The first study of the immunotherapy drug pembrolizumab as the initial treatment for patients with a rare but aggressive form of skin cancer known as Merkel cell carcinoma reports better responses and longer survival than expected with conventional chemotherapy.
Identifying molecular pathways that boost the immune response to tumor neoantigens opens up new ways to develop and amplify cancer immunotherapy.
Researchers have pinpointed how fibrosis develops in butterfly syndrome patients. The discovery points to a potential treatment for the debilitating complication.
Injection of a genetically modified virus that induces the body’s own immune cells to attack metastatic melanoma effectively treated almost 40 percent of patients with tumors that could not be surgically removed.
If a patient has private insurance, doctors can get prior approval to prescribe a drug “off-label” to make sure the medication will be covered, but these lists are incomplete, outdated, and frequently in conflict with each other.
Skin colour is one of the most visible and variable traits among humans and scientists have always been curious about how this variation evolved. Now, a study of diverse Latin American populations led by UCL geneticists has identified new genetic variations associated with skin colour.
A Ludwig Cancer Research study has uncovered a cellular mechanism by which melanomas that fail to respond to checkpoint blockade may be made susceptible to such immunotherapies. Led by Ping-Chih Ho of the Lausanne Branch of the Ludwig Institute for Cancer Research and reported in the current issue of Nature Immunology, the study also identifies an existing diabetes drug that could be used to accomplish that feat.
A study by researchers from Sweden and Hungary shows that white, painted stripes on the body protect skin from insect bites. It is the first time researchers have successfully shown that body-painting has this effect. Among indigenous peoples who wear body-paint, the markings thus provide a certain protection against insect-borne diseases.
The use of antibiotics to treat inflammatory skin conditions like acne and rosacea is decreasing over time, but there has been an increase in prescriptions associated with dermatologic surgical procedures.
Researchers at University of Utah Health conducted a state-by-state analysis to understand the geographic disparities for patients diagnosed with melanoma. The results of their study suggest that lower survival is associated with more practicing physicians in a region and higher population of Caucasians.
MD Anderson researchers have identified a new potential immunotherapy target in pancreatic cancer, which so far has been notoriously resistant to treatment with immune checkpoint blockade drugs effective against a variety of other cancers.
Scientists at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have discovered that squamous cell skin cancers do not require increased glucose to power their development and growth, contrary to a long-held belief about cancer metabolism. The findings could bring about a better understanding of many cancers' metabolic needs and lead to the development of more effective therapies for squamous cell skin cancer and other forms of epithelial cancer.
Fifteen years after a chance meeting started their partnership, a compound that Jeffrey Arterburn, PhD, and Eric Prossnitz, PhD, discovered may lead to new skin cancer treatments. Pre-clinical studies have begun.
Michigan becomes the 25th state to join the Interstate Medical Licensure Compact - offering an expedited pathway to licensure for physicians wishing to practice in multiple states.
Clinical services to prevent and treat wounds, abscesses and infections caused as a result of injection drug use are now being offered at the University of Illinois at Chicago’s Community Outreach Intervention Project’s, or COIP, west side field office. Services will be provided by physicians, nurses and students from UIC’s Urban Global Medicine Program and the UIC College of Nursing.
As more people flock to the gym for their New Year’s resolutions, dermatologists from the American Academy of Dermatology are offering words of caution for gym members. While working out has many benefits, including weight control, disease prevention and even mood improvement, germs can thrive at the gym. This could put gymgoers at risk for a variety of common skin infections — unless they take certain precautions.
A clinical-scientific team specializing in head-and-neck cancer has identified a way to manipulate metabolism to potentially curb skin fibrosis - a common side effect of radiotherapy affecting quality of life of cancer survivors.
When researchers unlock the mysteries of Castleman disease, they may single out 2018 as one of the years in which they laid the foundation to help them turn the key, and the University of Pennsylvania has been the epicenter.
Experts and research on important topics in the healthcare system
Some dermal fibroblasts can convert into fat cells that reside under the dermis, giving skin a youthful look and producing peptides that fight infections. University of California San Diego School of Medicine researchers and colleagues show how this happens and what causes it to stop as people age.
Cedars-Sinai Cancer drove major advances in cancer research in 2018. Among these was a study about a pancreatic cancer drug, Metavert, developed by Cedars-Sinai investigators to prevent the most common type of pancreatic cancer from growing and spreading. Other groundbreaking research this year focused on reducing health disparities, the latest treatment options for newly diagnosed melanoma patients, and a study outlining a new, more accurate system for assessing the severity of head and neck cancers and for predicting patient survival.
New year, new you – the pressure to be the best version of yourself builds in January, including the need to be comfortable in your own skin. That’s why experts at The University of Texas Health Science Center at Houston (UTHealth) are sharing their top tips on improving how your skin looks and feels both now and in the future.
Skin has a remarkable ability to heal itself. But in some cases, wounds heal very slowly or not at all, putting a person at risk for chronic pain, infection and scarring. Now, researchers have developed a self-powered bandage that generates an electric field over an injury, dramatically reducing the healing time for skin wounds in rats. They report their results in ACS Nano.
Rutgers Cancer Institute of New Jersey is leading a research study aimed at improving skin cancer protection behaviors in young adults through an online intervention.
A monthly roundup of research briefs showcasing recent scientific advances led by Beth Israel Deaconess Medical Center faculty.
People newly diagnosed with cancer, particularly blood cancers, and those treated with chemotherapy have a greater risk of developing shingles, according to a new study in the Journal of Infectious Diseases. The findings may help guide efforts to prevent the often painful skin condition in cancer patients through the use of new vaccines. The large prospective study expands on previous research by examining the risk of shingles before and after a new cancer diagnosis and across a range of cancer types among approximately 240,000 adults in Australia from 2006 to 2015.
A team from the GW School of Medicine and Health Sciences found emerging treatments, such as neurokinin-1 receptor antagonists, were the most promising against prurigo nodularis.
Research in mice identifies a set of neurons responsible for sustained pain and resulting pain-coping behaviors. Findings point to the existence of separate neural pathways that regulate threat avoidance versus injury mitigation Existence of separate pathways may account for failure to develop effective pain medications Study can inform new ways to gauge the efficacy of candidate pain therapies by assessing behaviors stemming from different pathways
According to dermatologists from the American Academy of Dermatology, dirty makeup brushes can wreak havoc on the skin. In addition to collecting product residue, dirt and oil, makeup brushes are a breeding ground for bacteria. This could compromise your complexion—in the form of acne breakouts and rashes—as well as your health, they say.
A team from the GW School of Medicine and Health Sciences found many dermatologists are interested in learning more about and recommending therapeutic cannabinoids to their patients.
Summaries of recent Fred Hutch research with links for additional background and media contacts.
Carson Bruns is working to put body art to use, designing high-tech inks that may one day signal your temperature or changes in blood chemistry.
Nursing and pharmacy researchers hope to find a replacement for prednisone with fewer and less-severe side effects.
The American College of Rheumatology (ACR) and National Psoriasis Foundation (NPF) have released a joint treatment guideline for psoriatic arthritis (PsA) that provides evidence-based pharmacologic and non-pharmacologic recommendations on caring for treatment-naïve patients with active PsA and patients who continue to have active PsA despite treatment.
Oils from garlic and several other common herbs and medicinal plants show strong activity against the bacterium that causes Lyme disease, according to a study by researchers at Johns Hopkins Bloomberg School of Public Health.
A monthly roundup of research briefs showcasing recent scientific advances led by Beth Israel Deaconess Medical Center faculty.
The PhRMA Foundation awarded more than $6 million over the last two years to more than 100 leaders in scientific research in the United States. The Foundation is proud to announce another successful year supporting innovative research efforts in areas of great importance: Alzheimer’s Disease, Melanoma, Parkinson’s Disease, Schizophrenia, Breast Cancer, Lung Cancer, Leukemia, Ulcerative Colitis, Vascular Disease, and Colorectal Cancer. This year the Foundation also funded two Centers of Excellence in Value Assessment.
BIDMC's Alexa Kimball, MD, shares important factors that influence how our skin looks and behaves.
Why do humans have hair on our arms and legs but not on the palms of our hands and the soles of our feet? It’s a fundamental question in human evolution that researchers at the Perelman School of Medicine at the University of Pennsylvania say they’ve found clues to in a new study.
A $2 million grant from the National Cancer Institute will support the expansion of Rutgers Cancer Institute of New Jersey research focused on sun protective behaviors among young melanoma survivors -- an intervention delivered through social media.
By stirring crosstalk among skin cells that form the roots of hair, researchers report they have regrown hair strands on damaged skin. The findings better explain why hair does not normally grow on wounded skin, and may help in the search for better drugs to restore hair growth, say the study’s authors.
Two leaders in the field of melanoma treatment – a surgeon and an oncologist – from The University of Texas MD Anderson Cancer Center have been named Fellows of the American Association for the Advancement of Science (AAAS).
When performed by a doctor, laser hair removal is a safe, effective and permanent solution for removing unwanted face and body hair. This clinically tested, FDA-approved treatment has been around since the mid-1990s and is a very common procedure among young adults ages 20 to 45. However, the results don’t occur overnight, say dermatologists from the American Academy of Dermatology, and in inexperienced hands, laser hair removal can be dangerous. Performed improperly, the treatment can result in burns, permanent skin color changes and even scars. To reduce the risk of possible side effects and ensure an effective treatment, the AAD recommends that consumers only seek laser hair removal from a medical doctor who is extremely skilled in using lasers and has in-depth knowledge of the skin.
Researchers at the Johns Hopkins Kimmel Cancer Center say they have added to evidence that measuring and monitoring tumor DNA that naturally circulates in the blood of melanoma patients can not only reliably help reveal the early stages of cancer growth and spread but also uncover new treatment options that tumor genetic analysis alone may not.
It’s safe to slap on the sunscreen next summer – in repeated doses – despite what you have read about the potential toxicity of sunscreens.
Researchers at the University of New Hampshire have created an easy-to-make, low-cost injectable hydrogel that could help wounds heal faster, especially for patients with compromised health issues.
With temperatures dipping below freezing, consider the toll that frost is taking on your skin. The good news is experts from The University of Texas Health Science Center at Houston (UTHealth) can help keep your skin in tip-top condition as the winter weather takes hold.
New research found allergy shots provided significant benefits to the eczema symptoms suffered by a 48-year-old man.
Acne is the most common skin condition in the United States, affecting up to 50 million Americans annually. However, despite its prevalence, accurate information about acne can be scarce. Many teenagers and young adults believe that they have to let acne run its course instead of treating it, while others turn to do-it-yourself treatments — like applying diaper cream or toothpaste to pimples — without much success. Yet left untreated, say dermatologists from the American Academy of Dermatology, acne often results in significant physical and psychological problems, such as scarring, poor self-esteem, depression and anxiety.
Dermatologists routinely engage in the care of patients with mucocutaneous manifestations of Human Papillomavirus infections [HPV]
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