A new study led by UNC School of Medicine researchers indicates that ozone has a greater impact on asthma patients than previously thought.
Fibromyalgia patients who regularly visit their physicians are much less likely to attempt suicide than those who do not, according to a new Vanderbilt University Medical Center study published in Arthritis Care & Research.
The discovery made by Notre Dame researchers and their collaborators tosses a new wrench into the process of building better molecules to develop immunotherapies
Researchers at University of California San Diego School of Medicine have unraveled new insights into the way cells leverage G-protein-coupled receptors (GPCRs) and their cellular waste disposal systems to control inflammation. The findings, published September 18 in Cell Reports, suggest some existing cancer drugs that inhibit these cellular activities might be repurposed to treat vascular inflammation, which occurs when artery-blocking plaques form in atherosclerosis.
– Primary care clinics experienced a significant decline in influenza vaccinations as the day progressed, researchers from Penn Medicine report in a new study published in JAMA Open Network. However, “nudging” clinical staff to order vaccines using a behavioral economics technique known as “active choice” may help curb some of that drop off, the study suggests. The study is the first to show how clinic appointment times can influence influenza vaccination rates.
A new study published in Annals of Allergy, Asthma and Immunology suggests African Americans have greater treatment challenges with AD than European Americans and require higher doses of some medications to get relief.
In a paper published in the journal Science, researchers have detailed a mechanism that sets the stage for the fate decision that gives rise to two major subsets of effector cells: T follicular helper cells and non-T follicular helper cells, known as Tfh and non-Tfh cells.
Rush is testing whether a vaccine can help people’s own immune system slow the spread of glioblastomas, a deadly form of brain cancer.
Vanderbilt-Ingram Cancer Center researchers have answered questions about the incidence and timing of rare but sometimes fatal reactions to the most widely prescribed class of immunotherapies.
A team led by Marc Ernstoff, MD, of Roswell Park Comprehensive Cancer Center found that a drug complex containing IL-15 is both safe and well tolerated in patients with advanced solid tumors.
Using new bioinformatics tools to analyze thousands of human tissue samples, researchers created a new database of daily rhythms in human gene activity—including many genes that regulate how drugs work. Reporting in Science Translational Medicine, scientists say their results could have significant implications for a growing field of study called circadian medicine.
Researchers at the University of Maryland School of Medicine have made a surprising discovery: during fetal development, a particular immune cell seems to play a key role in determining the male or female characteristics of the brain.
Padmanee Sharma, M.D., Ph.D., professor of Genitourinary Medical Oncology and Immunology at The University of Texas MD Anderson Cancer Center, has been recognized for her innovative work understanding factors that enhance and hinder cancer immunotherapy. Sharma will receive the William B. Coley Award for Distinguished Research in Tumor Immunology, awarded annually by the Cancer Research Institute (CRI), at an annual meeting co-sponsored by CRI in New York Sept. 30 to Oct. 3.
The Cancer Research Institute will bestow its highest honors on three scientists who have made fundamental contributions to the fields of immunology and cancer immunotherapy at its annual taking place on Thursday, October 25, 2018, at The Metropolitan Club in New York City.
he Cancer Research Institute will honor biotechnology company Regeneron, and journalist and filmmaker Perri Peltz with the 2018 Oliver R. Grace Award for Distinguished Service in Advancing Cancer Research at its annual gala taking place on Thursday, October 25, 2018, at The Metropolitan Club in New York City.
Macrophages are immune cells that are supposed to protect the body from infection by viruses and bacteria. Yet Zika virus preferentially infects these cells. Researchers at University of California San Diego School of Medicine have now unraveled how the virus shuts down the genes that make macrophages function as immune cells.
In mouse experiments, scientists have shown a way to hit an immunological “reset button” that ends inappropriately sustained inflammation. This reset reverses the pathologic enlargement and pumping failure of the heart, and it suggests a therapeutic approach to treating human heart failure.
A new article published in Annals of Allergy, Asthma and Immunology, walks allergists and other health care providers through the steps involved in shared decision-making (SDM). It also details what is, and what is not, SDM.
Mayo Clinic physicians Matthew Block, M.D., Ph.D. and Tina Hieken, M.D., have received a Stand up to Cancer (SU2C) Catalyst Award to fund melanoma research and a neoadjuvant clinical trial.
There’s promise in specific immune system peptides – amino acid compounds that signal cells how to function – affecting brain activity.
Paul Brindley, PhD, at the GW School of Medicine and Health Sciences, has received more than $1.7 million from the National Cancer Institute at the National Institutes of Health to investigate the cellular and molecular links between liver fluke infection and bile duct cancer.
A combination of a novel inhibitor of the protein CK2 (Casein kinase 2) and an immune checkpoint inhibitor has dramatically greater antitumor activity than either inhibitor alone, according to research from The Wistar Institute that was published online in Cancer Research.
The August tip sheet from Fred Hutch includes story ideas about next-gen CAR T-cell immunotherapies, cancer care disparities in rural and urban settings, organizing chromosomes in egg and sperm cells, decoding our immune system's memories and more.
Recently published results of a phase 2 clinical trial have shown the best outcomes to date for newly diagnosed older Hodgkin lymphoma patients treated with brentuximab vedotin given before and after doxorubicin, vinblastine and dacarbazine (AVD) chemotherapy, which is the standard of care.
Wistar scientists have applied their synthetic DNA technology to engineer a novel eCD4-Ig anti-HIV agent and to enhance its potency in vivo, providing a new simple strategy for constructing complex therapeutics for infectious agents as well as for diverse implications in therapeutic delivery.
The latest research, features and announcements in healthcare in the Healthcare News Source
A relatively simple effort to provide counseling and connect injection-drug users with resources could prove powerful against the spread of HIV in a notoriously hard-to-reach population, new research suggests.
The role of insulin as a boost to the immune system to improve its ability to fight infection has been detailed for the first time by Toronto General Hospital Research Institute (TGHRI) scientists.
High fever. Cough. Runny nose. Red, watery eyes. It may not be the flu. It could be measles.
The stigma associated with the autoimmune disease psoriasis may lead people to avoid patients who show signs of the condition, including not wanting to date, shake hands, or have people in their homes if they suffer from the disease. New multidisciplinary research involving both psychologists and dermatologists from the Perelman School of Medicine at the University of Pennsylvania is the first to examine how common this stigma may be among the general population of the United States as well as among medical students.
Immune reactions are usually a good thing--the body's way of eliminating harmful bacteria and other pathogens.
Gene therapy holds promise of a potentially safer, more effective path to a cure in infants born without the critical infection-fighting cells of the immune system.Out of every 60,000 births, a baby arrives to face the world without a fully functioning immune system leaving them unequipped to fight even the most common infections.
Mount Sinai researchers have discovered that a particular type of cell present in bladder cancer may be the reason why so many patients do not respond to the groundbreaking class of drugs known as PD-1 and PD-L1 immune checkpoint inhibitors, which enable the immune system to attack tumors.
Researchers at the University of North Carolina at Chapel Hill have found that crowdsourced campaigns can motivated men at-risk of HIV infection in China to get tested.
The immune system appears to put a premium on maintaining lung function in infants infected with the influenza virus by mounting a rapid response to repair damaged cells, according to research led by St. Jude Children’s Research Hospital.
Interactions between radiation therapy and the immune system can improve cancer treatment. The cellular carnage caused by radiation attracts scavengers, such as dendritic cells, that present cancer cell fragments to T cells. This study suggests novel ways to improve treatment by using radiation to boost immunotherapy.
Researchers are reporting the protein/protein interactome of Zika virus and its human host cells with a proteomic approach that gives unprecedented insight into membrane-bound protein interactions. The data reveal a new role for a familiar organelle in viral replication.
A UCLA-led study has found that a treatment that uses a bacteria-like agent in combination with an immunotherapy drug could help some people with advanced melanoma, an aggressive form of skin cancer, live longer.
Scientists at Scripps Research have developed a urine diagnostic to detect the parasitic worms that cause river blindness, also called onchocerciasis, a tropical disease that afflicts 18 to 120 million people worldwide.
The parasites that cause malaria make themselves at home inside a host’s red blood cells. An Iowa State University scientist has shown in a pair of newly published articles just how that process works. This new understanding could help to identify new ways to treat malaria.
The European Commission (EC) has approved a personalized cellular therapy developed at the University of Pennsylvania’s Abramson Cancer Center, making it the first chimeric antigen receptor (CAR) T cell therapy permitted for use in the European Union in two distinct indications.
Best known as a pathogen that causes food poisoning or steals nutrients away from its host, the E. coli bacterium actually plays a critical role in promoting health by producing a compound that helps cells take up iron.
CAR T-cell therapy, which reprograms immune cells to fight cancer, has shown great promise in people with some blood cancers who have not responded to other treatments. But until now, the underlying biological pathways enabling anti-cancer responses have not been thoroughly examined.
An international research group, which included an ISU scientist, has proven that three proteins that can help prevent the spread of HIV can be expressed in transgenic rice plants. Using plants as a production platform could provide a cost-effective means of producing prophylactics, particularly in the developing world.
Researchers at Hospital for Special Surgery (HSS) have discovered that a type of immune cell known as Langerhans appears to play an important role in photosensitivity, an immune system reaction to sunlight that can trigger severe skin rashes.
Muscles of the elderly and of patients with Duchene muscular dystrophy have trouble regenerating. A new nanohydrogel with muscle stem cells has boosted muscle growth in mouse models while protecting the stem cells from immune reactions that usually weaken or destroy them.
Discoveries by two HHMI investigators show how proteins that organize into liquid droplets inside cells make certain biological functions possible.
You may not want to think about fall allergies, but if you start planning now, your allergy symptoms will likely be much less severe, and you’ll be able to enjoy the beauty the fall season brings.
For the first time, Mount Sinai researchers have identified a way to make large numbers of immune cells that can help prevent cancer reoccurrence, according to a study published in August in Cell Reports.
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