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Medicine

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Dna Methylation, Genetics, Cancer

Harnessing Cancer’s Methylation Footprint for More Precise Diagnosis and Prognosis

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In a new study, researchers at University of California San Diego School of Medicine, with colleagues in Xijing Hospital and Sun Yat-sen Cancer Center in China, report that DNA methylation can provide effective markers for at least four major cancers, not only correctly differentiating malignant tissues from normal, but also providing information on prognosis and survival.

Medicine

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proteogenomics, NCI, Cancer

Grant Establishes Proteogenomics Center at U-M

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Researchers at the University of Michigan will lead one of five nationally funded centers dedicated to accelerating research into understanding the molecular basis of cancer and sharing resources with the scientific community.

Medicine

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Heart Disease, Stroke Risk, Genetic Mutation, Stroke, Heart, Ut Southwestern

Skin Cell Model Advances Study of Genetic Mutation Linked to Heart Disease, Stroke Risk

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Using a new skin cell model, researchers have overcome a barrier that previously prevented the study of living tissue from people at risk for early heart disease and stroke. This research could lead to a new understanding of disease progression in aortic aneurysm – ballooning of the large artery in the chest that carries blood from the heart to the body.

Medicine

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Retinitis Pigmentosa, hispanic health disparities, Hispanic, southwestern united states, Eye Disease, Genetics

Gene Mutation Linked to Retinitis Pigmentosa in Southwestern U.S. Hispanic Families

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Thirty-six percent of Hispanic families in the U.S. with a common form of retinitis pigmentosa got the disease because they carry a mutation of the arrestin-1 gene, according to a new study from researchers at The University of Texas Health Science Center at Houston (UTHealth) School of Public Health.

Medicine

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Icahn School of Medicine at Mount Sinai, The Mount Sinai Hospital, Mount Sinai Health System, myeloid cells, alzhiemer's disease, Alzheimer's Disease, Epigenetic, epigenetic alterations, APOE, PU.1, late-onset form, brain networks, Microglia, Macrophage, phagocytic activity

Risk of Developing Alzheimer’s Disease Linked to a Network of Genes Associated with Myeloid Cells

Mount Sinai researchers find this network central to Alzheimer’s disease susceptibility

Medicine

Science

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Cloning, genes, genetic sequencing, genetic, Health, Medicine, Genome, Human Genome, DNA, Proteins, Biology, Science, Genomics, Engineering, Biomedical Engineering, E. Coli, Bacteria, Animals, Plants, Microbes, LASSO probes, LASSO , Microbiome, human microbiome, Pharma, Pharmaceuticals, Drugs, Precision Medicine, Rutgers University, Rutgers, New Jersey, NJ

Cloning Thousands of Genes for Massive Protein Libraries

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Discovering the function of a gene requires cloning a DNA sequence and expressing it. Until now, this was performed on a one-gene-at-a-time basis, causing a bottleneck. Scientists at Rutgers University-New Brunswick in collaboration with Johns Hopkins University and Harvard Medical School have invented a technology to clone thousands of genes simultaneously and create massive libraries of proteins from DNA samples, potentially ushering in a new era of functional genomics.

Medicine

Science

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Epigenetics, epigenetic reprogramming, genes, Adolescence, Binge Drinking, Brain Development, Brain Chemistry, Psychiatric Problems, early life experiences

Genes Are Not Fixed, Experience and Exposure Can Change Them

Epigenetics refers to how certain life circumstances can cause genes to be silenced or expressed, become dormant or active, over time. New research shows that adolescent binge drinking can lead to epigenetic reprogramming that predisposes an individual to later psychiatric disorders such as anxiety. These data will be shared at the 40th annual scientific meeting of the Research Society on Alcoholism (RSA) in Denver June 24-28.

Medicine

Science

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Cells, Aging, Telomeres, heaving drinking, biological aging, cellular level, telomere shortening, thiamine deficiency

Drinking Makes You Older at the Cellular Level

The more alcohol that people drink, the more their cells appear to age. In a new study that will be shared at the 40th annual scientific meeting of the Research Society on Alcoholism (RSA) in Denver June 24-28, researchers found that alcoholic patients had shortened telomere lengths, placing them at greater risk for age-related illnesses, such as cardiovascular disease, diabetes, cancer and dementia..

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Cancer Cells May Streamline Their Genomes in Order to Proliferate More Easily

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Research from the Stowers Institute provides evidence suggesting that cancer cells might streamline their genomes in order to proliferate more easily. The study, conducted in both human and mouse cells, shows that cancer genomes lose copies of repetitive sequences known as ribosomal DNA. While downsizing might enable these cells to replicate faster, it also seems to render them less able to withstand DNA damage.

Medicine

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Biology, Biotechnology, Developmental Biology, Regenerative Medicine, gastrointestinal disease, Colon, Cell Biology, Genetics, human pluripotent stem cells, CELL STEM CELL, Cell Press , Science, Research, Cincinnati Children's Hospital Medical Center, National Institutes , Pediatrics, press release, press release distribution, Children

Lab Grown Human Colons Change Study of GI Disease

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Scientists used human pluripotent stem cells to generate human embryonic colons in a laboratory that function much like natural human tissues when transplanted into mice, according to research published June 22 in Cell Stem Cell. The study is believed to be the first time human colon organoids have been successfully tissue engineered in this manner, according to researchers who led the project.







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