Rutgers Cancer Institute of New Jersey and Tufts Medical Center Collaboration Published in Journal of Clinical Oncology
A new therapy that makes the immune system kill bone marrow cancer cells was successful in as many as 73 percent of patients in two clinical trials, according to researchers from The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai.
"This is a very striking and significant result that essentially separates LIGHT from any of the other inflammatory cytokines that have been implicated in the process in severe asthmatics."
This special edition features presentations by MD Anderson researchers at the 2022 American Society of Hematology (ASH) Annual Meeting on innovative targeted therapies, new combination approaches and novel targets to improve outcomes for patients with leukemias, Hodgkin lymphoma, non-Hodgkin lymphoma, myeloma and other hematologic cancers.
Usually, the scariest part of childhood vaccination, for both kids and parents, is the needles. In rare cases, however, vaccines can have unexpectedly negative effects, and the secret lies in our genes.
Scientists at Johns Hopkins Medicine say that a key to cellular movement is to regulate the electrical charge on the interior side of the cell membrane, potentially paving the way for understanding cancer, immune cell and other types of cell motion.
Researchers aiming to predict which staph-infection patients might develop a related kidney disease have found a high frequency of gene mutations in the infecting bacteria of affected patients, which suggests these variants may play a role in the body’s initiation of the renal damage.
Individuals who, despite having been vaccinated against COVID-19, develop the disease and are hospitalized are less likely to go to an intensive care unit (ICU), more likely to have a shorter hospital stay, and less likely to die in the hospital than individuals hospitalized for COVID who were never vaccinated, according to a national study from the Centers for Disease Control and Prevention’s VISION Network.
Autoimmune diseases are thought to be the result of mistaken identity. Immune cells on patrol, armed and ready to defend the body against invading pathogens, mistake normal human cells for infected cells and turn their weapons on their own healthy tissues.
"Vaccines such as JYNNEOS should be able to induce T cells that also recognize mpox and can provide protection from severe disease."
The Global Virus Network (GVN) announced eleven members of the 2022 GVN Rising Star Mentorship Program. The newly elected members span eight countries around the globe.
Researchers at Washington University School of Medicine in St. Louis have shown that the cancer therapy known as CAR-T can be applied to multiple sclerosis (MS), an autoimmune disease of the nervous system. The findings extend the powerful tool of immunotherapy to autoimmune diseases, a class of diseases that are often debilitating and difficult to treat.
Periprosthetic joint infection (PJI) is a devastating complication of knee and hip replacement surgery that can, in some cases, be difficult to distinguish from other causes of arthroplasty failure. An "omics"-based tool that measures predicted abundance of immune cells may aid in making the diagnosis of failed arthroplasty due to PJI, suggests a study in The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.
By August 2022, most children and adults younger than 60 years in Canada had been exposed to SARS-CoV-2 through a combination of vaccination and infection, according to a large study looking at blood antibodies published in CMAJ (Canadian Medical Association Journal)
Researchers at The Tisch Cancer Institute uncovered inflammatory markers that may predict which COVID-19 patients are more likely to respond to therapies like the anti-cancer drug pacritinib, according to phase 2 trial results published in JAMA Network Open in December.
B cells are critical to the proper functioning of the immune system.
Children living with type 1 diabetes miss an average of nine more sessions of school a year compared to children without the condition, a new study led by Cardiff University has found.
A new tool under development by University at Buffalo researchers could one day help clinicians better predict resistance to immunoglobulin therapy among children with Kawasaki disease in the United States.
Women with prolonged mental health problems up to three years after childbirth may be suffering from irregular immune system responses, according to new research by Cedars-Sinai investigators. The findings are published in the American Journal of Reproductive Immunology.
Immune T cells are continuing to target the spike protein of SARS-CoV-2 variants of concern, although mutations are making some T cells less effective, according to new research.
With COVID-19 and flu cases rising, and RSV (respiratory syncytial virus) affecting many young children, experts are bracing for a “tripledemic” of respiratory viruses this holiday season.
An innovative protocol called PepSeq is changing the way researchers test for contagious diseases—and this knowledge should change the way humanity responds to future pandemics. NAU researcher Jason Ladner and a team of collaborators from TGen published a comprehensive study about PepSeq that lays out the process, the tool and how to interpret the results.
A brief roundup of news and story ideas from the experts at UCLA Health.
Molecular biologist Yu Xin (Will) Wang, Ph.D., has joined Sanford Burnham Prebys as an assistant professor in the Development, Aging, and Regeneration Program to uncover the ways muscle, nerve and immune cells work together to overcome disease.
Researchers at the University of São Paulo (USP) in Brazil have found that severe COVID-19 is associated with an imbalance in an important immune system signaling pathway.
In a step likely to advance personalised cancer treatment, scientists have for the first time shown in patients that levels of biomarkers are not enough to tell which patients are likely to respond best to immunotherapy.
Three currently circulating omicron subvariants of SARS-CoV-2 – including two that currently make up almost 50% of reported COVID-19 infections in the U.S. – are better at evading vaccine- and infection-generated neutralizing antibodies than earlier versions of omicron, new research suggests.
Though antiretroviral therapy has made HIV a manageable disease, people living with HIV often suffer from chronic inflammation. This can put them at an increased risk of developing comorbidities such as cardiovascular disease and neurocognitive dysfunction, impacting the longevity and quality of their lives.
More than 20 UT Southwestern Medical Center scientists are among the 2022 Highly Cited Researchers listed in the top 1% of researchers from across the globe
New insights into the function of mitochondria reveal interfaces between the nervous and immune systems.
UC San Diego researchers expand and deepen understanding of how genetic aberrations fuel human papilloma virus-negative head and neck cancers and, potentially, provide paths to further refinement and improvement of immune checkpoint inhibitors for HPV-negative head and neck cancers.
A Ludwig Cancer Research study has revealed a single protein expressed at high levels by cancer cells across a broad range of malignancies that erects a multifaceted barrier to anti-cancer immune responses in mouse models of cancer and so shields tumors from immune detection and destruction.
Two studies published by The BMJ today provide up to date evidence on the effectiveness of both currently licensed and possible covid-19 treatments under everyday (‘real world’) conditions, helping to shed more light on whether these drugs can prevent people from becoming seriously ill.
Researchers at Karolinska Institutet in Sweden have shown that patients with acute COVID-19 infection have increased levels of the cytokine IL-26 in their blood.
Chronic alcohol misuse including Alcohol Use Disorder (AUD), is an overlooked risk factor for severe or fatal COVID-19, according to a review of medical and scientific studies.
COVID-19 reactivated viruses that had become latent in cells following previous infections, particularly in people with chronic fatigue syndrome, also known as ME/CFS.
The University of Texas MD Anderson Cancer Center today announced a $10 million gift to the James P. Allison Institute from the Andrew Sabin Family Foundation and Andrew “Andy” Sabin, a senior member of the MD Anderson Cancer Center Board of Visitors (BOV). The gift is the philanthropist’s second multimillion-dollar commitment to MD Anderson in less than 10 years.
The University of Texas MD Anderson Cancer Center’s Research Highlights provides a glimpse into recent basic, translational and clinical cancer research from MD Anderson experts. Current advances include a promising targeted therapy combination for patients with relapsed/refractory acute myeloid leukemia (AML), a link between the gut microbiome and therapy-related neutropenic fever, a novel therapeutic target for immunotherapy-related colitis, a telementoring model for training providers on cervical cancer prevention in limited-resource areas, a new understanding of the prognostic value of RUNX1 mutations in AML, and insights into the effects of opioid use on the pain sensitivity pathway.
COVID-19 reactivated viruses that had become latent in cells following previous infections, particularly in people with chronic fatigue syndrome, also known as ME/CFS.
The researchers discovered that T-cells recognizing the cardiac antigen α-myosin are the mechanism for this complication, setting the framework to identify biomarkers so at-risk patients can be recognized and medical strategies developed for them to tolerate the immunotherapy. Their findings are reported Nov. 16 in Nature.
In a small study, Johns Hopkins Kimmel Cancer Center researchers successfully trained a machine learning algorithm to predict, in hindsight, which patients with melanoma would respond to treatment and which would not respond.
The 2022 "Highly Cited Researchers" list from Clarivate includes several La Jolla Institute for Immunology (LJI) scientists well versed in lay friendly communication. These experts are ready to share exciting new research with media and podcast outlets. Contact [email protected] to set up an interview and make arrangements for high quality audio capture.
Seven researchers at La Jolla Institute for Immunology (LJI) have been named to the 2022 Highly Cited List, released today by Clarivate.
Immune checkpoint inhibitors such as Keytruda and Opdivo work by unleashing the immune system’s T cells to attack tumor cells. Their introduction a decade ago marked a major advance in cancer therapy, but only 10% to 30% of treated patients experience long-term improvement. In a paper published online today in The Journal of Clinical Investigation (JCI), scientists at Albert Einstein College of Medicine describe findings that could bolster the effectiveness of immune-checkpoint therapy.
Researchers at the Icahn Mount Sinai have identified 35 genes that are particularly highly expressed in people with long-term Lyme disease. These genes could potentially be used as biomarkers to diagnose patients with the condition, which is otherwise difficult to diagnose and treat. The findings, published November 15 in the journal Cell Reports Medicine, may also lead to new therapeutic targets. The study is the first to use transcriptomics as a blood test to measure RNA levels in patients with long-term Lyme disease.
mRNA vaccines for COVID-19 generate adverse reactions such as fever and fatigue which are considered normal and are transient in nature.
An immune response that likely evolved to help fight infections appears to be the mechanism that drives human immunodeficiency virus (HIV) into a latent state, lurking in cells only to erupt anew, researchers at Duke Health report.
Hosted by Chulalongkorn University the APRU APEC University Leaders' Forum 2022 is the first post-pandemic in-person APEC meeting held to foster high-level dialogue between CEOs, policy leaders, university presidents, and top researchers. This event begins Nov 15 at 9 PM EST.
A scalpel-free, high-tech form of brain surgery pioneered at UVA Health offers long-term relief for patients with essential tremor, a common movement disorder, a five-year review shows.
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