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Infectious Diseases

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Medicine

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Oklahoma, OSU, Poxviruses, Smallpox, Health, Disease, Medicine, Virus, Research, Biochemistry, Molecular, Biology

Researchers Make Breakthrough Against Poxviruses

A major breakthrough by Junpeng Deng, a structural biologist in the Division of Agricultural Sciences and Natural Resources at Oklahoma State University, and his first-year Ph.D. student, Brian Krumm, may be the first step towards a pharmaceutical medication for smallpox and the emerging human monkeypox.

Science

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Malaria, Mosquito, Plasmodium, Salivary Gland, Transmission, Protein, Receptor, Johns Hopkins Malaria Research Institute

Researchers Find Essential Proteins for Final Stage of Malaria Transmission Cycle

Researchers at the Johns Hopkins Malaria Research Institute (JHMRI) have identified, for the first time, the molecular components that enable the malaria-causing parasite Plasmodium to infect the salivary glands of the Anopheles mosquito"”a critical and final stage for spreading malaria to humans.

Medicine

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E. Coli, Persistance, Hipa Induced, Dormancy, Multidrug Resistant, Bacteria, Kinase, Inhibitors, Infection, M. D. Anderson, Richard Brennan, Ph.D., Maria Schumacher, Ph.D.

E. coli Persists Against Antibiotics Through HipA-Induced Dormancy

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Bacteria hunker down and survive antibiotic attack when a protein flips a chemical switch that throws them into a dormant state until treatment abates, researchers at The University of Texas M. D. Anderson Cancer Center report in the Jan.16 edition of Science.

Medicine

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Pneumonia, Influenza, Clindamycin, Azithromycin, Ampicillin

Study Finds More Effective Treatment for Pneumonia Following Influenza

Scientists at St. Jude Children's Research Hospital have demonstrated a more effective treatment for bacterial pneumonia following influenza. They found that the antibiotics clindamycin and azithromycin, which kill bacteria by inhibiting their protein synthesis, are more effective than a standard first-line treatment with the "beta-lactam" antibiotic ampicillin, which causes the bacteria to lyse, or burst.

Medicine

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Malaria, drug, Resistance, Polymedix, Disease, Artemisinin, Parasites, Lumefantrine, Chloroquine, University Of Pennsylvania, Mosquitos, Asia, Biochemical

New Malaria Drug May Meet Resistance Says Expert

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According to University of Pennsylvania pharmacologist Doron Greenbaum, Ph.D., although the exact mechanism by which artemisinin kills parasites is still open to considerable debate, the drug likely acts against one or more biochemical targets that may make it susceptible to resistance that has developed to every other drug that acts via a biochemical mechanism of action. Drug resistance has been shown to occur in the laboratory , and reports have already surfaced about potential resistance in southeast Asia.

Science

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Staph Aureus, Bacteriophages, Gene Transfer

Scientists Discover Dangerous New Method for Bacterial Toxin Transfer

Scientists have discovered a new way for bacteria to transfer toxic genes to unrelated bacterial species, a finding that raises the unsettling possibility that bacterial swapping of toxins and other disease-aiding factors may be more common than previously imagined.

Medicine

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Influenza, Virology, Viruses, Genetics

Scientists Isolate Genes That Made 1918 Flu Lethal

By mixing and matching a contemporary flu virus with the "Spanish flu" "” a virus that killed between 20 and 50 million people 90 years ago in history's most devastating outbreak of infectious disease "” researchers have identified a set of three genes that helped underpin the extraordinary virulence of the 1918 virus.

Medicine

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UIC, Leishmaniasis, Parasitic Disease, Research

Researchers Hunting Drugs for Devastating Parasitic Disease

Researchers at the University of Illinois at Chicago have discovered that compounds derived from a natural product can be used in developing a new drug to treat leishmaniasis, a parasitic disease spread by the bite of infected sand flies.

Science

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Acinetobacter, Baumannii

Genes Involved in Antibiotic Resistance Vary within a Species

Case Western Reserve University School of Medicine scientist leads comparative analysis of six genomes of Acinetobacter baumannii; First genome sequence to be completed in Cleveland.

Science

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Avian Flu, Pandemic, Poultry, PIGS, University Of Maryland, Daniel Perez, H5 N1, H9 N2, CDC, Virginia Maryland Regional College Of Veterinary Medicine, Avian Flue Virus Program, Virus

Maryland Researchers Take Aim at Avian Flu Vaccine

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Researchers at the University of Maryland are hot on the trail of a universal flu vaccine for animals - which could ultimately help prevent or delay another avian flu pandemic in humans.







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