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Science

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Bacteria defense, CRISPR, Cell DNA, Genetic Engineering, Molecular Biology, Genetics, Cornell University, Harvard Medical School

Bringing Bacteria’s Defense Into Focus

By taking a series of near-atomic resolution snapshots, Cornell University and Harvard Medical School scientists have observed step-by-step how bacteria defend against foreign invaders such as bacteriophage, a virus that infects bacteria.

Medicine

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Detroit Medical Center, Down Syndrome, ALL acute lymphoblastic leukemia, AML acute myeloid leukemia, Dr Jeffrey Taub, Pediatric Cancer Treatment

Detroit Pediatric Oncologist Leads Largest Single Study on Survival Outcomes for Children with Down Syndrome and AML or ALL

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Jeffrey W. Taub, M.D., FAAP, chief, Division of Oncology, at the DMC's Children’s Hospital of Michigan was the principal investigator of the study, which enrolled 204 children from 2007-2011 through the Children’s Oncology Group (COG), an international organization which links all major pediatric oncology centers in the U.S., Canada and other countries to develop treatments for children with cancer.

Medicine

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Genetics, Intellectual Disability, genomic diagnostics, WDR26 gene, Pediatrics, Human Genetics, WDR26 haploinsufficiency

New Genetic Syndrome Identified; May Offer Some Answers for Puzzled Parents

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Researchers have identified a rare genetic syndrome characterized by intellectual disability, seizures, an abnormal gait and distinctive facial features. The scientists pinpointed variants in the WDR26 gene as causes for this distinctive, yet unnamed condition. Their early research provides initial information for counseling patients and families coping with uncertainties for children with the rare, poorly recognized condition.

Science

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Growth Hormone, mice study, Aging, lifespan and aging, Lifespan Development, Lifespan Extension, Aging Research, Aging and Disease

Hormonal Changes During Early Development Limit Lifespan in Mice

The UAB study could help inform future health care management during early life and the development of interventions aimed at improving quality of life for older individuals.

Science

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Depression, Gene, DNA, Dopamine, Anxiety, Genetics

New Study Identifies Gene That Could Play Key Role in Depression

Depression affects more than 300 million people annually. Now, a new study has pinpointed how one particular gene plays a central role – either protecting from stress or triggering a downward spiral, depending on its level of activity.

Science

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Ben Larman, Gene, LASSO , DNA, Probe, Probing, Clone, Cloning

Powerful New Technique Can Clone Thousands of Genes at Once

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Scientists at Johns Hopkins, Rutgers, the University of Trento in Italy, and Harvard Medical School report they have developed a new molecular technique called LASSO cloning, which can be used to isolate thousands of long DNA sequences at the same time, more than ever before possible.

Science

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Affinity chromatography, Protein Purification, Membrane Proteins, nucleic acid binding proteins, Multisubunit Proteins, Pull-down assays, Binding assays, Colicin

One-Step Protein Purification Achieves High Yields, Purity and Activity

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A new method improves the high-yield, -purity and -activity purification of complex proteins by 10- to 500-fold, with crucial advantages for researchers and the pharmaceutical industry as potentially the most efficient and universal tool for high-throughput studies of significant biological systems.

Medicine

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Northwestern University, Research, Infancy, Genetics, Health

How Babies’ Environments Lead to Poor Health Later

New Northwestern University research underscores how environmental conditions early in development can cause inflammation in adulthood — an important risk factor for a wide range of diseases of aging, including cardiovascular diseases, diabetes, autoimmune diseases and dementia.

Medicine

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Charles Mullighan, St. Jude Children's Research Hospital, Jinghui Zhang, genomic sequencing, Acute Lymphoblastic Leukemia, genomic analysis, T-ALL, T-All Leukemia

First Large-Scale Genomic Analysis of Key Acute Leukemia Will Likely Yield New Therapies

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Charting the genomic landscape of T-lineage acute lymphoblastic leukemia patients revealed insights that will guide research and help to lay the foundation for more targeted therapy.

Medicine

Science

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Breast Cancer, Pregnancy, High Fat Diet, genetic, Oncology, Environmental Factors

Animal Study Finds High-Fat Diet in Pregnancy Increases Breast Cancer Risk Over Generations

Feeding pregnant female mice a diet high in fat derived from common corn oil resulted in genetic changes that substantially increased breast cancer susceptibility in three generations of female offspring, reports a team of researchers led by scientists at Georgetown Lombardi Comprehensive Cancer Center.







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