Feature Channels: Drug Resistance

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Released: 8-Nov-2023 5:05 PM EST
First evidence of how the Asian malaria mosquito is spreading drug-resistant malaria in Africa
Lancaster University

Asian malaria mosquito found to spread drug and diagnosis-resistant malaria in Africa.

3-Nov-2023 8:00 AM EDT
A step to prevent opioid overdose deaths with light-activated naloxone treatment
American Chemical Society (ACS)

In a proof-of-concept in ACS’ Nano Letters, a team has designed injectable nanoparticles that released naloxone ― which rapidly reverses opioid overdose effects ― when triggered by blue light. In experiments with mice, this system was activated a month after injection.

Newswise: New Research in JNCCN Suggests a Simple and Inexpensive Option for Reducing a Major Chemotherapy Side-Effect
3-Nov-2023 10:05 AM EDT
New Research in JNCCN Suggests a Simple and Inexpensive Option for Reducing a Major Chemotherapy Side-Effect
National Comprehensive Cancer Network® (NCCN®)

New research in the November 2023 issue of JNCCN—Journal of the National Comprehensive Cancer Network suggests that breast cancer patients who have insufficient levels of vitamin D before starting paclitaxel treatment are more likely to experience peripheral neuropathy.

Newswise: Obesity linked to neurodegeneration through insulin resistance
31-Oct-2023 5:05 PM EDT
Obesity linked to neurodegeneration through insulin resistance
PLOS

Researchers led by Mroj Alassaf at the Fred Hutchinson Cancer Research Center in the United States have discovered a link between obesity and neurodegenerative disorders like Alzheimer’s disease.

Released: 7-Nov-2023 7:45 AM EST
MD Anderson and Jazz Pharmaceuticals announce five-year collaboration to evaluate zanidatamab in HER2-expressing cancers
University of Texas MD Anderson Cancer Center

MD Anderson and Jazz Pharmaceuticals announced a five-year strategic research collaboration agreement to evaluate zanidatamab, Jazz’s investigational HER2-targeted bispecific antibody, in multiple HER2-expressing cancers.

Released: 3-Nov-2023 3:00 PM EDT
Researchers Utilize TriNetX Research Network to Analyze Postoperative Data and Better Describe Lines of Treatment
American Society of Regional Anesthesia and Pain Medicine (ASRA)

It is no secret that the mainstay of postoperative analgesia is opioid based, but studies confirm that the execution of a multimodal postoperative analgesic approach to postoperative pain control can help minimize opiate side effects.

Released: 3-Nov-2023 2:30 PM EDT
Different Anesthesia Techniques Effect Postoperative Recovery, According to a Survey of Pediatric Patient Data
American Society of Regional Anesthesia and Pain Medicine (ASRA)

Utilizing both high spinal anesthesia (HSA) and general anesthesia (GA) may lead to faster patient recovery times and overall better patient care when used in pediatric congenital heart surgery.

Released: 31-Oct-2023 9:30 AM EDT
Tiny model organs detect liver toxicity of new drugs
Michigan Medicine - University of Michigan

A University of Michigan-led study provided evidence of the efficacy of a new drug-induced liver injury screening platform using human liver organoids, or tiny 3D models of organs developed from patients’ stem cells that grow in petri dishes.

Released: 27-Oct-2023 5:05 PM EDT
Study: Metformin can help youth manage weight gain side effect of bipolar medications
University of Cincinnati

A new large-scale study led by researchers at the University of Cincinnati and Northwell Health, New York's largest health care provider, found the drug metformin can help prevent or reduce weight gain in youth taking medication to treat bipolar disorder.

Newswise: Common chemotherapy drugs don’t work like doctors thought, with big implications for drug discovery
Released: 26-Oct-2023 5:05 PM EDT
Common chemotherapy drugs don’t work like doctors thought, with big implications for drug discovery
University of Wisconsin–Madison

A new study from the University of Wisconsin–Madison suggests that chemotherapy may not be reaching its full potential, in part because researchers and doctors have long misunderstood how some of the most common cancer drugs actually ward off tumors.

Released: 24-Oct-2023 12:05 PM EDT
How to slow the spread of deadly ‘superbugs’
University of Technology, Sydney

Harnessing new advances in genomic surveillance technology could help detect the rise of deadly ‘superbugs’

Released: 19-Oct-2023 7:05 PM EDT
Ketamine’s effect on depression may hinge on hope
Stanford Medicine

In study after study, the psychoactive drug ketamine has given profound and fast relief to many people suffering from severe depression.

Released: 19-Oct-2023 7:05 PM EDT
Review: Drug for panic disorder less effective than previously believed
Oregon Health & Science University

New research reveals that the nation’s most widely prescribed type of sedative may be less effective than clinicians and scientists have been led to believe, based on publications in medical journals.

Newswise: WVU charting public policy model to address opioid crisis
Released: 10-Oct-2023 1:00 PM EDT
WVU charting public policy model to address opioid crisis
West Virginia University

While solutions for addressing the opioid crisis often involve either beefing up law enforcement or widening the scope of health services, West Virginia University researchers said they believe the best approach is a synergistic mix of both.

   
Released: 9-Oct-2023 6:05 PM EDT
Clinical trial demonstrates benefits of solriamfetol for adults with ADHD
Massachusetts General Hospital

Although several medications are approved to treat attention-deficit/hyperactivity disorder (ADHD), some individuals experience limited benefits from the drugs or develop side effects from their use.

Newswise: Researchers Discover Promising Treatment to Combat Hospital Superbug
Released: 2-Oct-2023 12:05 PM EDT
Researchers Discover Promising Treatment to Combat Hospital Superbug
California State University, Fullerton

Cal State Fullerton antibiotic-resistance researcher María Soledad Ramírez and her students have discovered a promising new therapeutic to treat Acinetobacter baumannii, a superbug commonly found in hospitals and resistant to many antibiotics.

Released: 22-Sep-2023 12:05 PM EDT
إيجاد التوازن: العقاقير أفيونية المفعول والسيطرة على الألم بعد الجراحة
Mayo Clinic

في دراسة حديثة أجرتها مايو كلينك، وجد الباحثون أن معظم المرضى الذين وصِف لهم عدد أقل من العقاقير أفيونية المفعول بعد الجراحة كانوا قادرين على الحفاظ على مستويات مُرضية من الراحة بدون الحاجة إلى تكرار صرف الأدوية لاحقًا.

Released: 22-Sep-2023 12:05 PM EDT
Encontrando o equilíbrio: os opioides e o controle da dor depois da cirurgia
Mayo Clinic

Em um estudo recente da Mayo Clinic, pesquisadores descobriram que a maioria dos pacientes que recebeu a prescrição de opioides depois da cirurgia foi capaz de manter níveis satisfatórios de conforto sem a necessidade de haver a renovação da receita posteriormente.

Released: 22-Sep-2023 11:05 AM EDT
Encontrar el equilibrio: Los opioides y el control del dolor después la cirugía
Mayo Clinic

En un estudio reciente de Mayo Clinic, los investigadores descubrieron que la mayoría de los pacientes a los que se les recetaron menos opioides después de una cirugía pudieron mantener niveles satisfactorios de bienestar sin necesitar más resurtidos de prescripción luego.

Newswise: When cancer takes a deadly turn: NUS study sheds a new light on cancer metastasis
Released: 22-Sep-2023 5:05 AM EDT
When cancer takes a deadly turn: NUS study sheds a new light on cancer metastasis
National University of Singapore (NUS)

The ability of cancer cells to metastasise, or spread from one part of the body to another, is one of the reasons why cancer can be extremely challenging to treat. However, the process that drives metastasis is complex and not fully understood.

Newswise: NIH awards SMU chemistry professor and his team $3.5M to refine and test new tuberculosis treatments
Released: 19-Sep-2023 6:05 AM EDT
NIH awards SMU chemistry professor and his team $3.5M to refine and test new tuberculosis treatments
Southern Methodist University

SMU chemistry professor John Buynak and his team have received a $3.5 million, 5-year grant from the National Institutes of Health to design and synthesize new antibiotics to fight some of the deadliest and most clinically challenging infections of the 21st century – drug resistant strains of bacteria that cause tuberculosis and leprosy.

Newswise: Sylvester study shows how thoracic surgeons who treat lung cancer are helping to reduce patients’ risk of opioid dependence
Released: 18-Sep-2023 2:05 PM EDT
Sylvester study shows how thoracic surgeons who treat lung cancer are helping to reduce patients’ risk of opioid dependence
Sylvester Comprehensive Cancer Center

Researchers at Sylvester Comprehensive Cancer Center found that robot-assisted surgeries and new patient-care protocols are enabling lung cancer surgery patients to go home earlier, with less pain and almost always without a need for potentially addictive opioids.

Released: 13-Sep-2023 3:05 PM EDT
Finding Fresh Approaches for Tried-and-True Antibiotics
Texas Tech University

Texas Tech researchers are taking a closer look at drug-resistant organisms and searching for new ways to attack them.

   
Newswise: Ultrathin nanotech promises to help tackle antibiotic resistance
Released: 12-Sep-2023 7:05 PM EDT
Ultrathin nanotech promises to help tackle antibiotic resistance
University of South Australia

Researchers have invented a nano-thin superbug-slaying material that could one day be integrated into wound dressings and implants to prevent or heal bacterial infections.

Newswise: Gene Discovery Nets FAU Researchers U.S. Patent for Molecular Approach to Treat Addiction
Released: 7-Sep-2023 8:30 AM EDT
Gene Discovery Nets FAU Researchers U.S. Patent for Molecular Approach to Treat Addiction
Florida Atlantic University

Researchers have received a U.S. patent for a novel method to identify therapeutic agents to treat addiction. The invention, related to the fields of pharmacology, medicine, neurology and psychiatry, targets the protein MBLAC1, which the Blakely lab identified as the mammalian form of a gene the group first identified in worms as a modifier of signaling by the neurotransmitter dopamine.

Released: 31-Aug-2023 4:05 PM EDT
Large proportion of Michigan’s C. jejuni infections are caused by antibiotic resistant strains
Michigan State University

Research from Michigan State University has shown that more than 100 strains of Campylobacter jejuni, a leading cause of foodborne illness, circulating in Michigan are resistant to at least one antibiotic.

   
Released: 28-Aug-2023 2:20 PM EDT
Patrolling honey bees exposes spread of antimicrobial resistance
Macquarie University

Bees could become biomonitors, checking their neighbourhoods to determine how far antimicrobial resistance (AMR) has spread, according to research by Macquarie University scientists.

   
Newswise: New drug combo could treat some resistant breast cancers
Released: 24-Aug-2023 11:05 AM EDT
New drug combo could treat some resistant breast cancers
UT Southwestern Medical Center

Breast cancers with mutations in the HER2 gene are initially sensitive to HER2 inhibitors like neratinib. However, most tumors eventually become resistant.

Released: 22-Aug-2023 11:55 PM EDT
New antibiotic from microbial ‘dark matter’ could be powerful weapon against superbugs
Utrecht University

A new powerful antibiotic, isolated from bacteria that could not be studied before, seems capable to combat harmful bacteria and even multi-resistant ‘superbugs’.

   
Newswise: St. Jude shows cancer resistance protein can have its cake and eat it too
Released: 21-Aug-2023 11:05 AM EDT
St. Jude shows cancer resistance protein can have its cake and eat it too
St. Jude Children's Research Hospital

Scientists at St. Jude Research Hospital unravel the mechanisms behind a key culprit in chemotherapy resistance.

Released: 17-Aug-2023 12:10 PM EDT
Scientists find ‘concerning’ flaw in malaria diagnostics
Cornell University

Current methods can vastly overestimate the rates that malaria parasites are multiplying in an infected person’s blood, which has important implications for determining how harmful they could be to a host, according to a new report.

   
Released: 16-Aug-2023 12:15 PM EDT
MD Anderson Research Highlights for August 16, 2023
University of Texas MD Anderson Cancer Center

The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention.

   
Released: 15-Aug-2023 1:25 PM EDT
Images of enzyme in action reveal secrets of antibiotic-resistant bacteria
Emory University

Bacteria draw from an arsenal of weapons to combat the drugs intended to kill them. Among the most prevalent of these weapons are ribosome-modifying enzymes. These enzymes are growing increasingly common, appearing worldwide in clinical samples in a range of drug-resistant bacteria.

   
Newswise:Video Embedded treating-back-to-school-ear-infections-without-antibiotic-resistance-video
VIDEO
7-Aug-2023 11:45 PM EDT
Treating back-to-school ear infections without antibiotic resistance (video)
American Chemical Society (ACS)

“Back-to-school” season means earaches. Today, a team reports a single-use nanoscale system unlikely to generate resistance. It can kill an ear-infection-causing bacterium in animals with a compound like bleach, and it could someday be used in a gel. They will present their results at ACS Fall 2023.

Released: 7-Aug-2023 5:10 PM EDT
How the hospital pathogen Acinetobacter baumannii quickly adapts to new environmental conditions
Goethe-Universität Frankfurt am Main

Each year, over 670,000 people in Europe fall ill because of antibiotic-resistant pathogens, and 33,000 die from the infections.

   
Newswise: New grant seeks to parse how the variegated nature of human breast cancer tumors helps cancer cells resist treatment
Released: 4-Aug-2023 8:00 AM EDT
New grant seeks to parse how the variegated nature of human breast cancer tumors helps cancer cells resist treatment
Sanford Burnham Prebys

The National Cancer Institute (NCI) has awarded a 5-year, $2.7 million grant to researchers at Sanford Burnham Prebys to investigate and elucidate the underlying cellular mechanisms that drive the most common form of breast cancer.

Newswise: Deadly fungus beaten with new type of treatment
Released: 1-Aug-2023 1:35 PM EDT
Deadly fungus beaten with new type of treatment
RIKEN

Researchers have discovered a new way to attack fungal infections. The key is to block fungi from being able to make fatty acids, the major component of fats.

Newswise: Researchers Identify Two New Subtypes of HPV-associated Head and Neck Cancers
Released: 31-Jul-2023 4:05 PM EDT
Researchers Identify Two New Subtypes of HPV-associated Head and Neck Cancers
University of North Carolina School of Medicine

Researchers in UNC School of Medicine’s Department of Otolaryngology/Head and Neck Surgery and collaborators at Yale Cancer Center and ECOG-ACRIN Cancer Research Group have identified two subtypes of human papillomavirus positive head and neck cancers, giving them a better glimpse into why some patients respond better to treatment than others.

Released: 28-Jul-2023 3:05 PM EDT
July 2023 Tip Sheet From Sylvester Comprehensive Cancer Center
Sylvester Comprehensive Cancer Center

A first-of-its kind drug for prostate cancer, an ancient retrovirus that may drive aggressive brain cancer, disparities in endometrial cancer rates among Black women, a new trial seeking answers for higher rates of aggressive prostate and breast cancer in Black men and women, and more are in this month’s tip sheet from Sylvester Comprehensive Cancer Center.

Released: 27-Jul-2023 2:20 PM EDT
Advances in Big Data for Precision Medicine, Novel Technologies to Determine a Pathogen’s Susceptibility to Antibiotics, the Microbiome’s Impact on Childhood Undernutrition, and More Draw Nearly 20,000 Attendees to 2023 AACC Annual Scientific Meeting
Association for Diagnostic and Laboratory Medicine (ADLM (formerly AACC))

The Association for Diagnostics and Laboratory Medicine (ADLM), formerly AACC, welcomed thousands of laboratory experts to the 2023 AACC Annual Scientific Meeting & Clinical Lab Expo from July 23-27. At this year’s special meeting celebrating ADLM’s 75th anniversary, the organization officially rolled out a new name that reflects the association’s role as advocate and champion for a larger community specializing in diagnostics and laboratory medicine, as well as its global reach.

Released: 19-Jul-2023 12:15 PM EDT
Towards new antibiotics with the first artificial synthesis of tanzawaic acid b
Tokyo University of Science

The discovery of antibiotics in 1928 was a major turning point in the history of medicine. For the first time since the dawn of human civilization, doctors had gained access to an extremely powerful and effective tool to fight against a wide variety of bacterial infections.

Newswise: World-first clinical trial to help millions with penicillin allergies
Released: 17-Jul-2023 11:55 AM EDT
World-first clinical trial to help millions with penicillin allergies
Vanderbilt University Medical Center

Penicillin allergy affects more than 25 million people in the United States (up to 1 in 10 Americans) and has been shown to lead to particularly poor health outcomes in pregnant women and surgical patients. It is also a public health threat, leading to antibiotic resistance and infections in hospitalized patients that can be life threatening.

Released: 12-Jul-2023 1:05 PM EDT
Study reveals new mechanism for rapid evolution of multi-drug resistant infections in patients
University of Oxford

A research study provides a transformational new insight into how antimicrobial resistance (AMR) emerges in patients with bacterial infections. The findings could help develop more effective interventions to prevent AMR infections developing in vulnerable patients.

7-Jul-2023 8:00 AM EDT
A step toward treating chemotherapy-resistant prostate cancer
American Chemical Society (ACS)

Prostate cancer is resistant to one of the most powerful chemotherapy medications — cisplatin. Now, researchers in ACS Central Science have developed the first therapy of its kind that disrupts prostate cancer cells’ metabolism and releases cisplatin into the weakened cells, causing them to die.

   
7-Jul-2023 8:00 AM EDT
A new tactic to take on leprosy
American Chemical Society (ACS)

Though antibiotics can treat leprosy, researchers are concerned about the increase in drug-resistant strains. Now, a team reporting in ACS Central Science has begun to understand the role certain immune receptors play in leprosy, which could lead to new types of treatments for this disease.

   
Newswise: Researchers discover drug-resistant, often deadly pathogen living in dogs’ ears, creating concern it may jump to humans
Released: 7-Jul-2023 10:25 AM EDT
Researchers discover drug-resistant, often deadly pathogen living in dogs’ ears, creating concern it may jump to humans
McMaster University

Scientists at McMaster University and India’s University of Delhi have discovered and isolated the first live culture of the drug-resistant pathogen Candida auris from an animal, specifically from the ear canals of stray dogs.

Released: 3-Jul-2023 1:45 PM EDT
A new bacterial blueprint to aid in the war on antibiotic resistance
Trinity College Dublin

A team of scientists from around the globe, including those from Trinity College Dublin, has gained high-res structural insights into a key bacterial enzyme, which may help chemists design new drugs to inhibit it and thus suppress disease-causing bacteria.

Newswise: June Research Highlights
Released: 30-Jun-2023 2:45 PM EDT
June Research Highlights
Cedars-Sinai

A roundup of the latest medical discoveries and faculty news at Cedars-Sinai for June 2023.

Released: 29-Jun-2023 5:30 PM EDT
Alarming antibiotic resistance discovered in war-torn Ukraine
Lund University

Researchers led by Lund University in Sweden have assisted microbiologists in Ukraine in investigating bacterial resistance among the war-wounded patients treated in hospitals.

Newswise: Phage pioneer Graham Hatfull helps when antibiotics can't
Released: 27-Jun-2023 12:05 PM EDT
Phage pioneer Graham Hatfull helps when antibiotics can't
University of Pittsburgh

Graham Hatfull has pioneered the use of bacteriophages, or just “phages,” to combat antibiotic resistant infections. He was honored with the Gardner Middlebrook Lifetime Achievement award for his research.



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