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  • Embargo expired:
    17-Apr-2018 2:00 PM EDT

Article ID: 692843

Abramson Cancer Canter Studies Show Promise of Immunotherapy Combinations, Including CAR T

Perelman School of Medicine at the University of Pennsylvania

As immunotherapies continue to make up a larger share of new cancer drugs, researchers are looking for the most effective ways to use these cutting edge treatments in combination with each or with other pre-existing options. New studies from the Abramson Cancer Center of the University of Pennsylvania are providing fresh clues on potentially effective combinations with CAR T therapy in brain cancer as well as a novel therapeutic target in head and neck cancer, and also providing greater understanding of the mechanisms of resistance in pancreatic cancer.

Released:
16-Apr-2018 9:00 AM EDT
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Article ID: 692963

Researchers Establish Link Between Hormone, Generosity in Birds

University of Nebraska-Lincoln

A new experimental study from the University of Nebraska-Lincoln has found that administering a naturally produced hormone to pinyon jays can increase food sharing among the highly social species.

Released:
17-Apr-2018 12:00 PM EDT
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  • Embargo expired:
    17-Apr-2018 12:00 PM EDT

Article ID: 692448

Global ROS1 Initiative Combines Patient Experience with Researcher Expertise to Target ROS1 Cancer Wherever It Grows

University of Colorado Cancer Center

University of Colorado Cancer Center study presented at AACR 2018 describes new model for patient-researcher collaboration organized not around cancer type but around oncogene that causes many cancers

Released:
9-Apr-2018 12:00 PM EDT
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  • Embargo expired:
    17-Apr-2018 11:00 AM EDT

Article ID: 692661

Machine Learning Techniques May Reveal Hidden Cause-Effect Relationships in Protein Dynamics Data

American Institute of Physics (AIP)

Machine learning algorithms excel at finding complex patterns within big data, so researchers often use them to make predictions. Researchers are pushing the technology beyond finding correlations to help uncover hidden cause-effect relationships and drive scientific discoveries. At the University of South Florida, researchers are integrating machine learning techniques into their work studying proteins. As they report in The Journal of Chemical Physics, one of their main challenges has been a lack of methods to identify cause-effect relationships in data obtained from molecular dynamics simulations.

Released:
12-Apr-2018 11:05 AM EDT
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Article ID: 692943

Is Caregiver Education About Sickle Cell Trait Effective?

Nationwide Children's Hospital

Despite universal newborn screening that detects the presence of sickle cell trait (SCT), only 16 percent of Americans with SCT know their status. To address this issue, in Ohio, in-person education is offered to caregivers of referred infants with SCT.

Released:
17-Apr-2018 10:30 AM EDT
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Embargo will expire:
25-Apr-2018 12:00 PM EDT
Released to reporters:
17-Apr-2018 10:05 AM EDT

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A reporter's PressPass is required to access this story until the embargo expires on 25-Apr-2018 12:00 PM EDT

Article ID: 692951

Could Statins Ease Deadly Heart Condition in Rare Neuromuscular Disease?

Perelman School of Medicine at the University of Pennsylvania

In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich’s ataxia (FA), a widely used cholesterol-lowering drug increased a precursor of HDL (high-density lipoprotein), the “good cholesterol.” Decreased HDL and ApoA-l levels in the general population are associated with an increased risk of death from cardiomyopathy and heart failure. Researchers found the FA patients had serum ApoA-I levels lower than healthy control subjects.

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17-Apr-2018 10:05 AM EDT
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Article ID: 692949

Top-Down Approach Gets to the Bottom of Cancer

Northwestern University

• When RAS genes mutate, they generate proteins that cause cells to proliferate uncontrollably • Researchers use ‘top-down proteomics’ to characterize intact proteins isolated from colorectal cancer cell lines and tumors • By understanding precisely how proteins change in cancer, researchers open door for new targets for treatment

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17-Apr-2018 10:05 AM EDT
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Article ID: 692954

Cancer Cells Actively Fuel Growth and Metastasis by Reprogramming Healthy Cells, Roswell Park Team Shows

Roswell Park Comprehensive Cancer Center

Roswell Park Comprehensive Cancer Center researchers have identified a potential key player promoting cancer progression through changes in the cell environment that are conducive to metastasis.

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17-Apr-2018 10:05 AM EDT
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Article ID: 692891

Ancient Bloodsuckers, Disposable Genes, and What It All Means

NIH, National Institute of General Medical Sciences (NIGMS)

Tune in today for a webcast of the 3rd annual NIGMS Director’s Early-Career Investigator Lecture where Dr. Jeramiah Smith, an assistant professor at the University of Kentucky, will describe how his research on the sea lamprey is shedding light on cancer biology, tissue regeneration, and vertebrate evolution.

Released:
17-Apr-2018 9:00 AM EDT
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