Feature Channels: Regenerative Medicine

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The New York Stem Cell Foundation’s (NYSCF) 16th Annual Conference – held virtually on October 19-20 – convenes global leaders in stem cell research to present their latest progress towards new treatments and cures for the most devastating diseases and injuries in the world.

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In this study, the Sánchez Alvarado Lab shows that whole-body regeneration involves transcriptional changes in cells from all three germ layers (muscle, epidermis, and intestine) of the body, and that tissue from areas distant from, as well as nearby to the site of injury, contribute to the process of regeneration.

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Expert Q&A: Do breakthrough cases mean we will soon need COVID boosters? The extremely contagious Delta variant continues to spread, prompting mask mandates, proof of vaccination, and other measures. Media invited to ask the experts about these and related topics.

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Scientists from Queen Mary University of London and UCL have shown that fetal membranes are able to heal after injury in a new study published today in Scientific Reports.

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The research found that photobiomodulation – a form of low-dose light therapy – sped up recovery from burns and reduced inflammation in mice by activating endogenous TGF‐beta 1, a protein that controls cell growth and division.

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Its powers may not rival Wolverine's, but a regenerative implant engineered by researchers at the University of Nebraska Medical Center and University of Nebraska–Lincoln could help repair bone-deep damage following physical trauma, surgery or osteoporosis.

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With the recent announcement of the RegeneratOR Test Bed to support regenerative medicine start up companies, the Wake Forest Institute for Regenerative Medicine (WFIRM) and the RegenMed Development Organization (RemDO) are embarking on the next step – to help create the future workforce.

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Phase Holographic Imaging is collaborating with the RegeneratOR Test Bed, a new regenerative medicine endeavor in North Carolina, by providing its technology to help support start-up companies in the regenerative medicine space.

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In the biomaterials industry, electrospinning is a ubiquitous fabrication method used to produce nano- to microscale fibrous meshes that closely resemble native tissue architecture. Alas, the process has traditionally used solvents that not only are environmentally hazardous but also a significant barrier to industrial scale-up, clinical translation, and widespread use. But now, Columbia Engineering researchers report that they have developed a "green electrospinning" process that addresses those challenges, from managing environmental risks of volatile solvent storage and disposal at large volumes to meeting health and safety standards during both fabrication and implementation.

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Frontotemporal dementias are a group of fatal and debilitating brain disorders for which there are no cures. In an article published July 26 in Cell, Mount Sinai researchers describe how they were able to recreate much of the damage seen in a widely studied form of the disease by growing special types of cerebral organoids in petri dishes.

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妙佑医疗国际正在尝试将再生医学作为多年来的医学难题——椎间盘退行性疾病的一种潜在长期解决方案。世界上有数百万人长期受到由于脊柱经年磨损导致的颈部和背部疼痛的困扰。对于这种常见病痛，目前的治疗通常只能提供暂时的缓解，找到治愈方法是摆在医学研究者面前的一项挑战。

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A Mayo Clinic está buscando a medicina regenerativa como uma solução em potencial a longo prazo para a doença degenerativa do disco que, há anos, não é contemplada pela ciência médica.

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Mayo Clinic estudia la medicina regenerativa como una posible solución a largo plazo para la enfermedad degenerativa de los discos, que ha evadido a la ciencia médica durante años.

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RegenMed Development Organization (ReMDO) releases the results of a national survey of regenerative medicine biomanufacturing knowledge, skills, and abilities needed for successful employment in the regenerative medicine field.

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The Polo Tecnologico Piemontese (PTP) is born in Candiolo (Turin), a hub of innovative companies that will host avant-garde technological companies and research institutes dedicated to medicine and which sees the HBW Group * as the leader.

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Cedars-Sinai has been awarded $11.99 million by California's stem cell agency to launch a clinical trial testing a potential gene and stem cell therapy for amyotrophic lateral sclerosis (ALS).

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The RegenMed Development Organization (ReMDO), a non-profit foundation headquartered in Winston-Salem, NC, and dedicated to advancing the regenerative medicine field nationwide, and the Wake Forest Institute for Regenerative Medicine (WFIRM), the largest regenerative medicine institute in the world, announce the launch of the RegeneratOR Test Bed.

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Nanodecoys made from human lung spheroid cells (LSCs) can bind to and neutralize SARS-CoV-2, promoting viral clearance and reducing lung injury in a macaque model of COVID-19.

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Hackensack Meridian Health Medical Group at Hackensack University Medical Center is proud to welcome board-certified orthopedic surgeon Stephen G. Silver, M.D. Dr. Silver specializes in arthroscopic treatment of sports injuries to the shoulder, elbow and knee.

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ACSM's comprehensive sports medicine and exercise science conference takes place virtually from June 1 to 5 with programming covering the science, practice, public health and policy aspects of sports medicine, exercise science and physical activity. View program highlights.

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The 2021 Virtual ACSM Basic Science World Congress focuses on regenerative medicine. Chaired by Marcas M. Bamman, Ph.D., FACSM, from the University of Alabama at Birmingham, this world congress brings together researchers to discuss cutting-edge science in this rapidly developing field.

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In a lab on the upper floors of Engineering Hall, something is growing. It’s not a plant. And it’s not an animal. What Ronke Olabisi is growing in her lab is us. From new skin and retinal tissue to hearts and livers, she’s developing the tools to rebuild and repair the human body. A UCI assistant professor of biomedical engineering, Olabisi has been working with regenerative tissue for the better part of seven years, using a hydrogel based on polyethylene glycol diacrylate.

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When trauma, illness, or injury causes significant muscle loss, reconstructive procedures for bioengineering functional skeletal muscles can fall short, resulting in permanent impairments. Finding a synergy in the importance of biochemical signals and topographical cues, researchers developed an efficient technique for muscle regeneration and functional restoration in injured rats. They describe results from the technique in Applied Physics Reviews.

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Irvine, Calif., May 5, 2021 – If you haven’t had knee surgery, you may have a friend or relative who has. But do you know anyone who has had an operation on their jaw? Although the temporomandibular joint is crucial to speaking, chewing and even breathing, treatments for TMJ disorders are far less common than those for the knee.

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There has been marked increase in the number of people over 65 who have needed spinal fusion surgery, and many researchers have focused on trying to create a biomimetic scaffold that induces vascularization. In Applied Physics Reviews, researchers present a solution to address the challenge: The team designed a microchannel scaffold made of a collagen and hydroxyapitite combination, with each strut consisting of micrometer-scaled microchannels. The microchannels have induced growth of blood vessels in a mouse model.

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Difficult-to-treat, chronic wounds in preclinical models healed with normal scar-free skin after treatment with an acellular product discovered at Mayo Clinic. Derived from platelets, the purified exosomal product, known as PEP, was used to deliver healing messages into cells of preclinical animal models of ischemic wounds. The Mayo Clinic research team documented restoration of skin integrity, hair follicles, sweat glands, skin oils and normal hydration. Ischemic wounds occur when arteries are clogged or blocked, preventing important nutrients and oxygen from reaching the skin to drive repair. This groundbreaking study titled, "TGF-β Donor Exosome Accelerates Ischemic Wound Healing," is published in Theranostics.

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The technique used in this preclinical study could aid tissue regeneration following severe accidents, surgical resections, or progressive muscle loss due to age or genetic disease.

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The Piotrowski Lab has reported newly identified invasive ionocytes in the sensory organs of larval and adult zebrafish fish that may provide clues to how sensory organs continue to function in changing environments.

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As regenerative therapies for blinding diseases move closer to clinical trials, the National Eye Institute’s functional imaging consortium, a part of the NEI Audacious Goals Initiative (AGI), is pioneering noninvasive technologies to monitor the function of the retina’s light-sensing neurons and their connections to the brain.

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A one-time injection of an experimental stem cell therapy can repair brain damage and improve memory function in mice with conditions that replicate human strokes and dementia, a new UCLA study finds.

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Researchers at Albert Einstein College of Medicine have developed a topical drug that regenerates and restores the function of erectile nerves damaged by radical prostatectomy, the most common treatment for localized prostate cancer. The drug was tested in rats, and the findings were published online today in JCI Insight.

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Reparative hydrogel mimics the composition and mechanics of the brain

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A UCLA-led research team has identified a chemical cocktail that enables the production of large numbers of muscle stem cells, which can self-renew and give rise to all types of skeletal muscle cells.

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Researchers at Children’s Hospital of Philadelphia (CHOP) have identified genes responsible for hematopoietic stem cell (HSC) regeneration via the assembly of the ribosome, the protein factories in cells that translate mRNA sequences into amino acid sequences. The findings, which were published in Cell Stem Cell, highlight the importance of proper ribosome assembly in stem cell regeneration and identify possible targets for future therapies for ribosomopathies, childhood disorders that lead to bone marrow failure (BMF).

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Using genetic engineering, researchers at UT Southwestern and Indiana University have reprogrammed scar-forming cells in mouse spinal cords to create new nerve cells, spurring recovery after spinal cord injury. The findings, published online today in Cell Stem Cell, could offer hope for the hundreds of thousands of people worldwide who suffer a spinal cord injury each year.