Scientists at The University of Manchester have shown for the first time that the numbers of opiate receptors in the brain increases to combat severe pain in arthritis sufferers.
Scientists have more precisely calculated heritability--the influence of underlying genes--in 9 autoimmune diseases that begin in childhood. The research may strengthen risk assessment for associated autoimmune disorders.
Announcement of Inaugural Autoimmune Walk to be held in Los Angeles, CA on Sunday, November 8, 2015
New research on sickle cell disease (SCD) has found that using antibiotics to deplete the body’s microbiome may prevent acute sickle cell crisis and could offer the first effective strategy for warding off the disease’s long-term complications, such as organ failure. The study, conducted by scientists at Albert Einstein College of Medicine and Montefiore Health System, could also lead to better treatment for other inflammatory blood-vessel disorders including septic shock. The findings were published online today in Nature.
Scientists who analyzed the genes involved in 10 autoimmune diseases that begin in childhood have found 22 genome-wide signals shared by two or more diseases. These shared gene sites may reveal potential targets for treatment with existing drugs.
In a new study, researchers managed to narrow down 900 million possibilities requiring examination of the connection between genetic markers and genetic expression to just 340,000, in the process identifying “social” genes that play a cooperative role
Molecular details of ADAMTS13 binding by autoantibodies reveal, for the first time, the mechanism of inhibition of ADAMTS13 by those autoantibodies and suggest an avenue for therapeutic intervention.
Individuals with new-onset type 1 diabetes who took two courses of alefacept (Amevive®, Astellas Pharma Inc.) soon after diagnosis show preserved beta cell function after two years compared to those who received a placebo.
Other topics include autism research, biofuel sources, nutrition supplements, and more...
Actress Haley Ramm and the cast of ABC Family's "Chasing Life" accept the pajama challenge for the Autoimmune Disease Association and autoimmune disease awareness.
Long-term use of naproxen (ALEVE), a type of nonsteroidal anti-inflammatory drug (NSAID), is often prescribed for chronic pain conditions such as osteoarthritis. However, because of NSAID-related gastrointestinal problems including stomach and intestinal inflammation and ulcers, many are unable to tolerate ongoing use. A new study, published in the American Journal of Physiology–Gastrointestinal and Liver Physiology, finds that a naproxen-derivative may provide both symptom relief and gastrointestinal protection. The research is highlighted as one of this month’s “best of the best” as part of the American Physiological Society’s APSselect program.
Other topics include dietary guidelines, smart traffic lights, breast cancer, and biomarker tests for cancer treatment.
One of the most prevalent and anxiety-provoking concerns among patients with lupus is whether it is safe to become pregnant. A study led by researchers at Hospital for Special Surgery finds that most women can expect a good pregnancy outcome if their lupus is inactive and they are free of risk factors.
New findings may help ease concerns for women with lupus who are interested in having a child. A new study concludes that most women with lupus whose disease is not very active will have a safe pregnancy. The results are to publish online June 22 in Annals of Internal Medicine.
Macrophage cells require agility to scavenge and digest dead cells and prevent an immune response to self. In lupus, the macrophages lose that agility.
Scientists from the Weizmann Institute and the University of Bergen have found that a hereditary autoimmune disease (autoimmune polyendocrine syndrome type 1), thought to be very rare, may have a less severe form that affects at least one in 1,000 people. The results suggest that other autoimmune conditions may be tied to mutations in a single gene.
Patients with acute exacerbations of idiopathic pulmonary fibrosis responded well to therapies similar to those used to treat autoimmune diseases, suggesting that autoantibodies may play an important role in patients with acute exacerbations of IPF, a devastating lung disease.
Trending news releases with the most views in a single day. Topics include: An anonymous donor for cancer research, solar storms and incidences of rheumatoid arthritis, vulnerabilities in genome’s ‘Dimmer Switches’, new treatments for Alzheimer's, How people make decisions for or against flu vaccinations.
New release reports correlation between incidences of rheumatoid arthritis and giant cell arteritis with solar cycles.
New research suggests people with multiple sclerosis (MS) may have double the risk of dying early compared to people without MS, with those younger than 59 at a three times higher risk. The study is published in the May 27, 2015, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Trending news releases with the most views in a single day. Topics include: genetics, cancer, nanotech, elderly care, marketing research, energy, children's health, and immunology.
New UK research has challenged the assumption that people with rheumatoid arthritis always take their medication as prescribed.
Experts from the Mayo Clinic, Cleveland Clinic, Stanford, PENN, UNC, and the NIH will offer education and networking opportunities for people, families, and friends living with vasculitis, a family of rare autoimmune diseases.
Researchers at the La Jolla Institute for Allergy and Immunology, in collaboration with colleagues the University of California, San Diego, identified a novel drug target for the treatment of rheumatoid arthritis that focuses on the cells that are directly responsible for the cartilage damage in affected joints.
A new study led by researchers at the University of Minnesota has found a three-way link among antibiotic use in infants, changes in the gut bacteria, and disease later in life.
Joslin researchers have uncovered the action of a gene that regulates the education of T cells, providing insight into how and why the immune system begins mistaking the body’s own tissues for targets.
23andMe, Inc., the leading personal genetics company, today announced the launch of the Lupus Research Study in collaboration with Pfizer Inc. The companies aim to enroll 5,000 individuals with systemic lupus erythematosus, more commonly known as lupus, into the study to help better understand the genetics of lupus. The effort is also in collaboration with the Lupus Research Institute, and in concert with Lupus Awareness Month in May.
Scientists have identified new biomarkers that could distinguish Sjögren’s Syndrome (SS) from other autoimmune diseases in days or weeks, improving on a current time to diagnosis of four-plus years. The research is being presented at the 2015 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO) this week in Denver, Colo
Researchers at NYU Langone Medical Center have identified an important role for calcium signaling in immune responses to chronic infection resulting from Mycobacterium tuberculosis, the bacterium causing tuberculosis (TB).
Researchers found that 70% of patients received a dose of hydroxychloroquine that exceeded safety guidelines, and can potentially cause vision loss, in an inner city hospital. The research is being presented at the 2015 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO) this week in Denver, Colo.
Arthritis Research UK-funded scientists at The University of Manchester have identified a new way in which genotyping can be used to predict disease outcomes among sufferers of rheumatoid arthritis.
Trending news releases with the most views in a single day. Topics include: diet supplements and cancer risk (3 days on top 10 list), oral mucositis in cancer treatment, updated breast cancer screening guidelines, climate change, materials science, asthma, mental health and gun violence, genetics and immunology, and multiple sclerosis treatment.
In the largest genome-wide analysis of common variable immunodeficiency disorder (CVID), scientists identified a gene that may be a "missing link" between overactive and underactive immune activity.
Researchers have identified a protein that offers a new focus for developing targeted therapies to tame the severe inflammation associated with multiple sclerosis (MS), colitis and other autoimmune disorders. St. Jude Children’s Research Hospital scientists led the study which appears today in the scientific journal Immunity.
Researchers from the Yale Cancer Center and the Veterans Affairs Greater Los Angeles Healthcare System have devised a way to re-engineer lupus antibodies to turn them into potential cancer killers. Findings from recent research were presented April 21 at the American Association for Cancer Research Annual Meeting 2015 Philadelphia.
Researchers found enhanced rather than suppressed immune function in animals with increased biodiversity. Publishing online in the April 8, 2015, issue of PLOS ONE, the findings add to the growing understanding of the complex environment in the digestive tract and its role in maintaining health.
CENTOGENE AG (“CENTOGENE”) announces the launch of the world’s largest genetic mutation database for rare diseases, CentoMD®.
Saint Louis University researcher Daniel Hawiger hopes that these breakthroughs will open the door to design better treatments for autoimmune diseases.
In a recent survey, AARDA has found that fatigue is a major component of autoimmune disease.
The American Autoimmune Related Diseases Association Inc. (AARDA) will host The State of Autoimmune Disease: A National Summit at the National Press Club on Monday, March 23, 2015.
The American Autoimmune Related Diseases Association (AARDA), a national nonprofit health organization dedicated to increasing awareness of autoimmune diseases, today released a statement concerning the Food and Drug Administration’s (FDA) approval of filgrastim, the first biosimilar product approved in the United States.
Drinking coffee may be associated with a lower risk of developing multiple sclerosis (MS), according to a study released today that will be presented at the American Academy of Neurology’s 67th Annual Meeting in Washington, DC, April 18 to 25, 2015.
Despite the prevalence of Sjögren’s syndrome – an autoimmune disease most commonly known for causing dry eyes and mouth - a lack of knowledge about how the condition starts has stalled the development of new treatments. Researchers have now developed a specialized animal model of Sjögren’s that engrafts human cells into mice, allowing scientists to track various factors that affect disease development and discover potential new therapies.
Mercury in seafood – even at low levels generally considered safe – was associated with disease risk factor.
• Researchers have shown that the messenger protein IL-6, which is rapidly produced at high levels during an acute inflammatory form of kidney disease, potently dampens activation of tissue-destructive immune cells called macrophages. • The findings may have broad clinical implications because elevated IL-6 is observed in many different inflammatory diseases, and macrophages are often crucially involved in their pathogenesis.
A harmless fluorescent probe injected into a joint may make it easier to diagnose and monitor osteoarthritis, leading to better patient care. A new study led by biomedical researchers at Tufts University reports that such a probe successfully tracked the development of early to moderate osteoarthritis in male mice.
Su-Chun Zhang, a professor of neuroscience and neurology at the University of Wisconsin-Madison Waisman Center, and his research team have published a unique model for learning more about the role of human astrocytes in the Journal of Clinical Investigation today. The findings may lay a foundation for the treatment of a number of neurodegenerative diseases, including ALS (amyotrophic lateral sclerosis) and debilitating spinal cord injuries.
A mosquito-borne virus that has spread to the Caribbean and Central and South America and has caused isolated infections in Florida often causes joint pain and swelling similar to that seen in patients with rheumatoid arthritis.
In a pair of related studies, scientists from the Florida campus of The Scripps Research Institute have shown their drug candidates can target biological pathways involved in the destruction of brain cells in Parkinson's disease.
The mutation and its functional effects that cause the genetic disorder Singleton-Merten Syndrome (SMS) has been described for the first time, by an international research team. SMS is now recognized as an autoimmune disorder.
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