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Science

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Stem Cell Biology, Stem Cell Research, Cell Replacement Therapy, sensory interneurons, spinal cord and brain injury, Paralysis, Sensory recovery, Neurobiology, Neurologic Research, Central Nervous System Injuries, central nervous system, morphogenic protein, Interneurons

UCLA Scientists Make Cells That Enable the Sense of Touch

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Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have, for the first time, coaxed human stem cells to become sensory interneurons — the cells that give us our sense of touch. The new protocol could be a step toward stem cell–based therapies to restore sensation in paralyzed people who have lost feeling in parts of their body.

Medicine

Science

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Breast Cancer, Diet, Estrogen, drugs, , Chemotherapy, Therapeutics

Estrogen-Mimicking Compounds in Foods May Reduce Effectiveness of Breast Cancer Treatment

Scientists from The Scripps Research Institute have discovered that two estrogen-mimicking compounds found in many foods appear to potently reverse the effects of palbociclib/letrozole, a popular drug combination for treating breast cancer.

Science

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Long-term Memory, Cognition, arc, Viruses, Brain Plasticity, Retroviruses, Retrotransposons

Surprise: A Virus-Like Protein is Important for Cognition and Memory

A protein involved in cognition and storing long-term memories looks and acts like a protein from viruses. The protein, called Arc, has properties similar to those that viruses use for infecting host cells, and originated from a chance evolutionary event that occurred hundreds of millions of years ago.

Medicine

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Cells, Immunology, T-Cell, Tubercolosis, Canada, University of Mon, McGill University , Vaccines, Infectious Desease, BCG, Stem Cells, Bone Marrow Cell Therapy, Immune Response, Innate Immune Response, Macrophages

Re-Programming Innate Immune Cells to Fight Tuberculosis

Canadian researchers’ innovative work promises to make vaccines more effective against tuberculosis and other infectious diseases like the flu.

Medicine

Science

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Neural Stem Cell, Neurogenesis, Neurogenetics, Schizophrenia, Adhd Attention Deficit Disorder, Depression, Gene Expression

Genetic ‘Switches’, Mapped for First Time, Drive Human Brain Development

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UCLA researchers have developed the first map of gene regulation in human neurogenesis, the process by which neural stem cells turn into brain cells and the cerebral cortex expands in size. The scientists identified factors that govern the growth of our brains and, in some cases, set the stage for several brain disorders that appear later in life

Medicine

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Melanoma, Immunotherapy, demoplastic melanoma, PD-1, PD-L1, anti PD-1 PDL-1 therapy

Rare Melanoma Type Highly Responsive to Immunotherapy

Desmoplastic melanoma is a rare subtype of melanoma that is commonly found on sun-exposed areas, such as the head and neck, and usually seen in older patients. Treatment is difficult because these tumors are often resistant to chemotherapy and lack actionable mutations commonly found in other types of melanoma that are targeted by specific drugs. However, Moffitt Cancer Center researchers report in the Jan. 10 issue of Nature that patients with desmoplastic melanoma are more responsive to immune-activating anti-PD-1/PD-L1 therapies than previously assumed.

Medicine

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Mitochondrial Disease, Vitamins And Supplements, nutritional interventions , mitochondrial medicine, Dietary Supplements, preclinical testing, Precision Medicine

Can Vitamins and Dietary Supplements Benefit Patients with Mitochondrial Disease?

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Defects in mitochondria, the tiny structures that power our cells by functioning as biological batteries, cause an array of complex, often life-threatening disorders that can affect any and all organs and systems. In the absence of validated, effective drug treatments, patients with mitochondrial disease often take a variety of vitamins and supplements, substances that are largely unstandardized, unregulated, and unproven. A group of medical experts recommend performing systematic scientific studies to test precise nutritional interventions for patients.

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Pancreatic Cancer May Be Accelerated by Stress, Finds Study

A new study shows how stress accelerates pancreatic cancer development. Beta-blockers, which block stress hormones, may increase survival for patients with the disease.

Medicine

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Stress, Immune System, Immune Cells, Allergens, Stress receptor, corticotropin-releasing factor, CRF1, Mast Cells, Histamine, Inflammatory And Autoimmune Diseases, Allergic Diseases, Irritable Bowel Syndrome, Asthma, Food Allergies, stress-related diseases, Psychological Stress, Allergic stress

Here’s How Stress May Be Making You Sick

A Michigan State University researcher is providing new insight into how certain types of stress interact with immune cells and can regulate how these cells respond to allergens, ultimately causing physical symptoms and disease.

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‘Decorated’ Stem Cells Could Offer Targeted Heart Repair

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“Decorating” cardiac stem cells with platelet nanovesicles can increase the stem cells’ ability to find and remain at the site of heart attack injury and enhance their effectiveness in treatment.







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