Feature Channels: Respiratory Diseases and Disorders

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The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back. Recent developments include a novel biomarker that may predict the aggressiveness of pancreatic cancer precursors, insights into the structure and function of a breast and ovarian cancer susceptibility gene, a new approach to overcoming treatment resistance in ovarian cancer, distinguishing features of young-onset rectal cancer, a biomarker and potential target for metastatic lung cancer, machine learning models to better predict outcomes of patients with mantle cell lymphoma (MCL), and a promising therapy for patients with relapsed/refractory MCL.

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Biofilms are highly resistant communities of bacteria that pose a major challenge in the treatment of infections.

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Based on decades of work to uncover the underlying mechanisms of asthma and other respiratory conditions, researchers at McMaster University and St. Joseph’s Healthcare Hamilton have produced a simple, rapid test that can identify the presence of a key driver of severe asthma.

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Ochsner Medical Center - New Orleans (OMC), inclusive of Ochsner Medical Center- West Bank and Ochsner Baptist, has been named by U.S. News & World Report to its 2023-2024 Best Hospitals. Additionally, OMC is the #1 hospital in the New Orleans metro area.

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On World Lung Cancer Day, Aug. 1, the Forum of International Respiratory Societies (FIRS) and its founding member, the American Thoracic Society, stress the importance of understanding lung cancer risk factors, as well as the importance of early detection through screening, and treatment.

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Newborn screening for cystic fibrosis (CF) was fully implemented in all 50 states in the U.S. by 2010, but delays in timeliness of evaluation for infants with positive newborn screen tests persist. Through evaluation of national patient registry data, Dr. Martiniano and her team determined that later initiation of CF care is associated with poorer long-term nutritional outcomes.

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The ultra-soft tentacle, which measures just 2 millimetres in diameter and is controlled by magnets, can reach some of the smallest bronchial tubes and could transform the treatment of lung cancer.

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In a new study, scientists at La Jolla Institute for Immunology (LJI) compared the immune response of individuals who received older versus newer versions of the whooping cough vaccine. The unexpected findings may help explain the recent rise in whooping cough cases and point to potential targets for the next generation of vaccines.

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PBD Biotech developers of Actiphage TB, a ground-breaking phage-based diagnostic for laboratory tuberculosis testing, has today announced it has secured the grant of a US patent for its diagnostic kit. The company is exhibiting in the AACC Clinical Lab Expo on booth #4578.

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Today, at the 2023 AACC Annual Scientific Meeting & Clinical Lab Expo, scientists will present new data about rates of co-infections with SARS-CoV-2, influenza, and respiratory syncytial virus (RSV) in the United States.

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Omega-3 fatty acids, which are abundant in fish and fish oil supplements, appear promising for maintaining lung health, according to a Cornell-led study supported by the National Institutes of Health (NIH).

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The first study in the world to compare cholesterol-lowering medications on a range of diseases has good and bad news for more than 200 million people.

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The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.

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Fiscal year 2023, which ended June 30, proved to be the busiest year yet for Cedars-Sinai’s Comprehensive Transplant Center and Smidt Heart Institute, with more than 600 organs transplanted.

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Research increasingly reveals health risks of e-cigarette use, and more studies are needed about the long-term impact e-cigarettes may have on the heart and lungs.

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As a result of the COVID-19 pandemic, respiratory syncytial virus (RSV) surges in young children occurred outside the usual November to March season, when immune-based prophylactic is available to protect children at high risk for severe illness.

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Surgeons in the Division of Thoracic Surgery at JFK University Medical Center first in the State of New Jersey to perform this surgery

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While pembrolizumab is an approved treatment for patients with stage III non-small cell lung cancer (NSCLC), only some patients respond to this therapy. Treatment failure, researchers say, is often caused by differences in the tumor microenvironment.

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The Tobacco Prevention and Evaluation program (TPEP) in the UNC School of Medicine has been awarded a two-year, $887,431 contract from JUUL Settlement funds received by the NC Department of Health and Human Services to better understand electronic cigarette use among our youth and young adults.

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The American Association for Thoracic Surgery (AATS) and Memorial Sloan Kettering Cancer Center’s (MSK) Thoracic Surgery Oncology Group (TSOG) completed its first clinical trial involving 330 patients who have ground glass lung nodules identified on a CT scan.

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Now that the emergency phase of the COVID-19 pandemic has ended, scientists are looking at ways to surveil indoor environments in real time for viruses. By combining recent advances in aerosol sampling technology and an ultrasensitive biosensing technique, researchers at Washington University in St. Louis have created a real-time monitor that can detect any of the SARS-CoV-2 virus variants in a room in about 5 minutes.

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Below are summaries of recent Fred Hutchinson Cancer Center research findings and other news. If you’re looking for resources who can comment on skin cancer awareness and skin protection during the summer months, see our list of experts and reach out to [email protected] to set up interviews.

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Mickey Rogers, a Linus Pauling Distinguished Postdoctoral Fellow at the Environmental Molecular Sciences Laboratory (EMSL) talks about her research on how algae particles in the atmosphere affect climate and human health.

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In support of the second annual World Bronchiectasis Day, July 1, the Forum of International Respiratory Societies, of which the American Thoracic Society is a founding member, is joining the COPD Foundation and several global organizations to raise global awareness, share knowledge, and discuss ways to reduce the burden of bronchiectasis for patients and their families worldwide.

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The Radiological Society of North America (RSNA) announced today that its leading medical imaging research journal, Radiology, maintains the largest impact factor in its category. In addition, RSNA’s subspecialty journals, Radiology: Artificial Intelligence, Radiology: Cardiothoracic Imaging and Radiology: Imaging Cancer have achieved impact factors for the first time, and RadioGraphics continues to excel, according to the newly released 2023 update to the Clarivate Analytics Journal Citation Reports.

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A blood-based four-protein panel (4MP), when combined with a lung cancer risk model (PLCOm2012), can better identify those at high risk of dying from lung cancer than the current U.S. Preventive Services Task Force (USPSTF) criteria.

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Using nanomagnets composites and conductive yarn, scientists have invented a smart textile that can sense and measure body movements—from muscles flexing to veins pulsing.

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A new collective named the Great Lakes Clinical Center (GLCC) for the ARDS, Pneumonia and Sepsis (APS) Phenotyping Consortium will be intensely focused on examining the various mechanisms underpinning these conditions to better understand their impact on disease development, trajectory and outcomes.

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Scleroderma is an autoimmune disease characterized by thickening and scarring of the skin and vital organs, and the narrowing of the blood vessels which lead to poor circulation.

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Graham Hatfull has pioneered the use of bacteriophages, or just “phages,” to combat antibiotic resistant infections. He was honored with the Gardner Middlebrook Lifetime Achievement award for his research.

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Therapy of the dangerous infectious disease of tuberculosis faces the challenge of pathogens frequently being resistant to several common antibiotics. Researchers of Karlsruhe Institute of Technology (KIT) have now developed nanoparticles to deliver new antibiotics directly to the lungs in future. Surfactants ensure that the highly fat-soluble antibiotics disperse very finely in water and can be inhaled. First tests at the Research Center Borstel, Leibniz Lung Center, reveal a high effectiveness and good compatibility of the nanocarriers of antibiotics. The researchers report in ACS Nano. (DOI: 10.1021/acsnano.3c01664)

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Clinical testing is underway for a potentially groundbreaking new treatment for cystic fibrosis.

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The Call for Input deadline for the ATS 2024 International Conference is approaching! You have until 5 p.m. ET next Wednesday, June 28 to submit your proposals for programming in all areas of respiratory, critical care, and sleep medicine with a clinical, basic science, and/or translational focus.

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Race-neutral lung function interpretation could increase access to lung transplants for Black patients with respiratory disease, according to new research published in the Annals of the American Thoracic Society online ahead of print.

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According to an accepted manuscript published in ARRS’ own American Journal of Roentgenology (AJR), preferential use of pulmonary MR angiography (MRA) for diagnosing pulmonary embolus (PE) in the general population helped conserve iodinated contrast media during the 2022 shortage.

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A laboratory at the Hackensack Meridian Center for Discovery and Innovation (CDI) has been issued a major grant to repurpose drugs to combat non-tuberculous mycobacteria (NTM), an emerging family of germs naturally found in soil and water and which can be deadly to those with compromised immune systems and pre-existing lung diseases.

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Loss of two key “protector” proteins initiates epigenetic changes that transform healthy lung cells into cancerous ones, according to new research from Van Andel Institute scientists.