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Genetics

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Medicine

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Multiple Myeloma, Gene, MYC, JQ1, Dana-Farber

Novel Approach Scores First Success Against Elusive Cancer Gene

Dana-Farber researchers successfully disrupted the function of the gene MYC by tampering with the gene's "on" switch and growth signals in multiple myeloma cells, offering promising strategy for treating myeloma and other cancers driven by the MYC gene.

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Mayo Clinic

Scientists Discover Genetic Mutation that Causes Parkinson’s Disease

A large team of international researchers have identified a new genetic cause of inherited Parkinson’s disease that they say may be related to the inability of brain cells to handle biological stress.

Medicine

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AMP-activated protein kinase , Excercise, genes

Researchers Find Missing Genes May Separate Coach Potato from Active Cousin

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Thousands of scientists around the world are working on AMPK but the McMaster team is the first to demonstrate its essential role in exercise. Their research appears in the current issue of the Proceedings of the National Academy of Sciences.

Medicine

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tuberculoisis, TB, TB Vaccine, Genetics, mycobaeterium tuberculosis, Immunology

TB Vaccine Candidate Shows Early Promise

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Researchers at Albert Einstein College of Medicine of Yeshiva University report in the September 4 online edition of Nature Medicine that they have developed a tuberculosis (TB) vaccine candidate that proved both potent and safe in animal studies. According to the World Health Organization, TB kills an estimated 1.7 million people each year and infects one out of three people around the globe. With drug-resistant strains spreading, a vaccine for preventing TB is urgently needed.

Medicine

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ALS, sporadic ALS, Genetics, Neurobiology, Familial ALS

Two Genes that Cause Familial ALS Shown to Work Together

Although several genes have been linked to amyotrophic lateral sclerosis (ALS), it is still unknown how they cause this progressive neurodegenerative disease. In a new study, Columbia University Medical Center (CUMC) researchers have demonstrated that two ALS-associated genes work in tandem to support the long-term survival of motor neurons. The findings were published in the September 1 online edition of the Journal of Clinical Investigation.

Science

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Mapping a Model: Researchers' International Collaboration to Sequence, Analyze Genome of Plant Species

Two Kansas State University researchers have been collaborating on an international project involving genomes of Arabidopsis thaliana, a model plant species that can offer insights into other plants. Their collaborative work, titled "Multiple reference genomes and transcriptomes for Arabidopsis thaliana," appears online in the journal Nature.

Science

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Cancer, Genetics, Genetic Testing, Cancer Diagnosis, Dna Testing

A Step Toward a Saliva Test for Cancer

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A new saliva test can measure the amount of potential carcinogens stuck to a person’s DNA — interfering with the action of genes involved in health and disease — and could lead to a commercial test to help determine risks for cancer and other diseases, scientists reported here today during the 242nd National Meeting & Exposition of the American Chemical Society (ACS).

Science

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Proceedings of the Royal Society B, Indiana University Department of Biology , Ellen Ketterson, Nicole Gerlach, dark-eyed juncos (Junco hyemalis)

It's for the Grandkids! Research Finds Promiscuousness Results in Genetic 'Trade-Up,' More Offspring

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It's all about the grandkids! That's what a team led by an Indiana University biologist has learned about promiscuous female birds and why they mate outside their social pair.

Medicine

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Mayo Clinic in Florida, Parkinson's Disease

Mayo Clinic Finds Genetic Variation That Protects Against Parkinson’s Disease

An international team of researchers led by neuroscientists at Mayo Clinic in Florida has found a genetic variation they say protects against Parkinson’s disease.

Science

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Haitian earthquake, Haitian cholera outbreak, whole genome sequencing, Translational Genomics Research Institute, TGen, Technical University of Denmark, Paul Keim, Northern Arizona University, mBio, Lance Price, Frank M. Aarestrup

Genomics Used to Find Source of Haitian Cholera Outbreak

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Employing technology that reads the entire DNA code, researchers led by the Translational Genomics Research Institute and the Technical University of Denmark have pinpointed the source of a cholera outbreak in Haiti that killed more than 6,000 people and sickened 300,000.







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