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Medicine

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GW Cancer Center, GW School of Medicine and Health Sciences, Prostate Cancer, cancer disparities, African American health disparities, African American Health, Genetics, genes, tumor aggressiveness , Cancer

Genetic Variation by RNA Splicing May Lead to Tumor Aggressiveness and Drug Resistance in African American Men with Prostate Cancer

A form of genetic variation, called differential RNA splicing, may have a role in tumor aggressiveness and drug resistance in African American men with prostate cancer, according to research published out of the George Washington University Cancer Center in Nature Communications.

Medicine

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Upper GI, Small Bowel Disorders, SBA, Adenocarcinoma, tumor sample testing, mutated gene

Subtle Molecular Changes Along the Upper Digestive Tract Could Guide Cancer Therapy

Based on a new molecular study of tissues biopsied from various parts of the upper digestive tract, researchers at Georgetown Lombardi Comprehensive Cancer Center have identified significant, if subtle, differences in gene mutations and other factors that could help in developing more tailored treatment options for cancer patients.

Medicine

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Astronauts, Spaceflight, Carbon Dioxide, Genetics, Vision, Eye Abnormalities

Genetic Differences May Alter Carbon Dioxide Sensitivity, Contribute to Changes in Astronauts’ Eyes

Researchers have found that genetic variation may increase susceptibility of some astronauts to develop higher-than-normal carbon dioxide levels in the blood, which may contribute to eye abnormalities, including grooved bands on the retina in the eye and swelling of the optic nerve.

Science

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Dna Replication, Dna Repair

Researchers ID New Mechanism for Keeping DNA Protein in Line

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Electrostatic forces known as phosphate steering help guide the actions of an enzyme called FEN1 that is critical in DNA replication and repair, finds a new study led by Berkeley Lab researchers. The findings help explain how FEN1 distinguishes which strands of DNA to target, revealing key details about a vital process in healthy cells as well as providing new directions for cancer treatment research.

Science

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CRISPR, Cas3, Cas9, Structure, Cryo Electron Microscope, cryo-EM, Harvard Medical School, Maofu Liao, Cornell University

Bringing CRISPR Into Focus

Harvard Medical School study generates near-atomic resolution images of key steps in CRISPR-Cas3 function, revealing layers of error detection that prevent unintended genomic damage. Structural understanding informs efforts to improve CRISPR systems for gene editing and reduce off-target effects.

Medicine

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DEAF, Deafness, Gene, hair cell, Protein, Hearing, EARS

New Research Identifies Key Mechanism Behind Some Deafness

Although the basic outlines of human hearing have been known for years – sensory cells in the inner ear turn sound waves into the electrical signals that the brain understands as sound – the molecular details have remained elusive. Now, new research has identified a crucial protein in this translation process.

Science

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Microbiome, skin

What’s On Your Skin? Archaea, That’s What

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It turns out your skin is crawling with single-celled microorganisms – ¬and they’re not just bacteria. A study by the Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) and the Medical University of Graz has found that the skin microbiome also contains archaea, a type of extreme-loving microbe, and that the amount of it varies with age.

Science

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Uc San Diego, San Diego Supercomputer Center, Genetic Engineering, CRISPR-Cas9, National Science Foundation (NSF) , National Institutes Of Health (NIH), xsede

Novel Molecular Dynamics Captures Atomic-level Detail of CRISPR-Cas9 Activity

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A team led by UC San Diego researchers has identified, for the first time, the myriad structural changes that activate and drive CRISPR-Cas9, the innovative gene-splicing technology that’s transforming the field of genetic engineering.

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Researchers Propose New Approach to Identify Genetic Mutations in Men with Prostate Cancer

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Scientists have had limited success at identifying specific inherited genes associated with prostate cancer. Researchers at University of Utah Health studied prostate cancer patients with multiple cancer diagnoses to identify genetic mutations that may influence cancer treatment and cancer risk.

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Ancient Antiviral Defense System Could Revolutionize a New Class of RNA-based Medicine, Mount Sinai Researchers Say

Medicinal payload could be delivered by engineered RNAs that can be controlled by a billion year-old “genetic fossil” found in all cells







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