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Newswise: Lumiradx to Present on Impact of Its Next-Generation Microfluidic Technology at American Association for Clinical Chemistry (AACC) Annual Conference in Chicago
Released: 25-Jul-2022 12:30 PM EDT
Lumiradx to Present on Impact of Its Next-Generation Microfluidic Technology at American Association for Clinical Chemistry (AACC) Annual Conference in Chicago
2022 AACC Annual Scientific Meeting Press Program

LumiraDx, a next-generation point of care diagnostics company will be hosting an industry workshop at this week’s American Association for Clinical Chemistry (AACC) Annual Conference in Chicago. The workshop, held on July 27th, will include data-backed insights on the impact of LumiraDx’s advanced microfluidic technology over lateral flow point-of-care antigen tests, and the role of these rapid immunoassays in response to the COVID-19 pandemic.

   
Released: 25-Jul-2022 12:00 PM EDT
In silico analysis of genes and pathways related to acute myeloid leukemia presenting leukopenia
Preprints

Ajeet Kumar, Ravi Bhushan, Pawan K. Dubey, Vijai Tilak, Vineeta Gupta, Nilesh Kumar, S. V.S Raju, Akhtar Ali

Released: 25-Jul-2022 12:00 PM EDT
Detection of second primary lymphoma in late diffuse large B-cell lymphoma recurrences
Preprints

Madeleine Berendsen, Diede van Bladel, Eva Hesius, Fleur de Groot, Leonie Kroeze, Jos Rijntjes, Jeroen Luijks, Brigiet Hoevenaars, Altuna Halilovic, Peet Nooijen, Ellen van der Spek, Joost Vermaat, Corine Hess, Konnie Hebeda,

Released: 25-Jul-2022 12:00 PM EDT
Non metastasis protein 2 (NME2) is a potential target for leukemia-specific immunotherapy
Preprints

Tobias Däbritz, Sabine Tschiedel, Michael Cross, Dietger Niederwieser

Released: 25-Jul-2022 12:00 PM EDT
Methylation genome wide profiling in lowly and highly efficient adipose somatic cell nuclear transfer in pigs
Preprints

Maciej Grzybek, Krzysztof Flisikowski, Tom Giles, Marta Dyjak, Rafal Ploski, Piotr Gasperowicz, Richard D Emes, Pawel Lisowski

Released: 25-Jul-2022 12:00 PM EDT
mTORC1 is required for differentiation of germline stem cells in the Drosophila melanogaster testis
Preprints

Marie Clémot, Cecilia D'Alterio, Alexa C. Kwang, D. Leanne Jones

Released: 25-Jul-2022 12:00 PM EDT
Application of Shear Stress for Enhanced Osteogenic Differentiation of Mouse Induced Pluripotent Stem Cells
Preprints

Phoonsuk Limraksasin, Praphawi Nattasit, Jeeranan Manokawinchoke, Watcharaphol Tiskratok, Naruephorn Vinaikosol, Hiroko Okawa, Chalida Nakalekha Limjeerajarus, Nuttapol Limjeerajarus, Prasit Pavasant, Thanaphum Osathanon, Hiroshi Egusa

Released: 25-Jul-2022 12:00 PM EDT
Cancer Stem Cells and Competing Endogenous RNAs
Preprints

Hamid Aria, Mahdieh Azizi, Shima Nazem, Maryam Bahmanyar, Ali Moravej, Mohammad Hosein Pourjafarian, Babak Pezeshki, Alireza Tavassoli, Mohammad Kazem Vakil, Yaser Mansoori

Released: 25-Jul-2022 12:00 PM EDT
Efficient generation of marmoset primordial germ cell-like cells using induced pluripotent stem cells
Preprints

Kotaro Sasaki, Yasunari Seita, Keren Cheng, John McCarrey, Nomesh Yadu, Ian Cheeseman, Alec Bagwell, Corinna N Ross, Isamar Santana-Toro, Li-Hua Yen, Sean Vargas, Christopher S Navara, Brian P Hermann

Released: 25-Jul-2022 12:00 PM EDT
Poor sensitivity of iPSC-derived neural progenitors and glutamatergic neurons to SARS-CoV-2
Preprints

Marija Zivaljic, Mathieu Hubert, Ludivine Grzelak, Giulia Sansone, Uwe Maskos, Olivier Schwartz

Newswise:Video Embedded cytovale-reveals-10-minute-510-k-pending-cytovale-system-and-intellisep-test-for-sepsis-at-aacc-2022
VIDEO
Released: 25-Jul-2022 10:40 AM EDT
Cytovale Reveals 10-Minute, 510(K) Pending Cytovale System and Intellisep Test for Sepsis at AACC 2022
2022 AACC Annual Scientific Meeting Press Program

Cytovale®, a medical diagnostics company focused on providing rapid and insightful tools to improve early detection of fast-moving and immune-mediated diseases, will reveal its 510(k) pending Cytovale system and 10-minute IntelliSep® sepsis risk stratification test at the American Association for Clinical Chemistry (AACC) annual meeting, where new data featuring the test will also be shared. The instrument can be seen in the Cytovale booth, no. 5045, in the exhibit hall during Clinical Lab Expo hours. The IntelliSep test was recently named an AACC Disruptive Technology Award Semifinalist and is also being featured in the Disruptive Tech area of the exhibit hall during the meeting.

Released: 24-Jul-2022 12:00 PM EDT
Cell cycle and temporal transcription factors regulate proliferation and neuronal diversity of dedifferentiation-derived neural stem cells
Preprints

Louise Cheng, Kellie Veen, Francesca Froldi, Qian Dong, Edel Alvarez-Ochoa, Phuong-Khanh Nguyen, Kieran F Harvey, John P D McMullen, Owen J. Marshall, Patricia R Jusuf

Released: 24-Jul-2022 12:00 PM EDT
Dynamic changes in the niche and transcription trigger early murine and human pluripotent stem cell-derived liver organogenesis
Preprints

Ogechi Ogoke, Daniel Guiggey, Sarah Thompson, Alexander Chiang, Tram Hoang Anh Nguyen, Daniel Berke, Cortney Ott, Allison Kalinousky, Claire Shamul, Peter Chen, Shatoni Ross, Zhaowei Chen, Pooja Srivastava, Supriya D Mahajan,

Released: 24-Jul-2022 12:00 PM EDT
Hydrogel Assisted Double Molding of 3D-Print Enables Prestress Regulation of Micro-Heart Muscle Physiology
Preprints

Daniel W. Simmons, David R. Shuftan, Jingxuan Guo, Kasoorelope Oguntuyo, Ghiska Ramahdita, Mary K. Munsell, Brennan Kandalaft, Missy Pear, Nathaniel Huebsch

Released: 23-Jul-2022 12:00 PM EDT
Self-organized anteroposterior regionalization of early midbrain and hindbrain using micropatterned human embryonic stem cells
Preprints

Abstract: To develop into the central nervous system, neuroepithelial cells must first form a neural tube consisting of a series of patterned neural progenitor cells along the anterior-posterior (AP) axis. Based on studies using model organisms, it has been revealed that AP spatial regionalization is dominated by gradients of morphogens that regulate retinoic acid (RA), sonic hedgehog (SHH), bone morphogenetic proteins (BMPs), and Wingless/int1 (WNT) signaling pathways.

Newswise: Scientists expand entomological research using genome editing
Released: 22-Jul-2022 2:35 PM EDT
Scientists expand entomological research using genome editing
Hiroshima University

Genome sequencing, where scientists use laboratory methods to determine a specific organism’s genetic makeup, is becoming a common practice in insect research.

Released: 22-Jul-2022 12:00 PM EDT
Screening of single nucleotide polymorphisms within HLA region related to hematopoietic stem cell transplantation using MassARRAY technology
Preprints

Abstract: A growing number of studies showed that single nucleotide polymorphisms (SNPs) in the human leukocyte antigen (HLA)-related genes were associated with the outcome of hematopoietic stem cell transplantation (HSCT).

Released: 22-Jul-2022 12:00 PM EDT
Knockdown of long noncoding RNA SAN rejuvenates aged adipose-derived mesenchymal stem cells via miR-143-3p/ADD3 axis
Preprints

Background Senescent adipose-derived stem cells (ASCs) exhibit reduced therapeutic efficacy during wound healing. Transcriptional regulation factors including long non-coding RNAs (lncRNAs) reportedly play essential roles in stem cell aging. However, the mechanisms by which lncRNAs influence mesenchymal stem cell aging have not been investigated.

Released: 22-Jul-2022 12:00 PM EDT
Differentially expressed circRNA and mRNA profiles of neural stem cells with radiation treatment
Preprints

Jiacong Hong, Shan Wang, Zhaopeng Cai, Peng Wang, Zhongyu Xie, Keng Chen

Released: 22-Jul-2022 12:00 PM EDT
The presence of BBB hastens neuronal differentiation of cerebral organoids - the potential role of endothelial derived BDNF
Preprints

Giorgia Fedele, Alessandra Cazzaniga, Sara Castiglioni, Laura Locatelli, Antonella Tosoni, Manuela Nebuloni, Jeanette A.M. Maier

Released: 22-Jul-2022 12:00 PM EDT
Molecular Underpinnings and Environmental Drivers of Spontaneous Loss of Heterozygosity in Drosophila Intestinal Stem Cells
Preprints

Lara Al Zouabi, Marine Stefanutti, Nick Riddiford, Natalia Rubanova, Mylene Bohec, Nicolas Servant, Allison J Bardin

Released: 22-Jul-2022 8:05 AM EDT
‘Smart Necklace’ Biosensor May Track Health Status Through Sweat
Ohio State University

Researchers have successfully tested a device that may one day use the chemical biomarkers in sweat to detect changes in a person’s health.

   
Newswise: Fast, Efficient COVID-19 Biosensor Under Development
Released: 21-Jul-2022 1:20 PM EDT
Fast, Efficient COVID-19 Biosensor Under Development
Indiana University

IUPUI researchers are developing a "biosensing platform" for COVID-19 that's fast, efficient, accurate and highly sensitive, which could help scientists stay on top of shifting virus variants.

   
Released: 21-Jul-2022 12:20 PM EDT
First electric nanomotor made from DNA material
Technical University of Munich

A research team led by the Technical University of Munich (TUM) has succeeded for the first time in producing a molecular electric motor using the DNA origami method.

Released: 21-Jul-2022 12:00 PM EDT
Preclinical investigation of expanded human adipose–derived stem cell dosage and timing for improved defecation function in immunodeficient mice
Preprints

Ryota Mori, Norikatsu Miyoshi, Shiki Fujino, Tsunekazu Mizushima, Ryohei Yukimoto, Takayuki Ogino, Hidekazu Takahashi, Mamoru Uemura, Yuichiro Doki, Hidetoshi Eguchi

Released: 21-Jul-2022 12:00 PM EDT
TLR3 stimulation improves the migratory potency of adipose-derived mesenchymal stem cells through the stress response pathway in the melanoma mouse model
Preprints

Fatemeh Eskandari, Samira Zolfaghari, Ayna Yazdanpanah, Rima Manafi Shabestari, Motahareh Rajabi Fomeshi, Peiman B. Milan, Jafar Kiani, Mina Soufi Zomorrod, Majid Safa

Released: 20-Jul-2022 5:10 PM EDT
Messe Düsseldorf to Promote International “MEDICAlliance” Portfolio at AACC 2022
2022 AACC Annual Scientific Meeting Press Program

Messe Düsseldorf will participate in the AACC Clinical Lab Expo 2022 in order to promote its “MEDICAlliance” program of regional and international medical trade fairs organized around the globe.

Released: 20-Jul-2022 5:05 PM EDT
MEDICA and COMPAMED 2022 Planning Enters Next Stage Exhibitor Registration Still Possible
2022 AACC Annual Scientific Meeting Press Program

The planning for the world’s leading medical trade fair MEDICA 2022 as well as for COMPAMED 2022, the No. 1 trade fair for suppliers of the medical technology industry, has entered the next stage. The current number of exhibitor registrations indicates that participation will surpass last year’s results (MEDICA 2021: 3,033; COMPAMED 2021: 490). Exhibitors can still register online for all segments at www.medica.de/2330 and www.compamed.de/2330 MEDICA and COMPAMED will take place concurrently from November 14 – 17, 2022 at the fairgrounds in Düsseldorf, Germany.

Released: 20-Jul-2022 12:00 PM EDT
Cas9+ conditionally immortalized neutrophil progenitors as a tool for genome wide CRISPR screening for neutrophil differentiation and function
Preprints

Robyn M Jong, Krystal Ching, Nicholas E Garelis, Alex Zilinskas, Xammy Nguyenla, Sagar Rawal, Bianca Hill, Bridget Luckie, Lillian Shallow, Jeffery S Cox, Gregory Barton, Sarah Stanley

Released: 20-Jul-2022 12:00 PM EDT
Human liver organoids model progressive inflammatory and fibrotic injury in non-alcoholic fatty liver disease
Preprints

Anja Hess, Stefan D. Gentile, Amel Ben Saad, Raza-Ur Rahman, Tim Habboub, Alan C. Mullen

Newswise: Engineers Develop New Tool That Will Allow for More Personalized Cell Therapies
Released: 20-Jul-2022 10:00 AM EDT
Engineers Develop New Tool That Will Allow for More Personalized Cell Therapies
University of Minnesota College of Science and Engineering

A University of Minnesota Twin Cities team has developed a new tool to predict and customize the rate of DNA editing, paving the way for more personalized, efficient genetic and cell therapies for diseases such as diabetes and cancer.

   
15-Jul-2022 12:30 PM EDT
‘iTEARS’ could help diagnose diseases by isolating biomarkers in tears
American Chemical Society (ACS)

In ACS Nano, researchers report a nanomembrane system that harvests and purifies tiny blobs called exosomes from tears, allowing researchers to quickly analyze them for disease biomarkers. Dubbed iTEARS, the platform could enable more efficient and less invasive diagnoses for many diseases.

   
Newswise: Biochemistry: Peptide “Fingerprint” Enables Earlier Diagnosis of Alzheimer’s Disease
Released: 20-Jul-2022 3:05 AM EDT
Biochemistry: Peptide “Fingerprint” Enables Earlier Diagnosis of Alzheimer’s Disease
Karlsruhe Institute of Technology (KIT)

Neurodegenerative diseases like Alzheimer’s disease or Parkinson’s disease are caused by folding errors (misfolding) in proteins or peptides, i.e. by changes in their spatial structure. This is the result of minute deviations in the chemical composition of the biomolecules. Researchers at the Karlsruhe Institute of Technology (KIT) have developed a simple and effective method for detecting such misfolding at an early stage of the disease. Misfolding is revealed by the structure of dried residue from protein and peptide solutions.

   
Released: 19-Jul-2022 6:05 PM EDT
Eliksa Therapeutics launched with University of Utah’s commercial and clinical-stage regenerative medicine technology
University of Utah

Eliksa Therapeutics, a regenerative medicine company developing novel therapeutics for a range of debilitating diseases, announced today it has launched with investments from the University of Utah (U) and Militia Hill Ventures (MHV) to develop and commercialize multiple clinical programs using the regenerative medicine technology developed at the U.

   
Released: 19-Jul-2022 12:00 PM EDT
Exosome-shuttled miR-126 mediates ethanol-induced disruption of neural crest cell-placode cell interaction by targeting SDF1
Preprints

Yihong Li, Ting Cai, Huina Liu, Yun Lei, Shun Zhang, Fuyu Sun, Jie Liu, Shao-Yu Chen, Huadong Fan

Released: 19-Jul-2022 12:00 PM EDT
Perfusable Apparatus For Thick-tissue Creation And Growth (patch) Of Cardiac Tissue
Preprints

Amatullah Mir, Isaree Pitaktong, Jason Yusheng He, Katherine Nurminsky, Tyler Dunn, Sarah Koljaka, Olivia Dunn, Stephanie Ran, Daniel Rodgers, Anya Wang, Hiroshi Matsushita, Narutoshi Hibino, Wesley Shih

Released: 19-Jul-2022 12:00 PM EDT
Pyruvate carboxylation identifies Glioblastoma Stem-like Cells opening new metabolic strategy to prevent tumor recurrence
Preprints

Ophelie Renoult, Catherine Gratas, Noemie Joalland, Melanie Laurent--Blond, Hala Awada, Marine Bourgeois, Lisa Oliver, Sophie Chiavassa, Mikael Croyal, Francois Paris, Claire Pecqueur

Released: 19-Jul-2022 12:00 PM EDT
Plant Volatile Signatures of Growth and Defense during Abiotic Stress
Preprints

Kolby Jardine, Rebecca Dewhirst, Suman Som, Joseph Lei, Eliana Tucker, Robert Young P, Miguel Portillo-Estrada, Yu Gao, Luping Su, Silvano Fares, Cristina Castanha, Jenny Mortimer

Released: 19-Jul-2022 10:00 AM EDT
Epiblast inducers capture mouse trophectoderm stem cells in vitro and pattern blastoids for implantation in utero
Cell Stem Cell

Here, Seong et al. identify an optimal set of epiblast inducers that captures mouse trophectoderm stem cells (TESCs) as a stable and highly self-renewing state reflecting the blastocyst stage. TESCs have enhanced capacity to form blastoids that indu

Released: 18-Jul-2022 12:00 PM EDT
Periodontal ligament stem cells inhibit THP-1 macrophage pyroptosis via modulating the NF-κB/NLRP3/GSDMD signaling axis
Preprints

Wenxuan Wang, Chun Fan, Xinbo Yu, Xu Qiu, Yingzhe Hu, Shuhan Li, Xiangru Gao, Qiuxia Ji

Released: 18-Jul-2022 12:00 PM EDT
Palifermin Compared to Supersaturated Calcium Phosphate Rinse in Prevention of Severe Oral Mucositis after Stem Cell Transplantation
Preprints

Tarik Hadid, Ayad Al-Katib, Jose Binongo, Gina M. Berteotti, Salman Fazal, James M. Rossetti, John Lister

Released: 18-Jul-2022 12:00 PM EDT
Influence of genetic ancestry on breast stromal cells provides biologic basis for increased incidence of metaplastic breast cancer in women of African descent
Preprints

Brijesh Kumar, Katie Batic, Poornima Bhat-Nakshatri, Maggie M Granatir, Rebekah Joann Addison, Megan Szymanski, Lee Ann Baldridge, Constance J Temm, George Sandusky, Sandra K Althouse, Anna Maria Storniolo, Harikrishna Nakshatri

Released: 18-Jul-2022 12:00 PM EDT
A cohort study on deficiency of ADA2 from China
Preprints

Guomin Li, Xu Han, Ye Wu, Wei Wang, Hong-Xia Tang, Mei-Ping Lu, Xue-Mei Tang, Yi Lin, Fan Deng, Jun Yang, Xin-Ning Wang, Cong-Cong Liu, Wen-Jie Zheng, Bing-Bing Wu, Fang Zhou



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