Scientists have grown ‘mini-placentas’ in the lab and used them to shed light on how the placenta develops and interacts with the inner lining of the womb – findings that could help scientists better understand and, in future, potentially treat pre-eclampsia.
A vaccine for Staphylococcus aureus, one of the most common bacterial infections, would be a game changer for public health. No vaccine candidates have succeeded in clinical trials, but nobody knows why. Researchers at UC San Diego may have figured it out.
An insight into preventing perovskite semiconductors from degrading quickly, discovered at the University of Michigan, could help enable solar cells estimated to be two to four times cheaper than today's thin-film solar panels.
A study of mutant models of fragile X syndrome (FXS), a genetic disorder related to autism and intellectual disability, shows that activation of the cerebellum mitigates aberrant responses in sensory processing areas of the brain and improves neurodevelopmental behaviors. The findings, published by UT Southwestern Medical Center researchers in Cell Reports, could offer an opportunity for developing new therapies for neurocognitive disorders.
Researchers from Osaka University find characteristic changes in CD4+ T cell categories and gene programs associated with autoimmune disease.
Researchers from UC San Diego have developed a noninvasive approach for predicting the quality of lab-fertilized embryos using leftover culture medium.
A new study from Washington University School of Medicine in St. Louis identifies, in mice, a critical communication pathway connecting the brain and the body’s fat tissue in a feedback loop that appears central to energy production throughout the body. The research suggests that the gradual deterioration of this feedback loop contributes to the increasing health problems that are typical of natural aging.
New research shows that the recently emerged BA.2.86 omicron subvariant of the virus that causes COVID-19 can be neutralized by bivalent mRNA vaccine-induced antibodies in the blood, which explains why this variant did not cause a widespread surge as previously feared.
In cooperation with research partners in Germany and France, the infectious disease specialist Dr Jan Rybniker and his team at University Hospital Cologne and the University of Cologne’s Faculty of Medicine have identified new, antibiotic molecules that target Mycobacterium tuberculosis and make it less pathogenic for humans.
Researchers at Washington University School of Medicine in St. Louis have determined how Eastern equine encephalitis virus attaches to a receptor it uses to enter and infect cells. The findings laid the groundwork for a receptor decoy molecule that protects mice from encephalitis caused by the virus.
Discover the first images of cytonemes during mammalian neural development, serving as express routes to establish morphogen gradients and tissue patterning.
Researchers have found new disrupted genes and an unexpected molecular pattern—dubbed BREACHes—related to Fragile X Syndrome (FXS), a genetic disorder estimated by the Centers for Disease Control and Prevention to impact about 1 in 7,000 males about 1 in 11,000 females.
Patient-specific mutation-engineered mouse reveals how sensory neurons may trigger some allergy conditions but block others, suggesting more precise design of JAK inhibitors is necessary.
UC Riverside scientists have discovered a stealth molecular weapon that plants use to attack the cells of invading gray mold.
Across the United States, about 2 million people are living with an amputation and another 185,000 amputations occur every year, according to the Amputee Coalition, a Washington, DC-based support group. About 54% of these lost limbs were caused by vascular disease, including diabetes and peripheral arterial disease (PAD)
Researchers at UChicago were able to predict postoperative infections in liver transplant patients by analyzing molecules in their poop — a key leap forward in exploring the connection between the gut microbiome and overall health.
Moffitt Cancer Center researchers are working to better understand the molecular mechanisms that promote the development and progression of breast cancer brain metastasis to help improve diagnostics and treatments. In a new study published in the December issue of Cell Reports, they report on identifying a cell signaling pathway that controls breast cancer brain metastasis.
A type of cell that plays a crucial role in tissue repair after a heart attack may also inadvertently be why cutting-edge cell therapies cause an increased risk of rhythm disorders, according to a new study from the Universities of Surrey and Oxford.
University of Virginia School of Medicine researchers have created an “atlas of atherosclerosis” that reveals, at the level of individual cells, critical processes responsible for forming the harmful plaque buildup that causes heart attacks, strokes and coronary artery disease.
A woman who never developed Alzheimer's despite a strong genetic predisposition may hold the key to stopping the disease in its tracks.
In a new study, published online December 8, 2023 in Cell Reports, researchers at Sanford Burnham Prebys, with collaborators elsewhere, describe a novel molecular link between vitamin B12 and MS that takes place in astrocytes – important non-neuronal glial cells in the brain.
According to new predictions by La Jolla Institute for Immunology (LJI) researchers, if the new SARS-CoV-2 Pirola variant wants to evade T cells, it isn't doing a very good job.
Researchers at Case Western Reserve University and University Hospitals have identified an enzyme that blocks insulin produced in the body—a discovery that could provide a new target to treat diabetes.
A new study led by UT Southwestern Medical Center molecular biologists presents a novel culture system to grow both embryonic and extraembryonic stem cells, potentially providing important insights into the genesis of congenital malformations and early developmental disorders.
While sugar is the most frequently named culprit in the development of type 2 diabetes, a better understanding of the role of fats is also essential.
In a recent study, scientists led by Professor Stefan Müller from Goethe University’s Institute of Biochemistry II investigated a specific form of blood cancer known as acute myeloid leukemia, or AML. The disease mainly occurs in adulthood and often ends up being fatal for older patients.
Scientists at the Department of Energy’s Oak Ridge National Laboratory have made a significant stride toward understanding a viable process for direct air capture, or DAC, of carbon dioxide from the atmosphere. This DAC process is in early development with the aim of achieving negative emissions, where the amount of carbon dioxide removed from the envelope of gases surrounding Earth exceeds the amount emitted.
Heart disease kills 18 million people each year, but the development of new therapies faces a bottleneck: no physiological model of the entire human heart exists – so far.
The method identified promising targets for precision oncology in two types of cancer
Our bodies are transversed by millions of nerve fibres that transmit information. This allows us to do things like control muscles and perceive sensory impressions. Peripheral nerves, like those in our arms and legs, are often damaged by acute injuries, for example, in accidents. As a result, those affected suffer from loss of muscle strength and sensory problems such as numbness. Peripheral nerves do have a strong regenerative potential, but complete recovery of nerve function is still rare for reasons that are not yet fully understood.
The gene-editing technology CRISPR shows early promise as a therapeutic strategy for the aggressive and difficult-to-treat brain cancer known as primary glioblastoma, according to findings of a new study from Gladstone Institutes.
In a new Cell study, scientists at La Jolla Institute for Immunology (LJI) and Massachusetts General Hospital, Harvard Medical School, show how a protein called IKAROS helps "weave" the genome.
Scientists show for the first time that bacteria can cause itch by activating nerve cells in the skin. The findings can inform new therapies to treat itch that occurs in inflammatory skin conditions like eczema and dermatitis.
There’s a popular saying in some circles that “a calorie is a calorie,” but science shows that it may not be true. In fact, it may be possible to eat more of some kinds of calories while also improving your health.“We like to say a calorie is not just a calorie,” says Dudley Lamming, a professor and metabolism researcher at the University of Wisconsin School of Medicine and Public Health.
Scientists at St. Jude Children’s Research Hospital mapped the difference in chromatin accessibility and regulation in different pediatric acute lymphoblastic leukemia subtypes.
The most effective way to prevent cervical cancer is to give HPV vaccines to both boys and girls, reports a collaborative study involving researchers from Karolinska Institutet published in Cell, Host and Microbe. Beside personal immunity, such use of the vaccine also induces a herd immunity that will help to eradicate the carcinogenic virus types more quickly.
Scientists synthesize a yeast chromosome as part of a global project to create the world's first synthetic eukaryotic genome.
Transient inflammatory pain causes long-lasting mitochondrial changes in sensory neurons, contributing to chronic pain.
Researchers at the Francis Crick Institute and Aalborg University in Copenhagen have shown that changes can be detected in blood tests up to eight years before a diagnosis of Crohn’s disease and up to three years before a diagnosis of ulcerative colitis.
Researchers at DZNE and Charité - Universitätsmedizin Berlin have pioneered a novel treatment for the most common autoimmune encephalitis.
Antibiotic-resistant bacteria pose a major challenge to healthcare systems worldwide. Due to numerous resistance mechanisms, infections with the pathogen Pseudomonas aeruginosa are particularly feared. Researchers at the German Center for Infection Research (DZIF), the University Hospital Cologne, the Helmholtz Centre for Infection Research in Braunschweig and the University Medical Center Hamburg-Eppendorf have now discovered antibodies that could lead to a highly potent treatment option of acute and chronic infections with P. aeruginosa. The study was published in the prestigious scientific journal Cell.
Investigators from Cedars-Sinai have made two important discoveries about fiber and the gut microbiome in patients with human immunodeficiency virus, or HIV.
A new study led by researchers at UChicago Medicine and Indiana University suggests that an existing drug could be repurposed to treat type 1 diabetes, potentially reducing dependence on insulin.
A new study published in Cell Reports Medicine presents exciting future possibilities for the management of type 1 diabetes and the potential reduction of insulin dependency. The study's findings' suggest repurposing of the drug α-difluoromethylornithine (DFMO) may open doors to innovative therapies.
First detailed explanation of why people with obesity and Type 2 diabetes are at an increased risk of pancreatic cancer
Two studies led by UCLA researchers offer new insights into the way neurons in the human brain represent time and space – the most basic ingredients of consciousness of human existence and the primary dimensions of experience that allow us to reconstruct the past and envision the future.
As the planet gets hotter, the need for cool living environments is becoming more urgent. But air conditioning is a major contributor to global warming since units use potent greenhouse gases and lots of energy.
The dependence between biomechanical properties of extracellular matrix and the development of tumor cells inside it was proven by scientists. This will allow to create more realistic models for studying growth of cancer tumors and metastases.
A sweeping new guide to menopause by a UVA Health expert and collaborators highlights the profound and sometimes surprising effects the “change of life” can have on women’s lives, health, workplaces and even finances
A research team from the UC Davis Comprehensive Cancer Center has identified a crucial epitope (a protein section that can activate the larger protein) on the CD95 receptor that can cause cells to die.
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