Curated News: NEJM

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A study published in New England Journal of Medicine confirms that circulatory death donor hearts that are reanimated and perfused with blood outside of the body are as safe and effective to transplant as brain death donor hearts preserved using traditional cold storage. These findings suggest that using hearts donated after circulatory death (DCD) may have the potential to widen the donor pool helping more patients in need of life-saving heart transplants.

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A new study led by Yale Cancer Center shows improved rates of survival and reduced risk of recurrence in patients with non-small cell lung cancer taking osimertinib (TAGRISSO), a targeted therapy, following surgery. Non-small cell lung cancer (NSCLC), the most common type of lung cancer, tends to recur when diagnosed at advanced stages, which makes treatment challenging.

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A study led by Duke Health physicians, appearing online June 8 in the New England Journal of Medicine, found that DCD hearts were equivalent to hearts procured through the current standard of care.

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Patients with early relapsed or refractory large B-cell lymphoma had significantly improved overall survival when treated with the chimeric antigen receptor (CAR) T cell therapy axicabtagene ciloleucel (axi-cel) when compared to the current standard-of-care chemoimmunotherapy, according to results of the Phase III ZUMA-7 trial reported by researchers from The University of Texas MD Anderson Cancer Center.

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In an international study co-led by UCLA, scientists have shown that a new targeted therapy drug can extend the amount of time people with a subtype of glioma are on treatment without their cancer worsening. The finding suggests a possible new treatment option for people with the slow-growing but deadly brain tumor.

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Read about new melanoma treatment practices, how models provide information about a rare adrenal cancer, a potential oral medication for brain cancer, and clinical trials for cancer patients with HIV.

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A global phase 3 clinical trial that included Ann & Robert H. Lurie Children’s Hospital of Chicago found that a year-long immunotherapy through a skin patch safely desensitized toddlers with peanut allergy, lowering the risk of a severe allergic reaction from accidental exposure. Results of this randomized, double-blind, placebo-controlled trial for children 1-3 years of age, funded by DBV Technologies, were published in the New England Journal of Medicine.

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A targeted kinase inhibitor added to a two-drug immunotherapy combination slowed the progression of advanced kidney cancer in previously untreated patients, according to research published in The New England Journal of Medicine and led by an oncologist from Dana-Farber Cancer Institute.

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In a study of 17 people from five families, Johns Hopkins Medicine researchers say they found that ultra-lengthy DNA endcaps called telomeres fail to provide the longevity presumed for such people. Instead, people with long telomeres tend to develop a range of benign and cancerous tumors, as well as the age-related blood condition clonal hematopoiesis.

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A new technique designed to allow surgeons to identify and remove residual tumor tissue during breast-conserving surgery showed promising results in a multi-center trial led by investigators from the Mass General Cancer Center, a member of Mass General Brigham.

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Ochsner Health is one of 20 sites in the U.S. participating in the PROMISE II clinical trial, which was recently published in the New England Journal of Medicine.

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After helping to develop and test new mRNA technologies for COVID-19 vaccines, University of Maryland School of Medicine (UMSOM) researchers and scientists are turning their attention to utilizing this innovative technology to ward off other infectious diseases like malaria and influenza.

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A study, co-led by University Hospitals Harrington Heart & Vascular Institute, could lead to the first FDA approval of a therapy giving thousands of patients hope for an alternative to amputation.

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El Dr. Sikander Ailawadhi, hematólogo y oncólogo del Centro Oncológico Integral de Mayo Clinic, comparte detalles sobre los nuevos avances en la investigación que conducen a mejores resultados en pacientes que padecen mieloma múltiple.

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O Dr. Sikander Ailawadhi, hematologista/oncologista do Centro de Câncer da Mayo Clinic, compartilha os detalhes sobre os novos avanços na pesquisa que levou a melhores resultados para pacientes com mieloma múltiplo.

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Researchers at UC San Diego School of Medicine and Moores Cancer Center at UC San Diego Health examined a new treatment approach for endometrial cancer.

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A new study finds some patients with early-stage lung cancer who receive a lobectomy do not fare better than patients who have less lung tissue removed.

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An investigational molecule has been shown to improve kidney function in people with one form of chronic kidney disease in a small phase 2 clinical trial. Martin Pollak, MD, discusses the journey from research question to potential cure.

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March is Myeloma Awareness Month, and Sikander Ailawadhi, M.D., hematologist/oncologist at Mayo Clinic Comprehensive Cancer Center, shares details about new advancements in research leading to better outcomes for patients with multiple myeloma.

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Founding director of UChicago Medicine’s Level 1 trauma center is first surgeon to hold the journal position in more than a decade.

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In a study published in the New England Journal of Medicine co-authored by Vibhor Krishna, MD, associate professor of neurosurgery at the UNC School of Medicine, researchers show that a new focused ultrasound treatment improved dyskinesia and motor impairment in patients with Parkinson’s disease.

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The trial, which concluded in 2021, found that 133 hemophilia patients treated weekly with injections of efanesoctocog alfafor a year improved their outcomes and quality of life compared to their previous treatment.

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The recent public health emergency declarations in New York and London due to polio infections and detection of the virus in these cities’ wastewater strongly indicate that polio is no longer close to being eradicated. Now, four members of the Global Virus Network (GVN) proposed changes in global polio eradication strategy to get the world back on track to one day eliminating polio’s threat.

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The recent public health emergency declarations in New York and London due to polio infections and detection of the virus in these cities’ wastewater strongly indicate that polio is no longer close to being eradicated.

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Breakthrough findings from study led by Mount Sinai researcher could improve outcomes for high-risk patients

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Psychiatry researchers at Washington University School of Medicine in St. Louis, led a multicenter study that found, in older adults with treatment-resistant depression, that augmenting an antidepressant drug with aripiprazole helped a significant number of patients.

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A team of researchers from institutions across the United States, including Moffitt Cancer Center, launched a phase 2 clinical trial evaluating a new treatment option for this patient population. Their results, published in The New England Journal of Medicine, show that treating resectable stage 3 and 4 melanoma patients with the immunotherapy drug pembrolizumab both before and after surgery greatly improves outcomes when compared to pembrolizumab given only after surgery.

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Patients with high-risk melanoma who received the immunotherapy drug pembrolizumab both before and after surgery to remove cancerous tissue had a significantly lower risk of their cancer recurring than similar patients who received the drug only after surgery.

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Seizures can be predicted more than 30 minutes before onset in patients with temporal lobe epilepsy, opening the door to a therapy using electrodes that could be activated to prevent seizures from happening, according to new research from UTHealth Houston.

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Patients with Parkinson’s disease achieved a significant improvement in their tremors, mobility, and other physical symptoms after having a minimally invasive procedure involving focused ultrasound, according to a new study today published in the New England Journal of Medicine.

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The New England Journal of Medicine (NEJM) Catalyst recently published an article by Ochsner Health neuropsychologist and a team of researchers discussing the critical need for value-based care models for patients with dementia.

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UCLA Health tip sheet: A brief roundup of news and story ideas from the experts at UCLA Health.

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A large international clinical study finds that patients with large strokes had a dramatically better recovery after endovascular thrombectomy plus medical management than patients receiving only standard medical management. The study was published Feb. 10 in the New England Journal of Medicine to coincide with its presentation at the International Stroke Conference in Dallas.

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Researchers tested lambda’s effectiveness using a randomized placebo-controlled trial involving adults with COVID-19 from both Canada and Brazil, who freely volunteered for the study. A total of 931 people received lambda and 1,018 received a placebo. Eighty-three per cent of the trial participants were vaccinated. Researchers ran the lambda trial from June 2021 to March 2022.

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A single-dose of the antiviral drug peginterferon lambda reduced by half the risk of hospitalization or a visit to the Emergency Department due to COVID-19, according to a study published today in the New England Journal of Medicine.

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Heart rhythm disorders like atrial fibrillation and sudden cardiac arrest have made headlines in recent months, prompting many to learn more about how the heart beats.

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Below is a brief roundup of news and story ideas from the experts at UCLA Health.