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Article ID: 696249

Seattle Children's Opens Immunotherapy Trial For Children With Relapsed Central Nervous System Tumors That Delivers CAR T Cells Directly Into the Brain

Seattle Children's Hospital

Seattle Children’s has opened a pioneering chimeric antigen receptor (CAR) T-cell immunotherapy trial for children and young adults with relapsed or refractory HER2-positive central nervous system (CNS) tumors where CAR T cells will be delivered directly into the brain. In the phase I trial, BrainChild-01, cancer-fighting CAR T cells will be infused through a catheter, either into the cavity where the tumor has been removed or the CNS ventricular system, depending on the location of the tumor.

Released:
19-Jun-2018 9:00 AM EDT
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Article ID: 696234

Deep-sea Marine Sponges May Hold Key to Antibiotic Drug Resistance

Florida Atlantic University

FAU’s Harbor Branch houses more than 1,000 strains of actinobacteria, one of the most prolific microbial groups for the production of natural products. Derived from sea sponges and other macro-organisms, several strains were identified for their potent antifungal activity, for anti-MRSA activity, and for both antifungal and antibacterial activities. A key finding was the identification of a strain that produced metabolites that are more potent than the bacterial antibiotic, vancomycin, against C. difficile.

Released:
19-Jun-2018 9:00 AM EDT
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Embargo will expire:
25-Jun-2018 9:00 AM EDT
Released to reporters:
19-Jun-2018 9:00 AM EDT

EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 25-Jun-2018 9:00 AM EDT

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  • Embargo expired:
    19-Jun-2018 9:00 AM EDT

Article ID: 695996

Breast Cancer Could Be Prevented by Targeting Epigenetic Proteins, Study Suggests

The Rockefeller University Press

Researchers at the Princess Margaret Cancer Centre in Toronto have discovered that epigenetic proteins promote the proliferation of mammary gland stem cells in response to the sex hormone progesterone. The study, which will be published June 19 in the Journal of Cell Biology, suggests that inhibiting these proteins with drugs could prevent the development of breast cancer in women at high risk of the disease.

Released:
12-Jun-2018 11:25 AM EDT
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  • Embargo expired:
    19-Jun-2018 9:00 AM EDT

Article ID: 696056

Cells can trap viruses in protein cage to stop their spread, study reveals

The Rockefeller University Press

Researchers at The Francis Crick Institute in London have discovered that cells can trap viruses in a protein cage to stop them from spreading to neighboring cells. The study, which will be published June 19 in the Journal of Cell Biology, reveals that the vaccinia virus can escape this trap by recruiting additional proteins to dismantle the cage and propel the virus out of the cell.

Released:
13-Jun-2018 9:40 AM EDT
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Article ID: 696287

Is the sky the limit?

University of Vienna

What stops a species adapting to an ever-wider range of conditions, continuously expanding its geographic range? The biomathematician Jitka Polechová, an Elise Richter Fellow at the University of Vienna, has published a paper in PLoS Biology which explains the formation of species’ range margins. The theory shows that just two compound parameters, important for both ecology and evolution of species, are fundamental to the stability of their range: the environmental heterogeneity and the size of the local population.

Released:
19-Jun-2018 6:05 AM EDT
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Article ID: 696258

Scientists isolate protein data from the tiniest of caches – single human cells

Pacific Northwest National Laboratory

Scientists have captured the most information yet about proteins within a single human cell, giving scientists one of their clearest looks yet at the molecular happenings inside a human cell. The team detected on average more than 650 proteins in each cell – many times more than conventional techniques capture from single cells.

Released:
19-Jun-2018 12:00 AM EDT
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Article ID: 696283

Mendelsohn shares Tang Prize for leadership in developing targeted therapy

University of Texas M. D. Anderson Cancer Center

Targeted cancer therapy pioneer John Mendelsohn, M.D., researcher and former president of The University of Texas MD Anderson Cancer Center, will share the 2018 Tang Prize in Biopharmaceutical Science for his leadership in developing antibodies to block cancer-promoting growth factor receptors on the surface of cancer cells.

Released:
18-Jun-2018 11:00 PM EDT
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  • Embargo expired:
    18-Jun-2018 3:00 PM EDT

Article ID: 696086

Microglia Protect Sensory Cells Needed for Vision After Retinal Detachment

Massachusetts Eye and Ear

A research team at Massachusetts Eye and Ear has shown that microglia, the primary immune cells of the brain and retina, play a protective role in response to retinal detachment.

Released:
13-Jun-2018 3:05 PM EDT
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  • Embargo expired:
    18-Jun-2018 11:00 AM EDT

Article ID: 696123

Study Suggests Well-Known Growth Suppressor Actually Fuels Lethal Brain Cancers

Cincinnati Children's Hospital Medical Center

Scientists report finding a potentially promising treatment target for aggressive and deadly high-grade brain cancers like glioblastoma. Publishing online June 18 in Nature Cell Biology, the study also reports the current lack of a drug that hits the molecular target keeps it from being advanced for testing as a therapeutic strategy for patients with few treatment options.

Released:
14-Jun-2018 11:05 AM EDT
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