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Medicine

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Niemann Pick Type C Disease (Np C), Cyclodextrin, Rare Diseases

Drug Trial Shows Promise for Deadly Neurological Disorder

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Results of a small clinical trial show promise for treating a rare neurodegenerative condition that typically kills those afflicted before they reach age 20. The disease, called Niemann-Pick type C (NPC), causes cholesterol to build up in neurons, leading to a gradual loss of brain function. In the drug trial, researchers have shown that treatment with a type of sugar molecule called cyclodextrin slows progression of the disease.

Medicine

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pain, widespread pain, Chronic Pain, Chronic Pelvic Pain, MRI, Fibromyalgia

Does Widespread Pain Stem From the Brain? MRI Study Investigates

Patients with different chronic pain diagnoses recorded similar brain changes, a new study finds, suggesting a need for new treatment approaches.

Science

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Neurons, Neuronal Types, Dna Methylation, Brain Cell Differences, epigenetic changes

Scientists Find New Way to Map Differences in the Brain

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A team from the Salk Institute for Biological Studies and the University of California San Diego has, for the first time, profiled chemical modifications in the DNA of individual neurons, giving the most detailed information yet on what makes one brain cell different from its neighbor.

Science

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CRISPR, Gene Editing, ALS, Huntington's Disease, Genetics, Cell Biology, Biotechnology, Molecular Biology, Neurology, Neurobiology

New Version of DNA Editing System Corrects Underlying Defects in RNA-based Diseases

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Until recently, CRISPR-Cas9 gene editing could only be used to manipulate DNA. In 2016, University of California San Diego School of Medicine researchers repurposed the technique to track RNA in live cells in a method called RNA-targeting Cas9. In a study published August 10 in Cell, the team took RCas9 a step further: they corrected molecular mistakes that lead to microsatellite repeat expansion diseases, which include a type of ALS and Huntington's disease.

Medicine

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Neurosurgery, spine damage , Back Pain Treatment, Back Pain, Spinal adjustment

Pennsylvania Hospital Neurosurgeon Performs the First Endoscopic Minimally Invasive Spinal Surgery in Pennsylvania

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Neil R. Malhotra, MD, an assistant professor of Neurosurgery and Orthopaedic Surgery and the vice chairman of operations in the department of Neurosurgery, performed the first endoscopic percutaneous lumbar spinal nerve decompression and discectomy in Pennsylvania

Science

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Connectome, connectomics, Fruit Fly, Brain, Neuroscience, Applied Mathematics, Computer Science, Cerebral Cortex, Neurons

Mapping the Brain, Neuron by Neuron

A mathematician and computer scientist joined an international team of neuroscientists to create a complete map of the learning and memory center of the fruit fly larva brain, an early step toward mapping how all animal brains work.

Medicine

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Men, Not Women, May Be Having Fewer Strokes

The overall rate of stroke in the United States has been declining in recent years and while that has been good news, a new study suggests it may be primarily good news for men. The research, published in the August 9, 2017, online issue of Neurology®, the medical journal of the American Academy of Neurology, found that while the stroke rate for men declined during the study period, for women it remained the same.

Medicine

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industry funding medical research, neurosurgery research, NIH, Neurosurgery Research and Education Foundation

Industry Will Play Critical Role in Funding Neurosurgery Research

With federal funding increasingly restricted, industry will play a critical role in funding neurosurgery research, according to a commentary by three prominent neurosurgeons in the journal World Neurosurgery.

Science

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Taste, Taste Buds, Neurosceince, Charles Zuker, Flavor, Bitter, Umami, Columbia University

Rewired Taste System Reveals How Flavors Move From Tongue to Brain

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By creating mice with mixed-up taste sensors, HHMI Investigator Charles Zuker and colleagues show how the taste system continually remakes itself.

Medicine

Channels:

Neuroscience, Taste

How the Tongue Keeps Its Tastes Straight

Signals sent by tongue’s taste cells prevent the brain from confusing bitter and sweet tastes







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