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Medicine

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Blood Thinner, Blood Clot, Clinical Trial

Treatment Rapidly Reverses the Effect of Blood Thinner Dabigatran

A new treatment rapidly removes the oral blood thinner dabigatran (PRADAXA®) from circulation within minutes, allowing life-saving clots to form normally

Medicine

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$3 Million Grant to Bring Precision Medicine to Heart Patients

Supported by a $3.3 million National Institutes of Health (NIH) RO1 grant, Fedak and Barker will use 4D-Flow MRI, a cutting-edge imaging technique that allows visualization of three-dimensional blood flow in real time, and tissue analysis to inform personalized treatment for BAV patients.

Medicine

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Type 2 Diabetes, Metabolic Disease, Endocrinology and Diabetes, Hepatology, Nonalcoholic Fatty Liver Disease, Gastroenterology, drug repurposing, Inflammation

Repurposed Asthma Drug Shows Blood Sugar Improvement Among Some Diabetics

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After 12 weeks of taking an anti-asthma drug, a subset of patients with type 2 diabetes showed a clinically significant reduction in blood glucose during a randomized, double blind, placebo-controlled clinical trial, report University of California San Diego School of Medicine and University of Michigan researchers.

Medicine

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Prescription Drug Cost, Senior Citizens, medication review, Adherence, Prescription Drug

Older Americans Don’t Get – or Seek – Enough Help From Doctors & Pharmacists on Drug Costs, Poll Finds

The majority of Americans over age 50 take two or more prescription medicines to prevent or treat health problems, and many of them say the cost weighs on their budget, a new poll finds. But many older adults aren’t getting – or asking for – as much help as they could from their doctors and pharmacists to find lower-cost options, the new data reveal.

Medicine

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Ancient Antiviral Defense System Could Revolutionize a New Class of RNA-based Medicine, Mount Sinai Researchers Say

Medicinal payload could be delivered by engineered RNAs that can be controlled by a billion year-old “genetic fossil” found in all cells

Medicine

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Hydrogel, Intracellular degradable, Poly(methacrylic acid), hydrophobic drug, BA-TPQ, Hepatocellular Carcinoma, Liver Cancer, Breast Cancer, Drug Delivery Systems

Micron-Sized Hydrogel Cubes Show Highly Efficient Delivery of a Potent Anti-Cancer Drug

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Researchers have developed micro-cubes that can sponge up a hydrophobic anti-cancer drug and deliver it to cancer cells. Tissue culture tests show these tiny, porous cubes, loaded with the hydrophobic drug, are more potent against liver cancer cells and less harmful to normal liver cells.

Medicine

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Heart Disease, Stroke Risk, Genetic Mutation, Stroke, Heart, Ut Southwestern

Skin Cell Model Advances Study of Genetic Mutation Linked to Heart Disease, Stroke Risk

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Using a new skin cell model, researchers have overcome a barrier that previously prevented the study of living tissue from people at risk for early heart disease and stroke. This research could lead to a new understanding of disease progression in aortic aneurysm – ballooning of the large artery in the chest that carries blood from the heart to the body.

Medicine

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Finding the Perfect Match: A New Approach to Battle Drug-Resistant Bacteria

Antibiotics were the wonder drug of the 20th century, but bacteria evolved resistance. According to the CDC, more than 2 million people in the U.S. develop MDR infections every year. Researchers at Univ. of Utah developed a rapid screen to pair existing FDA-approved drugs to combat MDR infections.

Medicine

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Muscle, Muscle Regeneration, Regeneration

SLU Researchers Find Key to Muscle Regeneration

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The nuclear receptor REV-ERB plays a key role in muscle regeneration, suggesting the receptor may be a good target for new drugs to treat a variety of muscle disorders and injuries.

Science

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Technology Unlocks Mold Genomes for New Drugs

Fungi are rich sources of natural molecules for drug discovery, but numerous challenges have pushed pharmaceutical companies away from tapping into this bounty. Now scientists at Northwestern University, the University of Wisconsin-Madison and the biotech company Intact Genomics have developed technology that uses genomics and data analytics to efficiently screen for molecules produced by molds to find new drug leads -- maybe even the next penicillin. From three diverse fungal species, the research team discovered 17 new natural products.







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