A new combination of immunotherapy and chemotherapy for pancreatic cancer caused tumors to shrink in the majority of evaluable patients
Combining immunotherapy with chemotherapy shrank tumors in 20 out of 24 patients with advanced pancreatic cancer, according to early phase 1b data being unveiled at AACR 2019 by Parker Institute for Cancer Immunotherapy (PICI) researchers at the University of Pennsylvania.
Final results from the first U.S. clinical study of CIMAvax-EGF show that this Cuban immunotherapy is safe and showed promising efficacy as part of a treatment combination with nivolumab in patients with advanced non-small cell lung cancer.
As current antibiotics dwindle in effectiveness against multidrug-resistant pathogens, researchers are seeking potential replacements in some unlikely places. Now a team has identified bacteria with promising antibiotic activity against known pathogens.
Fentanyl’s powerful effects are long-lasting, and even tiny amounts of the drug can lead to an overdose. Antidotes, do not last long enough in the body to fully counter the drug, requiring repeated injections. Now, scientists report that they are developing single-dose, longer-lasting opioid antidotes.
The American Association for Cancer Research (AACR) has announced that the 13th annual AACR Team Science Award will be presented to the Cancer Control and Survivorship Program at St. Jude Children’s Research Hospital. The Cancer Control and Survivorship Program is a multidisciplinary research program of the St. Jude Comprehensive Cancer Center, which strives to improve the quality of life of individuals surviving childhood cancer. Leslie L. Robison, PhD, chair of the Department of Epidemiology & Cancer Control, and Melissa Hudson, MD, director of the Division of Cancer Survivorship, lead the program.
Leading physiology and pharmacology researchers will speak in a four-part series centered on the gut microbiome—the microbe population living in the digestive tract—and its role in wound recovery, hypertension and nervous system function. The symposia series is organized by American Physiological Society (APS) President Jeff Sands, MD, and American Society for Pharmacology and Experimental Therapeutics (ASPET) President Edward T. Morgan, PhD, both of Emory University School of Medicine. The APS-ASPET Presidential Symposia Series will be part of the APS and APSET annual meetings at Experimental Biology 2019 in Orlando, Fla.
Four leading researchers will present the American Physiological Society’s (APS) most distinguished award lectures at the APS annual meeting at Experimental Biology (EB) 2019 (April 6–9 in Orlando, Fla.). APS is pleased to recognize this year’s exceptional honorees, who will present their lectures throughout the EB meeting, culminating with the APS Nobel Prize Award Lecture on Tuesday, April 9.
A recently approved contraceptive vaginal ring—the first that can be used for an entire year—is a highly effective birth control method, according to clinical trial data that will be presented Tuesday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.
Long-term testosterone therapy can help men with hypogonadism lose weight and maintain their weight loss, researchers from Germany and the United States report. Ten-year results of the ongoing study will be presented Monday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.
The 2019 American Pain Society Scientific Meeting will convene in Milwaukee, April 3-6, and the theme of the conference is "Combating the Opioid Epidemic Through Innovation in the Treatment of Pain.”
A new automated drug delivery system can help prevent dangerously low blood sugar in patients who have undergone weight-loss surgery, according to a study to be presented Monday, March 25 at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.
White women with polycystic ovary syndrome (PCOS) have significantly higher anxiety symptoms compared to black women with the condition, a new study suggests. These symptoms may be related to obesity, according to the research to be presented Monday, March 25 at ENDO 2019, the annual meeting of the Endocrine Society, in New Orleans, La.
Scientists have discovered a novel molecular pathway for an enzyme inhibitor in humans that plays a direct role in the development of high cholesterol and nonalcoholic fatty liver disease, which they then were able to reverse in mice with an investigational drug. The study results will be presented Monday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La., by researchers from Northwestern University Feinberg School of Medicine in Chicago, Ill.
Endocrine disruptors, hormone-altering chemicals that are widespread in our environment, can shape the brain through four generations, altering offspring’s maternal behavior, sexual development and reproduction, according to a new animal study. The results of this study will be presented Monday at the Endocrine Society’s annual meeting in New Orleans, La.
In transgender women who have had their testes removed as part of the gender-affirming process, a form of estrogen called estradiol strengthens connections between areas of the brain involved in fine motor skills, learning, emotions and sensory perception, according a study to be presented Monday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La. These findings reflect changes on the brain that might have implications, for instance, for treating hot flashes and other symptoms in transgender women, the researchers say.
Decreased sperm and testosterone production caused by abuse of performing-enhancing hormones may be fully reversible once men stop taking the drugs, but full recovery can take at least nine to 18 months, according to research to be presented Sunday, March 24 at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.
A new male birth control pill passed tests of safety and tolerability when healthy men used it daily for a month, and it produced hormone responses consistent with effective contraception, according to researchers at two institutions testing the drug. The phase 1 study results was presented Sunday, March 24 at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.
White blood cells known as B cells have been shown to be effective for predicting which cancer patients will respond to immune checkpoint blockade (ICB) therapy, according to a study at The University of Texas MD Anderson Cancer Center. Study results will be presented April 2 at the AACR Annual Meeting 2019 in Atlanta.
Changing when you eat rather than what you eat may prove to be a dietary intervention against breast cancer, suggests a new mouse study to be presented Saturday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.
Older men tend to have lower biological age if they have higher levels of sex hormones, particularly the estradiol form of estrogen, a large new study from Australia finds. The study results will be presented on Sunday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La., and appear online in the journal Clinical Endocrinology.
Walking downhill after eating can reduce bone resorption, the process in which old bone is broken down and removed from the body, in postmenopausal women with diabetes, according to research to be presented Sunday, March 24 at ENDO 2019, the annual meeting of the Endocrine Society, in New Orleans, La. Walking uphill does not have the same benefit, the study found.
The benefits of treating osteoporosis in postmenopausal women outweigh the perceived risks, according to a Clinical Practice Guideline issued today by the Endocrine Society. The Society introduced the guideline during a news conference on Monday at ENDO 2019, its annual meeting in New Orleans, La.
Increasingly aggressive insurance strategies have lowered the total costs and insurance costs of growth hormone drugs, but those savings are not being passed on to patients, according to new research to be presented Sunday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.
Despite an FDA approval of growth hormone treatment for children with idiopathic short stature (ISS), the mean cost burden to patients and their families has increased over time.
Researchers using the world’s largest twin registry to study seven autoimmune diseases found the risk of developing the seven diseases is largely inherited, but that some diseases are more closely related than others. These results will be presented Sunday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.
Endocrine-disrupting chemicals present in household dust promote the development of fat cells in a cell model and could contribute to increased growth in children relative to their age, according to research to be presented Monday, March 25 at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.
Exposure to tiny air pollution particles may lead to reduced sperm production, suggests new research in mice to be presented Monday, March 25 at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.
Exposure to the widely used chemical bisphenol A (BPA) during pregnancy, even at levels lower than the regulated “safe” human exposure level, can lead to changes in circadian rhythms, according to a mice study to be presented Monday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La. The researchers report these changes may be a contributing factor in hyperactivity seen in BPA-exposed mice.
The ketogenic diet recently has been touted for weight loss and improving blood sugar control, but a new study finds that females fail to show these metabolic benefits on this high-fat, very low-carbohydrate diet. Results of the animal study will be presented Sunday at the Endocrine Society’s annual meeting in New Orleans, La.
Burosumab, a new injectable medicine to treat X-linked hypophosphatemia (XLH), an inherited form of rickets, demonstrates superior improvements in rickets and other outcomes compared with conventional therapy in an international, phase 3 clinical trial in children. Results from what investigators called the first head-to-head study comparing the new drug with conventional treatment for this rare disease will be presented Sunday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.
New research suggests a hormone released from fat tissue is critical in the development of obesity-related asthma and may be a target of future treatments for the disease. The findings will be presented Saturday, March 23 at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.
The hormone oxytocin reduces the communication between different brain areas involved in the cognitive, sensory and emotional processing of food cues that people with obesity demonstrate when they look at high-calorie foods, according to research being presented Monday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.
Teens and young adults who were exposed to HIV and antiretroviral therapy before birth but are HIV-negative themselves are at increased risk of obesity and asthma-like symptoms, according to research to be presented Saturday, March 23 at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.
Teens who sit for hours watching TV, using the computer or playing video games while eating unhealthy snacks are at increased risk for a group of risk factors for heart disease and diabetes, according to research to be presented Monday, March 25 at ENDO 2019, the annual meeting of the Endocrine Society, in New Orleans, La.
Exposure to dim light at night, which is common in today’s lifestyle, may contribute to the spread of breast cancer to the bones, researchers have shown for the first time in an animal study. Results of the study will be presented Saturday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.
In recent years, women who start taking bisphosphonates (BPs) to treat osteoporosis and prevent fracture have trended from younger to older and from having osteopenia to having osteoporosis, researchers report. The results of the study will be presented on Saturday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.
When trying to lose weight by cutting calories, people who have obstructive sleep apnea (OSA) in addition to obesity can lose more weight if they treat their sleep disorder with an overnight CPAP, or continuous positive airway pressure, machine. This finding of a new study will be presented Saturday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.
For migraine sufferers with obesity, losing weight can decrease headaches and improve quality of life, researchers from Italy and the United States report. The results of their meta-analysis will be presented Saturday, March 23 at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.
Eating later in the day may contribute to weight gain, according to a new study to be presented Saturday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.
Caucasians and Hispanics with diabetes have a greater risk of fracture compared to those without diabetes, while African Americans with diabetes have little to no additional fracture risk, according to a study to be presented Saturday, March 23 at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.
Obesity may play a role in reproductive problems in women with type 1 diabetes, according to a new study to be presented Saturday, March 23 at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.
Young women are more likely to experience sleep disruption in the days leading up to their menstrual period, according to a new study that will be presented Saturday at ENDO 2019, the annual meeting of the Endocrine Society, in New Orleans, La.
Treating women who have thyroid antibodies, but normal thyroid function, with a medicine called Levothyroxine does not make them more likely to deliver a live baby, new research from the United Kingdom suggests. The research will be presented Saturday, March 23 at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La., and published in The New England Journal of Medicine.
Symptoms of polycystic ovary syndrome (PCOS) improved with exposure to healthy bacteria in the gut, according to a study in a mouse model of this common women’s endocrine disorder. The study results will be presented Monday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.
Many people who use opioid medications long term do not produce enough testosterone or another important hormone, cortisol, according to a new study. Results of what the researchers called “the most up-to-date and most comprehensive clinical review of endocrine effects of long-term opioid use” are being presented Sunday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.
Some cases of recurrent pregnancy loss may be caused by sperm DNA damage in the male partner, rather than by a problem in affected women, according to research to be presented Sunday, March 24 at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.
Transgender men preserve their fertility potential even after one year of treatment with the male hormone testosterone, according to a study that will be presented Saturday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.
Among first-time users of a new insulin pump that automatically delivers insulin to people with type 1 diabetes, nearly one-fifth stopped using the device, primarily because of difficulties meeting the technical demands system, researchers say. Results of a real-world study of the hybrid closed loop insulin pump (Medtronic MiniMed 670G) will be presented Sunday at the Endocrine Society’s annual meeting in New Orleans, La.
Using the hemoglobin A1c blood test to diagnose diabetes tends to underestimate the prevalence of the disease, according to a new study to be presented Saturday, March 23 at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.
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