• Concerning adherence to certain recommended measures of kidney disease care for veterans with diabetes within the Veterans Affairs Health Care System, there is modest facility-level variation for some measures and larger facility-level variation for others.
A team of researchers led by Jonathan Stamler, MD, of Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center, has discovered a pathway for enhancing the self-repair efforts of injured kidneys. The finding may pave the way for new drugs to stop or even reverse the progression of serious kidney disease in humans—and other potentially lethal conditions of the heart, liver, and brain as well.
In an effort to compile and summarize the latest knowledge about these immunotherapy combinations and their implications, a group of kidney cancer immunotherapy experts led by Saby George, MD, of Roswell Park Comprehensive Cancer Center have written a new research review article assessing current approaches to treating patients newly diagnosed with kidney cancer and also looking ahead to some of the most pressing questions still to be answered related to these emerging therapies. Published online Nov. 21 by the journal JAMA Oncology, the review article highlights the path to approval for the new standard of care for these patients — ipilimumab, also known as Yervoy, together with nivolumab, also known as Opdivo.
Are there changes that affect genes and fuel a person’s propensity to develop obesity? That’s a question under study at Texas Biomedical Research Institute. Associate Scientist Melanie Carless, Ph.D., is Principal Investigator of a $3 million, four-year grant from the National Institute of Diabetes, Digestive and Kidney Diseases to research this hypothesis.
Urinating into a cup may be a medical necessity at times, but it's often uncomfortable, embarrassing and messy -- especially for women. But what if there were a way to comfortably provide a sample without the splashback? Researchers have created a set of experiments using an anatomically correct female urethra that produced a jet of water with a pressure and flow equivalent to a human bladder. During the APS Division of Fluid Dynamics 71st Annual Meeting, Nov. 18-20, they’ll describe the findings and potential implications.
• A pilot program delivered by community health representatives in the homes of patients with chronic kidney disease in Zuni Pueblo in rural New Mexico promoted patients’ active involvement in their own care. • The program also led to modest improvements in several clinical measures, including decreases in body mass index, blood glucose levels, and inflammation, and improved mental health quality of life.
New research has identified rogue cells – namely brain and muscle cells – lurking within kidney organoids. The presence of such cells indicates that the “recipes” used to coax stem cells into becoming kidney cells inadvertently are churning out other cell types.
New study suggests activation of the protein ISGF3 could be a novel therapeutic strategy for patients with clear cell renal cancer.
David Charytan, MD, renowned expert in cardio-renal disease, named new division director of nephrology at NYU Langone.
RenalytixAI PLC, a Mount Sinai exclusive licensee and development collaborator, had completed a public listing that valued the company at $85 million on the London Stock Exchange’s Alternative Investment Market.
NIH Grant Supports Research That May Prevent Heart Disease in Chronic Kidney Disease Patients
A widely held and controversial myth that high-protein diets may cause kidney damage in healthy adults has been debunked by scientists at McMaster University, who examined more than two dozen studies involving hundreds of participants.
• In a study that compared uninsured patients starting hemodialysis with similar patients already covered by Medicare or Medicaid, patients with Medicare or Medicaid were more likely to receive dialysis through an arteriovenous fistula or graft by their fourth dialysis month. • Patients with Medicare at the start of dialysis also had fewer hospitalizations involving vascular access infection in dialysis months 4-12.
The American Society of Nephrology (ASN) today announced former ASN President Raymond C. Harris, Jr., MD, FASN, will serve as co-chair for its Kidney Health Initiative (KHI). Harris, a professor of medicine, molecular physiology, and biophysics, is Director of the Vanderbilt Center for Kidney Disease and former chief of the nephrology division of Vanderbilt University’s Medical Center in Nashville, Tenn.
The American College of Surgeons National Surgical Quality Improvement Program has recognized 83 of an eligible 568 hospitals participating in its adult program for achieving meritorious outcomes for surgical patient care in 2017.
PHILADELPHIA — A $17.5 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) will propel Penn Medicine research efforts to prevent Chronic Kidney Disease (CKD). Harold I. Feldman, MD, MSCE, chair of Biostatistics, Epidemiology and Informatics and director of the Center for Clinical Epidemiology and Biostatistics, and J.
The American Society of Nephrology (ASN), the world’s largest organization of kidney health professionals, has elected Mark E. Rosenberg, MD, FASN, as the next ASN President. Dr. Rosenberg officially assumes his role as ASN President during the society’s annual meeting, ASN Kidney Week 2018, the largest gathering of kidney care specialists in the world, and he will begin his term on January 1, 2019.
• Frailty is associated with decreased access at multiple stages in the pathway to kidney transplantation. Improvement in physical frailty may increase access to transplantation. • Results from the study will be presented at ASN Kidney Week 2018 October 23–October 28 at the San Diego Convention Center.
• An analysis reveals that many transplanted kidneys in France would have likely been discarded in the United States. • Results from the study will be presented at ASN Kidney Week 2018 October 23–October 28 at the San Diego Convention Center.
• Among patients with chronic kidney disease, individuals with pro-inflammatory diets had a higher risk of developing kidney failure. • Results from the study will be presented at ASN Kidney Week 2018 October 23–October 28 at the San Diego Convention Center.
• Nephrologists often lack confidence in managing women’s health issues that may be related to kidney disease. • Results from the study will be presented at ASN Kidney Week 2018 October 23–October 28 at the San Diego Convention Center.
• Within one year after initiating dialysis, patients on more frequent home hemodialysis were 23% less likely to die compared with patients receiving traditional in-center hemodialysis. • Results from the study will be presented at ASN Kidney Week 2018 October 23–October 28 at the San Diego Convention Center.
• Individuals with kidney disease have a higher likelihood of using prescription opioids, and the prevalence of prescription opioid use in the chronic kidney disease population has increased in recent years. • Certain factors are associated with opioid drug use in patients with chronic kidney disease. • Results from the study will be presented at ASN Kidney Week 2018 October 23–October 28 at the San Diego Convention Center.
The results of numerous high-impact clinical trials that could affect kidney-related medical care will be presented at ASN Kidney Week 2018 October 23–October 28 at the San Diego Convention Center.
• In a study of kidney transplant recipients, those with ideal BMI (18–25) had the best organ survival. There was no difference when comparing BMI 30–35 with >35. • There were no significant differences in patient survival across different BMI groups. • Results from the study will be presented at ASN Kidney Week 2018 October 23–October 28 at the San Diego Convention Center.
• From 1995 to 2014, patient survival after kidney transplantation improved overall for pediatric recipients in the United States; however, racial/ethnic disparities in long-term survival worsened over time. • Results from the study will be presented at ASN Kidney Week 2018 October 23–October 28 at the San Diego Convention Center.
• Patients with acute kidney injury had more than a 3-fold higher risk of developing dementia compared with those without acute kidney injury during a median follow-up time of 5.8 years. • Results from the study will be presented at ASN Kidney Week 2018 October 23–October 28 at the San Diego Convention Center.
• Compared with kidney transplant recipients who did not report a disability, recipients with a visual disability were at higher risk of organ failure and recipients with a walking disability were at higher risk of early death. • Results from the study will be presented at ASN Kidney Week 2018 October 23–October 28 at the San Diego Convention Center.
• In patients with type 2 diabetes at high risk for cardiovascular disease, targeting blood sugar to normal levels (HbA1c<6.0%) reduced the risk for macroalbuminuria (a high amount of protein excreted in the urine) over an average follow-up of 7.7 years, but it had no impact on more significant kidney outcomes such as serum creatinine doubling (a marker of worsening kidney function) or the need for dialysis or transplantation. • Targeting low blood pressures (<120mmHg) or the use of fenofibrate to lower cholesterol increased the risk for doubling of serum creatinine, although it had no impact on the need for dialysis or transplantation.
• Results from biopsies taken when kidneys were procured from donors were not reliable for determining whether the organs were suitable for transplantation.
Glyn R. Morgan, MD, MSc, FRCSC, FACS, one of the nation's leading liver and kidney transplant surgeons, has been named director of Loyola Medicine's division of intra-abdominal transplant.
The American Society of Nephrology’s Kidney Health Initiative is releasing its Technology Roadmap for Innovative Approaches to Renal Replacement Therapy.
Results of a phase II clinical trial show that novel drug sparsentan is an effective treatment for the rare kidney disease focal segmental glomerulosclerosis (FSGS), which currently has no FDA-approved therapies.
Mount Sinai nephrologists will be in attendance and available to comment on breaking news, in addition to their own research.
• Receiving high-dose vs. standard dose influenza vaccine in 2016-17 was associated with lower rates of hospitalization in dialysis patients, although this association was not seen in 2015-16 (when few dialysis patients received the high-dose vaccine). • There were no differences in rates of death between patients receiving the high-dose vs. standard dose influenza vaccine during either time period.
Using a novel biomarker panel to track and measure kidney function, researchers at University of California San Diego School of Medicine and University of California San Francisco School of Medicine report that lowering systolic blood pressure to less than 120 mm Hg does not damage the kidney organ itself. Instead, any negative changes to clinical results are more likely due to decreased blood flow.
American Society of Nephrology Kidney Week Press Briefing
Treatment of renal cell carcinoma with stereotactic radiation therapy is as safe and effective for patients with one kidney as it is for those who have two, according to an analysis of the largest-ever, international dataset of solitary kidney patients to receive this emerging treatment. Findings will be presented in a news briefing today at noon ET from the American Society for Radiation Oncology (ASTRO) Annual Meeting.
Five leaders in the kidney health community are being honored by the American Society of Nephrology (ASN), the world’s largest organization of kidney disease specialists.
The American Society of Nephrology (ASN), will bestow the President’s Medal to Griffin P. Rodgers, MD, MACP, for his leadership in kidney research and advocacy.
• Lower perceived quality of patient-physician interaction was associated with a higher risk of hospitalization in Hispanics with chronic kidney disease. • Quality of patient-physician interaction was not associated with risk of developing kidney failure or dying.
Researchers have developed a new test that could diagnose chronic kidney disease early in patients with type 2 diabetes. This novel method, published today in AACC’s Clinical Chemistry journal, could improve quality of life for diabetic patients by potentially catching chronic kidney disease in time to stop its progression to full-blown kidney failure.
UAB transplant surgeon Jayme Locke recently shared six steps to building a dream career. To be a surgeon, you have to have confidence. “I tend to be grandiose in my thinking,” said Jayme Locke, M.D., MPH, director of the University of Alabama at Birmingham’s Incompatible Kidney Transplant Program and vice chair for Health Services Research in the Department of Surgery.
According to a study recently published in the Journal of Cellular Physiology, even low, allowable levels of arsenic may be enough to cause kidney disease. The good news, however, is there may be a way to treat such kidney disease using a drug already approved by the FDA – just not for this purpose.
To further its mission of facilitating timely and broad dissemination of kidney science, the American Society of Nephrology (ASN) today announced an addition to its journal portfolio, Kidney360. The journal will available online monthly beginning January 2020.
• In a study of young adults with kidney failure, poor wellbeing and lower medication adherence were both associated with psychological morbidity. • Dialysis treatment (vs. kidney transplantation) was associated with poorer wellbeing and medication adherence.
In 2016, the ASN Foundation for Kidney Research launched the Securing the Future Campaign with the goal to endow the Career Development Grants Program. The campaign has since raised more than $22 million through generous contributions from industry, individual donors, and the American Society of Nephrology (ASN).
The American Society of Nephrology (ASN), the world’s largest organization of kidney health professionals, released a new report on the annual survey of nephrology fellows authored by George Washington University (GW) researchers.
Adult patients who received liver and kidney transplants at Rush University Medical Center had better-than-expected one-year survival rates, according to the most recent transplantation on the 5-tier system report by the Scientific Registry of Transplant Recipients (SRTR), which was released on Oct. 9.
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