The three-drug combination of encorafenib, binimetinib and cetuximab significantly improved overall survival (OS) in patients with BRAF-mutated metastatic colorectal cancer (mCRC), according to results of the BEACON CRC Phase III clinical trial led by researchers at The University of Texas MD Anderson Cancer Center.
Scientists at McMaster University have identified new biomarkers for Irritable Bowel Syndrome (IBS) in urine, which could lead to better treatments and reduce the need for costly and invasive colonoscopy procedures currently used for diagnosis.
A small chemical change – shifting the position of two hydrogen atoms – makes the difference between mice that are healthy and mice with insulin resistance and fatty liver, major risk factors for diabetes and heart disease. Making the change prevented the onset of these symptoms in mice fed a high-fat diet and reversed prediabetes in obese mice. The finding highlights the role of ceramides in metabolic health and pinpoints a “druggable” target that could be used to develop new therapies for metabolic disorders.
Researchers at Washington University School of Medicine in St. Louis and Rush University in Chicago have found a compound that promotes a vigorous immune assault on pancreatic cancer. The findings, in mice, suggest a way to improve immunotherapy for the deadly disease in patients.
Researchers have discovered two distinct subtypes of pancreatic neuroendocrine tumors – known as pNETs – that have dramatically different risks of recurrence following surgical treatment [or surgery]. The finding could yield predictive tests, ease anxiety in patients whose tumors are found to be unlikely to recur, while focusing vigilant follow-up monitoring on patients with pNETs having a higher rate of recurrence.
An adequate consumption of milk and dairy products at different life stages can help prevent various chronic diseases.
成人确诊乳糜泻时常伴有营养缺乏，包括维生素B12和D的缺乏，以及叶酸、铁、锌和铜的缺乏。根据Mayo Clinic研究人员开展的一项研究，此时应补充这些缺乏的营养。
A Rutgers-led study sheds light on one of the most enduring mysteries of science: How did metabolism – the process by which life powers itself, by converting energy from food into movement and growth – begin? To answer that question, the researchers reverse-engineered a primordial protein and inserted it into a living bacterium, where it successfully powered the cell’s metabolism, growth and reproduction, according to the study in Proceedings of the National Academy of Sciences.
Doctors know that screening for colorectal cancer reduces mortality. However, more than one-third of age-eligible Americans go unscreened every year even though colon cancer remains the second leading cause of cancer death in the United States.
Researchers at the Johns Hopkins Kimmel Cancer Center, the Greenberg Bladder Cancer Institute, the Bloomberg~Kimmel Institute for Cancer Immunotherapy, the Brady Urological Institute, and the Center for Computational Genomics at Johns Hopkins have received a $3.2 million grant from the National Institutes of Health to study new treatment options for early-stage bladder cancer.
يكون نقص التغذية عرضًا شائعًا لدى البالغين في وقت تشخيص الداء البطني، ويشمل ذلك نقص الفيتامينين ب-12 ود، وكذلك حمض الفوليك والحديد والزنك والنحاس. وينبغي معالجة هذا النقص في ذلك الوقت، وفقًا لدراسة أعدها باحثون من Mayo Clinic.
A study led by researchers at the Johns Hopkins Bloomberg School of Public Health found that individuals reported more gastrointestinal bloating when they ate a diet high in salt.
In experiments in mice, Johns Hopkins Medicine researchers say they have found additional evidence that Parkinson’s disease originates among cells in the gut and travels up the body’s neurons to the brain. The study, described in the June issue of the journal Neuron, offers a new, more accurate model in which to test treatments that could prevent or halt Parkinson’s disease progression.
New NCCN Guidelines for Patients: Bladder Cancer explains the lengthy surveillance process that follows active treatment for the sixth most-common cancer in the United States.
En el momento de diagnosticar la enfermedad celíaca entre los adultos, es común encontrar deficiencias nutricionales, tales como de vitamina B12, vitamina D, folato, hierro, zinc y cobre.
Metabolomics, the study of small molecules the body produces during metabolism (metabolites) may be a future key to identifying diabetes-related kidney disease. The finding will be presented today at the American Physiological Society (APS)/American Society of Nephrology (ASN) conference, Control of Renal Function in Health and Disease, in Charlottesville, Va.
Micronutrient deficiencies, including vitamins B12 and D, as well as folate, iron, zinc and copper, are common in adults at the time of diagnosis with celiac disease. These deficiencies should be addressed at that time, according to a study by Mayo Clinic researchers.
Researchers at Washington University School of Medicine in St. Louis have figured out how to grow the intestinal parasite Cryptosporidium in the lab, an achievement that will speed efforts to treat or prevent diarrhea caused by the parasite.
Scientists at Cincinnati Children’s Hospital Medical Center have identified an expression pattern of 14 genes at the time of diagnosis that predicts two year, transplant-free survival in children with biliary atresia – the most common diagnosis leading to liver transplants in children. The researchers also found that the antioxidant N-acetyl-cysteine (NAC) reduced liver injury and fibrosis (excess fibrous connective tissue) in mice with biliary atresia and increased survival times.
An increasing number of studies are finding intimate communication between the gut and brain, as well as complex interplay among the gut microbiome, the brain and the rest of the body. But does the gut affect epilepsy? More specifically, can certain populations of bacteria predispose to seizures, and can we harness the power of the microbiome to stop seizures?
Intermountain Healthcare and deCODE genetics have announced a major global collaboration and study focused on discovering new connections between genetics and human disease that will involve the collection of half a million DNA samples.
An unhealthy, inflamed gut causes breast cancer to become much more invasive and spread more quickly to other parts of the body, new research from the University of Virginia Cancer Center suggests.
تُعد الدراسات الجديدة حول الكشف المبكر عن سرطان القولون والمستقيم ونوعية تأثير الحياة للمعالجة بالخلايا من بين العروض التقديمية العديدة التي تقدمها Mayo Clinic في الاجتماع السنوي للجمعية الأمريكية لعلم الأورام السريري في شيكاغو.
A new study has found that not sticking to a regular bedtime and wakeup schedule--and getting different amounts of sleep each night--can put a person at higher risk for obesity
A multicenter team led by investigators at Washington University School of Medicine in St. Louis has taken a big step toward identifying the cysts likely to become cancerous. Testing fluid from cysts for a biomarker — an antibody called mAb Das-1 — the researchers were able to identify pancreatic cysts likely to become cancerous with 95 percent accuracy.
Entre varias presentaciones que Mayo Clinic hace durante la reunión anual de la Sociedad Americana de Oncología Clínica en Chicago, están estudios nuevos sobre la detección temprana del cáncer colorrectal y la repercusión de la terapia celular sobre la calidad de vida.
Treatment with the drug olaparib significantly reduced the risk of disease progression or death from metastatic pancreatic cancer, according to findings from the recently completed, international, phase-III POLO (Pancreas cancer OLaparib Ongoing) trial.
There are no approved treatment options for patients with advanced bladder cancer after standard chemotherapy and immune treatments, but the results of a phase II clinical trial led by Yale Cancer Center and Smilow Cancer Hospital researchers demonstrates an effective treatment for this deadly disease.
New studies on early detection of colorectal cancer and the quality-of-life impact of cell therapy are among several Mayo Clinic presentations at the American Society of Clinical Oncology annual meeting in Chicago.
A study from researchers at Washington University School of Medicine in St. Louis and Veterans Affairs St. Louis Health Care System has linked long-term use of drugs known as proton pump inhibitors (PPIs) to fatal cases of cardiovascular disease, chronic kidney disease and upper gastrointestinal cancer. The researchers found that such risks increase with the duration of PPI use, even when taken at low doses.
Mayo Clinic的研究人员与国际专家一起在2019年消化疾病周会议（Digestive Disease Week 2019）上发布研究结果，该疾病周是世界上最大的胃肠病学和相关领域的医生、研究人员和行业领导者的聚会。
Pediatricians are often reluctant to recommend bariatric surgery for teen-agers, but a Rutgers-led study concludes it is a justifiable treatment for adolescents with persistent extreme obesity if they can maintain a healthy lifestyle afterward.
Gary D. Steinberg, MD , a nationally recognized specialist in the surgical management of bladder cancer, has been named director of the Goldstein Urology Bladder Cancer Program at NYU Langone Health. His recruitment enhances the team of clinicians and scientists already assembled within the Department of Urology and NYU Langone Health’s Perlmutter Cancer Center who focus on this form of cancer.
The 10th Anniversary of Polly’s Run, the largest fundraiser for pancreatic cancer in New Mexico, will take place Sunday, June 2, at Tiguex Park near Albuquerque’s Old Town. All proceeds benefit the Polly Rogers Pancreatic Cancer Research Fund at The UNM Comprehensive Cancer Center.
قدم باحثو Mayo Clinic نتائج أبحاثهم مع غيرهم من الخبراء الدوليين في أسبوع أمراض الجهاز الهضمي 2019 ، وهو أكبر تجمع في العالم من الأطباء والباحثين وقادة المجال في ميدان الجهاز الهضمي والمجالات ذات الصلة.
Os pesquisadores da Mayo Clinic estiveram entre os especialistas internacionais que apresentaram descobertas na Digestive Disease Week 2019, a maior reunião mundial de médicos, pesquisadores e líderes do setor em gastroenterologia e áreas afins.
Mayo Clinic researchers are among international experts who will present findings next week at Digestive Disease Week 2019, the world's largest gathering of physicians, researchers and industry leaders in gastroenterology and related fields.
Gastric cancer, Q fever, Legionnaires' disease, whooping cough--though the infectious bacteria that cause these dangerous diseases are each different, they all utilize the same molecular machinery to infect human cells.
A recent study by researchers at University of California San Diego School of Medicine, San Diego State University and the Max Planck Institute for Developmental Biology found that the age and sex of an individual strongly influences the bacterial diversity of the gut microbiome.
Exposure to glyphosate, the primary ingredient in the popular weed killer Roundup, correlates to more severe cases of nonalcoholic fatty liver disease.
Scientists from Sanford Burnham Prebys and PHusis Therapeutics have shown that a compound called PHT-7.3 shrinks KRAS-driven tumors in mice. In contrast to directly targeting mutant KRAS, the potential drug candidate targets the protein’s partner in crime: the cellular scaffold to which mutated KRAS attaches. The study was published in Cancer Research.
If your car needs work on its front and rear axles, it’s obviously more convenient, efficient and cost effective to have both repairs done at the same time. Now, researchers at Johns Hopkins Medicine have shown similar benefits from “bundling” upper and lower gastrointestinal endoscopies on the same day to remedy what they say is the “disturbingly” large number of older Americans currently being scheduled for the procedures on two different days.
Blocking the action of an enzyme involved in protein digestion may improve metabolic health, according to a new study published ahead of print in the American Journal of Physiology—Gastrointestinal and Liver Physiology. The paper was chosen as an APSselect article for May.
A new study suggests that depression and GI trouble sometimes spring from the same source – low serotonin – and identifies a potential treatment that could ease both conditions simultaneously.
Scientists have shown that transplanting gut bacteria, from an animal that is vulnerable to social stress to a non-stressed animal, can cause vulnerable behavior in the recipient. The research may someday lead to probiotic treatments for human psychiatric disorders such as depression.
Researchers at Washington University School of Medicine in St. Louis have found that treating mice with an antibiotic reduces the size of lesions caused by endometriosis. The researchers are planning a clinical trial to test the strategy in women who have the painful condition.
Scientists have taken one of the most in-depth looks ever at the riot of protein activity that underlies colon cancer and have identified potential new molecular targets to try to stop the disease.
The vaccine proves safe in a small sample of human subjects, opening the way for the next phase of testing
Dr. Yasmin A. Zerhouni and colleagues from Brigham & Women’s Hospital in Boston sought to answer this question using data from health-related telephone surveys administered by the Centers for Disease Control (CDC).
Fight CRC’s Clinical Trial Finder App aims to make the web-based resource more accessible to Late-State, MSS colorectal cancer patients
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