Blood banks are looking for donors everywhere, but if you’re 17 to 35, step to the front of the line. A Penn State Health expert discusses why younger donors are needed more than ever.
Axi-cel CAR T targets the CD19 molecule on large B-cell lymphoma cells. The ZUMA-7 trial demonstrated that axi-cel reduced the risk of disease progression, the need for new therapy, or death by 60% compared to standard therapy. Despite these positive outcomes in event-free survival and overall survival, some patients did not respond well to therapy or relapsed quickly after treatment. Researchers wanted to assess if there were specific tumor characteristics associated with improved outcomes that could better inform treatment selection. Their findings were published today in Nature Medicine.
RUDN University doctors discovered that the body’s response to inflammation depends on individual sensitivity or resistance to oxygen deficiency.
Using CRISPR/Cas9, scientists at St. Jude Children’s Research Hospital identified RBM5 as a vital component of leukemia cell fitness, making it a promising target for drug development.
Renato Aguilera, Ph.D., a professor in the Department of Biological Sciences at The University of Texas at El Paso, is the principal investigator on the project that identified the promising compound, called thiophene F-8.
Scientists at St. Jude Children’s Research Hospital refined and enhanced the classification system for a type of pediatric leukemia using genomic and transcriptomic analysis.
Ten-year reductions in blood lead levels correlated with cardiovascular health improvements in American Indian adults.
A new paper in Molecular Biology and Evolution, published by Oxford University Press, finds that HIV populations in people with higher viral loads also have higher rates of viral recombination.
Researchers have linked a decade-long decline in the blood lead levels of American Indian adults to long-term cardiovascular health benefits, including reduced blood pressure levels and a reduction in a marker associated with hypertrophic cardiomyopathy and heart failure.
Elephant endotheliotropic herpesvirus is the leading cause of death for Asian elephant calves and is a danger to young African elephants as well.
Researchers at Dana-Farber Cancer Institute and the University of Trento, Italy, have developed a blood test, described in Cancer Discovery, that can reliably detect neuroendocrine prostate cancer and differentiate it from castration-resistant prostate cancer-adenocarcinoma.
Outdoor humidity and temperature levels during pregnancy could affect the future blood pressure of the unborn child, according to new research by the University of Bristol, published in JACC: Advances.
For the first time ever in New Mexico, doctors at UNM Comprehensive Cancer Center have treated blood cancer patients by transplanting cells from a donor. Late last year, Matthew Fero, MD, FACP, and the Stem Cell and Bone Marrow Transplant team completed the first procedure, known as an allogeneic stem cell transplant.
Differences in blood flow in the retina could explain why some migraine patients experience visual symptoms while others do not, according to UCLA study.
Find the latest research and features on fertility in the Fertility News Source on Newswise.
New research from Sylvester Comprehensive Cancer Center indicates that providing prophylactic treatment before immunotherapy can significantly reduce the rate of cytokine release syndrome (CRS) in multiple myeloma patients. Study appears Jan. 4, 2024, in Blood Cancer Discovery.
G3 Therapeutics ("G3"), a global leader in the use of multiomic biological Big Data, has initiated a groundbreaking initiative to unravel the contribution of Lipoprotein(a) ["Lp(a)"] to cardiovascular disease (CVD).
The blood-brain barrier blocks the entry of antibodies into the brain. This limits the potential use of antibody therapeutics to treat brain diseases, such as brain tumors.
A risk model developed by researchers can help to identify cancer patients who could benefit from immune checkpoint inhibitors, ICIs. Published in BMC Cancer, the study was conducted at the University of Eastern Finland and Kuopio University Hospital.
A team of Virginia Tech researchers was awarded nearly $2 million from the National Institute of Diabetes and Digestive and Kidney Disease, part of the National Institutes of Health, to explore novel approaches for treating Type 2 diabetes and obesity. Type 2 diabetes affects more than 38.4 million Americans, with an estimated 1.
New research from the Smidt Heart Institute at Cedars-Sinai found that women who developed signs of elevated blood pressure during pregnancy were more likely to have residual evidence of abnormal heart structure and function up to a decade after the pregnancy.
With the rise in machine learning applications and artificial intelligence, it's no wonder that more and more scientists and researchers are turning to supercomputers. Supercomputers are commonly used for making predictions with advanced modeling and simulations. This can be applied to climate research, weather forecasting, genomic sequencing, space exploration, aviation engineering and more.
How interactions between tumor genes, microenvironment affect multiple myeloma treatment responses, a new AI technique could guide glioblastoma treatment, new research shows birth country a key risk factor in stomach cancer, how petrochemicals fuel cancer risk and more are included in this month’s tip sheet.
In the event of an accident or an attack, members of the public can save lives by performing first aid measures until the arrival of emergency medical services. But it is not enough that people see themselves as life-saving immediate responders, prepared and able to act.
A microbial sensor that helps identify and fight bacterial infections also plays a key role in the embryonic development of blood stem cells, valuable new insight in the effort to create patient-derived blood stem cells that could eliminate the need for bone marrow transplants.
The National Comprehensive Cancer Network’s Oncology Research Program selects projects to evaluate the effectiveness of elranatamab in the treatment of multiple myeloma.
The American Heart Association® and the American Medical Association recognized 15 Loyola Medicine primary care practices for their commitment to improving blood pressure control rates by awarding them Gold+ level recognition as part of Target: BP™.
Northwestern University researchers have developed the first physics-based metric to predict whether or not a person might someday suffer an aortic aneurysm, a deadly condition that often causes no symptoms until it ruptures.
Researchers from University of California San Diego have found that people with depression and suicidal ideation have compounds in their blood that could help identify people at higher risk of becoming suicidal. They also found sex-based differences in how depression impacts metabolism.
In a landmark study led by the University of Maryland School of Medicine, researchers discovered for the first time that a certain kind of protein similar to hemoglobin, called cytoglobin, plays an important role in the development of the heart.
Lower back pain, primarily caused by IDD, poses a tremendous societal challenge. Current treatment strategies for IDD fall short in restoring the original function of the intervertebral disc. The research team focused on physiological hypoxia, a characteristic of the nucleus pulposus, due to its unique anatomical configuration.
Researchers at Atrium Health and Wake Forest University School of Medicine have been approved for a $9.9 million research funding award from the Patient-Centered Outcomes Research Institute (PCORI), for a five-year study called “Remote Hypertension Tracking Help and Management to Reduce Disparities in Black Patients (RHYTHM-B).”
Using cells from kidney biopsies, Johns Hopkins Medicine, researchers report progress in the search for more accurate and easier-to-obtain markers to help predict, manage and assess treatment of acute kidney injury (AKI).
Interstitial fluid plays a vital role in drug delivery and tumour treatment. However, few non-invasive measurement methods are available for measuring low-velocity biological fluid flow. Therefore, we developed a novel technology called interstitial flow velocity-MRI. Interstitial flow velocity-MRI has the potential to determine interstitial fluid flow velocity non-invasively and exhibits an intuitive velocity map.
Patients with a history of suicidality experience increased risk in the days surrounding menstruation
Results from mouse models presented at the prestigious American Society of Hematology show that nutrients consumed by an expectant mother during pregnancy can shape their offspring’s blood systems.
Renal dysfunction, especially chronic kidney disease, is the biggest risk factor of mortality among thrombolysed stroke patients, according to a retrospective cohort observational study published in Medicine®, a journal published in the Lippincott portfolio by Wolters Kluwer.
Physician-scientists and other researchers from Sylvester Comprehensive Cancer Center will make presentations at the American Society of Hematology’s 2023 annual meeting Dec. 9-12. This tip sheet highlights several of those presentations.
The targeted therapy combination of ibrutinib and venetoclax significantly improved progression-free survival (PFS) and achieved an overall remission rate in 82% of patients with relapsed/refractory mantle cell lymphoma (MCL), according to researchers at The University of Texas MD Anderson Cancer Center. Results from the Phase III SYMPATICO trial were presented at the 2023 American Society of Hematology (ASH) Annual Meeting.
By monitoring changes in circulating tumor DNA (ctDNA) among 30 patients treated with immunotherapies for metastatic non-small cell lung cancers, researchers were able to determine molecular response — the clearance of tumor genetic material in the bloodstream.
Baylor Scott & White Heart and Vascular Hospital – Dallas has added an innovative, minimally invasive option for patients with hypertension, or high blood pressure.
Non-Hispanic Black patients with acute myeloid leukemia (AML) are living longer, now that new therapies are available, according to a study presented by researchers from the University of Pennsylvania Perelman School of Medicine and Penn Medicine’s Abramson Cancer Center at the 65th American Society of Hematology (ASH) Annual Meeting and Exposition (Abstract 955).
In a study led by researchers at Sylvester Comprehensive Cancer Center, patients recently diagnosed with a common and aggressive form of acute myeloid leukemia reported having improved quality of life when a newly approved drug was part of the treatment plan.
New research conducted by investigators at Sylvester Comprehensive Cancer Center and collaborating cancer centers indicates that a new type of targeted therapy may offer new treatment options for patients living with advanced myelofibrosis, a bone marrow disorder. Study results will be shared at ASH 2023 in San Diego, Dec. 9-12.
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