PGK1, a glycolytic enzyme, has been found to play a role in coordinating cellular processes crucial to cancer metabolism and brain tumor formation, according to results published in today’s online issue of Molecular Cell.
Chung-Tse Michael Wu of the Wayne State University College of Engineering has been awarded a National Science Foundation (NSF) Faculty Early Career Development (CAREER) Award that aims to develop antennas made of novel transmission-line-based metamaterials that would enable a high-speed, microwave panoramic camera (MPC).
Neuroscientists at Duke Health have developed a brain-machine interface (BMI) that allows primates to use only their thoughts to navigate a robotic wheelchair.
Most doctors and nurses review a patient’s family history to identify risk factors for heart disease and cancer, often through a paper checklist or brief interview. But more deliberate efforts to map a patient’s family tree could identify additional risks and drive patients to timely screenings for illnesses that may unknowingly affect them, according to a new study from Duke Health.
Jianlin Cheng has been in the business of protein structure prediction since before coming to the University of Missouri College of Engineering in 2007. And thanks to new funding from the National Institutes of Health, he’s looking at ways to take his research even further. Cheng, an associate professor of computer science, and his co-PI — John Tanner, professor of biochemistry at MU — recently received a four-year, $1.3 million grant from NIH (project number 2R01GM093123-05A1) to continue their research on integrated prediction and validation of protein structures.
A new study shows that patients, who undergo elective hip and knee surgery in hospitals with inadequate nurse staffing and poor nurse work environments, are more likely to require re-hospitalization.
Children with brain cancer may soon get some help from mice with the same disease, thanks to new brain tumor model that could act as a testbed for potential treatments.
Latinas who eat processed meats such as bacon and sausage may have an increased risk for breast cancer, according to a new study that did not find the same association among white women.
Over the past decade, studies have found that obesity and eating a high-fat, high-calorie diet are significant risk factors for many types of cancer. Now, a new study from Whitehead Institute and MIT’s Koch Institute for Integrative Cancer Research reveals how a high-fat diet makes the cells of the intestinal lining more likely to become cancerous.
Kansas State University's Shuting Lei has received a National Science Foundation Manufacturing Machines and Equipment grant for his work on machining precision parts.
Research from an investigator at Rutgers Cancer Institute of New Jersey and colleagues from the National Cancer Institute and other facilities, shows differences in a certain type of small protein vary by race and may contribute differently to the development of lung cancer in African Americans and European Americans.
Whitehead Institute researchers have created a hydrogel scaffold that replicates the environment found within the human breast. The scaffold supports the growth of human mammary tissue from patient-derived cells and can be used to study normal breast development as well as breast cancer initiation and progression.
Chronic psychosocial and emotional stress has well-documented negative effects upon the human immune system but less is known about the health effects of acute but transitory episodes of stress. Do panic-inducing moments also raise the risk of stress-related conditions? A team of researchers at University of California, San Diego School of Medicine, Stony Brook University in New York and elsewhere addressed that question by taking blood samples from skydivers to measure key immune response indicators.
Sleep may be one of the most important factors for well-being; yet, according to the CDC, one in three adults does not get enough. Lack of sleep can lead to potential cognitive declines, chronic diseases and death. Now, research from the University of Missouri finds that older adults who have trouble sleeping, could benefit from participating in social activities, in particular attending religious events.
Researchers have identified three risk factors that make adults with mental illness more likely to engage in violent behavior. The findings give mental health professionals and others working with adults with mental illness a suite of characteristics they can use as potential warning signs, allowing them to intervene and prevent violent behavior.
A new study provides a major link between low levels of vitamin D and aggressive prostate cancer. Northwestern Medicine research showed deficient vitamin D blood levels in men can predict aggressive prostate cancer identified at the time of surgery.
Five exceptional early career scientists will receive new grants from the National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health. The awards, totaling $2.5 million, are part of the Outstanding New Environmental Scientist (ONES) program.
Do you see what I see? Maybe not, if you know more about it than I do.
Research led by St. Jude Children’s Research Hospital has advanced understanding of how the nucleolus is assembled through a process called liquid-liquid phase separation and has identified a protein that plays key role.
With apps and activity trackers measuring every step people take, morsel they eat, and each symptom or pain, patients commonly arrive at doctor's offices armed with self-tracked data. Yet health care providers lack the capacity or tools to review five years of Fitbit logs or instantaneously interpret the deluge of data patients have been collecting about themselves, according to new University of Washington research.
If you’re a lung or colorectal cancer patient, what’s in your wallet could determine your level of suffering and quality of life during treatment, according to a new study by Dana Farber Cancer Institute researchers.
Metastatic prostate cancer, where better therapeutic strategies are desperately needed, appears to be tailor-made for precision oncology, according to a new study by researchers at Fred Hutchinson Cancer Research Center in Seattle. They found that a single metastasis within an individual patient can provide consistent molecular information to help guide therapy in metastatic prostate cancer.
Different groups of neurons program biological clocks to orchestrate our behaviors by sending messages in a unidirectional manner downstream, a team of biologists has found.
Two thirds of urban farmers have a social mission that goes beyond food production and profits, finds new research led by NYU Steinhardt School of Culture, Education, and Human Development.
In a new preclinical study in Cancer Discovery, researchers from the Abramson Cancer Center (ACC) at the University of Pennsylvania have uncovered the poorly understood mechanics of how macrophages can be “re-educated” by an experimental immune therapy to help tear down the scaffolding that surrounds and protects pancreas cancer from chemotherapy.
In emergencies, people may trust robots too much for their own safety, a new study suggests. In a mock building fire, test subjects followed instructions from an “Emergency Guide Robot” even after the machine had proven itself unreliable – and after some participants were told that robot had broken down.
A study that revealed new findings about prostate cells may point to future strategies for treating aggressive and therapy-resistant forms of prostate cancer.
St. Jude Children’s Research Hospital scientists have discovered that an enzyme antibiotics rely on to kill bacteria also promotes survival of pneumococcus and sets the stage for serious, invasive infections
Researchers are using the unique electronic “voices” produced by devices on the electrical grid to determine which signals are legitimate and which signals might be from attackers.
Andrew DeFilippis, M.D., M.Sc., will study archived blood samples from thousands of patients to determine whether the presence of certain lipids in a person’s bloodstream can be used to pinpoint women at risk for having a heart attack.
A two-year clinical trial that compared three drugs for diabetic macular edema (DME) found that gains in vision were greater for participants receiving the drug Eylea (aflibercept) than for those receiving Avastin (bevacizumab), but only among participants starting treatment with 20/50 or worse vision. Gains after two years were about the same for Eylea and Lucentis (ranibizumab), contrary to year-one results from the study, which showed Eylea with a clear advantage. The three drugs yielded similar gains in vision for patients with 20/32 or 20/40 vision at the start of treatment. The clinical trial was conducted by the Diabetic Retinopathy Clinical Research Network (DRCR.net), which is funded by the National Eye Institute, part of the National Institutes of Health.
A new study from the University of Washington, believed to be the first to look at the mental health of transgender children who have “socially transitioned,” finds that they had rates of depression and anxiety no higher than two control groups of children. The findings challenge long-held assumptions that mental health problems in transgender children are inevitable, or even that being transgender is itself a type of mental disorder.
Extreme heat can pose several health risks, such as dehydration, hyperthermia and even death, especially during sustained periods of high temperatures. However, a uniform definition of a heat wave doesn’t exist. As a result, public health agencies may be unsure of when to activate heat alerts, cooling centers and other protective measures. A University of Missouri School of Medicine researcher has developed a uniform definition of a heat wave that may help public health agencies prepare for extreme temperatures.
In a small, placebo-controlled clinical trial, Johns Hopkins physicians report that the antidepressant paroxetine modestly improves decision-making and reaction time, and suppresses inflammation in people with HIV-associated cognitive impairment.
A new cooling technique can both protect the brain’s speech centers during surgery and pinpoint the areas separately responsible for word formation and speech timing.
Inflammation is a Catch-22: the body needs it to eliminate invasive organisms and foreign irritants, but excessive inflammation can harm healthy cells, contributing to aging and sometimes leading to organ failure and death. Researchers at University of California, San Diego School of Medicine have discovered that a protein known as p62 acts as a molecular brake to keep inflammation in check and avoid collateral damage.
Research led by St. Jude Children’s Research Hospital and the German Cancer Research Center shows molecular analysis is likely to improve classification and diagnosis of a rare brain tumor and advance precision medicine
A Kansas State University engineering team has received a three-year $400,000 National Science Foundation grant to track the wellness of special needs children at night and relate this sleep data to daytime learning and behavior.
People searching for something can find it faster if they know what to look for. But new research suggests knowing what not to look for can be just as helpful.
TAMPA, Fla. – Moffitt Cancer Center received a grant from the National Cancer Institute Center to Reduce Cancer Health Disparities to bring together researchers, trainees, new and early-stage investigators, and community health members to identify and prioritize region-specific cancer research, education, outreach and training needs.
Juvenile idiopathic arthritis, or JIA, is the most common form of childhood arthritis. It appears to be an autoimmune disease, caused by antibodies attacking certain proteins in a person’s own tissue. But no “autoantigens”—the proteins triggering an immune attack—have been linked to JIA.
Using a laser probe, neurosurgeons have opened the brain’s protective cover, enabling them to deliver chemotherapy drugs to patients with a form of deadly brain cancer. The findings also suggest that other exciting approaches such as cancer immunotherapy also may be useful for patients with glioblastomas.
U-M researchers genetically engineered a mouse that makes the protein that the body uses to produce human insulin, called proinsulin. By engineering the protein as a fluorescent protein, it reacted in a certain way when the researchers shined a fluorescent light on the mouse pancreas.
Rutgers Cancer Institute of New Jersey researcher Michael L. Gatza, PhD, has received a $747,000 Pathway to Independence Award from the National Cancer Institute to explore the mechanism behind the development of a subtype of ovarian cancer. The aim is to identify what drives cell pathway activity so that novel therapeutic strategies can be developed.
A new study finds most cancer screening guidelines do not clearly spell out the benefits and harms of the recommended actions.
Contrary to popular belief among world relief workers, children in developing countries may not be eating enough protein, which could contribute to stunted growth, a Johns Hopkins-directed study suggests.
Historically, when a family member is terminally ill, the caregiving responsibility falls disproportionately on women. However, in recent years, more men have assumed caregiving roles, and previous research has found that gender differences in caretaking have decreased. Now, a researcher at the University of Missouri School of Medicine has found women still report more negative caretaking experiences than men. The researcher says that interventions are needed to support female caregivers and teach alternative ways to cope and ask for help in stressful situations.
The pathway leading to increased expression of TGF-β1 — which provokes the destructive lung remodeling of pulmonary fibrosis — involves Akt1 kinase-induction of reactive oxygen species and mitophagy, and alveolar macrophages are the primary source of TGF-β1 in the lung.
Worldwide, an estimated 25 percent of children under age 5 suffer from stunted growth and development. A team of researchers has found that inadequate dietary intake of essential amino acids and the nutrient choline is linked to stunting.
Researchers discover how a bat’s brain screens out sounds not worth paying attention to..
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