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Medicine

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Parkinson's Disease, Rutgers, New Jersey, Alzheimer's Disease, Neurons, Neuroscience, Brain Disease, Neurological, Roundworm, C. Elegans, Proteins, Huntington's Disease, Science, Aging

Alzheimer’s May Be Linked to Defective Brain Cells Spreading Disease

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Rutgers scientists say neurodegenerative diseases like Alzheimer’s and Parkinson’s may be linked to defective brain cells disposing toxic proteins that make neighboring cells sick. In a study published in Nature, Monica Driscoll, distinguished professor of molecular biology and biochemistry, School of Arts and Sciences, and her team, found that while healthy neurons should be able to sort out and rid brain cells of toxic proteins and damaged cell structures without causing problems, laboratory findings indicate that it does not always occur.

Medicine

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Huntington's Disease, Neuro-degenerative disease, Alzheimer's Disease, Parkinson's Disease

Cellular Quality Control Process Could Be Huntington’s Disease Drug Target

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The loss of motor function and mental acuity associated with Huntington’s disease might be treatable by restoring a cellular quality control process, which Duke Health researchers have identified as a key factor in the degenerative illness.

Medicine

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Alzheimers disease, Neurosciences, Neurology, Leon Thal, Howard Feldman

Leon Thal’s Enduring Leadership in AD Research

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A remembrance of Leon Thal, MD, an early giant of Alzheimer’s disease research and treatment by Howard Feldman, MDCM, current director of the Alzheimer’s Disease Cooperative Study at UC San Diego School of Medicine.

Medicine

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Alzheimer's, Alzheimer's Disease, Trem 2, myeloid cells, Neuroscience, Amyloid Plaques

Alzheimer’s Disease Researchers Solve Mystery of Beguiling Protein

Leading neuroscientists have clarified the role of a controversial immune system protein in Alzheimer’s disease, showing it has opposing effects in early and late stages of the disease. Their discovery unites previous studies that left researchers conflicted and showed the protein both exacerbates and ameliorates disease symptoms. The updated model of disease progression, published in the Journal of Neuroscience, also highlights the need to align certain therapies with disease stages when treating the 1 in 9 Americans over 65 living with Alzheimer’s.

Medicine

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Magnet, MRI, Magnetic Resonance Imaging, Neuroimaging, Alzheimer's Disease, Dementia, Medical Device, Epilepsy, Autism, Construction

Photo Gallery: USC Stevens Hall Installs the First Next-Generation 7T MRI Machine in North America

Photo Gallery: Magnet the Weight of 30 Elephants Lowered Through Roof of USC Stevens Hall for Next-Gen 7T MRI Machine

Medicine

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Alzheimer's, Mayo Clinic Study on Aging, Yonas Geda, Research

Mayo Clinic Researchers Find Mental Activities May Protect Against Mild Cognitive Impairment

PHOENIX – Mayo Clinic researchers have found that engaging in mentally stimulating activities, even late in life, may protect against new-onset mild cognitive impairment, which is the intermediate stage between normal cognitive aging and dementia. The study found that cognitively normal people 70 or older who engaged in computer use, craft activities, social activities and playing games had a decreased risk of developing mild cognitive impairment. The results are published in the Jan. 30 edition of JAMA Neurology.

Medicine

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Tau Tangles, tau, Alzheimer Disease & Associated Disorders, Tauopathy, Oligonucleotides

Drug Compound Halts Alzheimer’s-Related Damage in Mice

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In some people, the brain protein tau collects into toxic tangles that damage brain cells and contribute to diseases such as Alzheimer’s. Researchers at Washington University School of Medicine in St. Louis have found a drug that can lower tau levels and prevent some neurological damage.

Medicine

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Alzheimer's Disease, Journal Of Alzheimer's Disease, Deep Brain Stimulation

Deep Brain Stimulation Studies in Alzheimer’s Disease Pose Ethical Challenges

Promising, early studies of deep brain stimulation (DBS) for the treatment of Alzheimer’s disease have paved a path for future clinical trials, but there are unique ethical challenges with this vulnerable population regarding decision making and post-study treatment access that need to be addressed as they ramp up, Penn Medicine researchers argue in a new review in the Journal of Alzheimer’s Disease.

Medicine

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Nilotinib, Alzheimers disease, Clinical Trials, neurotherapeutics, Drug Discovery

Georgetown Clinical Trial of Nilotinib in Alzheimer’s Disease Begins

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A clinical trial to examine the effect of nilotinib on clinical outcomes and biomarkers in people with mild to moderate Alzheimer’s disease has opened at Georgetown University Medical Center.

Medicine

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pm1, TDP-43, Alzheimer's Disease, ALS, Alzheimer Disease & Associated Disorders, neuronal disease, mitochondrial dysfunction

This Man Is Revolutionizing Our Understanding of Motor Neuron Diseases and Dementias

Xinglong Wang’s team published a study in the January 2017 issue of Molecular Therapy that is seen as confirming the relevance of this neurotoxic pathway, according to an accompanying editorial by Eloise Hudry, PhD, of the Alzheimer’s Disease Research Unit at Harvard Medical School. This paper also confirms TDP-43 inhibition as a viable therapeutic option for the treatment of neurologic disorders, including Alzheimer disease.







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