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Medicine

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Victor Velculescu, Cancer, Blood Test

Scientists Develop Blood Test That Spots Tumor-Derived DNA in People with Early-Stage Cancers

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In a bid to detect cancers early and in a noninvasive way, scientists at the Johns Hopkins Kimmel Cancer Center report they have developed a test that spots tiny amounts of cancer-specific DNA in blood and have used it to accurately identify more than half of 138 people with relatively early-stage colorectal, breast, lung and ovarian cancers.

Science

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Coral Bleaching, coral conservation, Coral Ecology, Marine Biodiversity, Climate Change, University of Washington, Genetics, Epigenetics, Coral Reefs

Modern Genetic Sequencing Tools Give Clearer Picture of How Corals Are Related

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As corals face threats from warming oceans, a new study uses modern genetic-sequencing tools to help reveal the relationships between three similar-looking corals.

Science

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Nuclear Physics, Physics, Advanced Scientific Computing Research, ASCR, NERSC, OLCF, National Energy Research Scientific Computing Center, Oak Ridge Leadership Computing Facility, Thomas Jefferson National Accelerator Facility, Thomas Jefferson National Accelerator Facility (Jefferson Lab) , JLAB, ORNL, LBNL, Oak Ridge National Laboratory, Lawrence Berk

Physicists Move Closer to Listening in on Sub-Atomic Conversation

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Calculations of a subatomic particle called the sigma provide insight into the communication between subatomic particles deep inside the heart of matter.

Science

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Brain, Neuroscience, Neurology, Biology, Genetics, Genetic Engineering, Magnetogenetics, Magneto-Thermal Stimulation, Magnetism, Health, Neurological Diseases

Scientists Use Magnetic Fields to Remotely Stimulate Brain — and Control Body Movements

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Scientists have used magnetism to activate tiny groups of cells in the brain, inducing bodily movements that include running, rotating and losing control of the extremities — an achievement that could lead to advances in studying and treating neurological disease.

Medicine

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Cell Cycle-Blocking Drugs Can Shrink Tumors by Enlisting Immune System in Attack on Cancer, Study Finds

• Study explains why CDK4/6 inhibitors can shrink tumor in some advanced breast cancers • CDK4/6 inhibitors trigger the immune system to attack tumor cells • CDK4/6 inhibitors can also enhance anti-cancer effect of immunotherapy agents

Science

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electrochromic polymer, Aqueous Chemistry, aqueous dispersions, electrochromic film, Conjugated Polymers, printable electronics, spray coatings

Spray-on Electric Rainbows: Making Safer Electrochromic Inks

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A flick of a switch, and electrochromic films change their colors, making sunglasses, windows, and mirrors tint, or textiles flip their shades. Now they can be applied more safely and more commonly thanks to an innovative chemical process that makes them water soluble.

Medicine

Science

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Schizophrenia, development and reproductive biology

Possible Roots of Schizophrenia Uncovered

An abundance of an amino acid called methionine, which is common in meat, cheese and beans, may provide new clues to the fetal brain development that can manifest in schizophrenia, University of California, Irvine pharmacology researchers report in the journal Molecular Psychiatry.

Medicine

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St. Jude Children's Research Hospital, J. Paul Taylor, Neuron, ALS, Lou Gehrig's Disease, , frontotemporal dementia , Frontotemporal Dementia, Amyotrophic Lateral Sclerosis, phase separation, ALS treatment

Researchers Discover Fundamental Pathology Behind ALS

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A team led by scientists at St. Jude Children’s Research Hospital and Mayo Clinic has identified a basic biological mechanism that kills neurons in amyotrophic lateral sclerosis (ALS) and in a related genetic disorder, frontotemporal dementia (FTD), found in some ALS patients. ALS is popularly known as Lou Gehrig’s disease. The researchers were led by J. Paul Taylor, M.D., Ph.D., chair of the St. Jude Cell and Molecular Biology Department and a Howard Hughes Medical Institute investigator; and Rosa Rademakers, Ph.D., of the Mayo Clinic in Jacksonville, Florida. The findings appear today in the journal Neuron.

Medicine

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MRI, MRI contrast agents, magnetic resonance imaging (MRI) contrast agents , Veins, internal organs, Disease Diagnosis, nature scientific reports, Case Comprehensive Cancer Center, Case Western Reserve School of Medicine, Cancer, Genetic Diseases, Cystic Fibrosis, Metabolic Diseases, Diabetes, imaging applications, biomarkers, molecular therapies

Multicolor MRIs Could Aid Disease Detection

Researchers at Case Western Reserve University School of Medicine have developed a method that could make magnetic resonance imaging—MRI—multicolor. Current MRI techniques rely on a single contrast agent injected into a patient’s veins to vivify images. The new method uses two at once, which could allow doctors to map multiple characteristics of a patient’s internal organs in a single MRI. The strategy could serve as a research tool and even aid disease diagnosis.

Science

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GOLD, Nanoparticles, Biosensors, Nanoclusters, gold particles, Fluorescence, bare Au20, biomarkers, Ligand, Chongqi Yu, Wolfgang Harbich, Luca Sementa, Luca Ghiringhelli, Edoardo Aprá, Mauro Stener, Alessandro Fortunelli, Harald Brune, Ecole Polytechnique Federale de Lausanne, Consiglio Nazionale delle Ricerche, Fritz-Haber-Institut der Max-Planck-Gesellscha

Gold Shines Through Properties of Nano Biosensors

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With their remarkable electrical and optical properties, along with biocompatibility, photostability and chemical stability, gold nanoclusters are gaining a foothold in a number of research areas, particularly in biosensing and biolabeling. An international research team has now shown that the fluorescence is an intrinsic property of the gold nanoparticles themselves. The researchers used Au20, gold nanoparticles with a tetrahedral structure. Their findings were reported this week in The Journal of Chemical Physics.







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