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Past Exposures Shape Immune Response in Pediatric Acute Respiratory Infections

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By analyzing immune cells of children who came to the emergency department with flu symptoms, researchers found that the suite of genes these early-response cells expressed was shaped by factors such as age and previous exposures to viruses. Better understanding how early infections influence long-term immune response has implications for the diagnosis and treatment of young patients who suffer from acute respiratory tract infections.

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Cancer’s Gene-Determined “Immune Landscape” Dictates Progression of Prostate Tumors

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The field of immunotherapy – the harnessing of patients’ own immune systems to fend off cancer – is revolutionizing cancer treatment today. However, clinical trials often show marked improvements in only small subsets of patients, suggesting that as-yet unidentified variations among tumors result in distinct paths of disease progression and response to therapy.

Medicine

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Scleroderma, University Of Virginia, UVA, University of Virginia Cancer Center, UVA Cancer Center, NCI-designated cancer centers, Cancer, Karen Ballen, University of Virginia School of Medicine, UVA School of Medicine, autoimmune disorder, Autoimmune Disease, skin, Skin Disorder, skin thickening, skin hardening, New Treatments, Medical Research, treatment f

Scleroderma: Study Suggests Hope for Longer Life for Patients with Rare Autoimmune Disorder

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The approach could represent the first new treatment to improve survival in patients with severe scleroderma in more than four decades.

Medicine

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Blood Stem Cell Transplant, bone marrow donor, Bone Marrow Stem Cells, Blood Stem Cells, Blood Stem Cell

Researchers Discover Faster, More Effective Way to Harvest Blood Stem Cells for Bone Marrow Donation

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A multi-institutional research team led by Indiana University School of Medicine scientists has developed a new way to harvest blood stem cells for bone marrow donation that is faster and more effective than the current standard of care.

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Alzheimber's Disease, Alzheimer Disease & Associated Disorders, Neurologic Conditions, Parkinson's Disease, Medical Research, Pharmaceticals

Pfizer Announcement on Alzheimer's and Parkinson's Diseases Underscores Need for Government Money for Medical Research.

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Discovery Suggests New Strategy for Attacking High- Profile but Elusive Target in Cancer

A discovery by scientists at Dana-Farber Cancer Institute and University of Texas Southwestern Medical Center presents drug developers with an entirely new tack in targeting one of the most-wanted molecular culprits in cancer.

Science

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Stem Cell Biology, Stem Cell Research, Cell Replacement Therapy, sensory interneurons, spinal cord and brain injury, Paralysis, Sensory recovery, Neurobiology, Neurologic Research, Central Nervous System Injuries, central nervous system, morphogenic protein, Interneurons

UCLA Scientists Make Cells That Enable the Sense of Touch

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Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have, for the first time, coaxed human stem cells to become sensory interneurons — the cells that give us our sense of touch. The new protocol could be a step toward stem cell–based therapies to restore sensation in paralyzed people who have lost feeling in parts of their body.

Medicine

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Breast Cancer, Diet, Estrogen, drugs, , Chemotherapy, Therapeutics

Estrogen-Mimicking Compounds in Foods May Reduce Effectiveness of Breast Cancer Treatment

Scientists from The Scripps Research Institute have discovered that two estrogen-mimicking compounds found in many foods appear to potently reverse the effects of palbociclib/letrozole, a popular drug combination for treating breast cancer.

Science

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Long-term Memory, Cognition, arc, Viruses, Brain Plasticity, Retroviruses, Retrotransposons

Surprise: A Virus-Like Protein is Important for Cognition and Memory

A protein involved in cognition and storing long-term memories looks and acts like a protein from viruses. The protein, called Arc, has properties similar to those that viruses use for infecting host cells, and originated from a chance evolutionary event that occurred hundreds of millions of years ago.

Medicine

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Cells, Immunology, T-Cell, Tubercolosis, Canada, University of Mon, McGill University , Vaccines, Infectious Desease, BCG, Stem Cells, Bone Marrow Cell Therapy, Immune Response, Innate Immune Response, Macrophages

Re-Programming Innate Immune Cells to Fight Tuberculosis

Canadian researchers’ innovative work promises to make vaccines more effective against tuberculosis and other infectious diseases like the flu.







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