An oncogene, UPS21, has been confirmed as a frequently amplified gene in pancreatic ductal adenocarcinoma, the most common and often lethal form of pancreatic cancer. The discovery could lead to new treatment options.
A new clinical guideline from the American Society for Radiation Oncology (ASTRO) provides recommendations on the use of radiation therapy to treat patients diagnosed with pancreatic cancer
A drug developed by researchers at the Renaissance School of Medicine at Stony Brook University that targets enzymes involved in the development of pancreatic cancer cells is showing promise for improved treatment of metastatic pancreatic cancer.
Les résultats des traitements du cancer colorectal pourraient être améliorés en modifiant génétiquement une protéine immunorégulatrice située dans les cellules cancéreuses, en rendant les cellules plus vulnérables à la chimiothérapie. C’est que révèlent les recherches menées par Mayo Clinic.
Os resultados do câncer colorretal podem ser aprimorados por meio da alteração de uma proteína imunorreguladora nas células cancerígenas, tornando essas células mais vulneráveis à quimioterapia. Isso de acordo com uma nova pesquisa da Mayo Clinic.
While weeding in her north Seattle garden, Miggie Olsson discusses how she, as a patient, became a unicorn.
Los resultados del cáncer colorrectal pueden mejorar cuando se altera genéticamente una proteína que regula la inmunidad de las células cancerosas con el fin de volverlas más vulnerables a la quimioterapia, dice un nuevo estudio de Mayo Clinic.
Finding May Create Opportunity to Test Patients to Avoid Ineffective Drugs
Mayo Clinic的一项研究发现，乳糜泻患者的父母、兄弟姐妹和子女具有患此疾病的高风险。该研究建议此疾病患者所有一级亲属均进行筛查，而不仅是已表现出症状的亲属。
A couple of molecules that nerve cells use to grow during development could help explain why the most common pancreatic cancers are so difficult to contain and for patients to survive
Les parents, les frères et sœurs et les enfants de personnes atteintes de la maladie cœliaque présentent un risque élevé d’être également atteints de la maladie, selon une étude de Mayo Clinic. Cette étude exige le dépistage de tous les parents au premier degré des patients, et non pas uniquement les personnes présentant des symptômes.
Eltern, Geschwister und Kinder von Menschen mit Zöliakie sind mit einem hohen Risiko auch mit der Krankheit, nach einer Mayo Clinic Studie. Diese Studie fordert ein Screening aller Angehörigen ersten Grades von Patienten
Attend press conferences live – online at http://bit.ly/acs2019sandiego or in person - at the American Chemical Society Fall 2019 National Meeting & Exposition. Press conferences will be held Monday, Aug. 26 and Tuesday, Aug. 27, 2019.
Colorectal cancer outcomes may improve by genetically altering an immune-regulatory protein in cancer cells, making the cells more vulnerable to chemotherapy.
As a disposable version of the instrument used in one of the most common medical procedures in the United States inches closer to widespread availability, a team of Johns Hopkins data researchers is studying the economic and safety implications associated with the devices used to perform colonoscopies.
For years, scientists have been trying to solve a medical mystery: Why do people with type 1 or type 2 diabetes have an increased risk of developing some forms of cancer? Today, researchers report a possible explanation for this double whammy.
Researchers have decoded a chain of molecules that are critical for the growth and survival of pancreatic ductal adenocarcinoma—the most common and also the most lethal form of pancreatic cancer.
Researchers at Washington University School of Medicine in St. Louis have discovered that an initial urinary tract infection (UTI) triggers changes to immune and other cells in the bladder that can prime the bladder to overreact to bacteria, worsening subsequent UTIs.
In an extensive “data mining” analysis of British medical records, researchers at the Johns Hopkins Kimmel Cancer Center conclude that taking even a single course of antibiotics might boost—albeit slightly—the risk of developing colon cancer—but not rectal cancer—a decade later. The findings, reported in the August 20 issue of the journal Gut, highlight the need for judicious use of this broad category of drugs, which are frequently improperly or overprescribed, the report authors say.
Scientists have analyzed the genetic repertoire of bacteria in the human mouth and gut The effort marks the first chapter in efforts to compile a compendium of all genes in the human microbiome Mapping the microbial genome can reveal links between bacterial genes and disease risk and could inform the development of precision therapies Analysis reveals staggering person-to-person variation in microbial gene content Unique microbial genes, specific to each person, have functions distinct from common, or shared, genes Unique genes may act as a microbe’s evolutionary organ Researchers have made the data publicly accessible at The Universe of Microbial Genes
A phase 1 clinical trial testing a new drug in pancreatic cancer had promising initial results, report researchers from the University of Michigan Rogel Cancer Center. The trial looked at AZD1775, an inhibitor designed to block an enzyme called Wee1, which plays a role in DNA damage repair.
Patients with metastatic colorectal cancer who engaged in moderate exercise while undergoing chemotherapy tended to have delayed progression of their disease and fewer severe side effects from treatment, according to the results of a new study.
Louis Battaglia's doctors initially could not determine the source of his pain, until he saw specialists at NYU Langone Hospital–Brooklyn, who found it was a rare form of stomach cancer.
The discovery of the previously unknown mutation, reported in Nature Genetics by investigators from Dana-Farber/Brigham and Women’s Cancer Center, could lead to routine testing of individuals with a strong family history of pancreatic cancer to determine if they carry the mutation, occurring in the gene known as RABL3.
Physicians have long suspected that red blood cell transfusions given to premature infants with anemia may put them in danger of developing necrotizing enterocolitis, or NEC, a potentially lethal inflammatory disease of the intestines. However, solid evidence for the connection has been difficult to obtain in part because of the lack of a practical animal model able to accurately represent what physically occurs when a baby gets NEC.
A new drug that penetrates the protective barrier around pancreatic cancers and accumulates in malignant cells may improve current chemotherapy, a study in mice suggests.
There is no cure for the more than 1.6 million people in the United States living with Crohn’s disease (CD) and its symptoms, including abdominal pain, intestinal distress and severe weight-loss. CD is a form of inflammatory bowel disease (IBD) in which the body’s own immune system attacks the gastrointestinal tract, and treatment is focused on controlling the symptoms of the disease in its acute phase and managing it in remission. But recently, researchers at Case Western Reserve University School of Medicine identified a pathway in the immune system activated in CD and which holds promise for investigating new treatments.
A rare, short-lived population of immune cells in the bloodstream may serve as ‘periscopes’ to monitor immune status via lymph nodes deep inside the body.
Newly published manuscript explores risk factors and etiology of sporadic colon and rectal (colorectal) cancer in young adults.
A newly developed technique that shows artery clogging fat-and-protein complexes in live fish gave investigators from Carnegie
A new study harnessed the unique genetic history of the people of Finland to identify variations in DNA that might predispose certain individuals to disease, whether or not they are Finnish themselves. The study was conducted by researchers at Washington University School of Medicine in St. Louis and collaborating institutions.
The much-talked-about "Coffee Study" is featured in the August 2019 issue of the medical journal Diseases of the Colon and Rectum.
A study of patients' gut bacteria highlights likely reasons behind the pandemic spread of resistant E. coli strains, and the need to re-think the clinical significance of bacteria in the urine without symptoms, because treatment-resistant strains can be highly pathogenic to the urinary system.
Scientists have known that bacteria in the gut, along with environmental and genetic factors, contribute to the debilitating intestinal ailment of Crohn’s disease (CD). But in 2016, Mahmoud A Ghannoum, PhD, FAAM, FIDSA, professor and director of the Center for Medical Mycology at Case Western Reserve School of Medicine and University Hospitals Cleveland Medical Center, was the first to identify a specific fungus in humans that interacted with bacteria in the development of the disease. Now, to learn precisely how that fungus interacts with bacteria to trigger CD, Ghannoum has received a five-year, $3M grant from the National Institutes of Health. His investigation will involve innovative molecular and cellular technologies, to delete specific genes in the fungus and note the effects on the inflammation that is a marker for CD using powerful microscopic analysis.
Targeting medical treatment to an ailing body part is a practice as old as medicine itself. A Band-Aid is placed on a skinned knee. Drops go into itchy eyes. A broken arm goes into a cast.
A specific class of bacteria from the gut prevents mice from becoming obese, suggesting these same microbes may similarly control weight in people, a new study reports. The beneficial bacteria, called Clostridia, are part of the microbiome — collectively trillions of bacteria and other microorganisms that inhabit the intestine. University of Utah Health investigators led the study which publishes online in the journal Science on July 25.
A Phase II clinical trial led by MD Anderson found that treatment with the FGFR inhibitor erdafitinib was effective in 40% of patients with metastatic bladder cancers marked by FGFR3 mutations. The trial results led to FDA approval of the drug.
A research team led by Tufts University engineers has developed a 3D printed pill that samples bacteria found in the gut -- known as the microbiome -- as it passes through the gastrointestinal tract (GI). The ability to profile bacterial species throughout the GI tract could have important implications for the diagnosis and treatment of many diseases.
Getting up close – and a little dirty – with farm animals just might help us fend off illness, say researchers who’ve further demonstrated the benefits of early exposure to a wide variety of environmental bacteria.
A new spectroscopic technique reveals that glucose use in live cells provides valuable information about the functional status of cells, tissues, and organs. Shifts in a cell’s use of glucose can signal changes in health and progress of disease.
Having healthy gut flora – the trillions of bacteria housed in our intestines – could lower the risk of infection following knee and hip replacement surgeries, while an unhealthy intestinal flora may increase the risk of infection.
Johns Hopkins Kimmel Cancer Center study coauthors Anne Marie Lennon, Simeon Springer, Marco Dal Molin, Christopher Wolfgang and Bert Vogelstein will participate in a press teleconference organized by the American Association for the Advancement of Science at 11 a.m. Tuesday, July 16. To RSVP, send an email to [email protected]. An audio recording and transcript will be available on the MedPak webpage (eurekalert.org/journls/scitransmed/) at the end of the teleconference.
Results suggest some forms of PD are an autoimmune disease triggered years before noticeable symptoms
Scientists created human pancreas on a chip that allowed them to identify the possible cause of a frequent and deadly complication of cystic fibrosis (CF) called CF-Related Diabetes, or CFRD. It may be feasible to also use the small two-chambered device, which features bioengineered human pancreatic organoids to study the causes of non-CF-related conditions such as type 1 and 2 diabetes, according to researchers who report findings in Nature Communications.
A new large-scale genome-wide association study published in Nature Genetics, has identified eight genetic variants significantly associated with anorexia nervosa; and the research shows that the origins of this serious disorder appear to be both metabolic and psychiatric.
A new study finds that trends in colonoscopy rates did not fully align with the increase in colorectal cancer (CRC) in younger adults
Findings published today in the journal Science Translational Medicine suggest that a type of white blood cell called tumor associated macrophages that have been deceived by pancreatic cancer cells into not attacking them can be “reprogrammed” by a specially designed molecule that activates a protein found on their surfaces.
A new type of therapeutic food, specifically designed to repair the gut microbiomes of malnourished children, is superior to standard therapy in an initial clinical trial conducted in Bangladesh.
Nearly ten years ago, a group of Israeli clinical researchers emailed Berkeley Lab geneticist Len Pennacchio to ask for his team’s help in solving the mystery of a rare inherited disease that caused extreme, and sometimes fatal, chronic diarrhea in children.
The males of one species of butterfly are more attracted to females that are active, not necessarily what they look like, according to a recent research conducted at Augustana University.The paper, “Behaviour before beauty: Signal weighting during mate selection in the butterfly Papilio polytes,” found that males of the species noticed the activity levels of potential female mates, not their markings.
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