatic Cancer Found in Tumor Microenvironment
Johns Hopkins Medicine

A new study that analyzed the tumor microenvironment of pancreatic cancer revealed the cause of tumor cell resistance to immunotherapy and resulted in new treatment strategies.

Released: 25-Jan-2023 4:55 PM EST
Corona vaccine based on new technology tested in clinical study
Radboud University Medical Centre Nijmegen

A new COVID-19 vaccine based on a different platform than current vaccines on the market has been tested in humans for the first time by researchers at Radboud university medical center.

Newswise: Michael Criscuolo joins The Wistar Institute as Vice President of Development
Released: 24-Jan-2023 1:45 PM EST
Michael Criscuolo joins The Wistar Institute as Vice President of Development
Wistar Institute

The Wistar Institute, which has recently launched a $75 million programmatic campaign investing in biomedical advances, announces the appointment of Michael Criscuolo as Vice President of Development.

Newswise: Female lymphoma patient's afternoon chemotherapy decreases mortality
Released: 24-Jan-2023 1:00 PM EST
Female lymphoma patient's afternoon chemotherapy decreases mortality
Institute for Basic Science

Female lymphoma patients undergoing the morning chemotherapy treatment show a lower survival probability than those undergoing the afternoon treatment.

Newswise: Want More Than Romance This Valentine’s Day? Halt Spring Allergy Symptoms Before They Start
Released: 24-Jan-2023 8:00 AM EST
Want More Than Romance This Valentine’s Day? Halt Spring Allergy Symptoms Before They Start
American College of Allergy, Asthma and Immunology (ACAAI)

Spring allergy symptoms will start to appear soon in parts of the country. Many allergists advise their patients to set a reminder for Valentine’s Day to start taking allergy medications.

Newswise: Study reveals new genetic disorder that causes susceptibility to opportunistic infections
Released: 23-Jan-2023 2:50 PM EST
Study reveals new genetic disorder that causes susceptibility to opportunistic infections
Vanderbilt University Medical Center

An international consortium co-led by Vanderbilt University Medical Center immunogeneticist Rubén Martínez-Barricarte, PhD, has discovered a new genetic disorder that causes immunodeficiency and profound susceptibility to opportunistic infections including a life-threatening fungal pneumonia. The discovery, reported Jan. 20 in the journal Science Immunology, will help identify people who carry this in-born error of immunity (IEI).

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This news release is embargoed until 23-Jan-2023 11:00 AM EST Released to reporters: 23-Jan-2023 9:30 AM EST

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Released: 21-Jan-2023 10:05 AM EST
Immunotherapy with two novel drugs shows activity in colorectal cancer
Dana-Farber Cancer Institute

A combination of two next-generation immunotherapy drugs has shown promising clinical activity in treating patients with refractory metastatic colorectal cancer, a disease which has not previously responded well to immunotherapies, according to a Dana-Farber Cancer Institute researcher.

Newswise:Video Embedded surviving-cancer-and-cooking-for-health
VIDEO
Released: 20-Jan-2023 1:10 PM EST
Surviving Cancer and Cooking for Health
Cedars-Sinai

In a brightly lit kitchen one recent afternoon, cancer survivors Patricia Rhodes and Evette Knight were part of a group gathered around a convection burner and a sauté pan filled with mushrooms. Cancer dietitian Meghan Laszlo, RD, explained why they shouldn’t stir quite yet. “We’re going to try our best to leave them alone so that they brown,” she said.

Newswise: Wistar Institute HIV Researchers Win Grant to Explore Genetically Engineered Natural Killer Cells as HIV Therapy
Released: 19-Jan-2023 2:35 PM EST
Wistar Institute HIV Researchers Win Grant to Explore Genetically Engineered Natural Killer Cells as HIV Therapy
Wistar Institute

amfAR, The Foundation for AIDS Research, has awarded Luis J. Montaner, D.V.M., D.Phil., in collaboration with Mohamed Abdel-Mohsen, Ph.D., a Target Grant for $397,663 over two years.

Newswise: An Unprecedented Look at Colorectal Cancer
13-Jan-2023 3:20 PM EST
An Unprecedented Look at Colorectal Cancer
Harvard Medical School

Researchers are building detailed maps of colorectal cancer to better understand the dynamics of the disease

Released: 19-Jan-2023 10:05 AM EST
Certain gene signaling rewires tumors after immunotherapy
Michigan Medicine - University of Michigan

Researchers from the University of Michigan Rogel Cancer Center have found a mechanism for why a subset of patients’ tumors grow, rather than shrink, when faced with immunotherapy.

Newswise: Commonly used antiretroviral drugs used to treat HIV and hepatitis B reduce immune cells’ energy production
Released: 18-Jan-2023 7:45 PM EST
Commonly used antiretroviral drugs used to treat HIV and hepatitis B reduce immune cells’ energy production
University of California, Los Angeles (UCLA), Health Sciences

New UCLA-led research suggests that antiretroviral drugs called TAF and TDF directly reduce energy production by mitochondria, structures inside cells that generate the power that cells use to function. Both drugs led to reduced cellular oxygen consumption rates, a measure of the ability of the mitochondria to produce energy, compared with controls.

Released: 18-Jan-2023 1:00 PM EST
People with HIV Experience Higher Rates of Inflammation and Immune Activity During Pregnancy
Rutgers University-New Brunswick

People with HIV have a higher chance of having chronic systemic inflammation during pregnancy, according to a Rutgers study.

Released: 18-Jan-2023 8:00 AM EST
Negative marital communications leave literal, figurative wounds
Ohio State University

A tendency for one or both spouses to avoid or withdraw from tough conversations could set up married couples for emotional distress, bad feelings about their relationship, chronic inflammation and lowered immune function, new research suggests.

   
Newswise: Durable SARS-CoV-2 antibodies bind to two viral targets at once
Released: 17-Jan-2023 4:20 PM EST
Durable SARS-CoV-2 antibodies bind to two viral targets at once
La Jolla Institute for Immunology

A new study led by scientists at La Jolla Institute for Immunology (LJI) shows how ideal antibodies against SARS-CoV-2 hit their marks. Now scientists are looking at how we might harness their power in new antibody therapeutics and even more effective COVID-19 vaccines.

   
Newswise: Increasing Robo4 expression may help with infections
Released: 17-Jan-2023 1:10 PM EST
Increasing Robo4 expression may help with infections
Osaka University

The researchers screened a library of drugs using a mouse endothelial cell line to identify pathways that are involved in the regulation of Robo4 and found that two competitive SMAD signaling pathways appear to regulate Robo4 expression. When the researchers treated LPS-injected mice with a drug that inhibits ALK1-SMAD signaling, they observed increased Robo4 expression, decreased vascular permeability, and reduced mortality.

Released: 17-Jan-2023 12:45 PM EST
Mucosal antibodies in the airways provide durable protection against SARS-CoV-2
Karolinska Institute

High levels of mucosal IgA antibodies in the airways protect against SARS-CoV-2 infection for at least eight months. Omicron infection generates durable mucosal antibodies, reducing the risk of re-infection.

Released: 17-Jan-2023 8:00 AM EST
Improving Adult Immunization Rates the Focus of Partnership Between ATS and Three Health Systems Across the U.S.
American Thoracic Society (ATS)

NEW YORK, NY – Jan. 17, 2023 – The American Thoracic Society is starting the new year poised to improve vaccination rates with three health system partners: University of Arizona/ Banner Health; West Virginia University Hospitals, Inc.; and San Francisco Health Network/ University of California.

Released: 17-Jan-2023 8:00 AM EST
MD Anderson’s Jennifer Wargo receives TAMEST O’Donnell Award for pioneering microbiome research
University of Texas MD Anderson Cancer Center

Jennifer Wargo, M.D., professor of Surgical Oncology and Genomic Medicine at The University of Texas MD Anderson Cancer Center, has received a 2023 Edith and Peter O’Donnell Award in Medicine from the Texas Academy of Medicine, Engineering, Science and Technology (TAMEST) for her contributions to the understanding of how the gut microbiome influences responses to immunotherapy and other cancer treatments.

Newswise: Using paleogenomics to elucidate 10,000 years of immune system evolution
Released: 13-Jan-2023 5:40 PM EST
Using paleogenomics to elucidate 10,000 years of immune system evolution
Institut Pasteur

Scientists from the Institut Pasteur, Université Paris Cité, the CNRS and the Collège de France have used paleogenomics to trace 10,000 years of human immune system evolution.

   
11-Jan-2023 1:15 PM EST
Gut bacteria affect brain health, mouse study shows
Washington University in St. Louis

Gut bacteria can influence brain health, according to a study of mice genetically predisposed to develop Alzheimer’s-like brain damage. The study, by researchers at Washington University School of Medicine in St. Louis, indicates that gut bacteria produce compounds that influence the behavior of immune cells, including ones in the brain that can cause neurodegeneration. The findings suggest a new approach to treating Alzheimer’s and other neurodegenerative diseases.

Released: 12-Jan-2023 1:35 PM EST
Ask the expert: What are nanomedicines?
Michigan State University

Morteza Mahmoudi, an assistant professor in MSU’s Department of Radiology, explains why addressing disagreements with stronger standards will help ensure future nanomedicines are safe, effective and successful.

Newswise: LJI scientists solve the mystery of why OGT enzyme is critical for cell survival
Released: 12-Jan-2023 1:10 PM EST
LJI scientists solve the mystery of why OGT enzyme is critical for cell survival
La Jolla Institute for Immunology

LA JOLLA, CA — Researchers at La Jolla Institute for Immunology (LJI) have at last uncovered how an enzyme called O-GlcNAc transferase (OGT) keeps cells healthy. Their findings, published in the Proceedings of the National Academies of Sciences, reveals a key aspect of cellular biology and may lead to important medical advances.

   
11-Jan-2023 11:05 PM EST
Scientists develop novel mRNA delivery method using extracellular vesicles
University of Texas MD Anderson Cancer Center

A team of researchers led by The University of Texas MD Anderson Cancer Center has developed a novel delivery system for messenger RNA (mRNA) using extracellular vesicles (EVs). The new technique has the potential to overcome many of the delivery hurdles faced by other promising mRNA therapies.

10-Jan-2023 9:35 AM EST
Scientists find more evidence that breast milk of those vaccinated against COVID-19 may protect infants
University of Florida

Findings from a newly published study provide further evidence suggesting that the breast milk of those vaccinated against COVID-19 may help protect babies from the illness

Newswise: Newly discovered surface structures may affect immune function
Released: 11-Jan-2023 7:10 PM EST
Newly discovered surface structures may affect immune function
University of Freiburg

Using new microscopic methods in combination with machine learning-based image analysis, researchers from Freiburg have discovered new structures on the surface of living B cells that affect the distribution and possibly the function of their antigen receptors.

Newswise: Surgery First for Colon Cancer? Not So Fast, According to New Study in JNCCN
10-Jan-2023 9:00 AM EST
Surgery First for Colon Cancer? Not So Fast, According to New Study in JNCCN
National Comprehensive Cancer Network® (NCCN®)

New research in JNCCN finds that immunotherapy from immune checkpoint (PD-1) inhibitors prior to surgery was strikingly effective for patients with localized mismatch repair-deficient or microsatellite instability-high (dMMR/MSI-H) colorectal cancer (CRC).

11-Jan-2023 9:35 AM EST
CAR T Cell Therapy May Eliminate Tumor Cells Missed by Surgery
Perelman School of Medicine at the University of Pennsylvania

CAR T cell therapy may enhance the effectiveness of surgery for solid tumors, according to a preclinical study from researchers in the Perelman School of Medicine at the University of Pennsylvania.

Released: 11-Jan-2023 12:00 PM EST
MD Anderson Research Highlights for January 11, 2023
University of Texas MD Anderson Cancer Center

The University of Texas MD Anderson Cancer Center’s Research Highlights provides a glimpse into recent basic, translational and clinical cancer research from MD Anderson experts.

   
Released: 11-Jan-2023 11:40 AM EST
COVID-19: New research about how antibodies are formed
Friedrich-Alexander-Universität Erlangen-Nürnberg

A team of researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen has gained new insights into the maturation of SARS-CoV-specific antibodies after multiple vaccinations with the mRNA vaccine Comirnaty.

Released: 10-Jan-2023 5:10 PM EST
Unraveling key determinant of successful therapeutic vaccination against chronic hepatitis B
Elsevier

Hepatitis B virus (HBV) infections remain a major global health problem – according to the World Health Organization (WHO) there are around 300 million HBV carriers worldwide. Current treatments rarely succeed in curing the infection.

Newswise: Analysis: A Longer View on COVID-19 Antibodies
Released: 10-Jan-2023 3:00 PM EST
Analysis: A Longer View on COVID-19 Antibodies
Cedars-Sinai

A new analysis by Cedars-Sinai investigators is furthering the scientific community’s understanding of COVID-19 immunity by showing that similar levels of COVID-19 antibodies are reached over an extended period of time in different population groups.

Newswise: RUDN neurosurgeons studied the immune response to multiple injuries
Released: 10-Jan-2023 4:05 AM EST
RUDN neurosurgeons studied the immune response to multiple injuries
Scientific Project Lomonosov

RUDN neurosurgeons studied the immune response in polytrauma - multiple serious traumatic lesions. The results will help specialists understand the features of the recovery period and adjust the treatment.

Released: 9-Jan-2023 5:35 PM EST
B.C. sea sponge has COVID-blocking powers
University of British Columbia

UBC researchers have identified three compounds that prevent COVID-19 infection in human cells, derived from natural sources including a B.C. sea sponge.



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