Feature Channels: Cell Biology

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‘Lymphatic plexus’ behind the nose drains cerebrospinal fluid from the brain, potentially impacting neurodegenerative conditions.

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A valuable molecule sourced from the soapbark tree and used as a key ingredient in vaccines, has been replicated in an alternative plant host for the first time, opening unprecedented opportunities for the vaccine industry.

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Staying hydrated and consuming appropriate amounts of salt is essential for the survival of terrestrial animals, including humans. The human brain has several regions constituting neural circuits that regulate thirst and salt appetite, in intriguing ways.

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The intricate dance of nature often unfolds in mysterious ways, hidden from the naked eye. At the heart of this enigmatic tango lies a vital partnership: the symbiosis between plants and a type of fungi known as arbuscular mycorrhizal (AM) fungi.

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One major hurdle in the development of safe and effective immunotherapies has been the risk of depleting healthy T cells during CAR-T treatment that seeks out and kills cancerous T-cells. In a new study published in Nature Communications, Yale Cancer Center researchers have developed a novel CAR-T cell therapy designed to efficiently kill cancerous T cells while leaving most healthy cells intact.

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New research indicates that it is possible to forestall the onset of menopause, perhaps indefinitely, by implanting a woman’s own previously harvested ovarian tissue back into her body.

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In a new article published in Nature Chemistry, Moffitt Cancer Center researchers describe their development of a new reagent that allows a more efficient approach to make sulfoximines, sulfonimidoyl fluorides and sulfonimidamides that may be used in medicines.

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Researchers have identified a receptor protein known as CHRM1 as a key player in prostate cancer cells’ resistance to docetaxel, a commonly used chemotherapy drug to treat advanced cancer that has spread beyond the prostate.

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As AD for Basic Sciences, Macleod will have oversight of basic research activities across the Center and oversee research program infrastructure.

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Live cell imaging is a foundational part of biological research. A variety of methods of time-lapse, 3-D microscopy platforms allow researchers to visualize and follow the dynamic processes of single cells, whole cell populations, and subcellular activity.

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Researchers from McGill University, led by Professor Alanna Watt of the Department of Biology, have identified previously unknown changes in brain cells affected by a neurological disease.

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Molecular defense system protects bacteria from viruses and at the same time makes them susceptible to antibiotics.

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Researchers with McMaster University have created the instruction manual that will help scientists across the globe find hard to detect B cells.

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New study provides insights on role of ‘hunger hormone’ receptor in obesity-realted chronic inflammation.

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A new study in Cell Metabolism by a team from the Monell Chemical Senses Center unravels the internal neural wiring of separate fat and sugar craving pathways in a mouse model. However, combining these pathways overly triggers a desire to eat more than usual.

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Researchers from The University of Texas MD Anderson Cancer Center reported promising results in a Phase I/II trial of 37 patients with relapsed or refractory B-cell malignancies who were treated with cord blood-derived chimeric antigen receptor (CAR) natural killer (NK) cell therapy targeting CD19.

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A new computational framework created by Oak Ridge National Laboratory researchers is accelerating their understanding of who’s in, who’s out, who’s hot and who’s not in the soil microbiome, where fungi often act as bodyguards for plants, keeping friends close and foes at bay.

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Cleveland Clinic researchers have successfully developed a therapeutic peptide that blocks aggressive cancer cells from multiplying rapidly. The results highlight a potential new strategy for developing targeted treatments for triple-negative breast cancer, which currently has no approved options. Targeted drugs attack cancer cell functions directly, offering a more precise approach to complement broader treatments like chemotherapy. A research team led by Ofer Reizes, PhD, and Justin Lathia, PhD, designed a peptide therapeutic that disrupts the molecular processes behind aggressive cancer growth when delivered into cells. The drug stopped cancer growth and induced tumor cell death, and only affected cancerous cells in preclinical work. The study was highlighted in the January issue of Molecular Cancer Therapeutics.

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Shengjie Feng, Ph.D. is an expert in cryo-electron microscopy, a Nobel Prize-winning imaging technology capable of creating stop-action movies of proteins and other biomolecules jostling and connecting with each other while mitochondria and other organelles generate energy, assemble new molecules and transport cargo. At Sanford Burnham Prebys, Feng will use cryo-EM to reveal new ways to stop or prevent cancers.

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While it is well known that cannabis can cause the munchies, researchers have now revealed a mechanism in the brain that promotes appetite in a set of animal studies at Washington State University.

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RUDN University scientists have discovered that in weightlessness the contractile activity of smooth muscles in the hollow organs of the gastrointestinal tract is disrupted. New data must be taken into account when planning long-term space missions.

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The Environmental Molecular Sciences Laboratory a Department of Energy user facility, will hold a free webinar on Jan. 24 to showcase available imaging platforms for live cell microscopy.

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A study of mutant models of fragile X syndrome (FXS), a genetic disorder related to autism and intellectual disability, shows that activation of the cerebellum mitigates aberrant responses in sensory processing areas of the brain and improves neurodevelopmental behaviors. The findings, published by UT Southwestern Medical Center researchers in Cell Reports, could offer an opportunity for developing new therapies for neurocognitive disorders.

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The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back. Recent developments at MD Anderson include insights into the effects of the gut microbiome on remote tumors, a screening strategy for ovarian cancer early detection, a combination approach to overcome PARP inhibitor resistance, further understanding of ferroptosis resistance, a ferroptosis-based strategy for overcoming treatment resistance in acute myeloid leukemia (AML), potential targets for p53 mutations that lead to cancer progression, a signature for more accurately predicting risk in patients with AML given low-intensity treatments, and a prognostic tool to stratify patients with colorectal cancer.

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Researchers at Dana-Farber Cancer Institute and the University of Trento, Italy, have developed a blood test, described in Cancer Discovery, that can reliably detect neuroendocrine prostate cancer and differentiate it from castration-resistant prostate cancer-adenocarcinoma.

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RUDN University biologist described a green method for obtaining copper oxide nanoparticles from the noni plant (Morinda citrifolia), common in Asia. These nanoparticles have pronounced bactericidal and fungicidal properties.

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While scientists have made significant progress in understanding the molecular mechanisms leading to melanoma development, it is still unclear how the PTEN protein regulates melanoma progression. In a new study published in Cancer Research, a journal of the American Association for Cancer Research, Moffitt Cancer Center researchers reveal how the antitumor activity of PTEN suppresses the cancer-promoting activity of the FRA1 transcription factor through the AKT signaling pathway.

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The Environmental Molecular Sciences Laboratory, a Department of Energy user facility at Pacific Northwest National Laboratory, is accepting research proposals for four open calls.

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For the first time ever in New Mexico, doctors at UNM Comprehensive Cancer Center have treated blood cancer patients by transplanting cells from a donor. Late last year, Matthew Fero, MD, FACP, and the Stem Cell and Bone Marrow Transplant team completed the first procedure, known as an allogeneic stem cell transplant.

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The body’s immune response to Epstein-Barr virus (EBV) may play a role in causing damage in people with multiple sclerosis, according to a new study led by UTHealth Houston.

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Scientists have solved a cellular murder mystery nearly 25 years after the case went cold. Following a trail of evidence from fruit flies to mice to humans revealed that cannibalistic cells likely cause a rare human immunodeficiency.

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Unknown germs are a common occurrence in hospitals. Researchers at the University of Basel have spent many years collecting and analyzing them. They have identified many new species of bacteria, some of which are significant for clinical practice.

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Mycelial fibers, the fibrous cells found in fruiting mushroom bodies, have gained momentum as a sustainable material for making leather and packaging owing to their excellent formability.

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Thanks to technological advances, scientists have access to vast amounts of data, but in order to put it to work and draw conclusions, they need to be able to process it.

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Cell replication in our bodies is triggered by a cascade of molecular signals transmitted between proteins. Compounds that block these signals show potential as cancer drugs. Recently, scientists uncovered the molecular mechanisms that underlie a step in the signal-transmission pathway that requires three proteins to link up. This points the way to new targets for drugs that fight certain types of cancer.

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Researchers at the University of Liège (ULiège) have identified microstructures in fossil cells that are 1.75 billion years old. These structures, called thylakoid membranes, are the oldest ever discovered.

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A pair of proteins could contribute to the development of healthy, strong bones by directing early cell movement and blood vessel generation

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Find the latest research and features on fertility in the Fertility News Source on Newswise.

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Disease-causing bacteria of the genus Salmonella or Yersinia can use tiny injection apparatuses to inject harmful proteins into host cells, much to the discomfort of the infected person.

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Scientists create ‘frogolotls’ - chimeric amphibians using surgical transplants - to see how competing cellular instructions create a unified organism

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Hydrothermal vents are an unlikely environment for animals to flourish, characterized by rapid changes in temperature and a challenging chemistry: acidic pH, rich in sulfur and methane.

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University of Utah biologists developed a method for illuminating the intricate interactions of the SC in the nematode C. elegans.