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Stem Cells

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Medicine

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Cancer, Breast Cancer, Cell Biology, Metastatic Disease

Drug Suppresses Spread of Breast Cancer Caused by Stem-Like Cells

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Rare stem-like tumor cells play a critical role in the spread of breast cancer, but a vulnerability in the pathway that powers them offers a strategy to target these cells using existing drugs before metastatic disease occurs, report University of California San Diego School of Medicine and Moores Cancer Center researchers.

Science

Channels:

multiple myelmoma, Cancer, Hematologic Cancers

Study Explores Use of Checkpoint Inhibitors After Relapse From Donor Stem Cell Transplant for Hematologic Cancers

Immunotherapy agents known as checkpoint inhibitors have shown considerable promise in patients with hematologic cancers who relapse after a transplant with donor stem cells. Preliminary results from the first clinical trial in these patients of one such agent – nivolumab – indicate that along with signs of effectiveness, it also produced significant side effects at the dose initially studied. The findings indicate a need for further clinical trials in this group before being considered for off-label use with these patients, Dana-Farber Cancer Institute investigators report.

Medicine

Channels:

Cancer, Hematology, stem cell tranplantation, Graft Versus Host Disease, Immunotherapy

Immunotherapy Drug for Rheumatoid Arthritis Nearly Eliminates Severe Acute Graft-Versus-Host Disease after Hematopoietic Stem Cell Transplant

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Results from a phase 2 clinical trial, presented by Seattle Children’s Research Institute at the 59th American Society of Hematology (ASH) Annual Meeting, show that the drug Abatacept (Orencia) nearly eliminated life-threatening severe acute graft-versus-host disease (GvHD) in patients receiving hematopoietic stem cell transplants.

Medicine

Channels:

Children's Hospital Los Angeles, Leukemia, Stem Cell Transplant, Donor, Acute Myeloid Leukemia, be the match, National Marrow Donor Program, Chemotherapy, Stem Cells, Cancer

#FiercePierce: 2-Year-Old Patient Beats Back Leukemia and Inspires Thousands of Potential Stem Cell Donors

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2-year-old Children's Hospital Los Angeles patient Pierce Kelly beats leukemia thanks to a stem cell donor in France and inspires thousands of potential donors.

Medicine

Channels:

Cancer, Multiple Myeloma, hematologic, Genetics, Stem Cell, Regenerative Medicine, Cancer Stem Cells, Molecular Biology, Cell Biology, Pharmaceutical Science

In Multiple Myeloma, High Levels of Enzyme ADAR1 are Associated with Reduced Survival

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Using a database of multiple myeloma patient samples and information, researchers at University of California San Diego School of Medicine found that high ADAR1 levels correlate with reduced survival rates. They also determined that blocking the enzyme reduces multiple myeloma regeneration in experimental models derived from patient cancer cells.

Medicine

Channels:

Stem Cells, Cancer, Leukemia, AML, Acute Myeloid Leukemia, California Institute For Regenerative Medicine, Cirm

State’s Stem Cell Agency Awards Nearly $8 Million for New Leukemia Therapies

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The Independent Citizens Oversight Committee of the California Institute for Regenerative Medicine (CIRM) unanimously approved yesterday two grants worth a total of almost $8 million to University of California San Diego School of Medicine researchers investigating novel stem cell-based treatments for acute myeloid leukemia or AML.

Medicine

Channels:

Ut Southwestern, TBI

Deletion of a Stem Cell Factor Promotes TBI Recovery in Mice

esearchers found that conditional deletion of Sox2 – the gene encoding the SOX2 stem cell transcription factor – and the associated dampening of astrocyte reactivity appear to promote functional recovery, including behavioral recovery, after traumatic brain injury, said Dr. Zhang, a W.W. Caruth, Jr. Scholar in Biomedical Research.

Medicine

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Stem Cells, Feinberg School of Medicine, Northwestern Medicine, JAMA, Peripheral Arterial Disease

Stem Cells Fail to Alleviate Peripheral Artery Disease

A stem cell therapy did not improve walking ability in people with peripheral artery disease, although exercise did lead to significant improvements, according to a new study. This is the largest trial of this type of therapy in people with blockages in leg arteries. Scientists were disappointed that stem cell therapy didn’t improve walking, because earlier research suggested it could be beneficial.

Medicine

Channels:

Stem Cell, iPSC, Differentiation, Neuronal Cell, Microrna, P53, Cell Fate Determination

Finding a Key to Unlock Blocked Differentiation in Microrna-Deficient Embryonic Stem Cells

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In a study published in Stem Cell Reports, Rui Zhao and colleagues have partly solved a long-unanswered basic question about stem cells — why are pluripotent stem cells that have mutations to block the production of microRNAs unable to differentiate?

Medicine

Channels:

Stem Cell, ophtahlmology

Stem Cell Therapy Shows Promise for Common Cause of Blindness

Results from two early clinical trials show that it may be possible to use human embryonic stem cells as treatment for the dry form of macular degeneration, according to presentations given today at AAO 2017, the 121st Annual Meeting of the American Academy of Ophthalmology.







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