SOX10 Expression Levels may be a Critical Mediator of White Matter Dysfunction in Schizophrenia
PreprintsDonna L McPhie, Boyu Ren, Juan Antonio Garcıa-Leon, Catherine M Verfaillie, Bruce M Cohen
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Released: 17-Jun-2022 12:00 PM EDT
Released: 17-Jun-2022 12:00 PM EDT
AKT1-FOXO4 Axis Regulates Hemochorial Placentation
PreprintsKeisuke Kozai, Ayelen Moreno Irusta, Khursheed Iqbal, Mae-Lan Winchester, Regan L Scott, Mikaela E Simon, Masanaga Muto, Marc R Parrish, Michael J Soares
Released: 17-Jun-2022 12:00 PM EDT
Daily administration of low-dose daunorubicin or doxorubicin inhibits hypoxia-inducible factor 1 and tumor vascularization
PreprintsYongkang Yang, David Z. Chen, Sergio Rey, Jun O. Liu, Gregg L. Semenza
Released: 17-Jun-2022 12:00 PM EDT
Inhibition of Fas Receptor Endocytosis Sensitizes Cancer Cells to Fas-induced Apoptosis
PreprintsMehmet Kural, Umidahan Djakbarova, Bilal Cakir, Yoshiaki Tanaka, Yasaman Madraki, Hong Qian, Jinkyu Park, Lorenzo Sewanan, Comert Kural, Laura Niklason
Released: 17-Jun-2022 12:00 PM EDT
Rescue of aged muscle stem cell intrinsic quiescence defects by AKT inhibition revealed with a 3D biomimetic culture assay
PreprintsErik Jacques, Yinni Kuang, Allison P Kann, Robert S Krauss, Penney M Gilbert
Released: 17-Jun-2022 12:00 PM EDT
Alterations in protein kinase networks in astrocytes and neurons derived from patients with familial Alzheimers Disease
PreprintsNicholas Daniel Henkel, Alex Joyce, Elizabeth Shedroff, Ali Sajid Imami, Khaled Alganem, Abdul-Rizaq Hamoud, Chongchong Xu, Benjamin Siciliano, Tao Ma, Zhexing Wen, Robert Erne McCullumsmith
Released: 17-Jun-2022 12:00 PM EDT
Cell fusion upregulates PD-L1 expression and promotes tumor formation
PreprintsHisao Masai, Youichi Tajima, Futoshi Shibazaki
Released: 17-Jun-2022 12:00 PM EDT
Differentiation of intestinal epithelial stem cells from parthenogenetic embryonic stem cells
PreprintsZhiqiang Wang, Leilei Li, Wanpu Wang, Lilin Luo, Shuai Dong, Menglong Li, Tianxing Chen, Qingyang Meng, Rui Liang
Released: 17-Jun-2022 12:00 PM EDT
De novo annotation of lncRNA HOTAIR transcripts by long-read RNA capture-seq reveals a differentiation-driven isoform switch
PreprintsEvdokiia Potolitsyna, Sarah Hazell Pickering, Ave Tooming-Klunderud, Philippe Collas, Nolwenn Briand
Released: 17-Jun-2022 12:00 PM EDT
CITED2 Is A Conserved Regulator Of Deep Hemochorial Placentation
PreprintsMarija Kuna, Pramod Dhakal, Khursheed Iqbal, Esteban M. Dominguez, Lindsey N. Kent, Masanaga Muto, Ayelen Moreno-Irusta, Keisuke Kozai, Kaela M. Varberg, Hiroaki Okae, Takahiro Arima, Henry M. Sucov, Michael J. Soares
Released: 16-Jun-2022 1:30 PM EDT
New Solution for Stem Cell Manufacturing
University of Technology, SydneyResearchers have developed a unique 3D printed system for harvesting stem cells from bioreactors, offering the potential for high quality, wide-scale production of stem cells in Australia at a lower cost.
Released: 16-Jun-2022 12:00 PM EDT
Sex-specific niche signaling contributes to sexual dimorphism following stem cell transplantation
PreprintsJulianne N.P. Smith, Brittany A Cordova, Brian Richardson, Kelsey F Christo, Jordan Campanelli, Alyssia V Broncano, Jonathan Chen, Juyeun Lee, Scott J Cameron, Justin D Lathia, Wendy A Goodman, Mark J Cameron, Amar B Desai
Released: 16-Jun-2022 12:00 PM EDT
Evaluation of targeted oxidative stress induced by oxygen-ozone gas mixtures in vitro after ischemic induction
PreprintsJéssica Rodrigues Orlandin, Sarah Ingrid Pinto Santos, Luciana Cristina Machado, Paulo Fantinato Neto, Fabiana Fernandes Bressan, Naira Caroline Godoy Pieri, Kaiana Recchia, Meline de Paula Coutinho, Priscilla Avelino Ferreira Pinto, Annalisa Santucci, Valter Travagli, Carlos Eduardo Ambrosio
Released: 16-Jun-2022 12:00 PM EDT
Characterization of EGFR-reprogrammable temozolomide-resistant cells in a model of glioblastoma
PreprintsLingli Gong, Ying Yin, Cheng Chen, Quan Wan, Die Xia, Mei Wang, Zhening Pu, Bo Zhang, Jian Zou
Released: 16-Jun-2022 12:00 PM EDT
Autologous hematopoietic stem cell transplantation improves long term survival – data from a national registry
PreprintsNorbert Blank, Marc Schmalzing, Pia Moinzadeh, Max Oberste, Elise Siegert, Ulf Müller-Ladner, Gabriela Riemekasten, Claudia Günther, Ina Kötter, Gabriele Zeidler, Christiane Pfeiffer, Aaron Juche, Ilona Jandova, Jan Ehrchen, Laura Susok, Tim Schmeiser, Cord Sunderkoetter, Jörg H. W. Distler, Margitta Worm, Alexander Kreuter, Gernot Keyzer, Hanns-Martin Lorenz, Thomas Krieg, Nicolas Hunzelmann, Joerg Henes
Released: 16-Jun-2022 12:00 PM EDT
Comprehensive Characterisation of Fetal and Mature Retinal Cell Identity to Assess the Fidelity of Retinal Organoids
PreprintsHani Jieun Kim, Michelle Ohara-Wright, Daniel Kim, To Ha Loi, Benjamin Y Lim, Robyn V Jamieson, Anai Gonzalez Cordero, Pengyi Yang
Released: 16-Jun-2022 12:00 PM EDT
The Role of QRSL1 in Clinical Subtypes and Prognosis of Childhood B-cell Acute Lymphoblastic Leukemia
PreprintsSha Yin, Wenjin Gao, Ye Fan, Rui Xia, Mingyue Duan, Xi Zhang, Ansheng Liu, Yanmin Zhang
Released: 16-Jun-2022 12:00 PM EDT
Stagnation in quality of next-generation sequencing assays for the diagnosis of hereditary hematopoietic malignancies
PreprintsGregory W Roloff, Reid Shaw, Timothy E O'Connor, Michael W Drazer
Released: 15-Jun-2022 12:00 PM EDT
Transit-amplifying progenitor with maturation-dependent behavior contributes to epidermal renewal
PreprintsSangeeta Ghuwalewala, Kevin Jiang, Sara Ragi, David Shalloway, Tudorita Tumbar
Released: 15-Jun-2022 12:00 PM EDT
Accelerating effect of Shilajit on osteogenic property of adipose derived mesenchymal stem cells (ASCs)
PreprintsParisa Kangari, Leila Roshangar, Aida Iraji, Tahereh Talaei-Khozani, Mahboobeh Razmkhah
Released: 15-Jun-2022 10:10 AM EDT
New Material Paves the Way for Remote-Controlled Medication and Electronic Pills
Chalmers University of TechnologyBiomedicines are produced by living cells and are used to treat cancer and autoimmune diseases among other things.
Released: 14-Jun-2022 3:05 PM EDT
Molecule That Combines Three Distinct Technologies Against Most Aggressive Type of Brain Cancer Is Tested
Sao Paulo Research Foundation (FAPESP)A drug carrier able to reach the brain, bind to an aggressive type of tumor called glioblastoma multiforme, and release a chemotherapeutic agent has been tested for the first time by Brazilian researchers.
Released: 14-Jun-2022 2:05 PM EDT
Stanford Engineers Develop Tiny Robots to Bring Health Care Closer to Precisely Targeted Drug Delivery
Stanford UniversityIf you’ve ever swallowed the same round tablet in hopes of curing everything from stomach cramps to headaches, you already know that medicines aren’t always designed to treat precise pain points.
Released: 14-Jun-2022 2:05 PM EDT
Streamlining Stem Cells to Treat Macular Degeneration
École Polytechnique Fédérale de Lausanne (EPFL)As we age, so do our eyes; most commonly, this involves changes to our vision and new glasses, but there are more severe forms of age-related eye problems. One of these is age-related macular degeneration, which affects the macula — the back part of the eye that gives us sharp vision and the ability to distinguish details.
Released: 14-Jun-2022 1:05 PM EDT
Scientists Create Nanoparticle That Helps Fight Solid Tumors
Wake Forest University School of MedicineResearchers from Wake Forest University School of Medicine have discovered a possible new approach in treating solid tumors through the creation of a novel nanoparticle.
Released: 14-Jun-2022 12:00 PM EDT
Gla-domain mediated targeting of externalized phosphatidylserine for intracellular delivery
PreprintsTerry Hermiston, Jonathan Hardy, Maxine Bauzon, Francis G Blankenberg, Masamitsu Kanada, Ashley Makela, Charles K. F. Chan, Christopher H Contag
Released: 14-Jun-2022 12:00 PM EDT
The abnormal expression of circ-ARAP2 promotes ESCC progression through regulating miR-761/FOXM1 axis-mediated stemness and the endothelial-mesenchymal transition
PreprintsPei Xu, Lei Wang, Qingtao Liu, Pengkai Gao, Fengqing Hu, Xiao Xie, Lianyong Jiang, Rui Bi, Fangbao Ding, Qi Yang, Haibo Xiao
Released: 14-Jun-2022 12:00 PM EDT
Connexin43 Overexpression Promotes Bone Regeneration by Osteogenesis and Angiogenesis in Rat Glucocorticoid-Induced Osteonecrosis of the Femoral Head
PreprintsXin Zhao, Changjun Chen, Yue Luo, Donghai Li, Qiuru Wang, Yuying Fang, Pengde Kang
Released: 14-Jun-2022 12:00 PM EDT
Structural analysis of SALL4 zinc-finger domain reveals a link between AT-rich DNA binding and Okihiro syndrome
PreprintsJames A. Watson, Raphaël Pantier, Uma Jayachandran, Kashyap Chhatbar, Beatrice Alexander-Howden, Valdeko Kruusvee, Michal Prendecki, Adrian P Bird, Atlanta G. Cook
Released: 14-Jun-2022 12:00 PM EDT
Public Opinion About Stem Cell Research and Human Cloning - The Bioethics of Stem Cell Research and Therapy
PreprintsDaniel Cebo
Released: 14-Jun-2022 12:00 PM EDT
Comparative effects of retinoic acid, granulosa cells conditioned medium or forskolin in combination with granulosa cell co-culturing on mouse germ cell differentiation
PreprintsSoghra Bahmanpour, Zia Moasses, Nehleh Zareifard
Released: 14-Jun-2022 11:50 AM EDT
Four Penn Scientists Chosen as 2022 Pew Scholars
Perelman School of Medicine at the University of PennsylvaniaThe Pew Charitable Trusts has named Maayan Levy, PhD, an assistant professor of Microbiology at the Perelman School of Medicine at University of Pennsylvania, a 2022 Pew Scholar in the Biomedical Sciences. The Pew Charitable Trusts and the Alexander and Margaret Stewart Trust have also selected Alexander Huang, MD, an assistant professor of Hematology-Oncology, and Chengcheng Jin, PhD, an assistant professor of Cancer Biology, as 2022 Pew-Stewart Scholars for Cancer Research. John James Tello Cajiao, PhD, a postdoctoral fellow in Pathology & Laboratory Medicine, has been named a 2022 Pew Latin American Fellow in the Biomedical Sciences.
Released: 13-Jun-2022 5:50 PM EDT
Study Describes New Way of Generating Insulin-Producing Cells
Karolinska InstituteResearchers at Karolinska Institutet in Sweden show how a molecule that they have identified stimulates the formation of new insulin-producing cells in zebrafish and mammalian tissue, through a newly described mechanism for regulating protein synthesis.
Released: 13-Jun-2022 5:05 PM EDT
Biochemists Use Enzymes to Change How Brain Cells Communicate with Each Other
Colorado State UniversityAs you’re reading this sentence, the cells in your brain, called neurons, are sending rapid-fire electrical signals between each other, transmitting information.
Released: 13-Jun-2022 12:00 PM EDT
Stretchable mesh microelectronics for the biointegration and stimulation of neural organoids
PreprintsThomas L Li, Yuxin Liu, Csaba Forro, Levent Beker, Zhenan Bao, Bianxiao Cui, Sergiu P Pasca
Released: 13-Jun-2022 12:00 PM EDT
Comparison of antibacterial effect of Plantaricin 149 suspension and traditional root canal irrigation solutions in root canal infections in vitro
PreprintsYing Wang, Keda Chen, Xiaolong Lin
Released: 13-Jun-2022 12:00 PM EDT
Nervous system reduction in branched-chain amino acid metabolism disrupts hippocampal neurogenesis and memory
PreprintsKhadar Abdi, Ramona Rodriguez, William C Wetsel, Michelle E Arlotto, Robert W McGarrah, Phillip J White
Released: 13-Jun-2022 12:00 PM EDT
Phospholipase D1 promotes astrocytic differentiation through the FAK/AURKA/STAT3 signaling pathway in hippocampal neural stem/progenitor cells
PreprintsMin-Jeong Kang, Nuri Jin, Shin-Young Park, Joong-Soo Han
Released: 13-Jun-2022 12:00 PM EDT
Generation of Cerebral Organoids with Enriched Cortical Cellular Diversity and Outer Radial Glial Cell Identity from Human Pluripotent Stem Cells
PreprintsYechiel Elkabetz, Sneha Arora, Anastasios Balaskas, Amèlia Aragonés Hernández, Daniel Rosebrock
Released: 13-Jun-2022 12:00 PM EDT
ΔNp63α Transcriptionally Represses p53 Target Genes Involved in the Radiation-Induced DNA Damage Response
PreprintsKen-Ichi Kudo, Naohiro Tsuyama, Kento Nagata, Tatsuhiko Imaoka, Daisuke Iizuka, Misaki Sugai-Takahashi, Moe Muramatsu, Akira Sakai
9-Jun-2022 12:40 PM EDT
Mount Sinai Researchers Develop a Rapid Test to Measure Immunity to COVID-19
Mount Sinai Health SystemMount Sinai researchers have developed a rapid blood assay that measures the magnitude and duration of someone’s immunity to SARS-CoV-2, the virus that causes COVID-19. This test will allow large-scale monitoring of the population’s immunity and the effectiveness of current vaccines to help design revaccination strategies for vulnerable immunosuppressed individuals, according to a study published in Nature Biotechnology in June.
13-Jun-2022 8:00 AM EDT
Estimating Tumor-Specific Total mRNA Level Predicts Cancer Outcomes
University of Texas MD Anderson Cancer CenterResearchers have developed a mathematical tool to estimate tumor-specific RNA levels from tumor samples with mixed cell types. Using this technique on thousands of samples found that higher mRNA levels are correlated with shorter survival.
Released: 12-Jun-2022 12:00 PM EDT
A Development-Inspired Niche for Homeostatic Human Mini-Intestines
PreprintsCharlie J Childs, Emily M Holloway, Caden W Sweet, Yu-Hwai Tsai, Angeline Wu, Joshua Wu, Oscar Pellon Cardenas, Meghan M Capeling, Madeline Eiken, Rachel Zwick, Brisa Palikuqi, Coralie Trentesaux, Charles Zhang, Ian Glass, Claudia Loebel, Qianhui Yu, Gray Camp, Jonathan Z Sexton, Ophir D Klein, Michael P Verzi, Jason J Spence
Released: 12-Jun-2022 12:00 PM EDT
Molecular phenotyping of colorectal neoplasia shows dynamic and adaptive cancer stem cell population admixture
PreprintsEster Gil Vasquez, Nadia Nasreddin, Gabriel N Valbuena, Eoghan J Mulholland, Hayley L Belnoue-Davis, Holly Eggington, Ryan O Schenck, Valerie M Wouters, Pratyaksha Wirapati, Kathryn Gilroy, Tamsin R M Lannagan, Dustin J Flanagan, Arafath K Najumudeen, Sulochana Omwenga, Amy M B McCorry, Alistair Easton, Viktor H Koelzer, James E East, Dion Morton, Livio Trusolino, Timothy Maughan, Andrew D Campbell, Maurice B Loughrey, Philip D Dunne, Petros Tsantoulis, David J Huels, Sabine Tejpar, Owen Sansom, Simon J Leedham
Released: 12-Jun-2022 12:00 PM EDT
Angelman syndrome patient neuron screen identifies a potent and selective clinical ASO targeting UBE3A-ATS with long lasting effect in cynomolgus monkey
PreprintsRavi Jagasia, Charlotte Bon, Soren V. Rasmussen, Solveig Badillo, Disa Tehler, Daniele Buchy, Marco Berrera, Megana Prasad, Marco Terrigno, Nikhil J. Pandya, Veronica Costa, Congwei Wang, Lykke Pedersen, Meghan T Miller, Kamille Dumong Erichsen, Lars Joenson, Joerg Hipp, Azad Bonni, Lutz Mueller, Annamaria Braendli-Baiocco, Thomas Kremer, Erich Koller, Marius Hoener
Released: 12-Jun-2022 12:00 PM EDT
Antiviral Therapy Defiant Polyviral Retinitis Post Hematopoietic Allogeneic Stem Cell Transplant
PreprintsNadia Gabarin, Mili Roy, Alexander J. Kaplan, Shariq Haider, Dina Khalaf
Released: 11-Jun-2022 12:00 PM EDT
A two-step in vivo CRISPR screen unveils pervasive RNA binding protein dependencies for leukemic stem cells and identifies ELAVL1 as a therapeutic target
PreprintsAna Vujovic, Laura P.M.H. de Rooij, Ava Keyvani Chahi, He Tian Chen, Brian Yee, Sampath K Loganathan, Lina Liu, Derek C.H. Chan, Amanda Tajik, Emily Tsao, Steven Moreira, Pratik Joshi, Joshua Xu, Nicholas Wong, Sasan Zandi, Stefan Aigner, John E. Dick, Mark D. Minden, Daniel Schramek, Gene W. Yeo, Kristin J Hope
Released: 10-Jun-2022 11:30 AM EDT
Pediatric Urologist Dr. Anthony Atala to Receive 2022 Jacobson Innovation Award of the American College of Surgeons for Pioneering Work in Regenerative Medicine
American College of Surgeons (ACS)The Jacobson Innovation Award is an international surgical honor that recognizes living surgeons who are innovators of a new development or technique in any field of surgery. It is made possible through a gift from Julius H. Jacobson II, MD, FACS, and his wife Joan. Dr. Jacobson is a general vascular surgeon known for his pioneering work in the development of microsurgery. This year's recipient, Dr. Anthony Atala, is a pediatric urologist, researcher, professor, and mentor who is renowned for developing foundational principles for regenerative medicine research, which holds great promise for people who require tissue substitution and reconstruction.
Released: 10-Jun-2022 11:05 AM EDT
Small Materials May Be Key to Reducing Cardiovascular Disease Deaths, Researchers Say
Tsinghua University PressCardiovascular diseases are the leading cause of death across the globe, responsible for about 17.9 million (32%) of all deaths worldwide every year.
Released: 9-Jun-2022 12:40 PM EDT
Ultra-thin, flexible probe provides neural interface that’s minimally invasive and long-lasting
University of California San DiegoResearchers have developed a tiny, flexible neural probe that can be implanted for longer time periods to record and stimulate neural activity, while minimizing injury to the surrounding tissue. The probe would be ideal for studying small and dynamic areas of the nervous system like peripheral nerves or the spinal cord.
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