Leukemia researchers led by Dr. John Dick have traced the origins of relapse in acute myeloid leukemia (AML) to rare therapy-resistant leukemia stem cells that are already present at diagnosis and before chemotherapy begins.
Researchers worked backwards, employing a series of drugs used in the clinic to understand a new way that cancer stem cells can be killed.
A discovery, described in a recent study by researchers at Beaumont Health, revealed ACL tears send a signal to stem cells throughout our body. This could lead to future breakthroughs to enable stem cells to repair injuries and reduce development of conditions like osteoarthritis.
A new study from the Monell Center and collaborating institutions advances understanding of how stem cells on the tongue grow into the different types of mature taste cells that detect either sweet, salty, sour, bitter, or umami. The findings may someday allow scientists to treat taste disorders, characterize new taste qualities, or even fine-tune a person’s taste perception to encourage healthier eating.
At present, the only FDA approved method of treating glaucoma is to lower eye pressure; this slows the progression of glaucomatous optic nerve damage but does not completely halt it, and certainly does not regenerate damaged nerve tissue.
Researchers believe this is the first study of its kind to reveal the body’s systemic stem cell response to an ACL injury. Osteoarthritis affects more than 30 million adults in the United States. Many cases occur after trauma to a joint. It’s also a leading cause of disability.
University of Colorado Cancer Center study pinpoints promising link in the chain of hedgehog signaling that, when broken, could reduce the metastatic potential of breast cancer.
The University of Illinois at Chicago College of Medicine will launch a new center that will focus on understanding tissue regeneration and pioneering future developments in stem cell biology as a means to repair diseased organs and tissues.
A team led by Igor Slukvin, a University of Wisconsin-Madison professor of pathology and laboratory medicine, and cell and regenerative biology, describes the developmental pathway that gives rise to the different types of cells that make up human vasculature.
A Cedars-Sinai-led team of investigators has successfully repaired severe limb fractures in laboratory animals with an innovative technique that cues bone to regrow its own tissue. If found to be safe and effective in humans, the pioneering method of combining ultrasound, stem cell and gene therapies could eventually replace grafting as a way to mend severely broken bones.
Scientists for the first time have assembled a "disease in a dish" model that pinpoints how a defect in the blood-brain barrier can produce an incurable psychomotor disorder, Allan-Herndon-Dudley syndrome. The findings point to a path for treating this syndrome and hold promise for analyzing other neurological diseases.
A team of scientists from the University of Wisconsin-Madison and Cedars-Sinai in Los Angeles have used the cells of AHDS patients to recreate not only the disease, but a mimic of the patient’s blood-brain barrier in the laboratory dish using induced pluripotent stem cell technology.
Researchers examined the mechanisms of B cell immune reconstitution in pediatric patients who had undergone bone marrow transplantation and discovered a disruption in the maturation of B cells – critical to the immune system – preventing the production of antibodies that fight infection.
A clinical trial to evaluate the safety and efficacy of a stem cell product injected directly into the brain to treat chronic motor deficits from ischemic stroke has begun at McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth).
Patients with double hit lymphoma (DHL) who undergo autologous stem-cell transplantation (autoSCT) after achieving remission are not more likely to remain in remission or live longer than patients who do not undergo autoSCT, according to a new analysis from the Perelman School of Medicine and the Abramson Cancer Center of the University of Pennsylvania.
New lung “organoids”—tiny 3-D structures that mimic features of a full-sized lung—have been created from human pluripotent stem cells by researchers at Columbia University Medical Center (CUMC). The team used the organoids to generate models of human lung diseases in a lab dish, which could be used to advance our understanding of a variety of respiratory diseases.
Researchers at the University of Cincinnati (UC) have found that a cancer stem cell vaccine, engineered to express a pro-inflammatory protein called interleukin-15 (IL-15) and its receptor (IL-15Ralpha), caused T cell production in animal models and enhanced immune responses against tumors.
Twenty years after undergoing a life-saving treatment at Loyola University Medical Center, cancer survivor Carolyn Gatenby returned to Loyola to donate 20 handmade quilts. “I wanted to give back,” Mrs. Gatenby said. “I’ve had 20 good years that I didn’t think I’d have.”
Engineers at the University of California San Diego have developed biomimetic bone tissues that could one day provide new bone marrow for patients needing transplants.
Scientists at The Scripps Research Institute (TSRI) have discovered why some cancers may reoccur after years in remission.
Researchers at Indiana University School of Medicine have successfully developed a method to grow inner ear tissue from human stem cells—a finding that could lead to new platforms to model disease and new therapies for the treatment of hearing and balance disorders.
Cell therapy company jCyte has received Regenerative Medicine Advanced Therapy designation from the FDA for their developmental retinitis pigmentosa therapy.
UCLA study identifies a potential test that may help select patients for whom combination therapy could be most effective
A new $5 million challenge gift aims to boost scientific research on bipolar disorder, while honoring the legacy of an automotive pioneer who battled the condition during his life.
A gene previously identified as critical for tumor growth in many human cancers also maintains intestinal stem cells and encourages the growth of cells that support them, according to results of a study led by Johns Hopkins researchers. The finding, reported in the Apr. 28 issue of Nature Communications, adds to evidence for the intimate link between stem cells and cancer, and advances prospects for regenerative medicine and cancer treatments.
Using CRISPR technology, a team of researchers led by Farshid Guilak, PhD, at Washington University School of Medicine in St. Louis, rewired stem cells' genetic circuits to produce an anti-inflammatory arthritis drug when the cells encounter inflammation. The technique eventually could act as a vaccine for arthritis and other chronic conditions.
A team of scientists led by Lorenzo Puri, M.D., Ph.D., has identified a previously unrecognized step in stem cell-mediated muscle regeneration. The study, published in Genes and Development, helps explain why muscle stem cells lose the ability to generate new muscle as they age and provides insight into accelerated muscle stem cell aging in muscular dystrophy.
On Monday, April 24, the Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research at Albert Einstein College of Medicine will host its third Stem Cell Symposium, focusing on the importance of cell metabolism and epigenetics. Leading scientists from the U.S., Japan and Germany will present their latest research and describe the hurdles to translating new finding into therapeutics.
New research by scientists at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA overturns a long-standing paradigm about how axons grow during embryonic development. The findings of the study, led by Samantha Butler, associate professor of neurobiology, could help scientists replicate or control the way axons grow, which may be applicable for diseases that affect the nervous system, such as diabetes, as well as injuries that sever nerves.
Cell-based therapy company jCyte is launching a Phase 2b clinical trial to study the effectiveness of its developmental therapy for retinitis pigmentosa.
Two Iowa State research groups are combining their expertise to change stem cells for nerve regrowth. The groups -- one led by a mechanical engineer and the other by a chemical engineer -- just published their findings in Advanced Healthcare Materials.
St. Jude Children’s Research Hospital study examines origin of blood stem cells during development and offers clues for making “donor blood” in the laboratory for therapeutic use
Researchers from the University of Illinois at Chicago have identified a molecular switch that converts skin cells into cells that make up blood vessels, which could ultimately be used to repair damaged vessels in patients with heart disease or to engineer new vasculature in the lab.
In a new paper, a large team of researchers led by senior author Kelly Frazer, PhD, professor of pediatrics and director of the Institute for Genomic Medicine at University of California San Diego School of Medicine describe a new collection of 222 systematically derived and characterized iPSC lines generated as part of the National Heart, Lung and Blood Institute’s NextGen consortium.
Encouraging more high school students to pursue careers in agriculture—that’s the idea behind USDA iLEARN professional development workshops for science and ag teachers.
Two prominent Cedars-Sinai investigators — one leading the development of biological treatments for heart disease, the other spearheading the design and analysis of clinical trials for cancer research — were inducted April 3 into the Johns Hopkins University Society of Scholars. Eduardo Marbán, MD, PhD, and Steven Piantadosi, MD, PhD, are among a select group of medical researchers to receive the honor.
Phase I clinical trial evaluating safety of neural stem cell transplantation being expanded to four more qualifying participants.
Researchers at Case Western Reserve University School of Medicine have successfully grown stem cells from children with a devastating neurological disease to help explain how different genetic backgrounds can cause common symptoms. They identified individual and shared defects in the cells that could inform treatment efforts.
Researchers from Case Western Reserve University School of Medicine have developed a breakthrough technique to harvest cells directly from urine, and grow them into durable, clinically relevant stem cells to study Down syndrome.
Scientists at the University of Wisconsin-Madison are using the decellularized husks of plants such as parsley, vanilla and orchids to form three-dimensional scaffolds that can then be primed and seeded with human stem cells to optimize their growth in the lab dish and, ultimately, create novel biomedical implants.
Using a technique that avoids the use of high-dose chemotherapy and radiation in preparation for a stem cell transplant, physicians at the University of Illinois Hospital & Health Sciences System have documented the first cure of an adult patient with congenital dyserythropoietic anemia.
The Galat laboratory at Stanley Manne Children’s Research Institute, Ann & Robert H. Lurie Children’s Hospital of Chicago, has developed an elegant system to derive blood cell precursors from human pluripotent stem cells (hPSC). This type of stem cell has the potential to develop into many different kinds of cells in the body, and is capable of participating in organ repair and function. These qualities have prompted scientists to test the use of hPSC to treat some diseases. However, the development of a fully defined system to generate functional blood cell precursors has proven to be a significant challenge. The Galat lab’s findings hold promise to overcome this challenge.
The effect of multipotent adult progenitor stem cells on stroke recovery were the focus of two recently published papers that include researchers at the Institute for Stroke and Cerebrovascular Disease at The University of Texas Health Science Center at Houston (UTHealth).
A new study published in the journal Stem Cells demonstrates how electroacupuncture triggers a neurological mechanism that can help promote tissue repair and relieve injury-induced pain. The findings provide the most comprehensive picture yet of how electroacupuncture stimulates the brain to facilitate the release of stem cells and adds new insight relating to the cells’ healing properties.
A discovery, several years in the making, by University at Buffalo researchers proves that adult skin cells can be converted into neural crest cells (a type of stem cell) without any genetic modification, and that these stem cells can yield other cells that are present in the spinal cord and the brain. The applications could be significant, from studying genetic diseases in a dish to generating possible regenerative cures from the patient’s own cells.
An international research team, led by scientists at University of California San Diego School of Medicine, has created the first cellular model of anorexia nervosa (AN), reprogramming induced pluripotent stem cells (iPSCs) derived from adolescent females with the eating disorder.
Intestinal stem cells rejuvenate daily so bowels will stay healthy and function normally, but a new study in Cell Reports suggests they also age along with people and lose their regenerative capacity. Reporting their data online March 14, researchers suggest that reactivating the signaling of a key molecule lost in aging intestinal stem cells could restore healthy intestinal function in older people.
Mount Sinai study on psychosis reveals the importance of clarifying the precise structure of any genetic mutation before moving forward with human-induced pluripotent stem cell studies
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